180 - AMA #28 [sneak peek]: All things testosterone and testosterone replacement therapy
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- Опубліковано 7 сер 2024
- In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to testosterone: what happens when testosterone levels are low, and the potential benefits and risks of testosterone replacement therapy (TRT). They explain the physiology of testosterone, how it works, and how its level changes over the course of a person's life. They have a detailed discussion about existing literature, which reveals vast potential structural, functional, and metabolic benefits of testosterone replacement therapy. They also take a very close look at potential risks of this therapy, with a focus on the controversial effects on cardiovascular disease and prostate cancer.
In this sneak peek, we discuss:
00:00 - Intro
00:10 - A primer on the hormone testosterone and how it influences gene expression
09:00 - How the body naturally regulates testosterone levels
In the full episode, we also discuss:
-The defining threshold for "low testosterone," how low T impacts men, and why free testosterone is the most important metric;
-When it makes sense to treat low testosterone;
-The structural and metabolic benefits of testosterone replacement therapy;
-Body composition changes with TRT;
-Changes in bone mineral density with TRT;
-The metabolic impact of TRT: glucose, insulin, triglycerides, and more;
-A study investigating testosterone replacement therapy for prevention or reversal of type 2 diabetes;
-The impact of TRT on metabolic parameters and body composition-A study comparing results from continuous vs. interrupted treatment;
-The controversy over TRT and cardiovascular disease;
-Two flawed studies that shaped perceptions of risks associated with TRT;
-The controversy over TRT and prostate cancer;
-Other potential risks with testosterone replacement therapy; and
-More
Show notes page: peterattiamd.com/ama28/
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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I really wish everyone had access to the full pod cast especially when I comes to trt. Please do more on TRT
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience symptoms like I use too experience, I now have strong Erections
Amazing content Dr. Attia. Need to resubscribe soon, didn't realize AMAs go this well into detail!
Peter is the man. Thank you sir!
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ........
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience symptoms like I use too experience, I now have strong Erections
Thanks Doc, I have been waiting for this!!!!!! God bless ya
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ......
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience symptoms like I use too experience, I now have strong Erections
People wanna watch your stuff but people aren't gonna subscribe just to see this video. Sometimes it may be worth releasing something that could be super appealing to a large audience where everyone can listen to the whole thing. That would bring more subscribers than teasing a little bit expecting people to sub for that. Hate to see such good content under viewed.
Eat meat.... Fatty meat
I take 15 mgs of exogenous testosterone per day
You found this video by accident, I bet. Dr. Attia has so much amazing content that this comment is borderline hilarious. Subscribe. You will not be disappointed.
I subscribed because of this an sneak peak. I wish I could have just bought this episode but it's okay
Just pay the 8 bucks or whatever, dude. lol
Great video, really appreciate the insight especially from a nurse that is on trt. thanks! Im 28 male, low T, suffering from panic attacks and mental decline for the last 2 years, bout to start trt cyp next week. wish me luck...
Might wanna add a cycle of HGH and nolvadex every now and then to not permanently lose testicular function on the long term if you plan on using it permanently..
@@Kaizen747 hgh or hcg?
How’d you end up doing?
Best of luck!
Peter got one thing wrong here. The negative feedback to the hypothalamus comes from estradiol, not from testosterone. This is why men can use aromatase inhibitors and selective estrogen reuptake modulators to increase gnh/LH/testosterone levels.
🤔
Who is Bob? Why not provide an introduction. Thanks.
His research assistant from the very inception of the podcast.
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ........
What is number of the episode for female HRT?
Love the Senna helmet in the background
Where would you recommend someone going to start this process? Regular doctor, Hormone specialist? Hard to find the best place to go in my area...
Marek Health is a great start. They do everything online
we need more on what happens to people on medication who have low t from it,and then how to restart
Numbers are helpful but symptoms are the most important. Ranges of hormones on labs are nothing more than averages and not a standard of what is optimal. Ranges include sick men and women
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience symptoms like I use too experience, I now have strong Erections
Nice video
Does TRT hurt your heart/affect your lifespan?
I think it's time for another appearance on Rogan !
long overdue!
Nah… i rather watch him here
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ......
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience Symptom's like I use too experience, I now have strong Erections
A Nordiques cap, awesome
Sweet hat Bob!
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ......
I can't see real good... is that Joel Sakic over there? 😁
yessss!!!
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ......
Cholesterol....... Pregnenolone...... DHEA...... Testosterone
➕①②①⑥②③⑨⑥④⑨③📍☎️...
ͲᎻᎪΝХ ҒϴᎡ ᏔᎪͲᏟᎻᏆΝᏀ
ՏᎬΝᎠ Ꭺ ᎠᏆᎡᎬᏟͲ ᎷՏᏀ ᎡᏆᏀᎻͲ ᎪᏔᎪᎽ ϴΝ ᏔᎻᎪͲᎪՏᏢ
➕❶②①⑥ ❷③⑨ ⑥④❾③
ҒϴᎡ ᎷϴᎡᎬ ͲᏆᏢՏ ᎪΝᎠ ՏႮᏢᏢϴᎡͲ......
Cats....dogs.....birds.......fish....
@@sallypointer4223 Those are the steps in the testosterone chemical pathway haha
Nice Nordiques hat
I'm 34 year old man with 3 children. I would say I'm healthy however do have quite a bit of stubborn fat around mid section I can't get rid off. This year I have lost 3 stone just from intermittent fasting and feel much healthier. I recently had 2 sex hormone blood tests a month apart and both came back with very low testosterone, however I don't have the typical symptoms of low T. For example I have a very high sex drive/libido and have high quality sperm. The issue I'm having is no matter how hard I work in the gym I can't seem to gain much muscle or lose weight. I eat lots of meat, fish, liver, eggs, yogurt and a small amount of carbs. I take supplements including vitamin D, B vitamins, Boron, Zinc, Magnesium and some other supplement that supposedly support healthy T levels. So basically I'm doing everything I can to raise T but it's not working. What am I not doing right?
Can you recommend someone in Las Vegas to see? The anti age clinics just aren't good enough.
Hi, I would love to hear how testosterone generates/metabolizes in people with uteruses - and also the effect of taking exogenous testosterone for us. Thank you for the informative video I learned a lot and my curiosity is thoroughly piqued
The healing rate of my Testosterone level increased very fast after I used the super herbs I got from Dr Igho UA-cam channel, he gave me a good impression that it is gonna work & it did work because right now I no longer experience symptoms like I use too experience, I now have strong Erections
"People with uterus's"? You mean women?
I been on TRT for 6 weeks
Before my treatment i used a couple T support and even Canadian Pine Pollen. L Arginine. L Carnitine L Glutamine Creatine. and Borron. Vitamine ABCDEFish and Zink But my T didn't go more than 320
Finally my endocrinologist prescribed me Androgel 40.5 daily.
I hope i go over 400 with Androgel
You should try to get injections. You can do them once a week. Even with an insulin syringe... (Don't even feel it) and is far better than the gel. The gel has to be applied daily. It stinks. It's greasy, and not much gets absorbed through the skin, and it's not as easy to maintain a stable level with the gel. It's a lesser medication. But the Pharma companies make a killing on the gel v. Testosterone Depot.
Please, please, please don't perpetuate the conventional wisdom whereby testosterone and TRT apply only to men. I heard your podcast with Drs. Bluming and Tavris and I bought their book shortly thereafter. If I'm not mistaken, testosterone is never mentioned in that tome. Thankfully, my doctor was not so rigid on the topic and a small dose has made ALL the difference in how I feel as a menopausal woman.
➕①②①⑥②③⑨⑥④⑨③📍☎️...
How small? My wife had a hysterectomy and is suffering.
@@jeffk.2736 I don't know the exact dosage, but women in their prime only make something like 10% of the amount that men make, so the dose in women's hormone replacement therapy (HRT) would be pretty small. My doctor recommended pellet therapy, which is inserted under skin for slow release for 3-4 months. The company that makes the pellet I use is called Biote, so you might look that up for more info on their approach (this is not a sales pitch for them; just one resource you could read up on). I have to pay out of pocket, but it's only about $100 per month, and worth it. Thanks for caring about your wife's symptoms! No two women are the same and her experimentation might take awhile, but don't give up.
But now your balls will shrink