You are such an excellent teacher. I'm a musician and college professor with no science background other than an intense interest in health for both my family and my career longevity. Not only could I follow this, but it beautifully connected and added depth to so many concepts I've been exploring. I can't thank you enough for your intellectual generosity and public service.
Ben Bikman is a living legend and living god for worldwide human race...who will share this knowledge free of cost and why is ben doing it free of cost... because deep inside he is a good human being born to beautiful mother and father who instilled these values of sharing and helping fellow humans since he was a child ...I'm sure Ben has immense gratitude for his upbringing and his mother and father guidance throughout his childhood and adulthood which has shaped him to be what he is now ...love hearing your classroom sir ...God bless you
It’s thinking how awesome it must be for Dr Bikman to teach over two hundred thousand of us who just want to know more about health, take control of our bodies and be well. No other reason, not to get a grade, a degree, get credits. You’re amazing Professor, and I am so grateful.
Absolutely Excellent! I’m understanding how my body built up the fat and what I’m actively doing now within the cell… Burning it!! I’ve listened 3 times at 25 minutes in… You are the best teacher and guide. I have been looking for you 20 years! SOOO happy to be apart of InsulinIQ! Can’t wait for the next year to unfold thanks to you changing my life! Cyndee
I heard a alleged medical expert on fat metabolism on Dr. Berry's channel this week and was horrified at the incorrect information she spewed and that Dr. Berry would give her a voice. I'm so THANKFUL for your generosity in educating me so I know when I hear WRONG information, half truths and theories based on just a notion instead of the real hard researched science.
Yep saw that. I think she’s spot on about seed oil toxicity but nothing trumps chronic high insulin as a metabolism killer. However seed oil consumption and the inflammatory state it causes should not be overlooked.
This is a breathtaking lecture and high-level, invaluable information most influencer and UA-cam metabolic-informed channels do not explain. Dr. Bikman should be charging money for this kind of information. God bless him.
Dr Ben, I love your each and every show, The most interesting part of your shows are reading, what people write about you, You are such a humble man and your teaching is so brilliant, that I feel like going back to school, at the age of 58 years old. Thank you so much.
I have only a very limited science background, but I could follow you all the way, with only the odd bit here and there I had to stop and go back over. I'm so glad you explain things so well, Ben, it must be an honour to be one of your students.
Thank you Dr. Bickman, you are a masive contributor to my carnivore journey back to health. Please keep up your excellent work. Stuart from Melbourne AU.
Will be revisiting this episode frequently to insure that I've taken it in thoroughly. As a linguist, I appreciate your precision with the definition and use of words, closing doors and windows to possible confusion and conflation. As a T2D in remission, I am both grateful for the deep, "owner's manual" level of education you offer and for how this piques my curiosity to keep learning and to dive deeper. Most of all, thank you for your time and willingness to share your expertise.
Thank you so much, Doctor. Yes this is very deep. As a complete layperson, I can grasp most of it if I really pay attention and listen a second time on another day. I appreciate this information so much. Myself, my family and even three generations back have struggled with obesity. It is good to understand the mechanisms. I have completely reversed pre diabetes, fatty liver, high BP, but the excess 50 lbs of fat defy me at every turn. 63 yr old female, 5'3". I would love to eliminate the excess fat. I am working at increasing insulin sensitivity.
Great explanation! Thanks Dr. Bikman! Now I'm able to find errors in texts I'm reading, like this sentence: "Dietary intake of saturated fat has been shown to increase serum ceramide and increase insulin resistance." in Wiki article about ceramides.
I have read many books, I listened to many UA-cam videos by many of the worlds leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.
OK, you opened another rabbit hole for me, one that sounds near and dear to you. Ceramides and sphingolipid family. I want to know more details as it this appears to be a primary key holder! Pathway interactions, how and where they fit! Sounds like you would be the perfect one to lead the way in informing us.
QUESTION TO YOU DR. BIKMAN: Here is my take away. You are saying in a nutshell that high insulin over long periods of time leads to insulin resistance. The inference is that insulin resistance IS ALSO a problem. But I am confused. Ultimately, it is high BLOOD GLUCOSE that defines a person as a diabetic and causes the body to, basically rot. In my understanding, insulin resistance is a FABULOUS PROTECTIVE MECHANISM for each cell - the bouncer so to speak. If the cell is keeping out a fuel source, be it glucose or fat, it is because the cell is either FULL and taking in more would be damaging, OR the cell is not yet ready to take in more fuel. Why a cell may keep out fuel even though it has room to store more stems from complications based on eating a mixed diet of carbs and fat together. As I understand that complication, it is that a cell needs to control the composition of the fuel source inside the cell. At one end of the spectrum, if there is only fat inside the cell, and a fat cell is knocking at the door wanting to get in, PLUS there is room in the cell for more fuel, the bouncer lets the fat in, no problem. If there is glucose in a cell and glucose is at the door knocking to get in, sure, plenty of room, the bouncer lets it in. NO INSULIN RESISTANCE in these examples. BUT if the cell is using fat and glucose is at the door, the bouncer will keep out the glucose until the cell is drained of fat, THEN it will let the glucose in. And the waiting game, all the time it takes to drain a cell of one fuel source before the other can enter, this leads to degeneration, fatigue, AND because there still exists the problem of high blood glucose, the body is basically slowly embalming itself as the sugar dehydrates everything it comes in contact with. I am a Korean Natural Farming - we make farming inputs by mixing equal parts brown sugar to plant material in order to extract the liquid from the plant material; this works based on the principle of osmotic pressure, and this is what diabetes is to my understanding. What artificial insulin injections do is arm all the glucose in the blood with a battering ram so glucose can FORCE its way into cells, REGARDLESS of whether or not the cell is full, REGARDLESS of what fuel source is already occupying the cell. For cells containing fat, the mixture of fat and glucose is like mixing diesel and ethanol fuel in the same fuel tank - it's very very bad - IT'S INFLAMATION (cell damage) - it's early cell death. Artificial insulin DOES keep down blood glucose but the tradeoff seems to be a slow degenerative death spiral. My conclusion is that a 100% carnivore diet IS our species specific diet. I am so novice to this subject. Please, if it is not too much trouble, correct me where I am misunderstanding.
So, please correct me if I am wrong, to summarize: Feeding on carbs every 3 hours sustains a high insulin level throughout the day. Extended high insulin is toxic as it prevents the use of fat as a fuel and promotes the conversion of carbs to fat for storage. You therefore can't use your fat, get repeatedly hungry and store yet more of what you eat. If the fat cells have maxed out and become insulin resistant due to the presence of ceramides then the new fat is stored in muscle cells and the liver. This metabolic imbalance leads to T2D and fatty liver disease. Annedotally, this condition also appears to be implicated as the root cause of CVD, cancer, mental illness from anxiety and depression through to the psychoses as well as the range of neurodegenerative diseases. ( Perhaps seed oils, oxalates and plant sterols are in there as well?) The cure is to keep the consumption of carbs to a minimum and then to allow long gaps, perhaps 5 or 6 hours, between such consumption to allow insulin to fall and the burning of fat as a fuel to resume. I am guessing that snacking on protein throughout the day would also cause insulin toxicity as it will lead to sustained gluconeogenesis and raised blood sugar levels/insulin. Perhaps eat one protein rich meal in the evening and otherwise focus on fat rich food for breakfast and lunch such as bacon, eggs, butter, cream and cheese?
Thank you, Dr. Bikman! QUESTION/REQUEST: Would you please address how long it takes to reverse insulin resistance? I guess it will be a range as people are different, but many people struggle with feeling like their efforts are not moving the needle much- despite going very low carb. I think it is fairly slow compared to lowering hyperinsulinemia and glucose- which is already 3-6 months. Needing some perspective!
We need a meter that can measure insulin but unfortunately they haven’t come up with one yet. All we can do at this point is get a fasting insulin test at a lab and check our blood glucose levels at home. It’s frustrating not to know. But if your BP is good, your A1C is good etc that’s an indicator that you’re getting better. It took me about six months of weight loss to get off meds. I had to lose a good amount of weight before I started getting results. No sugar, no alcohol and very low carb plus intermittent fasting worked for me. No processed food and no seed oils will cure a lot of problems.
Keep doing fasting insulin tests half yearly and measure it by that. I also think I heard someone comment that if you don't do a fasting insulin test that the triglycerides and HDL numbers will show the insulin levels coming down. Triglycerides are an inflammation marker so if they are coming down that's a good sign. 😊
I have been watching you for about 7 or 8 months now. I give recommendations to everyone I interact with who has diabetes as I do. I have been eating a carnivore diet for almost 11 months. My last fasting insulin was 5.3😍. However , I still am very insulin resistant. I was having improvement but after a recent colonoscopy my sugars have elevated into the 200-300 range and stay there and my inflammation is through the roof (again). I know that my diet is low enough in carbs that it should not be elevated like this. I am also exploring the MTHFR gene mutation theory but I am wondering if this has to do with my gut. Both parents are/were T2D and my son is also and one daughter is prediabetic. Could you please give me suggestions? Maybe links to more videos? I have been on this journey since having a bad experience with Ozempic it left me with optic neuropathy in both eyes so I am low vision (legally blind). So I am taking back control of my own health. Thank you so much for your generosity in educating the masses ❤️
Fascinating! Thank you for this episode, which I found particularly enlightening. I appreciate that imaging is not your field, but I found myself asking whether the difference between triglycerides, diglycerides and ceramides would be apparent on MRI images. The difference between athletes and obese people is readily apparent, as the muscle and fat appear (more or less) as black and white, and the sarcopaenia in diabetes and obesity is also clear. Sadly, such incidental findings are not documented in radiology reporting. And yet, I wonder how much more could be interpreted from an image, in terms of the tissue composition, ratio of muscle to fat, or, even more specifically, the types of fat, and what that tells us about metabolic health. Are we missing an opportunity here?
(~28m) Nice explanation of ketone generation: liver buring fat because insulin in low. This also makes home monitoring of insulin level (or sorts) obvious: if you are generating endogenous ketones, insulin is low enough for fat cells to release. Also really understandable following explanation of high fat high insulin harm!
I agree and sent Dr. Bikman a question regarding this. Especially the relationship between topically applying this and their effects on the body's production of ceramides since the skin is the largest organ and toxins are absorbed through our skin.
@insuliniq Ben: I beg you to read these research articles. They match perfectly with what you're saying about the dangers of high carb/ high sugar/ frequent booze. I agree we're getting more insulin resistant, BUT those "manmade carbs" & sugars or frequency of alcohol are actually depleting our B1 thiamin during krebbs cycle! Actually very common mimicking other diseases as the first article says. -"Hiding in Plain Sight: Modern Thiamine Deficiency" -"Sugar intake and thiamine" BY DERRICK LONSDALE MD, FACN, CNS -"Thiamin Deficiency (Beriberi; Vitamin B1 Deficiency)" By Larry E. Johnson, MD, PhD -"A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI" -"Wet Beriberi Associated with Hikikomori Syndrome"
02:30 How about "glucotoxicity"? After all, glucose is the molecule that the body will do anything to get out of the blood stream, and even when it has entered a cell, as I understand it, it more or less immediately gets phosphorylated to glucose 6-phosphate.
first, not anything. he body keeps producing glucose, even if i is in small amounts.The brain likes to run on at leas10..20% of its energy consumption on glucose. Second, glucose is weakly toxic, as it causes glycation, mainly of proteins. I s reflected in the hbA1c. It cause stiff connective tissue, from eyes, to arteries, and tendons. These processes are extracellular, hence it is not a classic toxin in the more narrow sense. Those are working intracellular, causing the death of cells
This was really great, I have listened to all these videos in order and I can see how everything ties together. Triglycerides have been the biggest suspect but it doesn't make sense anymore. If insulin isn't chronically elevated then it's not causing harm. Wow!
Hago una pregunta. Entonces la acumulación de grasa visceral que en principio suponemos que es perjudicial en atletas de largas distancias no tiene relación con la lipotoxicidad? Quiero decir que en ese caso, esa marmolización en el musculo del atleta de larga distancia no es perjudicial? Muchas gracias y no deje usted su labor informativa.
Dr Bikman what do you think about the personal fat threshold concept of dr. Roy Tailor? We know that each person has its own "capacity" of wealth subcutaneous fat accumulation and that once its exceeded we start to deposit it in ectopic places like liver and muscle. The extremes are the super obese people x the ones with lipodystrophy. Another thing. Have you seeing the studies from Amra medical using fast mri of whole body and linking subc X visceral fat with cardiovascular outcomes?
great job. Thank you. If able, why do you think my fasting sugar is going up 130 to 200 to 240 in the morning. I am on strict water, carnivore, salt. It seems as though my insulin levels have dropped to the point where even without any carbs, my sugar is remaining high per my CGM. I was hoping my sugar would have dropped, not increase. 50/50 protein fat ratio. For one month now, and little weight loss. BMI 38. Sending this info as an opportunity to review the carnivore diet for diabetics. Is there a way to restart my insulin resistance?
Dave Feldman talks on his podcast about energy balance and why it's important to have glucose for energy and that it's very common and expected that when people are on a low-carb diet for a long period of time they actually become insulin resistant they say that sugar is not the cause of insulin resistance but that keeping a low energy diet such as keto or carnivore causes insulin resistance because it's not being triggered properly
Good morning, I have a question. Why since starting carnivore is my fasting blood sugar 129? I have been on this diet 2 week today and my blood sugar has risen a lot even in a fasting state. I noticed I was getting headaches this last week, thought it was using a tiny amount of stevia or even the sugar content in cottage cheese, but it seems my glucose levels have risen and are staying there without even eating. When I do eat (3 hours) after, my glucose is 138 not a huge jump but still really high considering. My liver prior to starting this diet was (I was told by my physician) sequestering all the sugar I was eating causing me to be hypoglycemic. Each time I ate it would fall from fasting 90's to around 60 causing me to pass out. That's why I started this diet to correct all the autoimmune issues my body is dealing with. Now my glucose is high at all times. I'm confused as to why this is happening; can you please explain this and tell me what I'm doing wrong? Is this normal and will it stabilize? I was afraid to eat before now I have a headache all the time. Thank you so much for your time.
Dags turn on pkc. Saturated fats overwhelm complex 2, causes a backup and starts the ir cascade. The athletes don't have disabled pyruvate dehydrogenase or actived randle cycle
Two question, sir: First, If we inject insulin intramuscularly, does it bind to that muscle's IR more than it would bind to the IR on adipocytes? Second: Bodybuilders sometimes use insulin while cutting, Is it the case that due to their number and size of adipocytes with respect to their skeletal myocytes, the insulin would help their muscles to consume the carbohydrates available in the blood much more than the adipocytes storing them?
Are the ceramides in meat and dairy also contributing to insulin resistance..or just the ceramides produced by liver because of insulin resistance ? (Sorry i don't have a background in biology)
How do insoluble and soluble fiber contribute to insulin resistance? They are shown as carbs. Is pectin or other insoluble fibers as insulin generating as resistant starch? Does amylose starch fermented in the colon cause insulin resistance? Thanks
Excellent video! Clarified so much for me, but I do still have one curiosity. When going though fatty liver disease scenario where both free fatty acids and insulin high, the fat cells are releasing the free fatty acids due to insulin resistance, but then the liver/ muscle can’t burn the fatty acids as a result of the high insulin - could anyone explain whether the liver or muscle can also become resistant and therefore “ignore” the signal telling them to store it and instead continue burning it? Are fat cells more sensitive to insulin resistance?
The class would like to know what measures should we take to reverse energy toxicity or lipo toxicity. Is it simply to move a lot more and cut out high density carbs. Will this work when chronically insulin resistant as a result of lipo toxicity?
Can you comment on the effect of the Randle cycle that active within the cell? Professor Bart Kay claims that excess energy within the cell locks a second GLUTx door that prevents entry of glucose. Insulin unlocks the first door on lumin side of the GLUT4 receptor but the other door on cytoplasm side remains locked shut. Is that true?
Dr. Bikman, please explain, why is there zero ketonuria after a 20-hour fast in a fast-adapted and well-exercised middle aged person with a fasting insulin of less than 5( quest diagnostics units) ?
Very interesting discussion, Dr. Bikman. Thank you! It sounds to me that the culprit here is what Daniel Trevor calls CCOD - Corporate Carbohydrate Overdose Disorder.
In the athletes paradox the endurance athletes are accumulating ld in type one fibers, in diabetes and insulin resistance it is in the type 2 fibers. Saturated fats overwhelm complex two turning on pkc in the type 2 muscle fibers.
I’ve been on the carnivore diet for three months. It is working, absolute wonders, but now I want to understand why and that’s when I come to your channel.. thank you very much
Isn't the concept of high insulin plus high free fatty acids at the same time pretty much explained by the Randle cycle? The consumption of carbs and fats at the same meal would activate two separate biochemical pathways that inhibit one another, so when the fatty acid one "wins", one would end up with high blood sugar that would require high insulin to get rid of it. The cells would appear to be glucose-intolerant and the insulin would store the glucose as fat at the adipose tissues. Isn't this the cause of chronically elevated insulin?
Thank you for your very informative videos. I don’t normally comment but I enjoy them a lot. One question regarding the Athlete paradox: How do they store fat in their muscles in a low insulin context?
How do you block the ceramides? Will that help with controlling low blood sugar? Can you direct me to any of your videos explaining low blood sugar? I have been on the carnivore diet exclusively for three months, (mainly beef up to a pound daily, 4-6 T of butter daily, Himalayan salt, 3T heavy cream in coffee daily, water, occasional sugar free sparkling water, hoping to lose 50+ pounds) I’ve only lost four pounds after the first week and am now experiencing very low blood sugar at times, which I’ve had my whole life. I am confused as to why I’m not losing weight and still having low blood sugar. I am a 63 yr old female. Thank you!
You are such an excellent teacher. I'm a musician and college professor with no science background other than an intense interest in health for both my family and my career longevity. Not only could I follow this, but it beautifully connected and added depth to so many concepts I've been exploring. I can't thank you enough for your intellectual generosity and public service.
You mean you don't learn great science learning music theory?
😂😂
@@ianstuart5660 Ha! I know laryngeal anatomy, but my math tops out at a major 15th!😂
@rhshrimpton
Lol! Thanks for that and I'm glad you knew I was just joking around! Have a Majorly splendid day!..
👍😺❤️
So simple to understand even for a non-science major. Thank you for your service to mankind!
Ben Bikman is a living legend and living god for worldwide human race...who will share this knowledge free of cost and why is ben doing it free of cost... because deep inside he is a good human being born to beautiful mother and father who instilled these values of sharing and helping fellow humans since he was a child ...I'm sure Ben has immense gratitude for his upbringing and his mother and father guidance throughout his childhood and adulthood which has shaped him to be what he is now ...love hearing your classroom sir ...God bless you
When you look in the dictionary for the word CLARITY you will find Dr. B's picture next to it. Well done, ooooh soooo well done. Thank you
if I had a teacher like Dr. Bikman, I would have persued and enjoyed biology!
True👍🏻
It’s thinking how awesome it must be for Dr Bikman to teach over two hundred thousand of us who just want to know more about health, take control of our bodies and be well. No other reason, not to get a grade, a degree, get credits. You’re amazing Professor, and I am so grateful.
Dear Dr. Bikman I really appreciate and enjoy these classroom videos!
You are a wonderful teacher. I could listen to you for hours. Thank you so much for sharing your vast knowledge so articulately!
It’s great to see someone who LOVES teaching & helping people change their life!!!! Thank you! 🙏🏻 ❤
Absolutely Excellent! I’m understanding how my body built up the fat and what I’m actively doing now within the cell… Burning it!! I’ve listened 3 times at 25 minutes in… You are the best teacher and guide. I have been looking for you 20 years! SOOO happy to be apart of InsulinIQ! Can’t wait for the next year to unfold thanks to you changing my life! Cyndee
I heard a alleged medical expert on fat metabolism on Dr. Berry's channel this week and was horrified at the incorrect information she spewed and that Dr. Berry would give her a voice. I'm so THANKFUL for your generosity in educating me so I know when I hear WRONG information, half truths and theories based on just a notion instead of the real hard researched science.
Is that the "Dark Calories." Video?
Yep saw that. I think she’s spot on about seed oil toxicity but nothing trumps chronic high insulin as a metabolism killer. However seed oil consumption and the inflammatory state it causes should not be overlooked.
@@MelzCarnivoreJourney yes. She's only partially understanding this complex subject and got a lot of it wrong, unfortunately.
@@lindarichmond7814 I agree, but she does not have any knowledge of fat as being an endocrin organ.
I turned that one off too, alarm bells went off to me
This is a breathtaking lecture and high-level, invaluable information most influencer and UA-cam metabolic-informed channels do not explain. Dr. Bikman should be charging money for this kind of information. God bless him.
If he starts doing that, we'll know who to blame!
😂😂
Shut Yo Mouth! LOL He is a truly valuable individual in today's world of misinformation and agendas.
@@Metqa
IKR, even the Agendas have Agendas!
😢😢
Dr Ben,
I love your each and every show,
The most interesting part of your shows are reading, what people write about you,
You are such a humble man and your teaching is so brilliant, that I feel like going back to school, at the age of 58 years old. Thank you so much.
I have only a very limited science background, but I could follow you all the way, with only the odd bit here and there I had to stop and go back over. I'm so glad you explain things so well, Ben, it must be an honour to be one of your students.
Thank you Dr. Bickman, you are a masive contributor to my carnivore journey back to health. Please keep up your excellent work. Stuart from Melbourne AU.
This makes the idea of low carb style of eating all the more important. Thank you Dr. Bickman👍🏻
Listen to this lesson as I performed my daily resistance exercise. What a glorious way to start my day.!
I’ll need to listen 4-5 more times. This is dense 😊
When I think energy toxicity I immediately think seed oil poisoning.
And I remember my mother…
and Thomas Delauer is blaming saturated fats😂
@@powerguiller no he is not.
which is a wrong association. They are poisonous for other reasons than their energy. you may revise your pavlovian reflex.
Thomas Delauer is a clown.
You've got a great working brain and it's a privilege to learn from you. Thank You
Wow! You manage so well to explain it to “common” people! So interesting! Thank you 🙂
Will be revisiting this episode frequently to insure that I've taken it in thoroughly. As a linguist, I appreciate your precision with the definition and use of words, closing doors and windows to possible confusion and conflation. As a T2D in remission, I am both grateful for the deep, "owner's manual" level of education you offer and for how this piques my curiosity to keep learning and to dive deeper. Most of all, thank you for your time and willingness to share your expertise.
Oh I love your Metabolic Classes. Finally a resource I can rely on.
Thank you so much, Doctor. Yes this is very deep. As a complete layperson, I can grasp most of it if I really pay attention and listen a second time on another day. I appreciate this information so much. Myself, my family and even three generations back have struggled with obesity. It is good to understand the mechanisms. I have completely reversed pre diabetes, fatty liver, high BP, but the excess 50 lbs of fat defy me at every turn. 63 yr old female, 5'3". I would love to eliminate the excess fat. I am working at increasing insulin sensitivity.
Good job 👏! Keep going. Good for you for breaking out of your family obesity trend.
Beautiful talk!
I have CLARITY now!
Thank you so much!
This is incredible. As how easily understandable you've made it. lets share and continue to get this message out there.
Dear Dr. Bikman I really enjoy yours classroom videos!
Is it possible to use diagrams, pictures and slides in these clips? I am sure they would help clarify a lot of things.
Dr. Sean O'Mara advises sprints and max intensity exercises instead of endurance to get rid of visceral fat.
Great explanation! Thanks Dr. Bikman! Now I'm able to find errors in texts I'm reading, like this sentence: "Dietary intake of saturated fat has been shown to increase serum ceramide and increase insulin resistance." in Wiki article about ceramides.
My favorite metabolic scientist
Beautiful presentation, Ben! I always appreciate your repetition of key ideas... that greatly helps me to understand. Thank you
❤️
Thank you Professor Ben Bikman!! Love your content and I’ve learned so much from you 🎉
I have read many books, I listened to many UA-cam videos by many of the worlds leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.
Great teaching skills
Thank you
I don't know how I missed this lecture when it aired originally. So I thank you for re-broadcasting this important topic.
I'll have to listen to this one a few times to take in everything... Thank you!
Great lecture! Thank you, Professor!😊
Awesome presentation
OK, you opened another rabbit hole for me, one that sounds near and dear to you. Ceramides and sphingolipid family. I want to know more details as it this appears to be a primary key holder! Pathway interactions, how and where they fit! Sounds like you would be the perfect one to lead the way in informing us.
Great great great, it took me back to school. It also clinically makes so much sense. Thank you Dr Bikman! 😊
Excellent and very interesting overview.
QUESTION TO YOU DR. BIKMAN: Here is my take away. You are saying in a nutshell that high insulin over long periods of time leads to insulin resistance. The inference is that insulin resistance IS ALSO a problem. But I am confused. Ultimately, it is high BLOOD GLUCOSE that defines a person as a diabetic and causes the body to, basically rot. In my understanding, insulin resistance is a FABULOUS PROTECTIVE MECHANISM for each cell - the bouncer so to speak. If the cell is keeping out a fuel source, be it glucose or fat, it is because the cell is either FULL and taking in more would be damaging, OR the cell is not yet ready to take in more fuel. Why a cell may keep out fuel even though it has room to store more stems from complications based on eating a mixed diet of carbs and fat together. As I understand that complication, it is that a cell needs to control the composition of the fuel source inside the cell. At one end of the spectrum, if there is only fat inside the cell, and a fat cell is knocking at the door wanting to get in, PLUS there is room in the cell for more fuel, the bouncer lets the fat in, no problem. If there is glucose in a cell and glucose is at the door knocking to get in, sure, plenty of room, the bouncer lets it in. NO INSULIN RESISTANCE in these examples. BUT if the cell is using fat and glucose is at the door, the bouncer will keep out the glucose until the cell is drained of fat, THEN it will let the glucose in. And the waiting game, all the time it takes to drain a cell of one fuel source before the other can enter, this leads to degeneration, fatigue, AND because there still exists the problem of high blood glucose, the body is basically slowly embalming itself as the sugar dehydrates everything it comes in contact with. I am a Korean Natural Farming - we make farming inputs by mixing equal parts brown sugar to plant material in order to extract the liquid from the plant material; this works based on the principle of osmotic pressure, and this is what diabetes is to my understanding. What artificial insulin injections do is arm all the glucose in the blood with a battering ram so glucose can FORCE its way into cells, REGARDLESS of whether or not the cell is full, REGARDLESS of what fuel source is already occupying the cell. For cells containing fat, the mixture of fat and glucose is like mixing diesel and ethanol fuel in the same fuel tank - it's very very bad - IT'S INFLAMATION (cell damage) - it's early cell death. Artificial insulin DOES keep down blood glucose but the tradeoff seems to be a slow degenerative death spiral. My conclusion is that a 100% carnivore diet IS our species specific diet. I am so novice to this subject. Please, if it is not too much trouble, correct me where I am misunderstanding.
These are sooo good and informative.
Thank you!
I really learn a lot from your lectures and talks.
I would like to see Prof Bikman and Prof Kay have a discussion, they make their points so clear.
Such a great teacher, thank you very much !!
So, please correct me if I am wrong, to summarize:
Feeding on carbs every 3 hours sustains a high insulin level throughout the day. Extended high insulin is toxic as it prevents the use of fat as a fuel and promotes the conversion of carbs to fat for storage. You therefore can't use your fat, get repeatedly hungry and store yet more of what you eat.
If the fat cells have maxed out and become insulin resistant due to the presence of ceramides then the new fat is stored in muscle cells and the liver.
This metabolic imbalance leads to T2D and fatty liver disease. Annedotally, this condition also appears to be implicated as the root cause of CVD, cancer, mental illness from anxiety and depression through to the psychoses as well as the range of neurodegenerative diseases. ( Perhaps seed oils, oxalates and plant sterols are in there as well?)
The cure is to keep the consumption of carbs to a minimum and then to allow long gaps, perhaps 5 or 6 hours, between such consumption to allow insulin to fall and the burning of fat as a fuel to resume.
I am guessing that snacking on protein throughout the day would also cause insulin toxicity as it will lead to sustained gluconeogenesis and raised blood sugar levels/insulin.
Perhaps eat one protein rich meal in the evening and otherwise focus on fat rich food for breakfast and lunch such as bacon, eggs, butter, cream and cheese?
To much eating spikes insulin continuously
Thank you sir for sharing the information well done 👍
Thank you
BB, good vid, thanks for the lesson.
Thank you, Dr. Bikman!
QUESTION/REQUEST: Would you please address how long it takes to reverse insulin resistance? I guess it will be a range as people are different, but many people struggle with feeling like their efforts are not moving the needle much- despite going very low carb. I think it is fairly slow compared to lowering hyperinsulinemia and glucose- which is already 3-6 months. Needing some perspective!
We need a meter that can measure insulin but unfortunately they haven’t come up with one yet. All we can do at this point is get a fasting insulin test at a lab and check our blood glucose levels at home. It’s frustrating not to know. But if your BP is good, your A1C is good etc that’s an indicator that you’re getting better. It took me about six months of weight loss to get off meds. I had to lose a good amount of weight before I started getting results. No sugar, no alcohol and very low carb plus intermittent fasting worked for me. No processed food and no seed oils will cure a lot of problems.
Keep doing fasting insulin tests half yearly and measure it by that. I also think I heard someone comment that if you don't do a fasting insulin test that the triglycerides and HDL numbers will show the insulin levels coming down. Triglycerides are an inflammation marker so if they are coming down that's a good sign. 😊
I have been watching you for about 7 or 8 months now. I give recommendations to everyone I interact with who has diabetes as I do. I have been eating a carnivore diet for almost 11 months. My last fasting insulin was 5.3😍. However , I still am very insulin resistant. I was having improvement but after a recent colonoscopy my sugars have elevated into the 200-300 range and stay there and my inflammation is through the roof (again). I know that my diet is low enough in carbs that it should not be elevated like this. I am also exploring the MTHFR gene mutation theory but I am wondering if this has to do with my gut. Both parents are/were T2D and my son is also and one daughter is prediabetic. Could you please give me suggestions? Maybe links to more videos? I have been on this journey since having a bad experience with Ozempic it left me with optic neuropathy in both eyes so I am low vision (legally blind). So I am taking back control of my own health. Thank you so much for your generosity in educating the masses ❤️
Great info. Thank you
What about the Randle cycle, and excess citrate blocking GLUT4? And does dietary intake of citrate contribute?
I had the exact same questions!☺️
Thanks for sharing your abundant knowledge!
So how do you block the ceramides? 25:34
That’s what I want to know as well 😊
Thank you for another great session!
Thanks!
Hi Lisa. That is so kind of you. Certainly not expected, but appreciated. Thank you.
Fascinating! Thank you for this episode, which I found particularly enlightening. I appreciate that imaging is not your field, but I found myself asking whether the difference between triglycerides, diglycerides and ceramides would be apparent on MRI images. The difference between athletes and obese people is readily apparent, as the muscle and fat appear (more or less) as black and white, and the sarcopaenia in diabetes and obesity is also clear. Sadly, such incidental findings are not documented in radiology reporting.
And yet, I wonder how much more could be interpreted from an image, in terms of the tissue composition, ratio of muscle to fat, or, even more specifically, the types of fat, and what that tells us about metabolic health. Are we missing an opportunity here?
(~28m) Nice explanation of ketone generation: liver buring fat because insulin in low. This also makes home monitoring of insulin level (or sorts) obvious: if you are generating endogenous ketones, insulin is low enough for fat cells to release. Also really understandable following explanation of high fat high insulin harm!
I appreciate your videos, very helpful. Thanks
The only time the general public hears about ceramides is regarding cosmetics, that it softens and plumps up your skin.
I agree and sent Dr. Bikman a question regarding this. Especially the relationship between topically applying this and their effects on the body's production of ceramides since the skin is the largest organ and toxins are absorbed through our skin.
@@meatdog Did you get a response? I had the same question and I would be very interested in the answer.
Huuge fan of the degree of precision in his wording!
Thanks. How are the ceramides blocked?
Bedankt
Thank you very much. That is kind of you and I appreciate it.
@insuliniq Ben: I beg you to read these research articles. They match perfectly with what you're saying about the dangers of high carb/ high sugar/ frequent booze. I agree we're getting more insulin resistant, BUT those "manmade carbs" & sugars or frequency of alcohol are actually depleting our B1 thiamin during krebbs cycle! Actually very common mimicking other diseases as the first article says.
-"Hiding in Plain Sight: Modern Thiamine Deficiency"
-"Sugar intake and thiamine"
BY DERRICK LONSDALE MD, FACN, CNS
-"Thiamin Deficiency (Beriberi; Vitamin B1 Deficiency)"
By Larry E. Johnson, MD, PhD
-"A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI"
-"Wet Beriberi Associated with Hikikomori Syndrome"
02:30 How about "glucotoxicity"? After all, glucose is the molecule that the body will do anything to get out of the blood stream, and even when it has entered a cell, as I understand it, it more or less immediately gets phosphorylated to glucose 6-phosphate.
first, not anything. he body keeps producing glucose, even if i is in small amounts.The brain likes to run on at leas10..20% of its energy consumption on glucose. Second, glucose is weakly toxic, as it causes glycation, mainly of proteins. I s reflected in the hbA1c. It cause stiff connective tissue, from eyes, to arteries, and tendons. These processes are extracellular, hence it is not a classic toxin in the more narrow sense. Those are working intracellular, causing the death of cells
I'm curious about the lesser hormones that have an influence on insulin resistance and energy toxicity. Do we have influence on these?
This was really great, I have listened to all these videos in order and I can see how everything ties together. Triglycerides have been the biggest suspect but it doesn't make sense anymore. If insulin isn't chronically elevated then it's not causing harm. Wow!
hi Dr, please could you comment on fermented carbs in general and femented in particular, in relation with insulin resistance . thanks a lot
Hago una pregunta.
Entonces la acumulación de grasa visceral que en principio suponemos que es perjudicial en atletas de largas distancias no tiene relación con la lipotoxicidad?
Quiero decir que en ese caso, esa marmolización en el musculo del atleta de larga distancia no es perjudicial?
Muchas gracias y no deje usted su labor informativa.
Thank you very much!
Dr Bikman what do you think about the personal fat threshold concept of dr. Roy Tailor? We know that each person has its own "capacity" of wealth subcutaneous fat accumulation and that once its exceeded we start to deposit it in ectopic places like liver and muscle.
The extremes are the super obese people x the ones with lipodystrophy.
Another thing. Have you seeing the studies from Amra medical using fast mri of whole body and linking subc X visceral fat with cardiovascular outcomes?
Thank you Dr Ben, very informative as usual.
great job. Thank you. If able, why do you think my fasting sugar is going up 130 to 200 to 240 in the morning. I am on strict water, carnivore, salt. It seems as though my insulin levels have dropped to the point where even without any carbs, my sugar is remaining high per my CGM. I was hoping my sugar would have dropped, not increase. 50/50 protein fat ratio. For one month now, and little weight loss. BMI 38. Sending this info as an opportunity to review the carnivore diet for diabetics. Is there a way to restart my insulin resistance?
Some one said that Sean O" Mara recommended sprinting. Short burst of Hit my shake things up.
Dave Feldman talks on his podcast about energy balance and why it's important to have glucose for energy and that it's very common and expected that when people are on a low-carb diet for a long period of time they actually become insulin resistant they say that sugar is not the cause of insulin resistance but that keeping a low energy diet such as keto or carnivore causes insulin resistance because it's not being triggered properly
thank you for that explanation. It seems as though I have become even more insulin resistant on carnivore. I will read up on this. Thank you again.
Good morning, I have a question. Why since starting carnivore is my fasting blood sugar 129? I have been on this diet 2 week today and my blood sugar has risen a lot even in a fasting state. I noticed I was getting headaches this last week, thought it was using a tiny amount of stevia or even the sugar content in cottage cheese, but it seems my glucose levels have risen and are staying there without even eating. When I do eat (3 hours) after, my glucose is 138 not a huge jump but still really high considering. My liver prior to starting this diet was (I was told by my physician) sequestering all the sugar I was eating causing me to be hypoglycemic. Each time I ate it would fall from fasting 90's to around 60 causing me to pass out. That's why I started this diet to correct all the autoimmune issues my body is dealing with. Now my glucose is high at all times. I'm confused as to why this is happening; can you please explain this and tell me what I'm doing wrong? Is this normal and will it stabilize? I was afraid to eat before now I have a headache all the time. Thank you so much for your time.
Dags turn on pkc. Saturated fats overwhelm complex 2, causes a backup and starts the ir cascade. The athletes don't have disabled pyruvate dehydrogenase or actived randle cycle
Two question, sir: First, If we inject insulin intramuscularly, does it bind to that muscle's IR more than it would bind to the IR on adipocytes?
Second: Bodybuilders sometimes use insulin while cutting, Is it the case that due to their number and size of adipocytes with respect to their skeletal myocytes, the insulin would help their muscles to consume the carbohydrates available in the blood much more than the adipocytes storing them?
Are the ceramides in meat and dairy also contributing to insulin resistance..or just the ceramides produced by liver because of insulin resistance ? (Sorry i don't have a background in biology)
How do insoluble and soluble fiber contribute to insulin resistance? They are shown as carbs. Is pectin or other insoluble fibers as insulin generating as resistant starch? Does amylose starch fermented in the colon cause insulin resistance? Thanks
Excellent video! Clarified so much for me, but I do still have one curiosity. When going though fatty liver disease scenario where both free fatty acids and insulin high, the fat cells are releasing the free fatty acids due to insulin resistance, but then the liver/ muscle can’t burn the fatty acids as a result of the high insulin - could anyone explain whether the liver or muscle can also become resistant and therefore “ignore” the signal telling them to store it and instead continue burning it? Are fat cells more sensitive to insulin resistance?
QUESTION: Do ceramides in topical skin cosmetics have any effect upon this info?
The class would like to know what measures should we take to reverse energy toxicity or lipo toxicity.
Is it simply to move a lot more and cut out high density carbs. Will this work when chronically insulin resistant as a result of lipo toxicity?
You did not use the term Lean Mass Hyper Responder, perhaps because they have low triglycerides and high LDL? Does your explanation apply to them?
Can you comment on the effect of the Randle cycle that active within the cell? Professor Bart Kay claims that excess energy within the cell locks a second GLUTx door that prevents entry of glucose. Insulin unlocks the first door on lumin side of the GLUT4 receptor but the other door on cytoplasm side remains locked shut. Is that true?
Is it true that the Randle cycle regulates the entry of energy (fat or glucose) substrate into the cell?
Thank you from Germany
Dr. Bikman, please explain, why is there zero ketonuria after a 20-hour fast in a fast-adapted and well-exercised middle aged person with a fasting insulin of less than 5( quest diagnostics units) ?
You are amazing!
Thanks a lot, marvellous explanation!
Very interesting discussion, Dr. Bikman. Thank you! It sounds to me that the culprit here is what Daniel Trevor calls CCOD - Corporate Carbohydrate Overdose Disorder.
How low should our carbs be. Love all your lessons.
In the athletes paradox the endurance athletes are accumulating ld in type one fibers, in diabetes and insulin resistance it is in the type 2 fibers. Saturated fats overwhelm complex two turning on pkc in the type 2 muscle fibers.
Thank you for these great and informative videos. I really appreciate your lectures. I learn so much from them.
These classes are great. Have you ever thought about developing a metabolic health specialist certification?
I’ve been on the carnivore diet for three months. It is working, absolute wonders, but now I want to understand why and that’s when I come to your channel.. thank you very much
Thanks Ben
How does one "block the ceramides"? 😊
Stop eating carbs 24x7, eat non-inflammatory foods, take care of your leaky gut, reduce stress and stress hormones.
This is a big one!
Isn't the concept of high insulin plus high free fatty acids at the same time pretty much explained by the Randle cycle? The consumption of carbs and fats at the same meal would activate two separate biochemical pathways that inhibit one another, so when the fatty acid one "wins", one would end up with high blood sugar that would require high insulin to get rid of it. The cells would appear to be glucose-intolerant and the insulin would store the glucose as fat at the adipose tissues. Isn't this the cause of chronically elevated insulin?
"Inflammation as a cause..." Question:
What about the effects of chronic and intermittent systemic inflammation from Rheumatoid Arthritis?
Thank you for your very informative videos. I don’t normally comment but I enjoy them a lot.
One question regarding the Athlete paradox:
How do they store fat in their muscles in a low insulin context?
How do you block the ceramides? Will that help with controlling low blood sugar? Can you direct me to any of your videos explaining low blood sugar? I have been on the carnivore diet exclusively for three months, (mainly beef up to a pound daily, 4-6 T of butter daily, Himalayan salt, 3T heavy cream in coffee daily, water, occasional sugar free sparkling water, hoping to lose 50+ pounds) I’ve only lost four pounds after the first week and am now experiencing very low blood sugar at times, which I’ve had my whole life. I am confused as to why I’m not losing weight and still having low blood sugar. I am a 63 yr old female. Thank you!
Birkman has a lot of good theories, and cell based lab experiments. What you want is PROVEN Evidence in WHOLE HUMANS. Check out Pam Popper.