I’m 78. I’m a learning more about how my bodies works than I ever imagined I would. Thanks. I preference to heal / stay healthy thru lifestyle and diet. I refused to be one of those weak old women with a big belly, skinny legs and a drawer full of prescription drugs.
I only recently discovered the Insulin IQ series. I'm so excited to watch and learn from every single one. Thank you, Dr. Bickman. Your work is amazing and critically important.
Love this series. So good to get the science behind popular keto topics. I hear confusing and sometimes contradictory information. I’m very thankful for you taking the time to explain simply and clearly, complex subjects. Also, thanks for the myth-busting while remaining professionally courteous.
@@benbikmanIf allulose is created byGM0 glyphosphate/pesticide sprayed corn vs a organic fruit would they not be different in contamination or genetic make up?
Ben, it would be great if you could take over the TV channels (like the President does) and teach these classes. America (and other nations) need to hear this.
Isn’t it comical when people say your body will go into starvation mode when you skip a meal. Glad you said that the body is in fasting mode until all the fat stores are used up and the body starts breaking down muscle and bone.
You are amazing Ben. Your logic is sound and explanations are clear. I could watch this on repeat. Thank you for sharing your findings here for everyone!
Wow, excellent! This encourages me to continue on Keto/Carnivore. I had covid 2 years ago, hospitalized for 15 days, and was very ill. I'm just starting to get my energy back (and losing weight), by eating meat, meat fat, and a little vegetables. Thank you so much for helping me understand what is going on in my body, and how to continue to heal my health.
Get them greens into you! Magenisum omega 3 fats vitmin k ...and natto for fibrin and clotting. Iodine and selenium for your hormonal system the day i took iodine it was like my brain had had a shot of coffee the fog just lifted from my mind and i could think again. I didnt get energy with it as some do untill instarted selenium as well. Im almost normal now when i take everything when i forget for a while I go back down and my hair all got bad after covid that is still falling out when i brush it and getting thin...
Thank so much for this better understanding of insulin resistance!!! This information helps us helping others organize our thoughts around insulin resistance. A wonderful and very constructive tutorial.
Wow Amazing listening to someone that really understands the topic they’re covering. So that’s why I was getting intense muscle cramps, spider veins, etc…
Glad to have found this information, which really gives me a clearer picture. Thanks for helping people like me being a diabetic for twenty years and had a stroke last year!
Thank you Dr Bikman. I have been following you since reading your book a few years ago. Great course! I have also been doing courses through the Noakes Foundation…..so much to learn! The infinite complexity of the human being!
Ben, in your book, Why We Get Sick (a very good book worth every penny), you briefly touch on brown fat and cold skin. 1. Where is this brown fat on our bodies? 2. Where did the specific temperature come from? 3. How long does you skin need to be exposed to this temperature in order for it to work at lowering insulin? Thank you. And thank you for your very important work.
I have read many books, I listened to many UA-cam videos by many of the worlds leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.
Neither of the books on Dr B’s shelves is available at my county library and branches. Available, however, are 19 pages listing vegan cookbooks and how to be vegan, for both adults and children
Make a request that your library acquire his books. It is,after all, a public library. In my experience libraries are very open to getting requested books. Maybe the vegans in your community have been better at asking for what they want.
Thank you Prof. Bikman. I would love to learn more about the evidence for adipose tissue being the first domino piece to fall to insulin resistance, rather than e.g. skeletal muscle, as folks like Prof. Gerald Shulman propose. Also interested in any insight you have on the specific intracellular causes of insulin resistance. E.g. Doc. Jason Fung appears to support the hypothesis that it could be as simple as an excess of glucose inside the cell preventing the existence of a suitable gradient across the membrane to transport glucose into the cell, if I understand his argument correctly.
Dear Dr Bikman ❤, could you do a video o recommend me a video about food sensitivities and insuline resistance. I have non celiac gluten intolerance and histamine intolerance (I can't eat tuna in cans). I wonder how this is connected with my potential insuline resistance. Could you tell us more about this connection?❤
Thank you so much....wonderful to understand and solve problems my body has by cutting out carbs! Can insulin resistance help create thyroid problems? Very best wishes 😊
When the cell is insulin resistant and blocks the insulin receptor insulin stimulates TRPV1 that puts glucose into the cell without using the insulin receptor. This causes too much glucose and lipid oxidation and too much reactive oxygen species production in excess of the cell’s antioxidants. This leads to general inflammation and of course oxidized lipids are core component of atherosclerosis. The low carb or keto diet limits glucose available for oxidation secondary to TRPV1 putting glucose into the cell. When I maintained a low carbohydrate diet I reversed my insulin resistance measured by 6 hour oral glucose tolerance test and measured c-peptide also significantly reduced. At the same time my osteoporosis resolved and my atherosclerosis significantly reduced.
@@JasonBuckman yes, I am still on the low carb diet. I was trying to give a timeline of events as my bone mineral density loss switch from loss to gain and it began with the low carb diet and then accelerated 8 months later when I stopped Oxcarbazepine that up-regulates TRPV1. So the stimulation of TRPV1 by glp-1 with the consumption of carbohydrates and the up-regulation of TRPV1 both created the disease process.
Would love to be a part of this study. I do live in Weber county, but I would definitely travel to Utah county to do the study on this issue. I've been struggling with this for many years and been tough to get the water retention, inflammation down, so that I could lose the hundred pounds I need to, tried everything, please reach out if you see this message! 🙏🏽💜
Can you explain what the inflammatory pathways in muscle cells and fat cells are please. I can't find anything about it but that may be because I don't know what to ask in the searches on the net.
Thanks Dr. Bikman!! Love ya man!! God bless. I wish I could ask you about my unique situation. Not sure if have time to opine this but here it goes. I am a lean and workout a lot. I eat a ketogenic diet. My AIC is 5.9, fasting insulin 2.8, triglycerides 66, LDL 140, but my HDL 38.5?? Not sure why my HDL is so low. Should I be concerned? Again appreciate your knowledge so much!!✝️✝️🙏🏽🙏🏽🙂
Dr Bikman has said the ratio of triglycerides to HDL needs to be less than 1.5 not between 4-6. That's way too high. I just watched a video with him saying this yesterday and I wrote it down. 👍
22:30 omg this us very true! i noticed this as i tried to get to 5%bodyfat and i had absolutely no subcutaneous bodyfat left in my body , i started feeling very off and could barely walk of energy deprivation, even when i started upping my calories to 4000calories a day, it was still a really really big struggle until like 1week has past, and it was still bad but it was getting better, i had already assumed that this starvation mode causes insulin resistance but its good to hear ben talk about it too , so after the 1week i still had barely any subcutanous fat, however since i ate 4000-5000calories a day, i noticed that i have gained visceral fat instead of subcutanous fat. And from there on it felt like my insulin resistance was reversing again, also i had to stop caffeine to speed up the process
Just curious what your take on Cate Shanahan's writings/podcasts on why seed oils are bad are, since she tries to give a mechanistic reason for it, rather than just citing health statistics. This might factor into how the fat around a cell functions, depending on whether it is saturated or unsaturated - ? And by the way, thank you for these videos, and all your efforts and studies of insulin.
Crp might be good for showing somrthing but ive had inflamation and had crpless than 1 which is the norm. It doesnt seem to be much of a subtle scale. Untill its over 1. So if its raised maybe thats shows insane inflamation but you can have inflamation and not raised crp.
I agree that insulin infusions and insulin resistance itself create a cycle that will worsen insulin sensitivity. But I have to disagree that a diet with carbohydrates will necessarily cause insulin resistance, as you said at 15:20. - At 14:20 you say that proteins do not cause insulin release, but this is not true and has been demonstrated in several studies (PMID: 36695783). - Then you say that someone who eats carbohydrates throughout the day will become insulin resistant, but if this were true, practically all athletes would be insulin resistant. But in fact, the vast majority of athletes have been consuming carbohydrates at every meal for several years and have excellent insulin sensitivity. Whereas a sedentary person who has a terrible diet will become insulin resistant, but this is not because of glycemic spikes but rather due to the accumulation of visceral fat (which is why athletes do not become insulin resistant). Furthermore, it is extremely clear that insulin resistance appears and progresses the more fat you accumulate, while losing fat, whether through a low-carb or low-fat diet, causes insulin resistance to be reduced. Once insulin resistance is already established, I completely agree that eliminating glycemic/insulinemic spikes is the easiest modifiable factor and that a low-carb diet tends to be the most efficient. Honestly, I think I agree with everything you always say and you really are amazing at your explanations. But, in my opinion, it really seems that the fact that you sympathize with the low-carb diet makes you not really see what is happening in relation to glucose excursions.
The liver stores like 5 years of B12 so very difficult to deplete the bodies B12 stores. So the Stanford twin study about depleting B12 in 2 weeks is questionable.
Professor Bikman, can you please explain the effect HLA-B27 has on insulin resistance? And what effects eating certain foods such as going on a carnivore/keto based diet has on my condition? I have been diagnosed with mild plaque in my arteries now and severe joint pain from RA. Ive gone ketovore but worried about plaque building. My cardiologist is insisting i go on a statin, ive refused. PLEASE HELP, any advice is appreciated. Thank you.
40:38 THANK YOU!:) this has been a question/query/concern of mine for a while. When you said Aspartame does not cause an insulin response, I immediately had conflict as I remember the results of a study graphing the insulin response on different artificial sweeteners and sugar. They all had a response, it’s just that sugar was by far the greatest. I would love to know more about how the “cerfalic? response” (not sure of the spelling here) interacts with the addiction centre of the brain. I would love to see the results of studies to see what I can learn. It also proves to me why when on a Lion diet that if I tested eating only schnitzels only for at least 2 days (with the 3rd giving the strength of the cravings), I noticed the carb cravings coming back. It all makes sense. Can anyone point me into the right direction on this? Cheers
Really appreciate your explanation against how the "plant-based" people blame saturated fat as the cause for insulin resistance. Can you further refute/explain the confusion of the people who wrote "Mastering Diabetes", who not only make that claim, but further assert that while a keto diet will show improvement in many metrics, that ultimately you will be making yourself more insulin resistant (but with nothing to trigger the insulin, if you're not eating carbs, that doesn't matter. Oh, great, someone is asking about the Mastering Diabetes people's take on this (at about 35 minutes in - but you don't seem to have answered the question deeply enough). But I have to wonder how their method can be working for them, considering that they are Type 1 diabetics. I mean, if they were wrong, it wouldn't be working for them, right? And I am not trying to poke at you as a plant-based person here (I am far from it!) - I am seeking answers to this whole nutrition thing, to help my health, and I think you might have an answer. I sense that perhaps there is a larger answer, that explains why/how you could both be right (at least in part)? And one final question: Am I understanding it right that allulose is having a similar effect as ozempic?
I can't remember if it was in this video you said that uric acid causes an inflammation that raises the glucose level. And that this can lead to insulin resistance. Elsewhere I have read that insulin resistance causes an increase in uric acid. Is it a vicious circle? If so, can one break out of it without medication or is medication the way to go and then stop taking it when one is clearly no longer in MetS territory? I indicate that intermittent fasting is not enough.
I think if you have a lot of fat stored then a supervised fast could help release the stubborn fat. Even doinh Alternate day fasting and restricting carbs and a three day fast . My body refuses to part with its stores. Its frustrating. Its like the body saying I know what you are doing and the metabolism just plummets.
You may want to consider some personalized coaching for a few months to try to get to the bottom of these issues. We are all different... and sometimes a coach can help. We have lots of good ones: www.insuliniq.com/private-coaching
A lengthy water fast might help a lot. I did 21 days which totally cured my rosacea and I also lost weight. Curing my skin issues was the reason I did it though.
I'm eating carnivore and consuming around 70 to 100g of butter a day but my blood sugar levels are between 5,5 mmol/l to 7,2 mmol/l . My sleep hasn't improved. What would be the cause of this,?
One of the backup systems that makes glucose and releases it into the blood to be used for energy is the liver. When glucose levels go down, insulin stops being secreted by the pancreas and the low insulin level causes the liver to start making glucose and liberating it into the blood for distribution. When we eat, we no longer need the liver to continue to provide glucose. When we eat, blood glucose levels rise as the food is absorbed, the increased glucose levels stimulate the pancreas to produce insulin, the rising insulin level in turn acts as a signal to the liver to stop producing glucose because the body is now getting enough glucose from food. In the normal state, the production of glucose by the liver is regulated by insulin levels in the blood. When blood sugar levels rise, insulin is secreted; the increased insulin level signals the pancreas to stop production of glucose. In diabetics there is always insulin deficiency so the signal to the liver to stop glucose production is blunted. In addition there is almost always a degree of insulin resistance, because the liver is resistant to the effects of insulin, it keeps on producing glucose even if glucose levels are already high and insulin levels are high. The liver manufactures glucose in an unregulated manner all night and consequently the blood glucose level which may have been normal or slightly elevated at bedtime progressively increases overnight and the fasting glucose in the morning is too high (frequently the fasting glucose is the highest glucose of the day). A high glucose in the morning is an indication that the liver is overproducing glucose at night. Often the raised morning glucose is the first sign of diabetes that we see. Looks like your liver is insulin resistant... www.diabetesclinic.ca/en/diab/1basics/high_morn_glucose.htm#:~:text=One%20of%20the%20backup%20systems,into%20the%20blood%20for%20distribution.
I've noticed lately that when you're in the hospital, and they give you prednisone, they also usually give you insulin to keep your blood sugar from spiking. Is there a better alternative?
Thank you for both your comment, and for your kind gift. You’re very generous. Please reach out to me and my team if there is ever anything we can help you with: www.insuliniq.com
So fructose has a double whammy no ? it directly raises insulin and it also raises insulin via uric acid ? Fascinating how Uric acid can raise insulin. I just had some bloods done 3 months ago. My A1c was 5.7%, fasting glucose was 92. My fasting insulin though was 14. Funnily enough my Uric acid was outside of the upper normal range. I looked at my diet. Apart from eating copious amounts of white rice, pasta, chocolate and other refined carbs I used to drink a bucket load of apple juice, like 500ml a day easy. Also I was pretty heavy on the whole fruit but I'm sure it was the liquid fructose that was doing the damage. Needless to say I no longer drink liquid fruit.
Was there a retroactive study or retroactive research into offspring of women who had low B12 during pregnancy...? It seemed to me that the researchers found the offspring were all obese. I have seen something like that in my practice. The conundrum is that often the childten are underweight - even scrawny until mid childhood or puberty...
Only one Pfizer covid booster caused a massive jump in my CRP with body pain, since that time in 2021 my blood glucose has increased dramatically, I am thin and life before that jab was fine, blood glucose always returning to 4.5 no excess body pain. Grateful thanks for your work and lectures. PS, I hate the use of lab animals, so much suffering and waste, the thought of it disturbs my sleep, is this the best we can do..
My PURE allulose has 4 grams carbohydrates per tiny scoop, and lists "Other ingredients" as "NONE". It claims 0 NET carbs (???). It does raise my glucose according to CGM. What is going on here?
The idea that raised insulin itself creates insulin resistance I’ve never quite believed - it’s often said reductionism is nonsense yet we jump to it all the time. Eat a high sugar meal. Insulin rises ( the beta cells don’t really respond to glucose.. but that’s another story..). But insulin is a master hormone and regulates many other hormones. For the next 5 hours or so (according to experiments) as sugar levels start to drop this itself is perceived as an emergency and Adrenalin and cortisol rise. So we’re really back to the 2nd primary cause apparently. In the case of isolated cells in culture, don’t they require to produce inositol and it’s phosphates metabolites to allow insulin receptors to work - where are they getting the substrate force this - maybe I’m missing something here?
I watched a presentation a while ago that said C Diff loves trehalose and it’s often added to ice cream to adjust its texture/softness. Also in some mushrooms etc. In any case, I don’t really want to eat anything that C diff is like YUM. No thank you.
While there are specific benefits to specific diets, you can improve your health a lot by moving from a Standard American Diet to almost any diet with more restrictions. Just don't eat the maximum amount of junk food you can tolerate and you'll do better than someone who does.
Allulose gave me diarrhea so bad, I couldn’t leave the terlet. Perhaps some people cannot handle it… I would imagine the GLP went out of me with everything else, lol.
Alulose if it comes from corn or or starch, wouldn't it be like vitamin C.? Because it's sourced from a fruit or vegetables or plants it will always spike your glucose...?
Plenty of seriously strong muscled vegans around that if you stand them next to the average guy eating predominantly carnivore there's no comparison ? also you don't have to eat low fat on a plant based diet. That said I think the pescatarian diet is the best.
IF as you say Chronic Elevated Insulin Is Cause of Insulin Resistance THEN Why did my Dr tell me that I have elevated Blood Sugar I am Insulin Resistant Dr Prescribed So Increase Insulin By Injecting More Insulin Long Acting Every Day And Take even more Fasti Acting Insulin before every Meal I asked Dr are you going to measure How Much Insulin I have Now ? Dr said we'll measure that at some point Later ? ? ? Why would they Now Measure before you start artificially increasing ? This Dr plan to Lower Insulin Resistance Is By Giving MORE INSULIN and Told me to STOP eating only 1 or 2 Meals per day & START eating 4 to 6 Meals per day And She wants me to Start Taking Medication that has the side effect of Causing Weight Gain
I’m 78. I’m a learning more about how my bodies works than I ever imagined I would. Thanks. I preference to heal / stay healthy thru lifestyle and diet. I refused to be one of those weak old women with a big belly, skinny legs and a drawer full of prescription drugs.
Good for you. We’re behind you all the way. Thanks for commenting.
Well done. Wish I could get my friends to understand. Drugs are not good.
How are these people able to get to 500 pounds and and more on these shows about weight loss. It seems like an impossible situation!
@@pampuskar4778 I am at normal weight for my height. That’s an excellent question for Dr Bikman.
Me too
Loving these class room lecturers 😁 feeling very blessed to be able to watch Thank you Ben for sharing your knowledge 🙏 x
Glad you like them!
I only recently discovered the Insulin IQ series. I'm so excited to watch and learn from every single one. Thank you, Dr. Bickman. Your work is amazing and critically important.
Thanks. Be sure to sign up for a free Basic Membership on my website: www.insuliniq.com
it looks like free basic is only a trial then $49. a month
Love this series. So good to get the science behind popular keto topics. I hear confusing and sometimes contradictory information. I’m very thankful for you taking the time to explain simply and clearly, complex subjects. Also, thanks for the myth-busting while remaining professionally courteous.
Thanks, Chris, for watching and for taking your time to write this kind comment. I appreciate it.
@@benbikmanIf allulose is created byGM0 glyphosphate/pesticide sprayed corn vs a organic fruit would they not be different in contamination or genetic make up?
Ben, it would be great if you could take over the TV channels (like the President does) and teach these classes. America (and other nations) need to hear this.
Isn’t it comical when people say your body will go into starvation mode when you skip a meal. Glad you said that the body is in fasting mode until all the fat stores are used up and the body starts breaking down muscle and bone.
Obesity is epidemic
You are amazing Ben. Your logic is sound and explanations are clear. I could watch this on repeat. Thank you for sharing your findings here for everyone!
Professor Bikman.... Great lesson again! Thank you for your time and hard work,!🙏
Thanks for watching and commenting. I appreciate it.
He is a charlatan
@@erastvandoren you must have pretty miserable life that trolling is your idea how to spend your time......
Wow, excellent! This encourages me to continue on Keto/Carnivore. I had covid 2 years ago, hospitalized for 15 days, and was very ill. I'm just starting to get my energy back (and losing weight), by eating meat, meat fat, and a little vegetables. Thank you so much for helping me understand what is going on in my body, and how to continue to heal my health.
Thanks, Allie, for your comment.
Get them greens into you! Magenisum omega 3 fats vitmin k ...and natto for fibrin and clotting. Iodine and selenium for your hormonal system the day i took iodine it was like my brain had had a shot of coffee the fog just lifted from my mind and i could think again. I didnt get energy with it as some do untill instarted selenium as well. Im almost normal now when i take everything when i forget for a while I go back down and my hair all got bad after covid that is still falling out when i brush it and getting thin...
Great lecture❤!
I have read the "Why We Get Sick"
I loved it, my most favourite book.
Thank you.
Dr. Bikman is one of the very, very few sources I trust for metabolic information.
He has a really good way of teaching and explains things I've learnt so much from his videos
I am honoured to watch your lecture! Many thanks Mr.Bikman 👍
Thanks for watching.
Thank so much for this better understanding of insulin resistance!!! This information helps us helping others organize our thoughts around insulin resistance. A wonderful and very constructive tutorial.
Thanks for your kind comment.
Thanks for sharing this clinically relevant research.
Would love for you to do a deep dive video on LADA, Latent Autoimmune Diabetes in Adults, (aka type 1.5 diabetes).
Excellent expression of primary vs secondary.
Wow Amazing listening to someone that really understands the topic they’re covering. So that’s why I was getting intense muscle cramps, spider veins, etc…
Glad to have found this information, which really gives me a clearer picture. Thanks for helping people like me being a diabetic for twenty years and had a stroke last year!
Thank you Dr Bikman. I have been following you since reading your book a few years ago. Great course! I have also been doing courses through the Noakes Foundation…..so much to learn! The infinite complexity of the human being!
Well said. Thanks for your comment.
Ben, in your book, Why We Get Sick (a very good book worth every penny), you briefly touch on brown fat and cold skin.
1. Where is this brown fat on our bodies?
2. Where did the specific temperature come from?
3. How long does you skin need to be exposed to this temperature in order for it to work at lowering insulin? Thank you. And thank you for your very important work.
Thnak you Dr Binkman. I listen and see you from Argentina, South America
Thanks, Jose.
Thanks again SuperProff ...the more I listen the more I soooo nearly understand ❤❤❤❤❤
I have read many books, I listened to many UA-cam videos by many of the worlds leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.
Thank you for your objectivity and clarity in explanation. Beautiful
I love your lectures!
Love love these lessons. Never got to go to university but now I don’t feel like I’ve missed out 😊 thank you for all you do 👏🏼
Have learnt so much. Thank you for educating us. Your time and efforts are really appreciated.
Neither of the books on Dr B’s shelves is available at my county library and branches. Available, however, are 19 pages listing vegan cookbooks and how to be vegan, for both adults and children
😂 ironic
Make a request that your library acquire his books. It is,after all, a public library. In my experience libraries are very open to getting requested books. Maybe the vegans in your community have been better at asking for what they want.
Thank you Prof. Bikman. I would love to learn more about the evidence for adipose tissue being the first domino piece to fall to insulin resistance, rather than e.g. skeletal muscle, as folks like Prof. Gerald Shulman propose. Also interested in any insight you have on the specific intracellular causes of insulin resistance. E.g. Doc. Jason Fung appears to support the hypothesis that it could be as simple as an excess of glucose inside the cell preventing the existence of a suitable gradient across the membrane to transport glucose into the cell, if I understand his argument correctly.
Why is the fructosamine test useful? When would you use it?
Thank you for your classes. 💕💕🙏🙏
Congratulations for your teaching
Dear Dr Bikman ❤, could you do a video o recommend me a video about food sensitivities and insuline resistance. I have non celiac gluten intolerance and histamine intolerance (I can't eat tuna in cans). I wonder how this is connected with my potential insuline resistance. Could you tell us more about this connection?❤
When is the allulose study opening up for those in Utah? I want to participate in the study.
Thank you so much....wonderful to understand and solve problems my body has by cutting out carbs! Can insulin resistance help create thyroid problems? Very best wishes 😊
Could long COVID and or other chronic infections cause insulin resistance?
I hope he answers!
Heck yeah. I’m 6 weeks from contact and still up about 20.
When the cell is insulin resistant and blocks the insulin receptor insulin stimulates TRPV1 that puts glucose into the cell without using the insulin receptor.
This causes too much glucose and lipid oxidation and too much reactive oxygen species production in excess of the cell’s antioxidants. This leads to general inflammation and of course oxidized lipids are core component of atherosclerosis. The low carb or keto diet limits glucose available for oxidation secondary to TRPV1 putting glucose into the cell.
When I maintained a low carbohydrate diet I reversed my insulin resistance measured by 6 hour oral glucose tolerance test and measured c-peptide also significantly reduced.
At the same time my osteoporosis resolved and my atherosclerosis significantly reduced.
Awesome! #carnivorecure #revero
#lutherburbank #reindeerherdsman #transhumancy #lutherBurbankAndTheYogi
"When I maintained a low carbohydrate diet..."
Are not doing low carb anymore?
@@JasonBuckman yes, I am still on the low carb diet. I was trying to give a timeline of events as my bone mineral density loss switch from loss to gain and it began with the low carb diet and then accelerated 8 months later when I stopped Oxcarbazepine that up-regulates TRPV1. So the stimulation of TRPV1 by glp-1 with the consumption of carbohydrates and the up-regulation of TRPV1 both created the disease process.
Would love to be a part of this study. I do live in Weber county, but I would definitely travel to Utah county to do the study on this issue. I've been struggling with this for many years and been tough to get the water retention, inflammation down, so that I could lose the hundred pounds I need to, tried everything, please reach out if you see this message! 🙏🏽💜
Great stuff, as always ! Thank you
Can you explain what the inflammatory pathways in muscle cells and fat cells are please. I can't find anything about it but that may be because I don't know what to ask in the searches on the net.
33:02 Thank you this was really interesting.
Great show! Thank you!! ❤
Thanks Dr. Bikman!!
Love ya man!! God bless.
I wish I could ask you about my unique situation.
Not sure if have time to opine this but here it goes. I am a lean and workout a lot. I eat a ketogenic diet.
My AIC is 5.9, fasting insulin 2.8, triglycerides 66, LDL 140, but my HDL 38.5??
Not sure why my HDL is so low. Should I be concerned?
Again appreciate your knowledge so much!!✝️✝️🙏🏽🙏🏽🙂
Dr Ken Berry has a couple of videos on how to increase HDL. You can find 2 videos on YT by searching _dr ken berry raise hdl_
example, 200 (triglyceride level) ÷ 55 (HDL) = 3.6 (triglyceride HDL ratio).
Ideal triglyceride HDL ratios...
_ideal: 2.0 or less
_good: 4.0 to 6.0
Dr Bikman has said the ratio of triglycerides to HDL needs to be less than 1.5 not between 4-6. That's way too high. I just watched a video with him saying this yesterday and I wrote it down. 👍
FANTASTIC, THANKYOU 😊
Would you please list the study on more importance of triglyceride to HDL ratio than levels of increased LDL contributing to heart disease. Thank you
Hi Mary. Thanks for your question. You may want to go to our website and ask our team: www.insuliniq.com
Thank you. Will do.
22:30 omg this us very true!
i noticed this as i tried to get to 5%bodyfat and i had absolutely no subcutaneous bodyfat left in my body , i started feeling very off and could barely walk of energy deprivation, even when i started upping my calories to 4000calories a day, it was still a really really big struggle until like 1week has past, and it was still bad but it was getting better, i had already assumed that this starvation mode causes insulin resistance but its good to hear ben talk about it too , so after the 1week i still had barely any subcutanous fat, however since i ate 4000-5000calories a day, i noticed that i have gained visceral fat instead of subcutanous fat.
And from there on it felt like my insulin resistance was reversing again, also i had to stop caffeine to speed up the process
Just curious what your take on Cate Shanahan's writings/podcasts on why seed oils are bad are, since she tries to give a mechanistic reason for it, rather than just citing health statistics. This might factor into how the fat around a cell functions, depending on whether it is saturated or unsaturated - ? And by the way, thank you for these videos, and all your efforts and studies of insulin.
Excellent! Thank you!
Crp might be good for showing somrthing but ive had inflamation and had crpless than 1 which is the norm. It doesnt seem to be much of a subtle scale. Untill its over 1. So if its raised maybe thats shows insane inflamation but you can have inflamation and not raised crp.
Soooooo could my enlarged prostate and the inflammation associated with that affect my insulin response. Like driving up my sugar levels
Certainly
Which episode is no.1- the initial one on insulin? I can’t find it!
Superb!!
Ty. Nice to know about allulose. .
Thanks for commenting, Mary. You may want to watch this video with Dr. Bikman: ua-cam.com/video/Zf2XrIteKMw/v-deo.html
How do I start the lectures from the beginning?
I agree that insulin infusions and insulin resistance itself create a cycle that will worsen insulin sensitivity. But I have to disagree that a diet with carbohydrates will necessarily cause insulin resistance, as you said at 15:20.
- At 14:20 you say that proteins do not cause insulin release, but this is not true and has been demonstrated in several studies (PMID: 36695783).
- Then you say that someone who eats carbohydrates throughout the day will become insulin resistant, but if this were true, practically all athletes would be insulin resistant. But in fact, the vast majority of athletes have been consuming carbohydrates at every meal for several years and have excellent insulin sensitivity. Whereas a sedentary person who has a terrible diet will become insulin resistant, but this is not because of glycemic spikes but rather due to the accumulation of visceral fat (which is why athletes do not become insulin resistant). Furthermore, it is extremely clear that insulin resistance appears and progresses the more fat you accumulate, while losing fat, whether through a low-carb or low-fat diet, causes insulin resistance to be reduced.
Once insulin resistance is already established, I completely agree that eliminating glycemic/insulinemic spikes is the easiest modifiable factor and that a low-carb diet tends to be the most efficient.
Honestly, I think I agree with everything you always say and you really are amazing at your explanations. But, in my opinion, it really seems that the fact that you sympathize with the low-carb diet makes you not really see what is happening in relation to glucose excursions.
The liver stores like 5 years of B12 so very difficult to deplete the bodies B12 stores. So the Stanford twin study about depleting B12 in 2 weeks is questionable.
Professor Bikman, can you please explain the effect HLA-B27 has on insulin resistance? And what effects eating certain foods such as going on a carnivore/keto based diet has on my condition? I have been diagnosed with mild plaque in my arteries now and severe joint pain from RA. Ive gone ketovore but worried about plaque building. My cardiologist is insisting i go on a statin, ive refused. PLEASE HELP, any advice is appreciated. Thank you.
What is the relationship between exogenous opioid use and insulin production?
Hunger centar in CNS, dopamine, incretins....rewarding system integrating opioids, alcohol, food, tobacco...Insulin is lowered under the influence.
@@dusanjerinkic6330 Thank you. Have you published on this? Seeking citations. 🙏
40:38 THANK YOU!:) this has been a question/query/concern of mine for a while.
When you said Aspartame does not cause an insulin response, I immediately had conflict as I remember the results of a study graphing the insulin response on different artificial sweeteners and sugar. They all had a response, it’s just that sugar was by far the greatest.
I would love to know more about how the “cerfalic? response” (not sure of the spelling here) interacts with the addiction centre of the brain. I would love to see the results of studies to see what I can learn.
It also proves to me why when on a Lion diet that if I tested eating only schnitzels only for at least 2 days (with the 3rd giving the strength of the cravings), I noticed the carb cravings coming back.
It all makes sense.
Can anyone point me into the right direction on this?
Cheers
Really appreciate your explanation against how the "plant-based" people blame saturated fat as the cause for insulin resistance. Can you further refute/explain the confusion of the people who wrote "Mastering Diabetes", who not only make that claim, but further assert that while a keto diet will show improvement in many metrics, that ultimately you will be making yourself more insulin resistant (but with nothing to trigger the insulin, if you're not eating carbs, that doesn't matter. Oh, great, someone is asking about the Mastering Diabetes people's take on this (at about 35 minutes in - but you don't seem to have answered the question deeply enough). But I have to wonder how their method can be working for them, considering that they are Type 1 diabetics. I mean, if they were wrong, it wouldn't be working for them, right? And I am not trying to poke at you as a plant-based person here (I am far from it!) - I am seeking answers to this whole nutrition thing, to help my health, and I think you might have an answer. I sense that perhaps there is a larger answer, that explains why/how you could both be right (at least in part)? And one final question: Am I understanding it right that allulose is having a similar effect as ozempic?
Thank you sir!
Does this process also apply to lipodemic fat cells?
I could not RESIST this posting on insulin.
If allulose is created byGM0 glyphosphate corn vs a organic fruit would they not be different in contamination or genetic make up?
I can't remember if it was in this video you said that uric acid causes an inflammation that raises the glucose level. And that this can lead to insulin resistance. Elsewhere I have read that insulin resistance causes an increase in uric acid. Is it a vicious circle? If so, can one break out of it without medication or is medication the way to go and then stop taking it when one is clearly no longer in MetS territory? I indicate that intermittent fasting is not enough.
My understanding is that Allulose still causes advanced glycation end products.
I think if you have a lot of fat stored then a supervised fast could help release the stubborn fat.
Even doinh Alternate day fasting and restricting carbs and a three day fast .
My body refuses to part with its stores.
Its frustrating. Its like the body saying I know what you are doing and the metabolism just plummets.
You may want to consider some personalized coaching for a few months to try to get to the bottom of these issues. We are all different... and sometimes a coach can help. We have lots of good ones: www.insuliniq.com/private-coaching
A lengthy water fast might help a lot. I did 21 days which totally cured my rosacea and I also lost weight. Curing my skin issues was the reason I did it though.
Either you are eating too much or your body is living off muscle tissue. How do you know you are not burning stored fat?
I'm eating carnivore and consuming around 70 to 100g of butter a day but my blood sugar levels are between 5,5 mmol/l to 7,2 mmol/l . My sleep hasn't improved. What would be the cause of this,?
One of the backup systems that makes glucose and releases it into the blood to be used for energy is the liver. When glucose levels go down, insulin stops being secreted by the pancreas and the low insulin level causes the liver to start making glucose and liberating it into the blood for distribution. When we eat, we no longer need the liver to continue to provide glucose. When we eat, blood glucose levels rise as the food is absorbed, the increased glucose levels stimulate the pancreas to produce insulin, the rising insulin level in turn acts as a signal to the liver to stop producing glucose because the body is now getting enough glucose from food.
In the normal state, the production of glucose by the liver is regulated by insulin levels in the blood. When blood sugar levels rise, insulin is secreted; the increased insulin level signals the pancreas to stop production of glucose. In diabetics there is always insulin deficiency so the signal to the liver to stop glucose production is blunted. In addition there is almost always a degree of insulin resistance, because the liver is resistant to the effects of insulin, it keeps on producing glucose even if glucose levels are already high and insulin levels are high. The liver manufactures glucose in an unregulated manner all night and consequently the blood glucose level which may have been normal or slightly elevated at bedtime progressively increases overnight and the fasting glucose in the morning is too high (frequently the fasting glucose is the highest glucose of the day). A high glucose in the morning is an indication that the liver is overproducing glucose at night. Often the raised morning glucose is the first sign of diabetes that we see.
Looks like your liver is insulin resistant...
www.diabetesclinic.ca/en/diab/1basics/high_morn_glucose.htm#:~:text=One%20of%20the%20backup%20systems,into%20the%20blood%20for%20distribution.
"Vitamin" A
I have been low carb high fat for more than 7 years and still have high uric acid. Why?
I've noticed lately that when you're in the hospital, and they give you prednisone, they also usually give you insulin to keep your blood sugar from spiking. Is there a better alternative?
Interesting
would love some timestamps...
What do the animals eat that we eat?
My fasting Insulin showed 2.2. My fasting glucose was 77, A1C was 5.3 and C peptide .96. I don't know if the fasting Insulin means Insulin Deficiency?
If doctors knew as much as you about metabolism, we'd all be happy campers.
Thank you for both your comment, and for your kind gift. You’re very generous. Please reach out to me and my team if there is ever anything we can help you with: www.insuliniq.com
Thank you
How do you get rid of insulin resistance if you have non-diabetic gastroparesis?
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
So fructose has a double whammy no ? it directly raises insulin and it also raises insulin via uric acid ?
Fascinating how Uric acid can raise insulin. I just had some bloods done 3 months ago. My A1c was 5.7%, fasting glucose was 92. My fasting insulin though was 14. Funnily enough my Uric acid was outside of the upper normal range. I looked at my diet. Apart from eating copious amounts of white rice, pasta, chocolate and other refined carbs I used to drink a bucket load of apple juice, like 500ml a day easy. Also I was pretty heavy on the whole fruit but I'm sure it was the liquid fructose that was doing the damage. Needless to say I no longer drink liquid fruit.
Thanks again
Was there a retroactive study or retroactive research into offspring of women who had low B12 during pregnancy...? It seemed to me that the researchers found the offspring were all obese. I have seen something like that in my practice. The conundrum is that often the childten are underweight - even scrawny until mid childhood or puberty...
SUBSCRIBED!
*WATCH this video FIRST* Insulin Resistance and Metabolic Syndrome with Dr. Ben Bikman
❤❤❤ Dr. Ben !
Only one Pfizer covid booster caused a massive jump in my CRP with body pain, since that time in 2021 my blood glucose has increased dramatically, I am thin and life before that jab was fine, blood glucose always returning to 4.5 no excess body pain. Grateful thanks for your work and lectures.
PS, I hate the use of lab animals, so much suffering and waste, the thought of it disturbs my sleep, is this the best we can do..
My PURE allulose has 4 grams carbohydrates per tiny scoop, and lists "Other ingredients" as "NONE". It claims 0 NET carbs (???). It does raise my glucose according to CGM. What is going on here?
Thanks!
That is so kind of you. Thank you very much. Not at all expected, but appreciated.
The idea that raised insulin itself creates insulin resistance I’ve never quite believed - it’s often said reductionism is nonsense yet we jump to it all the time. Eat a high sugar meal. Insulin rises ( the beta cells don’t really respond to glucose.. but that’s another story..). But insulin is a master hormone and regulates many other hormones. For the next 5 hours or so (according to experiments) as sugar levels start to drop this itself is perceived as an emergency and Adrenalin and cortisol rise. So we’re really back to the 2nd primary cause apparently. In the case of isolated cells in culture, don’t they require to produce inositol and it’s phosphates metabolites to allow insulin receptors to work - where are they getting the substrate force this - maybe I’m missing something here?
It's proven that high insulin levels induce insulin resistance. It can be seen with people with insulinoma.
I watched a presentation a while ago that said C Diff loves trehalose and it’s often added to ice cream to adjust its texture/softness. Also in some mushrooms etc. In any case, I don’t really want to eat anything that C diff is like YUM. No thank you.
While there are specific benefits to specific diets, you can improve your health a lot by moving from a Standard American Diet to almost any diet with more restrictions. Just don't eat the maximum amount of junk food you can tolerate and you'll do better than someone who does.
That thumbnail deceived me, I thought this was a Hitman video.
❤❤❤❤❤❤
Allulose gave me diarrhea so bad, I couldn’t leave the terlet. Perhaps some people cannot handle it… I would imagine the GLP went out of me with everything else, lol.
Alulose if it comes from corn or or starch, wouldn't it be like vitamin C.? Because it's sourced from a fruit or vegetables or plants it will always spike your glucose...?
isn't aspartame toxic? there seems to be a correlation with brain tumors
For everyone reading this, finding the banned book called the hidden herbs by anette ray should be your top priority
Plenty of seriously strong muscled vegans around that if you stand them next to the average guy eating predominantly carnivore there's no comparison ? also you don't have to eat low fat on a plant based diet. That said I think the pescatarian diet is the best.
Aspartame does not sound good regardless of insulin effect.
IF as you say
Chronic Elevated Insulin
Is Cause of Insulin Resistance
THEN
Why did my Dr tell me that I have elevated Blood Sugar
I am Insulin Resistant
Dr Prescribed
So Increase Insulin
By Injecting More Insulin
Long Acting Every Day
And
Take even more
Fasti Acting Insulin before every Meal
I asked Dr are you going to measure How Much Insulin I have Now ?
Dr said we'll measure that at some point Later ? ? ?
Why would they Now Measure before you start artificially increasing ?
This Dr plan to Lower Insulin Resistance
Is
By Giving
MORE INSULIN
and
Told me to STOP
eating only 1 or 2 Meals per day
& START eating 4 to 6 Meals per day
And
She wants me to Start Taking Medication that has the side effect of Causing Weight Gain
Thanks for your questions. You may want to go to our website and ask my team: www.insuliniq.com
Thanks. Youre doing Gods work. For everyone else reading this that wants to go even further, go find the hidden herbs by Anette Ray.
🙏🙏🙏
Blue zones. The obvious conclusion is that literacy is bad for longevity. Chuckle.