Saturated Fat with Dr. Ben Bikman
Вставка
- Опубліковано 6 тра 2024
- In this episode of The Metabolic Classroom, Professor Ben Bikman, an expert in metabolic research, discusses the debate surrounding saturated fat and its impact on insulin resistance.
Dr. Bikman addresses misconceptions about saturated fat perpetuated by proponents of plant-based diets, who often blame meat-based saturated fats for insulin resistance. He refers to his own 2011 research, highlighting the role of toll-like receptor four (TLR4) activation in inducing inflammation and insulin resistance, particularly stimulated by saturated fats.
Acknowledging limitations in his earlier work, Dr. Bikman transitions to discussing fat digestion and absorption, setting the stage for studies on the impact of dietary saturated fat on metabolic outcomes. He cites a study by Volk et al. (2014) contradicting the direct link between dietary saturated fat intake and plasma saturated fat levels. Further, he discusses research challenging the low-fat emphasis of diets like DASH, including a study by Chiu et al. (2016) showing comparable blood pressure reduction with a high-fat version.
The lecture also covers a meta-analysis by Choi et al. (2020) supporting the benefits of ketogenic diets high in saturated fat for glycemic control and insulin resistance.
Dr. Bikman emphasizes the importance of considering context, suggesting that saturated fat consumption without excessive carbohydrate intake may not necessarily lead to insulin resistance. However, he acknowledges studies indicating potential concerns with high saturated fat intake in hypercaloric, high-carb diets, advocating for balanced macronutrient consumption.
#InsulinResistance #SaturatedFat #MetabolicHealth #NutritionScience #HealthEducation #DietaryMyths #CellBiology #ResearchInsights #FatDigestion #KetogenicDiet #CardiometabolicHealth #DASHDiet #Inflammation #MedicalResearch #HealthDebunked
00:01 - Introduction of the topic of saturated fat and insulin resistance, highlighting common misconceptions and his expertise in the field.
02:33 - Role of TLR4: Research on toll-like receptor four (TLR4) activation and its connection to inflammation and ceramide synthesis, leading to insulin resistance.
07:05 - Fat Digestion Primer: Explanation of fat digestion in the small intestine, emphasizing the formation of chylomicrons for fat transport into the bloodstream.
11:55 - Study by Volk et al. (2014): Key study that challenges the idea of dietary saturated fat directly increasing plasma saturated fat levels, despite high consumption.
16:41 - High-Fat DASH Diet Study: Research comparing a high-fat version of the DASH diet to the standard low-fat version, highlighting similar blood pressure reduction but improved lipid profiles with the high-fat diet.
19:46 - Meta-analysis by Choi et al. (2020): Demonstrating the benefits of ketogenic diets, typically high in saturated fat, in improving glycemic control and insulin resistance.
21:40 - Historical Trends: The paradox of decreasing saturated fat consumption over time while insulin resistance rates have increased, suggesting a more complex relationship.
25:58 - Overfeeding Studies: Studies showing that overconsumption of carbohydrates, particularly refined sugars and starches, can increase liver fat and saturated fat production, contributing to insulin resistance.
27:09 - Study by Luukkonen et al. (2018): Study indicating that in a hypercaloric, high-carb diet, high saturated fat intake may worsen insulin resistance compared to high unsaturated fat intake.
28:06 - Conclusion: The need for nuanced understanding, context, and critical appraisal of research findings regarding the relationship between saturated fat, carbohydrate intake, and insulin resistance.
www.insuliniq.com
www.jci.org/articles/view/57144
pubmed.ncbi.nlm.nih.gov/26718...
journals.plos.org/plosone/art...
www.ncbi.nlm.nih.gov/pmc/arti...
consensus.app/papers/glycogen...
consensus.app/papers/shortter...
diabetesjournals.org/care/art... - Наука та технологія
My granddaughter is headed off to medical school after having just graduated from BYU. I’m so happy that Dr. Bikman was her endocrinology professor. She’ll be a better doctor for having had his instruction.
😯 She is a lucky lady … learnt from the best 😊
Wow, that's really good to hear.
Lucky little lady !!! I wish I could sit all day in his classroom
how wonderful!!!! you must be so proud!
I was just thinking after listening to another podcast when he explained he was teaching pathophysiology how I would of learned so much more.
And speaking of Calgary... Hi from Calgary! Now, can you give my doctor a call? He's in a PANIC because my LDL is through the roof since I went all Keto last August. In my lifetime, I've lost more than 300 pounds. After being treated for t-2 diabetes for 30 years, I almost lost my foot in Nov 2022. The following August, I came across Dr. Pradip Jamnadas, who eloquently explained it. I did everything he and so many others have said, I cut out high carbs, processed food, and seed oil, lost 70 pounds, triglycerides way down, HDL up and LDL really up a complete reversal of t2 diabetes A1C of 5.7... after all of that. He wants me on a staten and to stop consuming saturated fat. Hello, news desk, I think I found the problem.
@@jigglesandwich You need to either educate your doctor or FIRE him!
@@nevillegoddard4966 I know, right. Unfortunately, it's not just my doctor. Sadly, I think it's the majority of them, especially in Canada. I spent more than two hours explaining the relationship between triglycerides, HDL, LDL and VLDL and how they relate, especially with a low-carb diet. I gave him a couple of links. I think he's gonna be alright, but it took 40 years of sales and marketing experience to bring him around. The sentence that hit him the hardest was "You treated me for diabetes for more than 30. years and I almost lost my foot. Three weeks on a low-carb high-fibre, moderate protein diet and I was off all diabetic drugs in two weeks and a perfect A1c 6 months later." Now that's medicine.
You don’t need doctors in your life. Take responsibility for your health fully. Don’t let them gaslight you. 2 of my brothers had heart attacks and have stents and claim it’s theirs genetics lol. Ones wife is medical doctor specializing in treatment of diabetes and his daughter is big harma rep. Younger brother’s is medical doctor and his wife worked for big harma now retired in the early 70’s. Statins since at least 20 years and other meds. Now fully injected with the newer marvels of pharmaceutical technology of nano lipids and synthetic modified RNA. They have other problems to. And they blame their genes because doctors determined they must have bad genetics. That twisted lol
Well done on reversing HbA1C! I did same with whole food, plant based. HbA1C normal, BP 110/70 and LDL normal.
Let your your doctor panic all he likes! Not your job to worry about that. You have done so well, get a supportive doc for where you are now. Good luck from Australia !
Professor Bikman your hard work is very much appreciated. You have changed my life for the better, I can't thank you enough.
Dr David Unwin gave the advice to his patients to eat plenty of saturated fat, meat, eggs and salt but avoid carbohydrates (bread, rice pasta, bananas, apple etc). Hundred patients lost weight, improved liver and kidney function, came off diabetes medications saving £70,000 in medicine costs for ten years. He recorded all stats over several years and published them in journals. If only every Doctor would do their job and above all first do no harm (conventional practice results in amputations, heart/kidney failure etc).
Thankfully Dr Unwin was one of the first videos I found after learning that I had diabetes and found out about the low carb lifestyle.
@@jobrown8146Keep it up. Congratulations! 🎉
I love Dr David Unwin, his journey is so inspiring.
@@jax9349 Yes, and I love the fact that he has documented the progress of his patients.
Dear Dr Bikman
Thank you for clearing up all the falsehoods and proving that millions of people have suffered for decades due to the greed of big pharma
Eating a Tasty Ribeye at this very moment with a couple Eggs too
That's the way to do it from a former plant based eater and now carnivore.
❤
Indeed! Carnivore is the PHD
There's No Carb or Sugar that Tastes as Awesome as I Feel and just keeps getting Better every Day 💪
About 2 1/2 years ago when i was diagnosed with T2 Diabetes my A1C was 10.4. I went on the lowest dose of metformin possible and went on a low carb high fat diet. 3 months later my A1C was 5.4.
The only time it went up was when I was eating Mission Low Carb Tortillas regularly (they're a lie; a glucose test showed my blood glucose spiked to 154 just from eating one). My A1C went to 5.7, but more relevant to this conversation is that my Triglycerides spiked to 320. Cutting those out, 3 months later my A1C was 5.4 again and my Triglycerides were 128. 3 months after that they were 99. I didn't change anything else about my diet.
Today I'm at 5.4-5.5 with no medication at all, and I'm not super-militant about my diet but I do avoid GPS (Grains, Potatoes, and Sugars) pretty heavily.
Next time you eat any kind of tortilla brand, keep some in your pantry and see how long it will last.
It will stay fresh for months, meaning super high amounts of preservatives, let alone, bunch of unnecessary ingredients.
It's just BS. Any type of bread you buy at your local grocery store are just all BS.
So strange I'm fairly lean (like 14 to 16% bf) and even on keto for 6 months my a1c only drops to 5.6 at best
@@JohnSmith-zs1bf I also do a lot of Zone 2 exercise to improve MItochondrial function, which has been tied to any number of metabolic diseases, including T2D. When I stopped that because I was walking every day my A1C went up a tenth.
@@johnwoodard8717 cool. what do you do for zone 2? jogging?
@@JohnSmith-zs1bf Biking. I can't get out of one 1 walking, and I can't not be in zone 3 or 4 jogging as I'm a terrible runner.
Biking for me is the easiest activity to control my zones. Even with hills so long as I leave my ego at home I have enough gearing to not leak out of zone 2 more than a minute or so.
What a fantastic way to start a Tuesday.
For me it's a fantastic way to start a Thursday😊
I feel like a superstar now.. vldl is 14, ldl is 191, hdl 102.3 and my triglycerides are 71.. this was after 1 year on carnivore. This diet works and improves nearly every single thing. Even my car is running better.
Thanks a million times over. I am down this rabbit hole and cannot get enough of this education you are providing. I wish I could turn back my clock and pursue this research as my lifes work, also. Your contribution is priceless and I hope you are able to continue for a very long time. I read your book from cover to cover on Saturday and just could not put it down. I will be studying and subsuming it until the pages wear out. Sincerely.
What wonderful comment.
It's interesting how we become scientists while learning about our physiology 😉👌
My scrambled eggs and sausage, fried in ghee, tastes even better than usual this morning!
😋
I had bacon and onion fried in butter and then scrambled the eggs into the pan with them for dinner last night. Very yummy and satisfying.
I'll be breaking my overnight fast with bacon and eggs at about 11 a.m. I've already had a brisk 4 mile hilly walk, viewed this graduate level lecture, and planned dinner, a 8 oz beef steak and steamed broccoli. LG!
Eating fish and butter while watching this episode..
Eating beef patties & bacon while watching this episode..
Scandalous.😅
Eggs and bacon 🎉
Fatty beef patty with salt and extra tallow for me.
Whatever you do don’t batter it!
On a keto diet I eat huge amounts of saturated fat through bacon, red meat, eggs etc. and my triglycerides are ROCK bottom at 43 and HDL is a VERY healthy 84 and my waste circumference is 34. Take that food industry that's forever trying to hook me on carbs!
What an irony! Saturated fats are to blame after all, but not dietary saturated fat, rather saturated fat made from excess carbohydrates as a result of dietary guidelines! My ‘model’ of insulin resistance has just taken a couple of steps forward thanks to learning this 😊
Thanks, Professor Bikman. You have expertly conveyed your message with your careful choice of words. You ROCK!
Two years ago I consulted a "preventive" cardiologist for my diabetes and known coronary artery disease. He just about threw me out his office when I told him I was considering a "ketogenic" diet. Then he went on to say I needed to be on a "plant based" diet, preferably the "Mediterrranean" diet, and that I needed to immediately embark on regular injections of PCSK9 inhibitors. Unfortunately, I believe that my experience is NOT rare. Thank goodness we have great scientists like Dr. Ben Bikman to set the record straight and help us progess toward better metabolic health!
It sounds like my same cardio. Does the last name starts with K?
I was more fortunate than you. I had a heart attack during my stress test at age 46. My cardiologist was doing thr test. When itcsll settled out he told me to immediately stop being a vegan because it caused my heart issue. That was in 1998! He was way ahead of his time and I am eternally grateful. Now as a carnivore, at age 73 I'm super healthy with no heart problems and perfect blood pressure, blood sugar, weight and no joint pain. They are few and far between.
That's the same advice a woman who suffered a heart attack was given to. Now she's gorging on bread, croissants, jam and coffee loaded with sugar every morning. She is high every day from so many carbs and confident in her doctor's advice. A friend of her already passed away and was eating an extremely hypocaloric diet based on carbohydrates and veggies. She had more wrinkles than a raisin.
I study nutrition, but you and Dr Lustig are my real professors. Thank you ❤
it is a Privilege to listen to Mr. Bikman 🍀👍
In an amazing way, you break down all that science and make it clear to everyone. I love your podcasts. keep going, Dr.
All respect 🙏
As a cell biology major in college and a med school dropout, I have thoroughly enjoyed this lecture. Thank you, Dr. Bikman. I have subscribed to your channel.
Fat Tuesday is the BEST day of the week!! Thank you Dr. Bikman. Oh and the glasses ROCK! I'd like to say you DASH'd my hopes, but in truth you have once again reinforced the idea of how a proper human diet includes saturated fats. Well done, and THANK you for providing links to the quoted studies.
The last study where saturated fat is combined with hypercaloric high carb diet brings to mind the Randle cycle where there’s a danger in combining fat and sugars together.
Your comments about high-carb-high-fat diets being terrible reminds me of mechanisms in the Randle Cycle. I'd love to see an episode dedicated to that topic and its relationship to insulin resistance, assuming the Randle Cycle is indeed a valid mechanism in the cells. I'm still trying to wrap my head around how it works and whether its even valid.
I watched this three times in a row to understand everything you were saying and the third time I started crying because our human body is so unbelievably beautiful. I understand now what’s happening, and the complexity of it is so mind-boggling. At the end we are simply left with only one thing to do, and that’s to treat our body with the respect it deserves ❤
Yeah and refuse the clot shots
Dr... I absolutely love the way you dig in and truly teach, you are a refreshing breath of medicine . Thank you.
I’m following you from 2021, and my health improved dramatically since then, thank you so much. You’re my best messiah !! Greetings from France 🇫🇷
Excellent explanation. Dr. Bikman sets the example of properly done science, and simple, easily understood concepts for the lay person.
Dr Bikman - Thank you, so much, for all the research you do, and the care you take to keep me informed of the truth of the matter! If I had to figure this out myself, I’d be lost. I appreciate you!
1988 was a great year, not only did Calgary, AB host the Winter Olympics I was giving birth to my first child during the event in Fort Mc Murray, AB. Great memories and as well , great video.
Ben there is a study that compared DASH to low carb in Type 2 diabetics. Low carb reduced blood pressure twice as much as DASH. If you put DASH into the search on Dr Berry's channel he talks about it. The study not that old.
I LOL when you said miserable diet. You NEVER complain, judge harshly, or made jokes. You are so very straight up. I was so surprised when you used the word miserable that it got me. Not to encourage you too much but that little Segway from your usual personality was great. Excellent work. This is an important topic and you are the first I’ve seen tackle this saturated fat in so much detail. I watch because I have stubborn high trigs. They do go down on low carb but I worry about the fat. My gene report from FYF by Dr. Rhonda Patrick says I might have trouble metabolizing saturated fat. I’m supposed to increase monounsaturated fat. I think better outcomes like Bp,sleep, trigs might be more important.
Once more a metabolic lecture which is so well organized & conceptually progressive that following along & learning is a joy. Well done!!
Just finished my eating window with some delicious andouille sausage while watching this. :) Keep doing what you do, Doc!
Someone need to inform Ms Charmaine Dominguez about these studies. She's a plant based dietition been all over youtube making shorts telling ppl that sat fat causes IR. When I asked her to explain the mechanism she said she will once I join her free training programme. Unless she knows something Dr Bikman doesn't which I highly doubt.....
Thank you, Dr. Bickman . I always look forward to watching.
Thank you for explaining this in a way that I can actually understand! You are truly a skilled professor and researcher, and your videos are a joy to watch.
I love nerding out with your videos; they inspire me to continue my weight loss, health journey in the most educated way. I feel 20 yrs younger with this lifestyle change. Thank you for providing us with the science. ❤
Dr.Bickman, I'm not a MD but your
Speeches are so easy to understand!! My son is about tof fnish to study medicine ad University, in Italy, and I can't talk with him about ketogenic diet, saturated fat...I think that many of the things you explain n your videos are not yet aknowledged by general pratictioners and/oe ininternationalguide lines...
Thank you so much!!!
Thank you for all you do! ❤
Excellent presentation. Thanks for sharing your helpful information.
Thank you, Dr. Bickman, for clear and understandable way of explaining complex issues!
What upsets me the most is people who should be curious about this kind of information don't care one bit. I just shared this on my Facebook page. I'm an RN many of my Facebook friends are in the healthcare field. I won't get one comment, but if I post a picture of my cats. Katy bar the door!
Wonderful talk.
Thank you so very much
Excellent info. Thank you!!
Thank you for taking the time to help all of us who aren’t doctors understand and therefore benefit from factual information.
Thank you for the great lecture and all you do!
Thank you❤ so much for all your hard work and wisdom ! Greatly appreciated!!
Excellent video Prof. Bickman! Thank you!
Wow - this is great information explained very well. Thank you ☺️
This is great!!! Thank you for you work and sharing this information. You are helping the world be healthier and better informed!
Thank you for another fantastic video, Dr. Bikman
I learn so much with each presentation, thank you for clearing any doubt on saturated fat in reference to serum fat.
Insulin Resistance is a protection mechanism of the cell against glucose. All by the beautiful mechanisms of the Randle Cycle
My Doctor pushes the DASH diet. I push the KETO diet and have had great results!
What do you have a doctor for? They're just pill pushers.
Thank you very much. Wonderful video
Dr. Bikman, I say it again, you are my hero ! Your info makes my work so much better, keep it comming!
Loved your book, love this info you share freely. Thanks so much, you've changed the way my family of 8 eats!
Thank you Dr Bikman!
Amazing explanation !!! Thank you very much! I love your work and how you explain all the mechanism! Thank you for all you do!
Great explanation as always
This is a fantastic lecture, Dr. Bikman!
Excellent video! Thanks!
Thank you, Dr. Bikman❤
Excellent video!
Thankyou.
Just so important to get this information from an authoritative source.
👍🏻
Thank you very much for educating...... greetings from Indonesia
I am glad to hear ...
Great subject 👌 Dr . I'm on my ketogenic way of eating (once again.) This time around is significantly different because I need to make this my lifestyle. **I am adding more fat this time. I'm adding more marbled red meat, also, extra butter to my meals to achieve longer lasting saity. I'm rarely hungry and losing about 2 lbs per week. Im 68yrs old and pretty much sedentary because of agressive, widespread osteoarthritis. I really enjoy your podcasts and shares. 🎉
To me it seems that your discussion strenghtens the argument of the randle cycle when fat in presence of high sugar contributes to insulin resistance.
It's not really an argument, the Randle cycle is an undisputable fact and the fact that it isn't taught (barely) is criminal.
thanks Dr. Bikman, great video, this is very informative, excellent info.
Yay! Lets learn!🙌
Brilliant, so clear, thank you!
Great presentation.
Thank you for such a well presented talk, the bravery to critique your own work and explain its misinterpretation by others. As a T1D I now better understand why, if my bsl happens to be higher than ideal, that avoiding intake of both carbs and saturated fat is best avoided, until blood glucose levels return to my normal range say, 70 to 120 mmg/dl (or 3.8 to 6.7 mmol/l. The wisdom of doing so for carbs is self-evident bot was not so much for saturated fat as perversely a highish blood glucose level sometimes makes me feel hungry. I also have found out that really those with T2D or T1D are likely to become insulin resistant to some degree- - in T1D because combating blood glucose rise with peripheral insulin administration cannot match the input and intricacy of insulin infused into the portal vein as a meal is arriving from eating, higher doses are needed. At 57 years on insulin; since age 13, and 5 years on a ketogenic diet with insulin injections (scar tissue making insulin absorption too unreliable for insulin pump infusions of insulin) consistent HBA1cs of 5.2% have made life so much better. I wish that diabetes education about low and very low carb diets included the caution about not eating carbs and saturated fats when blood glucose levels are elevated.
Thank you once again.
Another great lecture! Thank you ❤
So much fantastic information, thank you
Thank you Dr Bikman ♥️💙♥️
Great lecture!
Thank you for the presentation. Wondering if you have any concerns re competing interests of the sponsors of the 2014 Volk study?
What kind of fat is human body fat? Like, what never made sense to me is that people would say not to eat saturated fat… but what if human body fat is saturated fat??? I have done water fasts between 3-17 days long. On a most recent 7 day water fast, I had my blood drawn on day 5 and of course, my cholesterol and triglycerides were elevated. Now just looking at that bloodwork would appear that I am not healthy (according to mainstream doctors, like mine.) But once I began eating my usual low carb diet, my numbers went back to normal. Just wondering if the elevated because I was literally only consuming body fat (saturated fat???). The body is fascinating!
You are an amazing knowledgeable lecturer
Wow! The Metabolic Classroom is an absolute TREASURE TROVE of useful knowledge. I am too old to learn enough to build bridges in my remaining life, but I can learn enough to progress from building with tinker toys to building with an erector set. Thanks for the progress toward enlightenment.
Excellent times infinity! Loved it!
Thank you! 😊
Great one
I am a nurse and I would have loved to have been in your pathophysiology class!
We know that mainstream nutrition writers are terrified of writing positive comments about saturated fats......
Thank you very much for this presentation. Do you by chance have the cite for the paper at 18:00 regarding outcomes of low vldl vs ldl? Thank you
Bravo!! Highly accessible presentation (for the exact question I'd ask Ben if we met.)
Finally. I am T2 my blood sugar rises after cheese binges. Now I have a clue why. It probably links back to Prof Taylor’s work in the UK. So glad you are looking at this.
Could you comment on your thoughts about the Randal Cycle.
I'm exteemely curious about ceremides. Are the ceremides advertised in skin lotion dangerous as they are absorbed through the skin??? And do they contribute to insulin resistance. And are they molecularly the same as blood ceremides? I have lots of questions about this process.
My understanding is that excess carb and polyunsaturated fat consumption leads to tissue glycosylation and incorporation of polyunsaturated fats into cell and mitochondrial membranes, where they become oxidized. Oxidation and glycosylation ultimately lead to insulin receptor damage, inactivation, and finally insulin resistance. Triglycerides increase with carb consumption but are not directly responsible for disease, any more than yellow fingers from smoking cause lung cancer.
I eat about 70g of saturated fat a day and I'm lean my triglycerides are half that of my HDL. my fasting blood sugar is about 60-70. blood pressure is 100/60 on average etc
In summary, combining high carb high saturated fat is dangerous; high saturated dietary fat on very low carb diet (e.g. Eskimos) provides zero insulin resistance worries.
Brilliant!
Very informative
Would be interested in IR and effects on puberty
I think my immune system has improved with this change in nutrition,thank you