That sucks, man. I have bad health too. If it gets the better of you, you might want to talk to someone about it. I don’t recommend the comment section of the internet. If you have serious problems with mental health, for any reason, try to find a good professional.
@@macstreamer8943 I’ve had tinnitus for about 20 years. I just ignore it. I gather that there are some treatments for it but to be truthful, I don’t care. I’ll be 100 in 23 years and will let you know if my opinion has changed by then.
@@DennisSmithGrandCayman My tinnitus is louder than anything, and I have different tones and types of noises, how can I ignore it? Life has become very difficult, maybe I can do it in the future, but for now I would prefer not to wake up again.
Interesting discussion. At 23:46, yes the pace of discovery has definitely slowed. Perhaps we are looking in the wrong place, for example resident tissue macrophages aren't being measured in many studies, nor is immune function. I've begun to wonder whether the biology of aging doesn't move easily because the network is extensively interconnected, with many links to disease. You can modify the network in a coherent way with overall inputs like calorie restriction, but improving the biomarkers through typical interventional approaches doesn't get you as far because of the links to disease and compensation in the nodes/subnetworks.
Understandibly, the show wants to reach as broad an audience as possible, which is why you get a discussion as to whether feeling good = being healthy 🙄, on the level of "is hitting yourself in the head with a hammer healthy". It is what it is. What is a great pity, is that having as substantial a scientist as MK, real deeper scientific questions are not being asked, it's a wasted opportunity. Instead, we ask MK 101 questions that a first year med school could answer. A great resource not being utilized. However, for the general audience, unfortunately Nick's questions are just what the doctor ordered. So, congrats to Nick, a job well done. Timid suggestion: maybe once in a while have a fellow scientist query MK about deeper issues, for us nerds 🙏. Thank you for all the great work!
Thank you for your comment. There are plenty of deep dives with Matt and other aging biologists on this channel that I think you’ll enjoy, with many more to come. I’d say these “101” videos are few and far between. But you’re right-we’re trying to reach a broad audience, including those without a background in geoscience. This episode was for them. Nick
As for the "two labs replicating a huge effect", I'm kinda excited about the fact that the ITP is currently testing glycine + NAC given how exciting the data is, but with the "problem" of it all coming from a single lab. The one thing that makes me a little pessimistic about it though is the fact that said lab used C57BL/6J mice, which is not ideal for research involving oxidative stress due to their spontaneous mutation in the Nnt gene, so the 24% lifespan extension they observed could be largely due to that. The rapamycin + trametinib combination also has me kinda excited, it would be really cool if they could break the "rapamycin ceiling" with that combination, which could plausibly happen both due to the anti cancer and the supposed senolytic effect of trametinib (although I don't know how well that hypothesis has hold out, given the problems with other supposed senolytics like quercetin).
ITP is 3 labs, with merged results, but also shows the results from each. It can be slow to find some optimal level. And it would be nice to have mice with excellent diet, mice with ho-hum diet and mice with a crummy diet. The only way to know if you are really moving the needle is to exceed what can be achieved by a good diet, but we also want to know whether it can help the average person and those who may have no choice but to eat poorly, because of time or location. I know truckers are often forced to eat very poorly, because there are very limited options at truck stops and parking an 18-wheeler at a grocery is usually not going to fly. Sometimes. My sister is a trucker, and she has to take a month off for every 2 working, so she can restore her health. Truckers, who just work all the time, die like flies. Other people commute 4 hours a day, and just can't spend much time cooking. And fast food is very dubious, almost without exception. I am enjoying a nice boiled fresh artichoke as I type, and wonder under what conditions that would ever be an option at a fast food restaurant. Heck, I can't recall that being offered on any menu at any restaurant I have been at. Maybe artichoke hearts from a jar, but that is very different. Even if you are looking for asparagus at a restaurant, if you find it, they will destroy it by grilling it. Some better foods have made inroads. I see pomegranate, some places. Go back 15 years and there are no pomegranates. Grenadine, that is it, (though, now actual grenadine is more pricey). Maybe occasionally in a produce section. 10 years ago, there was no fresh turmeric root. 20 years ago, I don't remember any fresh ginger. In San Diego, until my 20s, I never saw an actual blueberry. Just pictures of them. And even today, what passes for figs in the stores is a joke. The fresh figs from my grandparent's tree were fantastic, juicy and nothing like these pathetic tasteless things they are charging an arm and leg for in the groceries. The real thing only lasts 2 days in the fridge. And it is best less than 6 hours after being picked and not refrigerated. That is just the way it is. How realistic is it to get things to the stores and sold that fast? Not very.
@@ChessMasterNate By "two labs" I mean the original lab that published the paper + the ITP team, not as in "the ITP counts as multiple labs". I do agree that having a great diet/lifestyle is gonna give you 90% or more of the longevity/healthspan results, especially with our current rudimentary understanding of the biology of aging, but I do think we are close to having some drugs with proven lifespan/healthspan benefits in the next decades, although I doubt is gonna be something massive like "living to 150 years", but a modest 5-15% lifespan/healthspan extension on top of what you would get solely with lifestyle factors (maybe even allowing some outliers with great genetics, lifestyle and using the right pharmacological interventions to reach the 130 year goalpost Matt mentioned) seems like something we can be cautiously optimistic about.
@@ChessMasterNate That being said, I do agree that it would be nice to test at least the most robust interventions (such as rapamycin) alongside some level of caloric restriction in order to see if the intervention is truly "delaying aging" or just preventing the development of problems associated with mice eating too much, it could also prevent the old conundrum of "are the mice just eating less?" given that with limited food availability it is more likely that they will just eat all they have available.
Thanks for the podcast--great stuff, as always. Been wondering if you're friends with fellow PNW-er Mario Kratz? And have you seen these two (of his many) UA-cam videos? [1] Insulin Resistance Syndrome: A Neglected Risk Factor for Chronic Disease; [2] Causes of Insulin Resistance: The Personal Fat Threshold. I'd say you guys are on the same team! Thanks.
Zosimus says in his history (500AD) that the maximum human lifespan is 110 years. He states this in a discussion of the Roman Secular Games which were performed every one hundred years, well ine theory though in practice they were celebrated irregularly.
I think humans and animals have evolved to be able to make an assessment of good genetics by sight, what is attractiveness in reality but a human assessing another individual as having desirable genetics
I would say that the assessment is biased to a "reproductive" view (for the sex or sexes you're attracted to) and/or for "performance" (eg. That guy looks like he can wrestle a bear), but that doesn't necessarily correlate with achieving great healthspan or reducing all cause mortality risk.
@@pedro.almeida Attractiveness even involves the observer looking for mathematical proportions in the body of the person being observed and looking for errors in those proportions which probably correlates to errors in the genome
Vegan just seems to be some sort of nutrient scarcity that mimics CR and wouldn't even exists without modern supplements. Omnivore with nutrient rich animal protein is yielding the best healthspan and lifespan
Another misalignment is between longevity and financial interests. The system does not want retirees that live to 100. They want us to drop dead at 65 😂
Thank you so much for your honesty, Matt. I wish there were more people like you on the internet ❤
After acquiring tinnitus I want to live another year at most. The question is how to live with tinnitus.
That sucks, man. I have bad health too. If it gets the better of you, you might want to talk to someone about it. I don’t recommend the comment section of the internet. If you have serious problems with mental health, for any reason, try to find a good professional.
@@ivojager2143 tinnitus > other level,
@@macstreamer8943 I’ve had tinnitus for about 20 years. I just ignore it. I gather that there are some treatments for it but to be truthful, I don’t care. I’ll be 100 in 23 years and will let you know if my opinion has changed by then.
@@DennisSmithGrandCayman My tinnitus is louder than anything, and I have different tones and types of noises, how can I ignore it? Life has become very difficult, maybe I can do it in the future, but for now I would prefer not to wake up again.
Interesting discussion. At 23:46, yes the pace of discovery has definitely slowed. Perhaps we are looking in the wrong place, for example resident tissue macrophages aren't being measured in many studies, nor is immune function.
I've begun to wonder whether the biology of aging doesn't move easily because the network is extensively interconnected, with many links to disease. You can modify the network in a coherent way with overall inputs like calorie restriction, but improving the biomarkers through typical interventional approaches doesn't get you as far because of the links to disease and compensation in the nodes/subnetworks.
9:05 this was a great response
Understandibly, the show wants to reach as broad an audience as possible, which is why you get a discussion as to whether feeling good = being healthy 🙄, on the level of "is hitting yourself in the head with a hammer healthy". It is what it is. What is a great pity, is that having as substantial a scientist as MK, real deeper scientific questions are not being asked, it's a wasted opportunity. Instead, we ask MK 101 questions that a first year med school could answer. A great resource not being utilized. However, for the general audience, unfortunately Nick's questions are just what the doctor ordered. So, congrats to Nick, a job well done. Timid suggestion: maybe once in a while have a fellow scientist query MK about deeper issues, for us nerds 🙏. Thank you for all the great work!
Thank you for your comment. There are plenty of deep dives with Matt and other aging biologists on this channel that I think you’ll enjoy, with many more to come.
I’d say these “101” videos are few and far between. But you’re right-we’re trying to reach a broad audience, including those without a background in geoscience. This episode was for them.
Nick
@ Thank you Nick, I sincerely think you do an outstanding job!! I'm just being slightly selfish 🤣
As for the "two labs replicating a huge effect", I'm kinda excited about the fact that the ITP is currently testing glycine + NAC given how exciting the data is, but with the "problem" of it all coming from a single lab. The one thing that makes me a little pessimistic about it though is the fact that said lab used C57BL/6J mice, which is not ideal for research involving oxidative stress due to their spontaneous mutation in the Nnt gene, so the 24% lifespan extension they observed could be largely due to that. The rapamycin + trametinib combination also has me kinda excited, it would be really cool if they could break the "rapamycin ceiling" with that combination, which could plausibly happen both due to the anti cancer and the supposed senolytic effect of trametinib (although I don't know how well that hypothesis has hold out, given the problems with other supposed senolytics like quercetin).
ITP is 3 labs, with merged results, but also shows the results from each. It can be slow to find some optimal level. And it would be nice to have mice with excellent diet, mice with ho-hum diet and mice with a crummy diet. The only way to know if you are really moving the needle is to exceed what can be achieved by a good diet, but we also want to know whether it can help the average person and those who may have no choice but to eat poorly, because of time or location. I know truckers are often forced to eat very poorly, because there are very limited options at truck stops and parking an 18-wheeler at a grocery is usually not going to fly. Sometimes. My sister is a trucker, and she has to take a month off for every 2 working, so she can restore her health. Truckers, who just work all the time, die like flies. Other people commute 4 hours a day, and just can't spend much time cooking. And fast food is very dubious, almost without exception. I am enjoying a nice boiled fresh artichoke as I type, and wonder under what conditions that would ever be an option at a fast food restaurant. Heck, I can't recall that being offered on any menu at any restaurant I have been at. Maybe artichoke hearts from a jar, but that is very different. Even if you are looking for asparagus at a restaurant, if you find it, they will destroy it by grilling it. Some better foods have made inroads. I see pomegranate, some places. Go back 15 years and there are no pomegranates. Grenadine, that is it, (though, now actual grenadine is more pricey). Maybe occasionally in a produce section. 10 years ago, there was no fresh turmeric root. 20 years ago, I don't remember any fresh ginger. In San Diego, until my 20s, I never saw an actual blueberry. Just pictures of them. And even today, what passes for figs in the stores is a joke. The fresh figs from my grandparent's tree were fantastic, juicy and nothing like these pathetic tasteless things they are charging an arm and leg for in the groceries. The real thing only lasts 2 days in the fridge. And it is best less than 6 hours after being picked and not refrigerated. That is just the way it is. How realistic is it to get things to the stores and sold that fast? Not very.
@@ChessMasterNate By "two labs" I mean the original lab that published the paper + the ITP team, not as in "the ITP counts as multiple labs". I do agree that having a great diet/lifestyle is gonna give you 90% or more of the longevity/healthspan results, especially with our current rudimentary understanding of the biology of aging, but I do think we are close to having some drugs with proven lifespan/healthspan benefits in the next decades, although I doubt is gonna be something massive like "living to 150 years", but a modest 5-15% lifespan/healthspan extension on top of what you would get solely with lifestyle factors (maybe even allowing some outliers with great genetics, lifestyle and using the right pharmacological interventions to reach the 130 year goalpost Matt mentioned) seems like something we can be cautiously optimistic about.
@@ChessMasterNate That being said, I do agree that it would be nice to test at least the most robust interventions (such as rapamycin) alongside some level of caloric restriction in order to see if the intervention is truly "delaying aging" or just preventing the development of problems associated with mice eating too much, it could also prevent the old conundrum of "are the mice just eating less?" given that with limited food availability it is more likely that they will just eat all they have available.
Thanks for the podcast--great stuff, as always.
Been wondering if you're friends with fellow PNW-er Mario Kratz? And have you seen these two (of his many) UA-cam videos? [1] Insulin Resistance Syndrome: A Neglected Risk Factor for Chronic Disease; [2] Causes of Insulin Resistance: The Personal Fat Threshold.
I'd say you guys are on the same team! Thanks.
When is Optispan swag going to be available? I like that zip-up Matt is wearing.
We will announce it on here as soon as it is. - Tara
the disscusion is great doc but would be great if you can give more "instructions" and easy take aways
A longevity song: Hoping for a breakthrough, longing for a breakthrough...
Zosimus says in his history (500AD) that the maximum human lifespan is 110 years. He states this in a discussion of the Roman Secular Games which were performed every one hundred years, well ine theory though in practice they were celebrated irregularly.
Goddamn some random asshole from 2500 years ago said a thing??? EVERYBODY COME HERE AND LISTEN 🤡🤡🤡🤡
There are two kinds of researchers, those who are have a plant-based, whole food diet and those researchers who struggle with their personal choices.
Yep. Half of scientist don’t practice what they preach and the other half eats a mostly plant based diet
You, sir, are a religious extremist, as are the Carnivores.
I always looked young for my age.
I think humans and animals have evolved to be able to make an assessment of good genetics by sight, what is attractiveness in reality but a human assessing another individual as having desirable genetics
I would say that the assessment is biased to a "reproductive" view (for the sex or sexes you're attracted to) and/or for "performance" (eg. That guy looks like he can wrestle a bear), but that doesn't necessarily correlate with achieving great healthspan or reducing all cause mortality risk.
@@pedro.almeida Attractiveness even involves the observer looking for mathematical proportions in the body of the person being observed and looking for errors in those proportions which probably correlates to errors in the genome
4.50 he really couldn't bring himself to say a primarily plant based diet, even though I am sure he knows what the science says.
Vegan just seems to be some sort of nutrient scarcity that mimics CR and wouldn't even exists without modern supplements. Omnivore with nutrient rich animal protein is yielding the best healthspan and lifespan
Yeah I'm sure it's big meat pulling the strings too hard 🤦
There are two kinds of researchers those who are plant based whole food diet and those who struggle with their personal choices.
Another misalignment is between longevity and financial interests. The system does not want retirees that live to 100. They want us to drop dead at 65 😂
9:05 - Many if not most of the influencers on YT health are cancer