Відео

The problem (I think) sometimes with dr Mike Is that a lot of thing he says is on the presumption that everybody wants to build huge muscles.

4 minutes in he has already critiqued 2 things so far he did not claim xD

Thank you for this explanation. I'm a huge proponent of damping down inflammatory cytokines. So here's my problem with monoclonal antibodies for inhibiting IL-11: The cost. Which I do not actually know but google says some mcab cost $96,000 per year...just guessing, these for IL_!! will be in that (horrendous) ballpark. Know what else inhibits IL-11??? Omega three. At a cost of roughly $50 a month for a huge dose to do the same thing and has a ton of other benefits. What's wrong with this picture?

This conversation kind of dances around the idea that big animals live less, however, the animal with the longest lifespan is huge and lives up to around 500 years.

Can someone direct me to the podcast where Matt talks about when Rapamycin can actually INCREASE aging? I think I saw a reference to that somewhere. I'm asking because my biological age was great before I started taking rapamycin in January of this year. My bio age was 63 and my actual age was 74 so that was 11 years to the good. That was duplicated two months into my taking rapamycin (5mg once per week), i.e. 11 years "younger." Since then, I've had two more blood tests and age calculations and my bio years have gone up to only 7 years "younger" and now today its 6 years "younger." It looks like I would be better off not taking rapamycin.

Ohh come on 10 years?!?!? FDA approved Cov!d vacc!ne in less than a year.

best episode yet had you pegged as a rapamycin promoter for business reasons, glad that I was wrong you are a true believer in rapamycin based on the data available so far and I share your frustration at the lack of efficacy data in humans

Thanks 👍

Dr Matt what's your Rapa protocol? Is it 12 weeks per year or you resume after a break?

Out of the usual prospective anti-aging therapies (supplements or drugs) apparently effective in mice or rats, which are likely to be redundant, partly redundant, independent (the sum), and complementary (more than the sum), when combined with rapamycin? I understand any reply to be mostly, if not entirely, speculative. I am hoping it is time to start combining things, at least in mice/rats. It would be really great to see a 50% or more increase in lifespan, at least where there is no concrete reason for believing it would never work in humans. Maybe shaking some money out of the trees to get more studies done?

How does rapamycin affect male fertility? It seems that younger people are hopping on to take it - will it affect fetuses or baby development if the male continues to take it before pregnancy?

Phenomenal video, thank you so much!

What do you think about using grapefruit juice or ketoconazole to increase Sirolimus levels?

You mention that topical rapamycin is available. Only compounded, or is there a standard prescription topical rapamycin? If so, what is it called?

Thanks for a great video. One thing I would like to know and many others from what I have read would like to know is how does Rapamycin affect Testosterone and fertility in men

This is your best episode so far

How does grapefruit juice increase the effects of rapamycin?

Can I come next time?!? I'm local! We can carpool and take my car 🤙🏻🙌🏻

Excellent presentation. Thank you. I receive 60 1mg pills from my provider every 12 weeks for a 5 mg once per week dose. I think I'm going to switch my dosing to 6 mg once per week for 10 weeks and then 2 weeks off. Or I could do 5 weeks on, 1 week off, twice through the 12 week supply. Edit: or I could stop taking it. See my other comment made after my most recent blood test that shows a disturbing "aging trend" with rapamycin.

Very interesting as usual! I would like to know if some rapalogs can be purchased without prescription, since the true Rapamycine is impossible to get in France for longevity purposes... Keep the great show running, greetings from Paris.

My experience with rapamycin has been horrible. The side effects are psychological as well. Caloric restriction is far safer.

A combination study might be nice to see? What if the males are given 17-alpha estradiol next to rapamycin? Would they see the same benefits as the female group?

It was an unfortunate mistake not to test the bioavailability of the new compounded product before initiating the trial. The vast majority of people taking rapamycin are in the 5-8 mg per week dosage

Could Vit D supplementation cause calcification say in the veins? In the heart?

**also fact checking the 2040 joke** 😂

Central Florida here, and approximately 1/2 of the year, we avoid doing any significant type of outside work in the sun. These past few weeks it has been so hot and humid that working in the shade causes excessive sweating, having to make sure to add electrolytes during the day. Both my husband and myself, late 6th decade, supplement with D3/K2/K4 or K7 to keep our levels in high normal ranges. We also have a functional doctor who tests for this throughout the year.

Cholesterol denier. If you enjoy listening to flat earthers, you'll love Mike Mutzel.

The problem with emphasizing that there is some small subset that can get away with high LDL, every week on a show, is that everyone who wants to eat BBQ and fried chicken daily deludes themselves that hey belong in that category. And it is far from proven that it even exists. We have not tracked these people for decades. They may have been vegans or vegetarians before they became carnivores or whatever, and it may take decades to destroy their health. I actually do think things are more complicated. I think lead is a major player, as well as bacteria in the plaques, but it is not like people know the levels of these things. And Blood Pressure as well. I think BP has to be above some level for the cholesterol packets to get pushed through the arterial lining at a higher rate than they return. One HUGE problem with butter and meat is Advanced Glycation End-products. These things are associated with every major disease of aging. AGEs are aptly named. And of course they are associated with cardiovascular disease, Alzheimer's, Diabetes, Kidney disease... AGEs are in the food before being cooked but nowhere near the same level. If you fry or grill or roast and such where any of the meat you eat gets raised more than a little above boiling, you are making a ton of AGEs. And it is not just association. We know how these things are damaging health. They lodge themselves in the intercellular matrix obstructing the movement of molecules delaying the quenching of free radicals and such, and just stiffening the tissues because of the clogging. The RAGE inflammation pathway is also activated, increasing inflammation. These AGEs also make a lot of work for the kidneys. The kidneys help remove these AGEs...but not all of them. Glucosepane cannot be removed from the body. It accumulates stiffening tissues including blood vessels, the lens of the eye, and many other tissues. This brings with it many of the things we think of as aging. Now if you want to eat homemade stew where you did not otherwise sear or cook the meat first, say with chili, and soup, as well, fine. Though, we know the carotenoids in vegetables and fruits are important for health. I can't see someone being long term healthy without those. Then there is ergothioneine from mushrooms, various berries have things, spices, even flowers like hibiscus. Going carnivore is just as silly as eating only foods with your favorite color...it is just irrationally limiting.

Frankenstein medical procedures, would have lived longer without it.

Let’s see, stay lean, exercise and eat healthy. That’s some groundbreaking stuff.

Hi! Just thought I would provide my critique on HighIntensityHealth’s views on LDL’s relationship to cardiovascular disease from 1:00:36 to 1:18:06. My response to HighIntensityHealth’s views on LDL’s relationship to cardiovascular disease is as follows: Why reference comparatively extremely low quality epidemiological studies on LDL, that are rife for confounders and so are poor at establishing causation, and not even mention the much higher quality randomised controlled trials and the Mendelian randomisation studies that we have on this topic, where the randomisation process gets rid of confounders and therefore is much better at establishing causation? Based on the scientific evidence hierarchy we should be giving more weight to evidence higher on the scientific evidence hierarchy that is superior at establishing causation, not lower. You allude to not believing LDL is causative of cardiovascular disease with the ambulance analogy at 1:10:20. That’s actually precisely the problem with focusing on epidemiological studies as, similar to the ambulance analogy, seeing a correlation in epidemiological studies does not mean there is a causation-with epidemiological studies being inferior at inferring causation compared to randomised controlled trials and Mendelian randomisation studies. You also say at 1:16:00 that we should care more about the triglyceride and HDL ratio and care more about triglycerides and HDL compared to LDL. Let’s look at the evidence for LDL: separate meta analysis of over 200 prospective cohort studies, Mendelian randomisation studies and randomised trials including more than 2 million participants with over 20 million person years of follow up and over 150,000 cardiovascular events demonstrate a remarkably consistent dose-dependent log-linear association between the absolute magnitude of the exposure of the vasculature to LDL-C and the risk of ASCVD; and this effect appears to increase with increasing duration of exposure to LDL-C. What is the evidence for the triglyceride to HDL ratio, triglycerides or HDL that includes more and higher quality evidence than this evidence I provided for LDL, with higher quality evidence ceteris paribus being higher on the scientific evidence hierarchy, that shows that the triglyceride to HDL ratio, triglycerides or HDL is more relevant in terms of their causative effect on cardiovascular disease compared to LDL?

Hi Matt, I'd love to hear your response to Ben Bikman's warnings against rapamycin. Just search "Ben Bikman Rapamycin" to find his yt video from 6 days ago. Thanks for all your helpful content!

that is actually worrying

For me ,NAC= Bad Breath

You guys afraid to mention the negative side effects of that medical intervention everyone was forced to take? That's weird, it's not a political thing

This guest isnt realizing what they are saying. If you tell mistruths in 1 research study 2 as we know it why would you trust any other he is doing. If you bemd the rules or the outcomes why should you trust ?? This is fact science. It is either showing a result or not - grey area shouldn't be held to standard. And the "iam Right" attitude drives me nuts Put the ego down

I wonder if we could build a chemical model of a human and then apply AI to do complex what ifs?

Take Vitamins D and K2 whose job is to move calcium from artery walls to the bones 🩻 where they belong.

Damn! I randomly thought about this dude today after having unsubscribed from him months ago, check my feed and here he is. 😅

Thanks for having me on, guys! This was a lot of fun especially @ 01:01:49. Thank you!

Yo, Matt! Long time lurker, first time commenter. Love your channel. Thanks for putting out content! Also, have you heard of Dave MacLeod? @climbermacleod You two having a chat is my dream team 🤩

1:01:11 - I think some of the negativity might stem from the fact that Mike discusses the Minnesota Coronary Experiment and other like studies without mentioning critical information (ie. mass drop out rate of participants, high trans fat consumption, etc.). In addition, the cholesterol paradox isn’t with CVD events, but with mortality (higher rates of death with lower lipoprotein concentration), but that *is* explained. Basically, it boils down to only addressing certain studies and leaving the majority of the data on the table. If you do that, anyone can make it seem like we have more questions than answers (to be clear, there are still questions, just not as many if you include *all* the data as opposed to just some).

@dr.Alo explains well about LDL

Excellent conversation! Thank you very much! 🙏

Liver enzymes especially alt and ast can be elevated in athletes due to muscle damage from training as well… especially in muscular individuals. In this scenario it does not indicate liver stress or poor metabolic health

I don't think fruit juice is a good choice no matter what. It's way too much fructose with nothing to offset it (no fiber). I can't believe you guys don't recognize that. Otherwise I agree with most of the advise. I'm Whole foods almost exclusive with no meat or dairy and my labs are near perfect. I do supplement Omega 3's and all the supplements you mentioned. No covid as yet and I'm 82, exercise regularly, sleep well with a C-pap machine, So far so good. Watch a lot of health related videos. Good info out there but also some not so good. It doesn't take long to discover who is legit and who is not.

I appreciate Matt's open-mindedness. As a scientist myself, I don't know why it is such a rare trait amongst our creed these days. It was especially frustrating working amongst clinicians in Clinical Endocrinology and Metabolism that I often heard tell their patients that no lifestyle changes can reverse their metabolic ill health. They would cite epidemiological research to underscore the futility of this approach. It was really an eye opener to me how we train people to be beholden to the greater wisdom of the medical industry to both make and break our health. All personal agency is removed - which likely is why we are where we are now.

The misinformation this guy spews is next level. It’s dangerous to platform someone who vehemently denies cholesterol. I expect better from Matt

I take ice cream for calcium. Taurine and Nac. 6 foot 161 lbs

Thanks!