Reversed 35 Years Biological Age In 5 Years: A Human Study | Review By Modern Healthspan
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- Опубліковано 5 вер 2024
- In this video we have a look at a case study of one person who has undergone hTERT gene therapy. The paper does not identify the subject I would guess it is Liz Parrish. The gene therapy was administered two times over a period of five years.
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Papers mentioned in the video:
Systemic Human Htert Aav Gene Transfer Therapy And The Effect On Telomere Length And Biological Age, A Case Report
maplespub.com/...
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Things like fish oil and meditation lengthen our telomere. Stress decreases our telomere. However telomere is just one aging marker of many like Glycation, Methylation, inflammation , telomere , antioxidants, NAD ,
Hi Thanks for the comment. Yes it is just one of the markers. One thing to think about is that we are systems and there is a school of thought that all the markers are intertwined so improving one will have a positive impact on the others. But it would have been good to see some data on this!
I'm so glad you showed the second paper. You read my mind. My big hangup with this paper was that they used telomere length to measure age, a technique rendered outdated since AI based epigenetic clocks have been developed. I even guessed that BioViva was involved before I looked under the listed authors. But I still think telomere elongation could turn out to be an important component of future age attenuation therapies. It might even be part of the reason that model organisms still die after experiments that do result in amplified healthspan.
Consider that hTert has effects beyond lengthening of telomeres, such as interaction with proteins and gene regulation. Would be interesting to see the epigenetic effect of this therapy.
Hi Dorian, thanks for your comment. It would certainly have been nice to have also had epigenetic age tests. Or even just one now, to see how it correlates with the telomere age.
I have been watching your chanel and see the younger appearance of you. Thankyou for sharing.
Hi Kristi, thanks! That's very encouraging!
I'd have to see more. Telomere loop dynamics, not just length. Expression of genes involved in protein production(integrated stress response) and mitochondrial quality control.
Hi thanks for your comment. More data certainly would have been good. Both in terms of the impact on telomere function and any wider effects on the body.
Thanks, Richard. It would have been nice if they'd released info about any improvement in age-related muscle, skin, eye deterioration.
Hi Fide, thanks for your comment. Yes a more data on any changes in other biomarkers would have been helpful.
Let me give you the biomarker of aging reversal that counts Richard, show me a picture of this lady at 62 before the gene therapy and then a picture after this 5 year study. . It's the one biomarker that counts
I agree. Telemere length is unlikely to be the tallest tent pole for most people, but it will be the tallest tent pole for a few people. Since various aging mechanisms can set up feedback loops, this could also potentially avoid a subset of the unfortunate feedback loops.
Hi Jeff, thanks for sharing. I do agree telomere length may not be the best but may help some people. It might have been a case of doing what is possible, especially as the first treatment was back in 2015, rather than doing what would be the best.
Hi Richard. Certainly appreciate your research and informative videos. Something is certainly working for you as you continue to appear to reverse your own age. You continue to appear younger and so getting an update from you on your daily/weekly regiment would be welcomed by your viewers.
True, even the voice.
I hope the test subject lives to 200👍
Hi thanks. We certainly wish her the best and it would be great if she can live to 200. It was very brave of her both from a medical and reputational aspect to take the treatment and make it public.
But did she actually look like she was 25? I've heard many people say their biological age is say 30 when they are about 60, due to something they have done, but they still look 60, and they probably only have about 30 more years to live. So what difference does it make?
Hi David, thanks for sharing. I think this is a much larger topic and something that Prof Kaeberlein has raised. Changing a biological age does not mean anything if there are not phenotypic changes as well. And this is certainly valid. I would say it is not simple though. If the metabolism is improved (better blood markers etc.) then that would be associated with better health outcomes even if the outward appearance did not change. It is a Rittel Wicked Problem. It is so difficult to answer, does she look better than she would have done if she had not taken the treatment?
@@ModernHealthspan Yes; and will she live longer and/or maintain good health for longer? It's still interesting, though, and I hope we see some genuine progress in this field soon.
I stood about 3 feet from her for several minutes in a casual group conversation at a conference in Oct 2022. In my opinion she looked about 35 or a really great 40. In other words, she looked great. I’m 10-15 years her junior and frankly, she appears healthier than me (totally subjective, I obviously know nothing about her personal health).
@@embr9723 Thanks for the feedback, Embr.
Hie Richard.. I'm from India.. I always watch your videos regularly.. Thanks..🙏
Thank you Richard. Very Promising, so many labs including George Church & Sinclair's Lab are working on Genes therapy as well, hopefully later can be available like seasonal vaccine to reverse our age every year!😉
Hi Sparkling thanks for the comment.
That would be miraculous! I’m guessing that tech is 25 years away when I’m 80 💀😂.
Yep, preety sure that's Liz. They (Bioviva)did some work on myostatic inhibition about 6 years ago as well. Be interesting to see follow ups on that. Exciting news all round.
Hi Thanks for the comment. Liz actually took 4 treatments as I recall, including klotho and myostatin. It would be great to see reports on these as well.
Thank you for informative podcasts! I hope you will address the latest short David Sinclair podcast about "pulsing" and if it will change your supplement regimen.
Hi Jill thanks for the comment. Yes I saw that and I do know that Dr Sinclair has mentioned it before (though I also thought he took NMN everyday). Let me have a look at the video, it is time we did a supplement update.
Research shows that taking nicotinamide mononucleotide (NMN) improves intestine bacteria composition and telomere length. NMN doubles the telomere length of humans over a 90-day period of time.18 Jan 2022
Hi Ryan, thanks for sharing. That is interesting, I will have a look at the paper.
Definitely Liz. She did mention a few years back that her biological age was higher than her chronological age prior to her gene therapy. But I didn't know it was 62!! And now 25!! Remarkable....
Liz is only 50 or 51, not 62.
@@stephenrose1902 biological/health age was 62. Her chronological age is ~51. And that seemed to be only one measure...telomere length. Another measure could've made her biologically less than 62.
Hi Armando, thanks for your comment. I do think it is remarkable and a very interesting proof of concept. Very brave of her to take the treatment and publish the results.
Liz Parish has had it and, without knowing her exact age, I think she looks 49-50. Is she 60+? That would be cool. Also, how do we know this gene therapy doesn't set a person up for cancer in a few years? Thanks for the video!
Also, how do we know this gene therapy doesn't set a person up for cancer in a few years?
For starters, you pick candidates that just have an actuarial decade left in the first place, IMO.
Hi J, Liz is currently 50 or 51. Her biological age (based on telomere length) was 60 at the start of the study. The paper did not talk much about cancer (which surprised me a bit). They did mention that in vitro tests of hTERT upregulation had not shown cancer development but nothing in vivo and apart from saying that Liz was fine on the physical and blood tests, they did not mention anything specific.
@@jefflittle8913 I agree Jeff, it seems that a few of these life extension therapies could wake up the REAL Immortal, NMN is another potentially problematic one.
This is an interesting paper, but it's a big step getting from 'shorter telomeres are associated with aging' to 'extending telomere length reverses aging'...
Hi thanks for your comment. I agree, and telomere length as a measure of aging has been largely replaced now. Although that does get into the larger question of whether changes in any of the markers that we use (e.g. epigenetic age) actually means we are getting younger.
Liz Parrish had short telomeres for her chronological age. Now your guess, and mine, she has longer telomeres than her chronological age would calculate. This is great news for Liz, but for most of us our telomere length will not be the thing that kills us, after all at average life expectancy normal telomere length is still around 50% of birth length. As you say this is also good news for other “large molecule” therapy delivery. Let’s hope we all live long enough to require or telomeres lengthened!
Hi David, thanks for sharing. It is a good point that running out of telomeres is not the cause of death! The hope would be that the longer telomeres would encourage more systemic youthfulness. Though, as I mentioned they did not report on this in the study.
Pretty sure the first person that lives to over age 130 is already born. But the real magic is probably still a few centuries away imho. Since we're just starting to grasp the basics. Also "Astragalus" is known to lengthen telomeres. You can find some research about that.
Hi Mark, thanks for sharing. I will have a look at astragalus.
there already are cases of people living up to 130 lol
Very intriguing report, thank you! Were there any data, or even qualitative statements, in the communication indicating changes in other biomarkers or measurable gain-of-function/rejuvenation effects? Perhaps this is common knowledge, but I'm unaware of how lengthening telomeres, as extraordinary as I know that is, otherwise effects an organism's health and vitality.
Since telomere shortening is one of contributing factors of aging, it makes sense that halting it slows the corresponding types of degeneration. However, even those degenerations should only be stopped in their track at the age of the gene therapy: the cells whose genes had already been damaged prior to gene therapy don't get those genes restored. Thus age is not reversed to the level of youth corresponding in normal aging to the increased telomere length.
Hi Richard. Thanks for sharing.
Hey Ron, thank you!
What are the odds this person gets cancer?
It would also be very interesting to hear their subjective well being and how they’ve felt.
If it's Liz she is around my age, about 50, and so no she did not turn into a 15 year old. The white blood cell telomeres are dynamically changeable so even though this is a good thing and shows that Htert works and seems safe this is not the fountain of youth.
Hi Lord Mon, thanks for sharing. Liz's original biological age was over her chronological age, and that was where the calculation came from. I agree with your summary. It is really not clear how important white blood cell telomere length is, but showing the safety and efficacy (even if it is an N of 1) of gene therapy is interesting.
Literally
But Liz Parrish is only 50 or 51 chronological years old.
Hi Stephen, thanks for the comment. It is true that Liz is now about 50. The study was based on biological age. At the beginning of the study her telomeres were not good for her age and she had a biological age of just over 60. It is a good point though and I should have pointed this out.
If she's biologically 25 she should be pre-menopausal again.
Hi, thanks for the comment. No data on this. It is a good point, how strongly is telomere length, in white blood cells, associated with system wide biological age.
@@ModernHealthspan Would be great to find out.
So two tests split by 5 years, hmm?
Literally anything that she did within those 5 years can be responsible for the positive change. But we're told it's the product she's selling.
Thanks for your comment. It is a case study not a scientific paper. Something to think about would be, we need long term studies (short term do not show meaningful effects for aging), we need large cohorts (so we can make inferences for the population at large), we need to change one thing at a time and keep everything else unchanged (so we can say with reasonable confidence that that specific intervention made the difference).
When do you think we will have this data in humans?
You look younger
I wonder what genes they used.. Dr Sinclair seems to be doing very interesting studies in glaucoma in rats. Literly reversed blindness!
I did this at 32 and became a fetus. Beware!
So when are you going to do this for yourself.