Which Hallmarks Of Aging Affect Epigenetic Age | Review By Modern Healthspan
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- Опубліковано 2 чер 2022
- In this video we have a look at a new paper from Dr Steve Horvath which examines which of the hallmarks of aging affect the epigenetic age of cells as measured by the skin & blood clock. Not all of the hallmarks affect the epigenetic age.
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Papers mentioned in the video:
The relationship between epigenetic age and the hallmarks of ageing in human cells
www.nature.com/articles/s4358...
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We need a study with data for blood transfusion from young to old and test that result against Horvath clocks.
Hi thanks for the comment. It is true that Dr. Katcher used factors from young blood, rather than the blood itself, but he did see a significant reduction in epigenetic age. In a similar study Dr Goya used young blood and I thought he was planning to have epigenetic age tests done but I have not seen any results published. It would be interesting to see the result.
Another important insight into the complexity of the aging process. Thanks for sharing.
Metformin, Nicotinamide-Adenine Dinucleotide (NAD) and Nicotinamide Riboside (NR) increase the "Proliferative Capacity" of the cellular lifespan, but not effect the epigenetic clock. AKG does get picked up by the clock.
Does it implies reverse aging really need combination therapies instead of only one? Or may be reprogramming has potential to fix all?
Thx Richard for this informative video.
Epigenetic age is influenced by stem cells exhaustion, among others. Does this mean that production of new stem cells ( through water fasting for 3-5 days fo instance) could improve epigenetic age ?
Hi Abdelilah, thanks for the question. You would think so. If nothing else the stem cells should have a younger epiage and the more of them you have the younger the tissue will be. We just talked with Dr Blander who said that the issue with epigenetic clocks was that they are black boxes and so difficult to impact. Studies like these may show a way that we can do this.
Fascinating! Thank you for the review, Richard!👍👍
Hi Ray, thanks!
Excellent review, thanks. More support for my alternate day fasting. [To promote MTOR cycling.]
I just realized you look kind of younger than a year ago !!!
and me too.
Hi thanks, that is very kind of you!
Thanks Richard. Enjoy the weekend.
Hi Ron, thanks! You too!
Things that we punters can do fairly simply that may help is look after mitochondria...exercise, ketones, herbs to stimulate uncoupling
Richard this begs the obvious question. As nutrient sensing effects epigenetic age, does Rapamycin effect epigenetic age?
Wow, you made this video fast! I may still make a video on it, too!
Hi Dr Lustgarten, thanks for your comment. Great, looking forward to it!
Absolutely looking forward to it.
Interesting!
Hi thanks! I certainly thought so. It is great to find a paper which is surprising!
maybe dna damage is still too rare to be detected by the clock... whereas the mitochondria genesis is global and can be detected
Hi Brandon, thanks. My understanding is that double strand breaks are quite common but are generally repaired. So I did wonder how good a proxy for Genomic instability irradiating the cells is.