AKG Supplements: A Firm But Fair Review!
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- Опубліковано 21 лип 2024
- AKG Supplements in a human study reversed biological age by 8 years, and in mice, a 2020 study showed a 16.6% lifespan increase. Let’s have a deep dive into AKG or alpha-ketoglutarate supplements
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www.ncbi.nlm.nih.gov/pmc/arti...
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pubmed.ncbi.nlm.nih.gov/34952...
pubmed.ncbi.nlm.nih.gov/17896...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/22510...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/12297...
pubmed.ncbi.nlm.nih.gov/10890...
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What about Liposomal AKG products?
This video is a bit confusing, and even misleading, as it agglomerates all forms of AKG, and then draws general conclusions. Yet only calcium-alphaketoglutarate is promoted as a longevity supplement, not the other forms, precisely because it is absorbed at a much slower rate in our bodies and thus can enter the cells. Thus dismissing Ca-AKG on the basis of studies made on A-AKG or O-AKG seems a bit dishonest to me, because the main argument against these forms of AKG doesn''t hold for Ca-AKG.
I noticed in some older studies they deliver the AKG to the small intestine to avoid the stomach acids breaking it down. I use enteric coated capsules.
Further more , in some of the studies the AKG is delivered to the small intestines bypassing stomach acids .
Agree this doc is covering a lot of ground, I have massive problems with some of his assertions.
@@johna5484where do you purchase it with the coated capsules?
Exactly! Dr. Brad needs to re-do this video.
It works!!! As a person in remission from stage 4 cancer, I can tell you this has made a tremendous difference in my recovery.
Which kind of Akg You take
@@user-el5yv6vy3b I use the CA-AKG.
What kind of akg you take?
@@user-el5yv6vy3b CA-AKG from Do Not Age
Spill the beans!
Work for me Brad . I do blood tests every 3 weeks plus monitor via oura Apple Watch and CGM . Better blood flow. Lower resting heart . Have to be careful not to use too much as can take calcium level in blood too high. Reduces Mtor 1 in studied .
There is a lot of anecdotal information that Ca-AKG drastically reduces epigenetic age. This doesn't mean anything by itself but is interesting to note.
Im 64 years old and I’m taking as supplement for numbers of years now coz I am running 4-5 y a week it does help me to gain more strength my family doctor is asking me if I am taking something sort of vitamin she ask me because my blood test show everything very good in my age , I’m 64 and wrinkle free probably is the effect of AKG
I started taking AKG a month ago, and noticed a definite improvement in exercise capacity. For example, at our Karate school, we run around and various calisthenics as a warmup, followed by a set of burn-out pushups. I can now outlast everyone else in the school, and feel like I can easily do more after they call time, when everyone else including people less than half my age, are done and wiped out. If the effect is pure placebo, it's an amazing placebo effect that I'll happily keep paying for, especially since it isn't all that expensive.
Placebo effect? It's incredible just how powerful it can be. If so the effect will fade.
@@ingramdw1 If it was placebo effect, then it's still worth it, but since I've experimented with many different supplements, and have not seen such an effect, I doubt it.
There is definitely a difference,I use AAKG
What kind of AKG are you taking and which brand?
I bought c akg but Not sure that I should use it . Akg is antioxidant can stop body to adapt to training same like vit c,e resveratr etc… it might give me energy and better recovery but have that other side!!
Thanks. I have not taken AKG & appreciate your input that says it isn't needed. I did add creatine after your video. I was surprised that my wife's doctor takes it and he is 40 years younger than me.
Thanks for reviewing Dr. Brad! Interesting articles.
Its weird. Ive been taking random supplements for years but recently I've had a lot more energy and going to the gym and I can correlate that to the exact time I started AKG
my personal experience with CA- AKG and weight lifting appears to be as much as 20% increase in strength while lifting shortly after taking 1 Gram ,As compared to the same attempt on days not taking the supplement,
Exactly why I'm a subscriber. Just saved me so much researching time. Thanks.
Yes, we need real controlled human trials. BUT there are several fly and worm studies showing significant life span improvements - up to 12 percent. I personally take the Novos Core longevity mix which includes 1,100 mg of CaAKG.
AKG is one of the four enzyme cofactors involved in collagen synthesis. Is there a reliable test for AKG deficiency at some meaningful level? Vitamin C is also a cofactor but the test for deficiency is that small amount to prevent scurvy, not for the best health overall.
Thank you so much for your honesty! 😍So thats why I can't see any improvement taking Alpha Keto Gluterate besides Sirt6 Activator and NMN!
Are you saying that no improvements bcuz you are taking both?
@@Kit--Kat No, I don't think so that one blocks the other supplement. I wanted to say that *I even though I take the other anti aging supplements* I got no result from Alpha KG. Also I do many other anti aging things (workout, LED, 8-9 hours of sleep, collagen, Quercetin etc., Vitamin D, daily smoothys, bone broths, no fast foot and avoiding fast carbohydrates...) 🤔 I have the feeling that nothing changes. Maybe its because I always looked 15 years younger, maybe you can look younger just a certain amount, I already reached?
Lol iif Brad was honest he would have talked about CaAKG and not AKG
If a main uncertainty is about cellar delivery why do you ignore the Liposomal protectant and delivery to the cells?
Thank you Doc for shedding some light on the use of this supplement. I had read about AKG but after your comments, I can see it's not for me.
I wouldn't be put off by this video
Ignore this nonsense and listen to the people who actually take Ca-AKG.
have you looked into astragalus? also related to longevity
Well this saves me lots of money on stuff I already had doubts about.
Dude you are the best... Thank You!
It's a little early to make a call on this one, it will be interesting to see where it ends up with more research..
Hello Brad. I really appreciate the effort you put in for educating everyone. Your video content is very well organized, concise and professional. I have derived much benefit from your studies into questions concerning health. Just some positive feedback here. 👍
Nothing can replace a good diet and exercise
One of the few channels I trust, thanks to your immense dedication to the truth. Thank you!
I found research that AKG does enter muscles cells. Its a performance enhancing supplement like Nitric Oxide boosters. Its about helping the mitochondria run more effectively.
Would love to hear your opinion on ashwagandha helping with anxiety and if there are any side-effects to taking it? Like liver toxicity, downregulation of certain neurotransmiters in the brain after stopping taking ashwagandha. Anyways I want to thank you for the great effort you put into this videos and research! Please keep the videos coming!
Anecdotal, but I have always gotten seratonin syndrome after taking Ashwaganda (multiple brands) Took me forever to figure out what was happening..
Pharmaceutical drugs work better with less risk (besides benzos).
What is serotonin syndrome? as far as I'm aware Ashwaganda has been shown to improve a sluggish thyroid and buffet the impact of cortisol, but I'd also like to see more studies. I 'very also learned that it's recommended that you take it intermittently, so there must be a reason why.
Ashwagandha works like rapamycin. I took a high dosage 3-5g/day and got sick all the time. I think its better to take 3-5 days a month.
Ashawanda + magnesium + vitamin D helped me greatly with anxiety and depression. And with B complex added I also felt more regulated energy and no brain fog. And always remember to meditate as well, have a gratefulness diary it all really helps. Hope you can find peace soon, anxiety is one hell of a thing to suffer with.
Any thoughts on liposomal CaAKG? I have been buying it for my parents from Renue by Science
What are THEIR thoughts? Is it helping?
I'm giving it to a 91yr old man and there is a definite improvement.
Joke or serious?
@@pierrejeanes Completely serious
What improvements are you seeing ? My wife and I are going to try 6 months of Novoscore with ca-Akg.
Some random 91 year-old guy? As an experiment before you take it yourself? LOL Evil.
@jimdandy8996 92 now and soon to be 93 if God wills it. And I take AKG myself as well. He was diagnosed with heart failure at 88 and was told to call hospice. He's beat the odds baffled his doctors got to see 5 new Great Grandchildren and live in his home without having to go to a nursing home. Evil? Try looking into a mirror.
Yeah, I was reluctant after finding out about these studies.
What about CaAKG as opposed to Orthinine AKG or AKG on its own?
Q: Please research in depth how much vitamin B3 Niacin in grams is required for the human body to produce 1gr of Niacinamide Mononucleotide (NMN), I need a speculated round estimation.
ChatGPT-4 A:
Niacinamide mononucleotide (NMN) is a derivative of vitamin B3, also known as niacin or nicotinic acid. The body can convert niacin into NMN through a series of biochemical reactions. However, it is important to note that the exact amount of niacin required to produce 1 gram of NMN is not well established and may vary depending on several factors, including individual differences in metabolism, diet, and overall health.
There is limited research available on the specific amount of niacin required to produce NMN. However, studies have shown that the conversion of niacin to NMN in the body occurs via the enzyme nicotinamide phosphoribosyltransferase (NAMPT). This enzyme catalyzes the transfer of a phosphoribosyl group from nicotinamide to NMN, producing nicotinamide mononucleotide and pyrophosphate.
One study published in the journal Nature Communications in 2018 estimated that NAMPT has a turnover rate of approximately 1-2 molecules of NMN per second. Based on this estimate, it would take approximately 1-2 grams of niacin to produce 1 gram of NMN in the body. However, it is important to note that this is a speculative estimate and may not reflect the actual amount of niacin.
Brad can you confirm this?
Thanks Brad :)
I take AKG daily, the cheaper Arginine version. It may be a waste, but it's not that expensive and Arginine can be useful for workouts. So as long as I don't have any bad side effects I will keep taking it. However I will keep my eye on it ..
Arginine is negative for lifespan fyi as it heavily spikes mTOR
You mean aakg. Compounded with arginine
Thanks Dr. Brad.
Great evaluation of the study. Yeah I agree about being cautious with AKG usage for any benefits
Great job!!
Dose it contribute to calcium build up in the veins & arteries etc also Alzheimer’s or dementia ?
No Bullshit, just pure Information. Love it❤
When I was reading biochemistry in my medical college there was alpha ketoglutarate everywhere in multiple pathways including precursor of amino acid synthesis, cellular signalling, krebs cycle rate limiting step, epigenetic control. I wonder if not alpha keto glutaric acid then some other precursor of it might assist in creating akg where it is required immediately. Because supplemented one breaks in very less time.
yeah, that seems like the best thing to look at. That 5 minute half life is a joke. Often times precursors are much better. But I imagine that depending on WHERE it is used in the body, it might have a different precursor. So that can be good or bad. Good because perhaps we will learn more about different supplements and how they work in specific cases once they convert to AKG. However bad because now you are looking at non-systemic boost of AKG potentially. Though krebs cycle is pretty much everywhere, we might find other ways to use it. A cool concept. I think you are correct.
Brad, there are various forms of AKG but Calcium AKG seems to be the only form studied. Is there one that that is efficacious?
Brad covers at least three forms in this video, arginine, ca, and ortho.
What about ca-akg against the breakdown of AKG?
Is calcium akg like resveratrol as antioxidants can stop body aerobic adaptation ?????
If AKG is difficult to absorb into the body in it's whole form, is it possible to instead take supplements that the body can use to synthesize it's own AKG, very similar to the formation of glutathione from NAC and gly (TMG) ? Thanks. Always enjoy your material.
It’s not nac and tmg. It’s nac and glycine. Tmg (trimethyl glycine) is not the same thing as glycine. Tmg is betaine and involved in methylation while glycine is an amino acid.
I realize this is a bit Off-Topic, and apologies for that. But I'm wondering what you think of Molecular Hydrogen (in the form of tablets that dissolve in water, a bit like the old fashioned "Alka Selzer" tablets, and release the Hydrogen gas in drinkable form, assuming you drink it quickly - per directions) as an overall Anti-Oxidant, that is beneficial for the body. One of the claims, of proponents of this technology (particular supplement), is that it is not an indiscriminate antioxidant. But rather quenches inflammation - already existent in the body - in a selective way. Also, one gets some magnesium in the process -- which is absorbed much more efficiently, than by taking magnesium supplements in the more typical way. Do you think Molecular Hydrogen can be part of an effective anti-aging strategy? Or might it be beneficial for the body, and mind, in other ways?
Thanks for presenting such excellent videos. Occasionally, they really save me some money, and give me peace of mind.
Did be nice to know if a "time release" is any different from "sustained release" when come to half life.
It might be the vitamin D & C in these AKG supplements that are key! Yep- we need actual anti aging supplements that will absorb into to cells & turn them over. Thank-you Dr. Stanfield😊
I was taking off and on so my cells don't FORGET who they are as appears to be a huge reason we age. study below said it helped maintain celluar identity and cellular identity is based on methylation pattern. So can ca-akg get the methylation pattern to reset itself from original secret copy that has yet to be discovered? Though maybe I need to try taking it liposomally. I need to learn more about stability in water and other things as don't mind running in an ultrasonic machine, but then do I even need calcium version then? I do get a slight headache sometimes when taking CA-AKG, but nothing major. AKG was found to enhance Oct3, also known as Pou5f1 said AI. AKG has been shown to enhance the expression of Oct3, Oct4, and Sox2, as well as other pluripotency-associated genes in human and mouse pluripotent stem cells said AI. It has also been shown to increase the efficiency of iPSC generation from human fibroblasts.
Additionally, AKG has been reported to promote the reprogramming of somatic cells into iPSCs by upregulating Klf4 expression said AI. AI is wrong a lot of the time and it mostly just makes up citations and fake research journals all the time. I once had it generate from APA 7 citations and did it perfect but later ruined them all. doi: 10.1038%2Fnature13981 Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cell
Renue by science have Lipo ca-Akg so maybe it is longer lasting than other ca-Akg supplements.
Anyway, Can the placebo effect really make blood age go back eight years? Exercise and good sleep won’t make blood age go back eight years.
How come AKG works in mice?
AKG assists in activating some of the yamanaka genes or so I’ve heard.
No, 8 years is not placebo effect, rather it very well may be cheating of article writers to help their sponsor!!! It happens all the time, date is mis represented to achieve a jaw dropping outcome.
Yes too acidic. I get little chest pains, liver I think. One every week is enough I think. By all means, lick the power to verify.
So a carrier like quercetin into cells..?
I had stopped taking arg-akg but still have several kilograms. I might start again, it doesn't taste bad
Thank you:)
Why not directly add it to the blood
I am currently taking a calcium supplement. If I start taking Ca Akg do I need to stop the calcium? Please help!
Yes you do.
Lifestyle may be the way to go. Recall that Adam Antebi noted in a lecture I saw (2022 I believe) that low insulin (in animal model) resulted in major increases in AKG and NMM. We really need good cheap lab tests for a range of things (SIRT 6 expression, AKG, NAD+, CD38, etc) as it would help us dial in our lifestyle and avoid throwing money away on supplements. NAD+ has been shown to be raised by exercise to youthful levels in older people, so it would not surprise me if AKG followed suit.
*suit
All salient points.
Also worth considering is the central role that mitochondria play in this (they are central to the Krebs cycle). This is probably at least as significant as CD38.
Regular exercise helps here as do some herbal supplements. Particularly promising for the function and number of mitochondria are ashwaganda and ginger, the main component in ginger being 6-gingerol. The loss of mitochondrial function is one of the key factors in ageing, significantly affecting both healthspan and lifespan.
Exercise and well balanced whole plant diet with great sleep.
Right on, Pete! Intermittent fasting, proper diet, exercise, regulation of circadian rhythm and proper sleep all improve these processes.
As long as we are still talking about "good diet, exercise and sleep" it is obvious, longevity studies are still far off...
what about lipo akg?
What do you think of MitoQ Brad?
I personally wouldn’t spend my money on it
As it's broken down. doesn't it mean that the body just has more precursors of akg and knows wether to make it or not?
Body has its precursors. It is one of the step in krebs cycle where it is created from its precursors in plants and animals. I wonder if we can supplement those precursors so that they convert to it wherever it is needed.
Oh and its precursors are isocitric acid and citric acid. The one found in lemon, orange, lime and similar fruits.
What I found with ca akg was that it reversed some of my gray hair, not all but about half of my gray hair had restored color. I could tell since you could see half the hair gray and the other half near the root with the actual color. I also think if it lengthened lifespan in mice that sounds promising.
I have seen this grey hair reversal phenomenon reported on other fora
Which branch you are buying???
I have been taking He shu wu for a year and almost all of my grey hair has disappeared.
Do you drink green supplements?
@@patrickodonnell3270 Nope I do not like supplements unless there is a need , the only one I take is vitamin D. I have concerns about purity, identity and in general mega dosing something. I would like organic sourced herbs if taken and prepared correctly.
It's relatively cheap, safe and has shown life extensions in various animals. If you can afford and are interested in longevity it seems a no brainer, although i understand it's only once you get over 40 that it's necessary.
But which ones do you take or recommend
@@sooie27 do not age as it's the cheapest
In some of the studies I read the AKG is delivered to the small intestine , bypassing stomach acid. That’s the way I take it , enteric capsules.
Ca akg, taurine, TMG, NMN, NR, QUCERTIN, FISETIN, SIRT-6 activator, creatine, collagen, b complex, c, zinc, selinium, iodine, K, Omega oil, magnesium and theonate, d3, ashwaganda, cholera, spirulina, wheat grass, kale, moringa, Kefir, @@sooie27
The study being funded by a supplement company selling akg is a big NO for me on the effectiveness of akg.
There have been some data that Urolithin A is an emerging superstar (or at least, so say "Do not Age" which is a bias opinion, but there are others on UA-cam citing data (e.g. Modern Healthspan) that might seem to back that up.... but until Dr Stanfield says it's legit, it's not legit... hope you have thoughts on this soon Dr Stanfield.
I personally have a problem with “Substitution Therapy” that is to give the body something it makes on its own from an outside source, at a very large dose, specially when the molecule you give the body is a molecule involved in main and multiple cellular pathways. AKG and NAD are such molecules, they are involved in many many cellular pathways, and my concern is the biological adaptation and dependency to exogenous source, and ultimately disturbance of the incredibly complex molecular machinery inside cells. I think a lot of research is needed to understand the true safety of the long term intake of these molecules, we are not mice and there may be unknown consequences… On the other hand intake of some other endogenous molecules through supplements, things like creatine or collagen, are almost certainly fine since they have been tested for a very long time, the safety data is overwhelming and are unlikely to alter the cell functions fundamentally over the long term.
well stated. I agree.
In mice, berberine, metformin and NAD boosters interfere with CaAKG's bioage reversing properties according to the CEO of the manufacturer of Rejuvant. Thanks for all you do.
Where did you read this? I'm curious.
He (Rejuvant CEO) talked about it in one of his interviews. I think it may be smth to do with mTor activation (AKG) and deactivation (berberine, Metformin) canceling each other out
Thanks, I guess I'll add AKG to the list of supplements I'm wasting money on...
The integrity of your videos will take you far. I trust you a lot more than other related channels. Thank you for taking a look at the actual research and explaining things in an easy to understand manner.
I am taking 3000mg with magnesium before bedtime. Never had a better and deeper sleep( since teenage years)
What brand do you take?
Thanks for saving me money
No we can’t say there’s a trend towards. Why does Brad keep saying this? It just continues to prove he’s no epidemiologist “This expression might be best considered a form of special pleading whereby authors, however unwittingly, are claiming something that their study has not achieved. The unpredictability of change in P values with additional data also illustrates the risk of concluding too much from a finding of modest statistical significance, such as two sided P0.01. In that case, simply increasing the data by 20% could reasonably be expected to lead to less significant results about 30% of the time.”
thank you
is there really anything for the folks that need Dummies Guide to Supplements for men over 50 ?
Brilliant Dr Brad. You just saved me some money and false hope. No point taking a supplement for years when no real evidence of its effectiveness. So much media hype based on such poor evidence.
Ok….people should do studies for themselves! My first experience with arginine AKG years ago, was phenomenal; of course I tried for gym exercises, I lifted more, most notably i did not tire quickly, my rest time between sets were shorter. I showed dynamic strength with weights, I felt less hesitation in my energy through the sets. I always verify via my experience. Recently tried again, and I remembered and relived positive experiences. Granted everyone is different, but not so far far different all the time, unless in extreme cases. This produced more juice than epicachetin, Creatine, many others. It feels cleaner. I am in the fitness industry; this however is not professional representation. It’s a try for yourself approach
I take AKG and niacin, but my best hope is that fasting will help with logevity or at least youthfulness. Some of the many benefits of doing occasional extended fasting: Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. Blood pressure is quickly and dramatically lowered.
Fribrosis/scarring is reversed over time and telomeres are lengthened, which also helps with lung fibrosis.
Fasting increases nitric oxide.
Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' that is not supposed to be there.
Reflexes and short term memory are increased.
Fasts from 36-96 h actually INCREASE metabolic rate due to norepinephrine release!
After 72 hours or more fasted, your body recycles as much as 1/3 of all immune bodies and creates new ones, rejuvenating your entire immune system.
Vitamin D plasma levels are increased, and vitamin D in turn increases autophagy.
Fasting increases anti-aging Yamanaka factors!
Fasting can help with MS, Depression, BPD, Autism and seizures.
Weight loss from fasting only loses10% lean tissue and 90% fat compared to the typical 25% lean tissue and 75% fat lost when calorically restricting for long periods. The hunger hormone ghrelin lowers with extended fasting and rises from dieting.
Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.
When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.
What breaks a fast? Anything with protein or carbohydrates in it will break a fast, though if the amount is tiny you will go back into ketosis very quickly. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many medications are dangerous to take while fasting so you may have to talk to your dr. about discontinuing them during a fast.
Fasts of several days will not affect short term female fertility and may increase long term fertility, especially in women with PCOS.
Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone and helps build muscle by increasing insulin sensitivity!
The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!
Does the body preferentially prefer glucose as a fuel? No, your body always runs mainly on fat except for brief periods of very intense exercise. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose.
Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses.
Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which also help your immune system and anti-oxidative system, especially in the brain. Ketones also provide an additional energy source during infection, which is critical when trying to fight off a bug. In fact you can have as much as three times the total energy available in your blood when you are in deep ketosis, or even more.
It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!
When you fast, this stimulates apoptosis in senescent or genetically damaged cells. This kills these cells off completely. Senescent cells are responsible for the effects of aging and are the root cause of the development of cancer. If it were possible to destroy them all it would completely stop aging and cancer. That is not possible but fasting can help limit these effects by killing off many of the affected cells and limiting the future effects of aging.
Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth, helping a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate
Fasting also increases telomere length, negating some of the effects of aging at a cellular level.
A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and under 18 g of carb.
Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.
Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.
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www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
pubmed.ncbi.nlm.nih.gov/20102774/
pubmed.ncbi.nlm.nih.gov/31877297/
pubmed.ncbi.nlm.nih.gov/23707514/
clinical.diabetesjournals.org/content/36/3/217
pubmed.ncbi.nlm.nih.gov/27569118/
pubmed.ncbi.nlm.nih.gov/21410865/
pubmed.ncbi.nlm.nih.gov/28235195/
www.ncbi.nlm.nih.gov/pubmed/24905167
www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
pubmed.ncbi.nlm.nih.gov/20921964/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10
www.biorxiv.org/node/93305.full
www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/
n.neurology.org/content/88/16_Supplement/P3.090
www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits
medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html
pubmed.ncbi.nlm.nih.gov/7714088/
pubmed.ncbi.nlm.nih.gov/6859089/
www.ncbi.nlm.nih.gov/pubmed/23876457
repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
www.cell.com/cell/fulltext/S0092-8674(19)30849-9
www.ncbi.nlm.nih.gov/pubmed/25686106
This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!
My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.
Great post!
If there is anything as close as to a fountain of youth that is prolonged fasting, done safely properly in cycles in my opinion, since it triggers all of the systems in the body and is much much more powerful than a handful of molecules, no surprise even the most dramatic lifespan extension in mice such as reprogramming and removal of scene-sent cells still underperforms caloric restriction in extending mice lifespan.
Your definition of "some" seems questionable though.
Did you see this same drs video on intermittent fasting ? Basically says it’s useless and actually bad for you.
@@johna5484 The studies here say otherwise. But IF is not the same as extended fasting anyway.
AKG + L-Carnosine + DMSO perfect .
Please explain
If the company that paid for the study has a financial incentive then we can't trust the study at
We recently just seen how biased these things can be
so not recommended
Hhmmmm... maybe make a pill that surives the gut and make the delivery liposomal.
Arginine AKG is more effective than just AKG, and the arginine provides a good pump
I take 2 grams of that one.
@@enalo6261 It made an immediate difference for me
I been taking akg supplements now for around a year, but I supplement different supplements.
What about AAKG? ANY GOOD?
AAKG is not worth it. We are doing a study on AKG but I know that AAKG studies didn't show it to be useful for anything. C-AKG seems to some what help with workouts. AKG with Ascorbic acid is the best to take and is better absorbed and it also works great.many recent studies have confirmed its effectiveness, including the one in 2023 that used it in their chemical cocktails. Also, life increases is up to 30% Ive read 43 studies that mention or study AKG, including 2 dermatology studies. I also make my own AKG.
Rejuvant variant helped me get some of the best exercise results I got in years (cardio). For the same reason, I'm encouraging my mom to take it. AKG is similar to most others -- works well in mice, if you're adventurous and getting benefits that you can discern, I believe it's good for you.
Good video
Main cofactor for AKG thiamine. As far as I'm concerned AKG is a miracle supplement.
My elderly mother and I both tried it and it did nothing. Waste of money.
How did your supplements taste/smell; maybe I can help you verify if the product was authentic
@@Tsug2803 It was chalky and didn't dissolve well. No flavor that I could identify.
Thank you so much for breaking theses down, the devil is in the details
Bryan Johnson
I had massive hair loss and a lot of cardiac arrythmia with creatine. Disappointed!
My ammonia level in my brain back to normal .I have cirrhosis .till now it has saved my life .I am taking it for 2 years .
Can you tell more? So CaAKG has helped you?
Yes .at least for healthy brain regard to cirrohsis
Thanks for this. I bought some AKG (I can't remember why. I just randomly see something and buy the supplement - I know, not good). Anyway it gave me CRAZY HEARTBURN. So that is one side effect. Too much for me, I can't tolerate it.
You need ca-Akg. Not Akg. That’s to acidic!
We need more AKG studies.
Find it odd that donotage has it when there aren't enough studies.
Debatable about not enough studies
Can you do one on MNM
It's like comparing Vegetarians to the general public. Many vegetarians are health conscious, whereas most Americans eat junk food, drink alcohol, and use tobacco. Without accounting for lifestyle differences, that data is useless.
Vegetarians can be extremely unhealthy...in fact ..some of the sickliest people I've met were vegetarians. They bottomed out on iron, b6, B12, vitamin D amongst others and are in a terrible state. Vegetarianism is no guarantee of health...in fact it can for many people be a death sentence
If vegetarians were health conscious they would know that vegetable's, fruits and wholegrains are NOT healthy nor are they essential for the human body, pmsl.
How many carcinogens in a cigarette ? now compare to Brussel sprouts, lol.
Antiaging drug is not have a our country nepal mind it
Hey, aint't that a great supplement? No benefit but it doesn't harm, so: take it ... 😆
The opposite is true. It's a no-brainer when you see how it benefits everyone over 40 who's ACTAULLY tried it.
👍👍👍
Till now, I rather stick with Tru Niagen only. No NMN, No AKG and other mislead products.
There is no sound to your video
I hear him
@@GetNLine strange, i opened the video in a few hours and it works now. Must be UA-cam bug as my volumes were ok.
Que mal
Warning!!! This was the first supplement I had to throw away. Too acidic and very difficult on my body. Niacin was just as bad but AKG also attacked the enamel on my teeth. I don’t do energy drinks because it has too much niacin. Every one’s body is different so please be careful because some of us are VERY sensitive to these supplements.
How did it attack your teeth enamel? Isn't it just a pill that you swallow?
You can avoid letting it touch your teeth by putting it inside a capsule.
@@thomasmuller1850 it was so acidic that I didn’t want to risk damage to my gut biome. Too harsh for my system.
@@thomasmuller1850 instead I switched to eating lots of fruit/nuts and vegetables and absolutely no animal fats after 6pm and that was what changed everything for the better for me. Gained muscle and lost fat by doing this with no restrictions on the amount I ate. I think it fixed my gut biome. I’m a new person. Thx.
@@felixmay6443 Your gut biome that lives in your stomach with sulfuric acid?