The Type 2 Diabetes Onset It’s Not Carbs, Then What?

Technology in healthcare is helping people & healthcare practitioners lay hands on insights which were never possible in the analog world.
While the healthcare sector is moving from analog to digital, still the incidence of metabolic dysfunction is increasing more than ever. Specifically, the onset & progression of type 2 diabetes is increasing more than ever.
The more wearable tech we have, the more people are developing type 2 diabetes
The more CGM we have, the more the blood sugar level are spiking
The more human driven nutrition personalisation we have, the more people are developing insulin resistance
What is the reason?All these tech driven interventions cannot measure biochemistry at molecular level, cannot measure cellular functions
Most nutrition recommendations would recommend to reduce the consumption of carbohydrates on the assumption that all carbohydrates spike your sugar level. Unfortunately, this is where we are going wrong.
Every food we eat is a sack of 100 plus molecules. However each of these molecules interact with our own genes & microbial genes & what byproducts /metabolites are released as a result drives your glycemic response. Depending upon what genes you express & what your microbiomes are doing determine the glucose spike from various foods.
But it is important to understand the biochemistry & cellular functions that drive insulin resistance. Pancreas gets a signal from your oral microbiome to release signals even before glucose enters your bloodstream. Insulin released by pancreas binds to insulin receptors on various cells which starts intercellular signaling cascades & activates specific enzymes to express particular protein GLUT 4 which goes to cell membrane binds glucose, clear it from the circulation & transport inside of cells for storage or energy. Activating GLUT 4 needs a signal which is nothing but nitric oxide.
For Nitric oxide to be produced, your cells should be healthy & maintain its structure & fluidity which helps cells to sense what is outside of the cell & do whatever it takes - produce nitric oxide, activate PGC-1 alpha & more. Our cells need fats & fatty acids to maintain their structure. Therefore consumption of healthy fats- saturated fats- ghee, butter, Pentadeconic acid(C15) & monounsaturated days are most vital to maintain our metabolic health. Seed oils & vegetable oils can alter cell structure & fluidity & cells cannot sense what is outside & cannot product nitric oxide which is starting point of type 2 diabetes.
Therefore it is bad fats that may be making you develop type 2 diabetes.