00:37 Cliff Notes 14:02 Symptoms of experimentally induced pantothenic acid deficiency 15:57 It is thought that pantothenic acid deficiency doesn’t occur naturally. 18:59 Experiments inducing pantothenic acid deficiency 26:06 Signs and symptoms of suboptimal pantothenic acid status 26:54 Is there pantothenic acid toxicity? 30:52 Hypothetical problems of taking high doses of pantothenic acid 31:53 What pantothenic acid is 35:28 Comparisons to niacin and riboflavin 37:14 Roles of coenzyme A 46:02 Roles of 4’-phosphopantetheine 48:12 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences. 53:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways 01:01:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A. 01:03:03 Synthesis of coenzyme A 01:06:47 How coenzyme A synthesis is regulated 01:11:38 Degradation of coenzyme A 01:15:44 The physiology of pantothenic acid absorption 01:25:29 A 2015 paper showed that 4’-phosphopantetheine can cross cell membranes via passive diffusion. 01:29:00 The physiology of pantothenic acid transport in the blood 01:32:11 Cellular uptake of pantothenic acid from the blood 01:33:21 Tissue distribution of pantothenic acid 01:36:00 There may be a particularly high need for pantothenic acid in adolescence. 01:37:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense. 01:39:29 Pharmacokinetics of supplementation 01:48:20 A case for why food is superior to supplements for vitamin B5 01:52:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).
Suspect I have had a low chronic B5 deficiency for 30+ years inc bouts of skin itching, adrenal fatigue, irritability, dry nose, eye problems, poor balance, prematurely grey hair, fat dismetabolism etc. This is really huge. Truly awesome job.
Chris Masterjohn, PhD, I am 83 years old man, general active doing gym workout with weights. I just started taking B5 Pantothenic Acid for two weeks now, though I have been taking B-Complex B1, B2, B6 and B12 daily for more than 2 years. So my question is my B5 is 500mg per capsule per day according to the label on the bottle. Can I take one capsule at breakfast and another capsule at dinner, in other words, two capsules total 1000 mg daily. Is 1000 mg too much for me daily and taking it together with other B-Complex not advisable?
Hey , appreciate your hard effort. I would like to ask can vitamin B5 turn off my acid production and make me fell depressed? Because I took 500mg of d-calcium-panthotenate and my digestion is totally non existent. Riboflavine used to help me with digestion now it not helping. I would really appreciate some theory what could turn off my acid production after this vitmin and make me feel depressed and sad for days.
Thank you thank you!!! Been trying to decipher some of the stuff CoA which I see generated in the breakdown of fats and amino acids and carbs and not understanding much of it..
You had an 84 year old man ask a question about his B5 levels and if he was doing the right thing. This was 2 years ago and I only see 40 comments here so you might have thought of answering his question. Just a thought!
I believe there might be some misconceptions, especially in cases like mine. The superiority of food is evident only when one has normal digestion and can absorb B5 from it. In my situation, adequate food posed no issues. However, having SIBO (Small Intestinal Bacterial Overgrowth) means that for individuals with absorption issues in the intestine, an injection might be a more effective solution. Unfortunately, it's not readily available at the moment. I wish you had covered injection form in your podcast!
In your riboflavin video you say that all molecules are dephosphorylated in the digestive system... So does this change your idea about R5P? Could it also be absorbed through the stomach wall?
I'm not convinced by all the inferences you make of the type "... level reflects ... flux/transport". Like in the enterocytes, the blood of mothers, etc. You can't infer transport by looking at levels. Basic transport phenomena. If serum pantothenate were high in lactating mothers you'd say: "Mother is increasing blood levels to push more of it into the milk." It being low you say: "So much pantothenate is pushed into the milk that the blood levels drop." All we can say is, if there's pantothenate in the milk, then it came from the mother. We can't even say if it got there on purpose (nutrient) or despite efforts to prevent it (toxin). To distinguish between those, you'd need multiple mothers, some with deficiency and some with abundance of pantothenate, and look at their milk. If those with deficiency have relatively higher (or not as low as you'd expect) pantothenate levels in their millk (despite deficiency), we can conclude the body means to put it there and pantothenate is probably good for the baby. This is how in the field of medicine and many other sciences, anything can be proven on demand, and dogmas persist. Measure some stuff and draw inferences. Never mind that if you look at it with a contrarian view you can prove the exact opposite thesis from the same data with equally good sounding logic.
The symptoms you describe are not pathognomonic for B5 deficiency. You are confusing people and encouraging them to take supplements which are unnecessary.
@@harveymorgan1749 Most people are incapable of independent thought: they latch onto the advice of 'gurus' and follow it blindly. This is why he is being irresponsible.
As a medical doctor, I can tell this podcast is well done and plenty of useful info.. they're not saying that you HAVE TO take B5.. they're just explaining the argument. Please apreciate instead of being so uselessly critic..
@@davide6848 >>As a medical doctor Am I supposed to be impressed by that? If you are a medical doctor your knowledge of nutrition will be marginal, at best. I don't understand what you find helpful about this presentation. What is the value in telling people that their symptoms are a result of a deficiency when they are much more likely to be a result of something else? There is more than enough noise and misinformation on the Internet.
@@davide6848 >>As a medical doctor, Maybe you should go back to prescribing oxycontin to hide the symptoms of atherosclerosis in your patients' lower backs. Understanding nutrition is probably not one of your strengths.
00:37 Cliff Notes
14:02 Symptoms of experimentally induced pantothenic acid deficiency
15:57 It is thought that pantothenic acid deficiency doesn’t occur naturally.
18:59 Experiments inducing pantothenic acid deficiency
26:06 Signs and symptoms of suboptimal pantothenic acid status
26:54 Is there pantothenic acid toxicity?
30:52 Hypothetical problems of taking high doses of pantothenic acid
31:53 What pantothenic acid is
35:28 Comparisons to niacin and riboflavin
37:14 Roles of coenzyme A
46:02 Roles of 4’-phosphopantetheine
48:12 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences.
53:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways
01:01:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A.
01:03:03 Synthesis of coenzyme A
01:06:47 How coenzyme A synthesis is regulated
01:11:38 Degradation of coenzyme A
01:15:44 The physiology of pantothenic acid absorption
01:25:29 A 2015 paper showed that 4’-phosphopantetheine can cross cell membranes via passive diffusion.
01:29:00 The physiology of pantothenic acid transport in the blood
01:32:11 Cellular uptake of pantothenic acid from the blood
01:33:21 Tissue distribution of pantothenic acid
01:36:00 There may be a particularly high need for pantothenic acid in adolescence.
01:37:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense.
01:39:29 Pharmacokinetics of supplementation
01:48:20 A case for why food is superior to supplements for vitamin B5
01:52:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).
Suspect I have had a low chronic B5 deficiency for 30+ years inc bouts of skin itching, adrenal fatigue, irritability, dry nose, eye problems, poor balance, prematurely grey hair, fat dismetabolism etc. This is really huge. Truly awesome job.
Did supplementing with B5 help you?
Wow, in depth! Looking forward to part 2. : )
Chris Masterjohn, PhD, I am 83 years old man, general active doing gym workout with weights. I just started taking B5 Pantothenic Acid for two weeks now, though I have been taking B-Complex B1, B2, B6 and B12 daily for more than 2 years. So my question is my B5 is 500mg per capsule per day according to the label on the bottle. Can I take one capsule at breakfast and another capsule at dinner, in other words, two capsules total 1000 mg daily. Is 1000 mg too much for me daily and taking it together with other B-Complex not advisable?
careful woth B6. easy to overdose
Did you find the answer? I hope you're doing well at 87 now.
@@johngoh767 stay far away from B6
Love your podcasts! Thank you so much! Very helpful! 🙏🙂
Hey , appreciate your hard effort. I would like to ask can vitamin B5 turn off my acid production and make me fell depressed? Because I took 500mg of d-calcium-panthotenate and my digestion is totally non existent. Riboflavine used to help me with digestion now it not helping. I would really appreciate some theory what could turn off my acid production after this vitmin and make me feel depressed and sad for days.
Are you talking thiamine?
Did you stop taking it or did you continue to see if the results were still the same?
Listened to Dr Stasha Gominak who used B5 with her pts- very interesting - thank you for your talk. B5 used to clear acne also!
Thank you thank you!!! Been trying to decipher some of the stuff CoA which I see generated in the breakdown of fats and amino acids and carbs and not understanding much of it..
Thank you I am learning to help my body be healthy.
You had an 84 year old man ask a question about his B5 levels and if he was doing the right thing. This was 2 years ago and I only see 40 comments here so you might have thought of answering his question. Just a thought!
Brilliant vid. Many many thanks.
I believe there might be some misconceptions, especially in cases like mine. The superiority of food is evident only when one has normal digestion and can absorb B5 from it. In my situation, adequate food posed no issues. However, having SIBO (Small Intestinal Bacterial Overgrowth) means that for individuals with absorption issues in the intestine, an injection might be a more effective solution. Unfortunately, it's not readily available at the moment. I wish you had covered injection form in your podcast!
You’ve mentioned fatty acid oxidation disorders in this series but it is not clear if Pantothenic is needed for these cases or if it could be harmful
Hi Chris! Does pantethine have any special benefits?
Wow so much good Information
Danke
In your riboflavin video you say that all molecules are dephosphorylated in the digestive system... So does this change your idea about R5P? Could it also be absorbed through the stomach wall?
Is there a coenzym a suplement ? Can one get it as Liposomal?
No
@chrismasterjohn,phd any reason why b5 causes more abdominal gas?
What is its role with uric acid?
most energy drinks have 3x the us rda of B6 ... frightening
Where is the part two?
I'm not convinced by all the inferences you make of the type "... level reflects ... flux/transport". Like in the enterocytes, the blood of mothers, etc. You can't infer transport by looking at levels. Basic transport phenomena.
If serum pantothenate were high in lactating mothers you'd say: "Mother is increasing blood levels to push more of it into the milk." It being low you say: "So much pantothenate is pushed into the milk that the blood levels drop."
All we can say is, if there's pantothenate in the milk, then it came from the mother. We can't even say if it got there on purpose (nutrient) or despite efforts to prevent it (toxin). To distinguish between those, you'd need multiple mothers, some with deficiency and some with abundance of pantothenate, and look at their milk. If those with deficiency have relatively higher (or not as low as you'd expect) pantothenate levels in their millk (despite deficiency), we can conclude the body means to put it there and pantothenate is probably good for the baby.
This is how in the field of medicine and many other sciences, anything can be proven on demand, and dogmas persist. Measure some stuff and draw inferences. Never mind that if you look at it with a contrarian view you can prove the exact opposite thesis from the same data with equally good sounding logic.
Cheers!!!
neat
Alas ,'doctor' Chris masterjohn nose precious little about true nutrition! What a schmoozer...
The symptoms you describe are not pathognomonic for B5 deficiency. You are confusing people and encouraging them to take supplements which are unnecessary.
I am still listening but ppl can take this info and do with it what they will.
@@harveymorgan1749
Most people are incapable of independent thought: they latch onto the advice of 'gurus' and follow it blindly. This is why he is being irresponsible.
As a medical doctor, I can tell this podcast is well done and plenty of useful info.. they're not saying that you HAVE TO take B5.. they're just explaining the argument. Please apreciate instead of being so uselessly critic..
@@davide6848
>>As a medical doctor
Am I supposed to be impressed by that? If you are a medical doctor your knowledge of nutrition will be marginal, at best.
I don't understand what you find helpful about this presentation. What is the value in telling people that their symptoms are a result of a deficiency when they are much more likely to be a result of something else? There is more than enough noise and misinformation on the Internet.
@@davide6848
>>As a medical doctor,
Maybe you should go back to prescribing oxycontin to hide the symptoms of atherosclerosis in your patients' lower backs. Understanding nutrition is probably not one of your strengths.