High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children

Original paper: rupress.org/jem/article/221/9...
Video summary by Timothy Watkins (Yale University)
Children being tested for SARS-CoV-2 show heightened nasal innate immune responses compared to adults. Here, comprehensive PCR testing and cytokine profiling reveal that nasal respiratory viruses and bacterial pathobionts are highly prevalent in children and drive heightened nasal innate immunity.
Keywords: SARS-CoV-2, innate immunity, interferon response, respiratory viruses, mucosal immunity, rhinovirus