Type I interferons drive MAIT cell functions against bacterial pneumonia

Original study: rupress.org/jem/article/220/1...
Video summary by Juan Carlos Lopez Rodriguez (Kings College London / The Francis Crick Institute)
Description: Mucosal-Associated Invariant T (MAIT) cells play anti-microbial roles during infections, yet the signals controlling their activation remain unclear. We show that during pulmonary infection with Klebsiella pneumonia Type I interferons (but not MAIT cell antigens) are key drivers of MAIT cell responses, by governing the activation, effector functions and transcriptional program of murine and human MAIT cells.
Keywords: MAIT cells, bacterial infection, Klebsiella pneumoniae, MR-1, Type I interferons