Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium

Original paper: rupress.org/jem/article/221/7...
Video summary by Ian Cohn (University of Pennsylvania)
Cryptosporidium is an enteric pathogen that is a major cause of diarrheal disease worldwide. In this work, the authors engineer transgenic C. parvum to express MHCII-restricted model antigens and thereby dissect priming and effector functions in parasite-specific CD4+ T cells.
Keywords
Cryptosporidium, Immunology, Intestine, Infection, CD4 T cells, Dendritic cells

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This is incredibly fascinating! Thank you, Ian Cohn, for sharing your research!