Journal of Experimental Medicine
Journal of Experimental Medicine
  • 43
  • 39 437
Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension
Original paper: rupress.org/jem/article/221/11/e20231568/276992/Mitochondria-as-a-primary-determinant-of
Video summary by Maki Niihori (Indiana University)
This work reveals the crucial role of impaired mitochondrial function in pulmonary angiogenesis deficiency, a key factor in the mortality of pulmonary arterial hypertension (PAH) patients. Chronic lipoic acid supplementation improves mitochondrial function, prevents angiogenic deficiency, and may offer a promising therapeutic option.
Keywords: pulmonary arterial hypertension, mitochondrial dysfunction, angiogenesis
Переглядів: 129

Відео

The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis
Переглядів 4062 місяці тому
Original paper: rupress.org/jem/article/221/9/e20240656/276875/The-RNA-binding-protein-Arid5a-drives-IL-17 Video Summary by Sarah Gaffen (University of Pittsburgh) There is a major unmet need to understand kidney-intrinsic events that control pathology in autoimmune conditions. Li et al. demonstrate that a noncanonical RNA binding protein, Arid5a, is a biomarker and driver of IL-17-dependent gl...
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Переглядів 18 тис.3 місяці тому
Original paper: rupress.org/jem/article/221/9/e20230911/276830/High-burden-of-viruses-and-bacterial-pathobionts Video summary by Timothy Watkins (Yale University) Children being tested for SARS-CoV-2 show heightened nasal innate immune responses compared to adults. Here, comprehensive PCR testing and cytokine profiling reveal that nasal respiratory viruses and bacterial pathobionts are highly p...
Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium
Переглядів 4313 місяці тому
Original paper: rupress.org/jem/article/221/7/e20232067/276779/Intestinal-cDC1s-provide-cues-required-for-CD4-T Video summary by Ian Cohn (University of Pennsylvania) Cryptosporidium is an enteric pathogen that is a major cause of diarrheal disease worldwide. In this work, the authors engineer transgenic C. parvum to express MHCII-restricted model antigens and thereby dissect priming and effect...
Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement
Переглядів 1773 місяці тому
Original paper: rupress.org/jem/article/221/8/e20232160/276789/Ki67-deficiency-impedes-chromatin-accessibility Video summary by Zhoujie Ding (Monash University, Australia) Ding et al. discover a unique requirement for Ki67 in regulating chromatin accessibility in the early stages of lymphocyte development undergoing V(D)J rearrangement, thus ensuring normal immunoglobulin gene recombination, ce...
Five Decades of Natural Killer Cell Discovery
Переглядів 3443 місяці тому
Original paper: rupress.org/jem/article/221/8/e20231222/276790/Five-decades-of-natural-killer-cell-discoveryFive Video summary by Lewis Lanier (University of California, San Francisco) NK cells were first described five decades ago and named in 1975. This brief Perspective highlights a timeline of a few selected advancements in NK cell biology in each decade from a personal perspective of being...
Dominant negative OTULIN Related Autoinflammatory Syndrome
Переглядів 2175 місяців тому
Original paper: rupress.org/jem/article/221/6/e20222171/276701/Dominant-negative-OTULIN-related-autoinflammatory Video Summary by Sophia Davidson, The Walter and Eliza Hall Institute of Medical Research (WEHI), Australia This video describes our study of two patients with a rare heterozygous mutation in the gene OTULIN. The dominant negative mutation in OTULIN: C129S is sufficient to drive ORAS...
Dual fluorescence reporter mice for Ccl3 transcription, translation and intercellular communication
Переглядів 1965 місяців тому
Original paper: rupress.org/jem/article/221/7/e20231814/276716/Dual-fluorescence-reporter-mice-for-Ccl3 Video summary by Maria Belen Rodrigo (University Hospital of Bonn University) Dual fluorescence reporter mice were developed to identify cells that secrete and/or sense chemokines and to delete producing cells. Thereby, the authors found that the chemokine Ccl3 facilitates auto/paracrine NK c...
Interview with Arlene Sharpe and Kristen Pauken #DayofImmunology #WomeninSTEM
Переглядів 1,1 тис.5 місяців тому
JEM Deputy Editor Gaia Trincucci speaks with Dr. Arlene Sharpe (Harvard University) and Dr. Kristen Pauken (MD Anderson Cancer Center) in celebration of the 2024 World Day of Immunology. Dr. Sharpe and Dr. Pauken share their stories of becoming immunologists, how they made transitions in their careers, and provide insights on the roles everyone can take to support women in science. The Editoria...
Epithelial alarmin TL1A is a co-factor of IL-33
Переглядів 3455 місяців тому
TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation. Original paper: rupress.org/jem/article/221/6/e20231236/276690/TL1A-is-an-epithelial-alarmin-that-cooperates-with Authors: Pauline Schmitt, Anais Duval, Mylène Camus, Emma Lefrançais, Stéphane Roga, Cécile Dedieu, Nathalie Ortega, Elisabeth Bellard, Emilie Mirey, Emmanuelle Mouton-Barbosa, O...
Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation
Переглядів 3946 місяців тому
Original paper: rupress.org/jem/article/221/5/e20231200/276657/Functional-diversity-of-NLRP3-gain-of-function Video summary by Benedicte Py (Inserm, CIRI, France) Functional characterization of 34 NLRP3 variants identifies benign polymorphisms versus a spectrum of gain-of-function pathogenic variants with variable effects and highlights diversities in the signals controlling their activation an...
Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure
Переглядів 3467 місяців тому
Original paper: rupress.org/jem/article/221/3/e20231144/276569/Regenerating-murine-CD8-lung-tissue-resident Description: Dr. Mariah Hassert from the Harty lab at the University of Iowa describes their new study published in JEM, which focuses on the loss of lung tissue resident memory T cells after radiation exposure and describes ways to restore this critical cell subset. Keywords: Radiation, ...
The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling
Переглядів 17610 місяців тому
Original paper: rupress.org/jem/article/220/11/e20221466/276259/The-guanine-nucleotide-exchange-factor-Rin-like Video summary by Lisa Sandner (Medical University of Vienna) Sandner et al. uncover a key role for the guanine nucleotide exchange factor Rinl in restraining Tfh differentiation via CD28 signaling in homeostasis, immunization models, virus infection, and aging in mice, and in cultures...
RPE biomarkers of transplant efficacy
Переглядів 283Рік тому
Original paper: Identifying biomarkers of heterogeneity and transplantation efficacy in retinal pigment epithelial cells rupress.org/jem/article/220/12/e20230913/276285/Identifying-biomarkers-of-heterogeneity-and Video summary by Farhad Farjood and Nathan Boles (Neural Stem Cell Institute) Farjood et al. characterize the RPE subpopulations composing the RPE stem cell-derived RPE cell product an...
Auto-antibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ~40% of patients
Переглядів 194Рік тому
Original paper: rupress.org/jem/article/220/9/e20230661/214186/Autoantibodies-neutralizing-type-I-IFNs-underlie Video summary by Alessandro Borghesi (San Matteo Research Hospital, Italy) and Adrian Gervais (Imagine Institute, France) Gervais, A. et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ~40% of cases of West Nile virus (WNV) encephalitis. Blood and c...
Skin mesenchymal niches maintain and protect AML-initiating stem cells
Переглядів 325Рік тому
Skin mesenchymal niches maintain and protect AML-initiating stem cells
Type I interferons drive MAIT cell functions against bacterial pneumonia
Переглядів 531Рік тому
Type I interferons drive MAIT cell functions against bacterial pneumonia
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
Переглядів 461Рік тому
IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
Neutrophil extracellular traps jumpstart periodontal inflammation
Переглядів 746Рік тому
Neutrophil extracellular traps jumpstart periodontal inflammation
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa
Переглядів 470Рік тому
Depleting CD103 resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain
Переглядів 356Рік тому
Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain
Spatial mapping reveals granuloma diversity & histopathological superstructure in human tuberculosis
Переглядів 975Рік тому
Spatial mapping reveals granuloma diversity & histopathological superstructure in human tuberculosis
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Переглядів 331Рік тому
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Age-Associated B Cells are Heterogeneous and Dynamic Drivers of Autoimmunity in Mice
Переглядів 672Рік тому
Age-Associated B Cells are Heterogeneous and Dynamic Drivers of Autoimmunity in Mice
Augmenting neurogenesis rescues the engram in Alzheimer's disease
Переглядів 131Рік тому
Augmenting neurogenesis rescues the engram in Alzheimer's disease
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
Переглядів 245Рік тому
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
Переглядів 132Рік тому
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury
Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies
Переглядів 96Рік тому
Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies
Arachnoid granulations are lymphatic conduits that communicate w bone marrow & dura-arachnoid stroma
Переглядів 7 тис.Рік тому
Arachnoid granulations are lymphatic conduits that communicate w bone marrow & dura-arachnoid stroma
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly
Переглядів 216Рік тому
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

КОМЕНТАРІ

  • @AAWolf314
    @AAWolf314 27 днів тому

    when you say diseases you mean systemic mastocytosis?

  • @maipai101
    @maipai101 Місяць тому

    Alrighty kids. Pick us noses for immunity! 😎

  • @isabellanugent1704
    @isabellanugent1704 3 місяці тому

    This is incredibly fascinating! Thank you, Ian Cohn, for sharing your research!

  • @kaoulkae
    @kaoulkae 5 місяців тому

    Congratulations Jean-Philippe and your team. Please continue educating us 🙂

  • @lillithdelaney9205
    @lillithdelaney9205 6 місяців тому

    Hello. Very helpful video ✌️ I wanted to know, does my ANCA positive vasculitis cause my functional neurological disorders?

  • @dbehistun2767
    @dbehistun2767 Рік тому

    Thanks

  • @franciscojaviersobrinomeji587

    Just perfect bravo

  • @3x21wu
    @3x21wu Рік тому

    🐭🧠✨💕

  • @nanallen1
    @nanallen1 Рік тому

    Thank you for exploring the “ micro structures” of the central nervous system. Importantly, please begin to explore the sophisticated system of micro cranial bone movement, in conjunction with the reciprocal movement of the sacrum and occiput , to move spinal fluid back to brain, against gravity - and to balance pressures in the CNS. Old clinical diagnostic microbiologist here - lived through extreme CNS dysfunction following neck/ pelvis injury. Two expert neurosurgeons finally helped figure out what happened to me and why. As well, the expert craniosacral chiropractors. An important book : Chiropractic : The Anatomy and Physiology of Sacro Occiptal Technique by Jonathan Howat. I gave this detailed, large text to one of the neurosurgeons - the expert in tethered cord syndrome who defined the disorder - highly published of course, now passed away. He read it. I asked what he thought. He walked around the room, silent - then looked out the window and said, “ It will take 20 years.” The people who are having consistent neuro issues that are hard to solve may have underlying fusion of the filum off center in the sacrum. Published by Hansasuta, Tubbs, Oaks - Univ. Of Alabama - 3 out of 27 “ normal” cadavers had an off midline fusion. I think that this off midline fusion, perhaps combined with a short, tight filum , may be the cause of idiopathic scoliosis - and a torque in the entire neural tube. Hoping that someday the research gets done.

  • @ClassicalContrarian
    @ClassicalContrarian Рік тому

    Excellent work, thank you for doing this study!

  • @nataliogarbi7502
    @nataliogarbi7502 Рік тому

    Great video, Rayk!

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    @hindatumuhammedfaruk4809 2 роки тому

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  • @hindatumuhammedfaruk4809
    @hindatumuhammedfaruk4809 2 роки тому

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    @tiffanybryan6291 2 роки тому

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  • @tiffanybryan6291
    @tiffanybryan6291 2 роки тому

    I CURED MY HERPES VIRUS COMPLETELY USING DR ERAYO HERBAL MEDICATION ON UA-cam 💙💙💙

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    @kamaluabubakar2706 2 роки тому

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  • @jlcasanova5981
    @jlcasanova5981 2 роки тому

    Great job Andres and Qian ! Movie stars ;-)