Skin mesenchymal niches maintain and protect AML-initiating stem cells

Original paper: rupress.org/jem/article/220/1...
Video summary by Lakshmi Sandhow (Karolinska Institute)
The video summarizes the main findings in a new publication in Journal of Experimental Medicine, 2023, by Sandhow et al from Karolinska Institute. The study demonstrates that AML cells infiltrated in skin tissue are highly leukemogenic in transplantation-induced mouse models. In addition, the work reveals the features of skin mesenchymal progenitor cells and their protective function for AML-initiating stem cells. This video also illustrates AML cell distribution in skin tissue under steady state and following chemotherapy, as well as unique molecular profiles of their niche cells - skin mesenchymal progenitor cells. Finally, the video provides evidence for the protective mitochondrial transfer from skin mesenchymal progenitors to AML and the impact of Lama4 expression in skin mesenchymal niches on the maintenance and chemosensitivity of AML cells in the skin.
Key words: Leukemia cutis, AML, skin, mesenchymal progenitor cells, Lama4, Ebf2