Dual fluorescence reporter mice for Ccl3 transcription, translation and intercellular communication

Original paper: rupress.org/jem/article/221/7...
Video summary by Maria Belen Rodrigo (University Hospital of Bonn University)
Dual fluorescence reporter mice were developed to identify cells that secrete and/or sense chemokines and to delete producing cells. Thereby, the authors found that the chemokine Ccl3 facilitates auto/paracrine NK cell crosstalk to amplify their response against cytomegalovirus infection.
Keywords: dual reporter mouse, type I IFN signaling, cytokine-chemokine networks, Ccl3 / MIP1α, intravital microscopy, cell-cell communication