Clopidogrel medicine (ක්ලොපිඩොග්‍රෙල්) clopid 75mg | medicine sinhala
#clopidogrel_ sinhala #clopid75mg #medicine_sinhala
00:00 -clopidogrel medicine introduction
00:40 - what is clopidogrel
01:25 - why clopidogrel recommended , machnism
02:51 - clopidogrel side effects
03:38 - drug interaction (aspirin /warfarin )
05:49- summary
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1. What is Clopidogrel?
Clopidogrel, commonly known by its brand name Plavix, is an antiplatelet medication used to prevent blood clots in patients at risk of heart attacks and strokes. It is often prescribed for individuals with conditions like acute coronary syndrome, peripheral artery disease, and after certain types of heart procedures such as angioplasty.
2. Uses of Clopidogrel
- Heart Attack Prevention. Reduces the risk of heart attack in people with a history of myocardial infarction.
- Stroke Prevention: Helps prevent strokes in patients who havhad a transient ischemic attack (TIA) or a previous stroke.
-Peripheral Artery Disease:** Used to improve blood flow in patients with peripheral artery disease.
3. Mechanism of Action**
Clopidogrel works by inhibiting the binding of adenosine diphosphate (ADP) to its platelet receptor, which prevents the activation of the glycoprotein IIb/IIIa complex. This inhibition blocks platelet aggregation and prevents blood clots from forming, thus maintaining smooth blood flow through the arteries.
**4. Side Effects**
While clopidogrel is generally well-tolerated, some patients may experience side effects, including:
- **Common Side Effects:** Easy bruising, minor bleeding (such as nosebleeds), diarrhea, and stomach upset.
- **Serious Side Effects:** Severe bleeding (such as gastrointestinal bleeding), allergic reactions (rash, itching, swelling), and liver problems (yellowing of the skin or eyes, dark urine).
**5. Drug Interactions**
Clopidogrel can interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. Important drug interactions include:
- **Other Antiplatelet or Anticoagulant Drugs:** Concurrent use with aspirin, warfarin, or other blood thinners increases the risk of bleeding.
- **Proton Pump Inhibitors (PPIs):** Certain PPIs like omeprazole can reduce the effectiveness of clopidogrel.
- **Selective Serotonin Reuptake Inhibitors (SSRIs):** These antidepressants can also increase the risk of bleeding when taken with clopidogrel.
- **Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):** These drugs can further increase the risk of gastrointestinal bleeding.