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Genomics Guru
United Kingdom
Приєднався 3 сер 2015
Accessible videos helping to explain aspects of human genome biology.
Brought to you by Dr Katherine West (School of Life Sciences) and Dr Adam West (Institute of Cancer Sciences) at the University of Glasgow, Scotland.
Brought to you by Dr Katherine West (School of Life Sciences) and Dr Adam West (Institute of Cancer Sciences) at the University of Glasgow, Scotland.
FASTER SPREAD OF NEW CORONAVIRUS VARIANTS IS SUCH A GAME CHANGER
A quick look at why the faster transmission rates seen with the new coronavirus variants from the UK, South Africa and Brazil is such a game changer. We present a scenario where we compare a faster spreading variant with a more lethal one. We show how preventing the rapid growth of infections seen with new variants is key to preventing high levels of mortality.
Current spread of each new variant at cov-lineages.org/global_report.html
This presentation is brought to you by Dr Adam West in the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. We hope you found this video useful. Please support us by liking the video and consider subscribing for more informative content. Feel free to ask questions or provide feedback in the comments section below. Thank you.
www.gla.ac.uk/people/adamwest
GenomicsGurus
GenomicsGurus
Current spread of each new variant at cov-lineages.org/global_report.html
This presentation is brought to you by Dr Adam West in the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. We hope you found this video useful. Please support us by liking the video and consider subscribing for more informative content. Feel free to ask questions or provide feedback in the comments section below. Thank you.
www.gla.ac.uk/people/adamwest
GenomicsGurus
GenomicsGurus
Переглядів: 1 265
Відео
QUICK LOOK AT 3 NEW CORONAVIRUS VARIANTS
Переглядів 17 тис.3 роки тому
A quick look at the three new coronavirus variants from the UK, South Africa and Brazil. We quickly summarise the SARS-CoV-2 mutations and what the main clinical features of these variants are. We also give a mid-January 2021 update on where these variants are spreading in the globe, including the percentage of COVID-19 cases that are the variant in the UK, Ireland, Denmark and the USA. Useful ...
THE SPREAD OF 3 NEW CORONAVIRUS VARIANTS - A close look at the scientific data
Переглядів 2,4 тис.3 роки тому
This presentation gathers together all the scientific data about the rapid spread of three new coronavirus variants that are changing how we need to manage the COVID-19 pandemic. Mainstream media is too short a form to explain the data behind the decisions being made by governments. We carefully take you through the data that shows these strains have faster transmission rates, carry mutations t...
NEW CORONAVIRUS VARIANTS - EXPLAINED SIMPLY
Переглядів 44 тис.3 роки тому
This video explains coronavirus variants, mutations, PCR tests in simple terms, so that you can make more sense of media reports and the changing restrictions to our daily lives. You will also learn some cool molecular biology! The video is intended for a wide audience. The video will cover four areas of science so you will be able to follow the facts behind the global pandemic: • The main feat...
Genome Editing With CRISPR - Training the next generation of Nobel Prize winning scientists!
Переглядів 1,2 тис.4 роки тому
The Nobel Prize in Chemistry has recently been won by Jennifer Doudna and Emmanuelle Charpentier for their pioneering work on genome editing using CRISPR. This "genetic scissors" technology has the potential to revolutionise the treatment of genetic diseases. Here at the University of Glasgow we have developed a new CRISPR laboratory practical to help our students develop their skills and learn...
How to use DAVID for functional annotation of genes
Переглядів 82 тис.4 роки тому
This tutorial shows you how to generate a variety of functional annotations of a gene list, such as that generated by differential gene expression analyses like RNA-seq. DAVID is an open bioinformatics resource accessed through a web browser that provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes. For any giv...
HOW TO PERFORM GSEA - A tutorial on gene set enrichment analysis for RNA-seq
Переглядів 161 тис.4 роки тому
In this tutorial, we explain what gene set enrichment analysis (GSEA) is and what it offers you. We show you how to run the analysis on your computer and take you through how to interpret the outputs. The tutorial also covers leading edge analysis and analysis of gene networks with Cytoscape. Editors note: If you are having trouble loading your gct file, you should save it as .gct.txt rather th...
MAKE YOUR GENOMIC DATA LOOK STUNNING WITH THE UCSC GENOME BROWSER - The Secrets Of Custom Tracks!
Переглядів 13 тис.4 роки тому
In this video, we show you how to visualise your own data on the UCSC genome browser using “custom tracks”. We use the example of ChIP-seq files for big datasets. We explain file formats and show you the steps of how to upload your data via your own free web server space. We also show you how to create your own colourful genomic annotations so that you can generate attractive and professional s...
GET STARTED WITH THE UCSC GENOME BROWSER - What you need to know
Переглядів 16 тис.4 роки тому
In this introduction to the UCSC Genome Browser, I describe what the browser is and what it can be used for. I also quickly take you through some example applications of the browser. Subsequent videos in this course will help you get started quickly and then guide you through many different applications that will accelerate your learning and research. These three fully functional mirrored Genom...
EPIGENETICS & CHROMATIN STATES - An introduction to histone modifications & gene transcription roles
Переглядів 39 тис.4 роки тому
This lecture introduces you to histones and histone modifications and how they contribute to transcriptional regulation. It is an ideal starting point for those who are new to the subject or professionals in other fields needing a quick primer. Contents: 0:35 Defining the epigenetic memory of gene expression 2:37 Chromatin and histones 7:12 Histone modifications 7:59 Histone acetylation and rea...
GENE ONTOLOGY using TOPPGENE - Free tutorial
Переглядів 13 тис.4 роки тому
This tutorial takes you through the use of ToppGene Suite for gene ontology analysis. This a one-stop web portal for gene list enrichment analysis and candidate gene prioritisation. Hints and tips on interpreting the output of gene ontology analysis are also given. Toppgene can be found at toppgene.cchmc.org/ This tutorial is brought to you by Dr Katherine West in the College of Medical Veterin...
RNA-SEQ WITH THE UCSC GENOME BROWSER
Переглядів 3,8 тис.4 роки тому
In this video, I show you how to interpret RNA-seq data on the UCSC genome browser. I use the alternatively expressed human CDKN2A and CDKN2B genes, which are critical regulators of the cell cycle and tumourigenesis. 3:05 I show you how to interpret gene annotation tracks and how the RNA-seq alignments from different cell types can align to different alternatively transcribed exons. 10:07 I giv...
DISPLAY AND NAVIGATE THE GENOME - UCSC Genome Browser Tutorial series
Переглядів 9 тис.4 роки тому
This tutorial is for new or inexperienced users of the UCSC Genome Browser. You will be shown how to 0:53 Adjust the display of the browser so that the data and text labels are clear and easy to read. You will also be shown the many different ways you can navigate the genome using 5:53 Genomic coordinates 7:11 Gene names 9:20 Zooming in and out 10:12 Panning left and right 12:44 Selection. You ...
VISUALISE THE SARS-CoV-2 CORONAVIRUS GENOME - UCSC Genome Browser Tutorial series
Переглядів 2,6 тис.4 роки тому
This tutorial on the UCSC Genome Browser is brought to you by Dr Adam West in the College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. This is part of series of tutorials on using the UCSC Genome Browser. We hope you found this video useful. Please support us by liking the video and consider subscribing for more informative content. Leave us a comment if you t...
GENE EDITING EXPLAINED! - A comprehensive guide to the principles, methods and technologies!
Переглядів 21 тис.4 роки тому
An “In Depth” lecture on gene editing brought to you by Dr Adam West, College of Medical Veterinary and Life Sciences at the University of Glasgow, Scotland. www.gla.ac.uk/people/adamwest Time stamps: 3:41 Introduction 9:04 DNA repair pathways 17:20 Possible genome editing outcomes using sequence-specific nucleases 23:32 Zinc finger nucleases (ZFNs) 34:38 Transcription activator-like effector n...
PRECISION EDITING USING CRISPR - GENE EDITING EXPLAINED!
Переглядів 12 тис.4 роки тому
PRECISION EDITING USING CRISPR - GENE EDITING EXPLAINED!
HOW TO IMPROVE CRISPR SPECIFICITY - GENE EDITING EXPLAINED!
Переглядів 3,3 тис.4 роки тому
HOW TO IMPROVE CRISPR SPECIFICITY - GENE EDITING EXPLAINED!
CRISPR/Cas9 GENOME EDITING - GENE EDITING EXPLAINED!
Переглядів 8 тис.4 роки тому
CRISPR/Cas9 GENOME EDITING - GENE EDITING EXPLAINED!
WHAT IS CRISPR? - GENE EDITING EXPLAINED!
Переглядів 4,5 тис.4 роки тому
WHAT IS CRISPR? - GENE EDITING EXPLAINED!
TALENs - TALE NUCLEASES - GENE EDITING EXPLAINED!
Переглядів 43 тис.4 роки тому
TALENs - TALE NUCLEASES - GENE EDITING EXPLAINED!
ZINC FINGER NUCLEASES - GENE EDITING EXPLAINED!
Переглядів 48 тис.4 роки тому
ZINC FINGER NUCLEASES - GENE EDITING EXPLAINED!
Introduction to epigenetics and histone modifications
Переглядів 5 тис.5 років тому
Introduction to epigenetics and histone modifications
Introduction to chromatin structure
Переглядів 1,4 тис.5 років тому
Introduction to chromatin structure
How to visualise chromatin and epigenetic data on the UCSC genome browser (tutorial 4)
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How to visualise chromatin and epigenetic data on the UCSC genome browser (tutorial 4)
How to visualise RNAseq gene expression data on the UCSC genome browser (tutorial 3)
Переглядів 4,9 тис.6 років тому
How to visualise RNAseq gene expression data on the UCSC genome browser (tutorial 3)
Visualising tracks, genes, splice variants and SNPs on the UCSC genome browser (tutorial 2)
Переглядів 7 тис.6 років тому
Visualising tracks, genes, splice variants and SNPs on the UCSC genome browser (tutorial 2)
Getting started with the UCSC genome browser (tutorial 1)
Переглядів 6 тис.6 років тому
Getting started with the UCSC genome browser (tutorial 1)
Excellent video! Thank you for being so thorough, 10/10
Thank you! Why are some SNPs in blue color and others in red color?
If you right click over the track you'll be able to see the track information which will tell you the colour coding
quite useful, understanduing the basics of david
Thank you so much for this tutorial! I'm new to proteomics and this video helped me a lot to get started on my data analysis
Thank you so much, very helpful!
Hola, muchísimas gracias por su video.
Buenas noches, me gustó mucho su video. He estado tieniendo problemas al cargar la lista de proteinas con código uniprot y no consigo observar las figuras, me podrías indicar algún consejo para resolver el problema?
Hi. Can u make a tutorial on Depmap... telling all the features. That will be very useful.
3:20 my understanding from reading the paper is that the genes ranking is based on some measure of correlation between the gene expression and the phenotype class, not just the average of the expressions for that gene. I don't think they are the same.
such a enjoyment to listening this clear explanation with such clear English speaking
Can you link the file u use
Interesting!
Finally a real tutorial! Thank you!
Ma'am what is the significant functional annotations score. Please tell
Very helpful and clear tutorial, really appreciate it
I can't thank you enough! You made my day! 🙏🏻🙏🏻🙏🏻
👌👌👌👌👌
Mandatory viewing for using the tool, thank you!
Great presentation
in the enter gene list can we provide the id of our circular rna?
Awesome
In the first step, do you mean about id the accession number or another id ?
It was a great tutorial. It would be nice if you could expand on the meaning of each part and their function in another video. For example, maybe explain how the acquired data can be used in research (or at least provide resources for beginners to follow and learn more). Also, if there are technical or specific types of plots that can visualize the results taken from DAVID, it would be very nice if you can cover them as well.
what is the alternative for Drosophila?
Thankyou
Your explantions are very clear, I enjoyed your videos and learned a lot. Thank you very much!!!
Very clear and specific ¡¡thanks
Fabulous! I haven't paid attention to epigenetic advancements in a decade or more, and am amazed at how much more has been discovered. The complexity blows me away!!
So how to use this software to do GSEA based on a specific subset genes or a defined subset genes by ourselves?
You can create your own list of genes. Download one of the genesets so you can see the format - it's very straightforward.
Thanks. Where I can upload my own list of the genes in the software?@@GenomicsGurus
@@chuanyuguo3232 Upload your gmx file using the load data process. Then, when you choose the gene sets database, there is a tab called gene matrix (localgmx.gmt), and you should see your file listed there. Good luck!
This was very helpful thanks!
What means enrichment?
If something is enriched, it means there is more of it in the sample
I'm going to have to watch the Prime editing part 10 times more to understand it. It's simple yet complicated.
thank you
Hi, thanks for the tutorial. I had some trouble downloading the GSEA software so I ended up using the GenePattern UI. Is there any downside to using this website instead of the GSEA desktop application? Thanks
Really nice and useful video. Thank you.
Glad it was helpful!
So much help. Thank you.
Glad it helped!
Thank you so much for this tutorial! I'm new to proteomics and this video helped me a lot to get started on my data analysis
Glad it was helpful!
great
Thanks! Beatifull lecture. Really sad that you stopped making videos
thanks god, someone finally made all these clear. great job.
better explanation than my prof. who only says useless nonsense during the lectures.
Thank you! It is very well explained complext topic
This is GOLD! I am a biologist who does not know anything about bioinformatics, i've done a differential expression analysis of genes using RStudio and then i was like, what now, what to do with these DEGs? And then i found this amazing tutorial! THANK YOU! <3
Superb concept So much Thank
Very useful, thank you!
A great help. Thankyou mam
Thank you very much for the video! It helps! I have my functional annotation chart of GO TERM, now how could I export it to excel?
You would need to download the spreadsheet data (there is button to do that) and then plot your own graph in excel
@@GenomicsGurus thank you!
This video is amazing, so far my favorite. Really clear and straightforward, I truly appreciate it! Great job! many thanks :)
Thanks!
Very helpful - I have dabbled with DAVID from occasionally but this is the first time I really understood how to move beyond the initial set of results it gives.
Great :)
Excellent talk Katherine