SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

Original paper: rupress.org/je...
Video summary by Anna Onnis (University of Siena, Italy)
We report a new mechanism of immune evasion by SARS-CoV-2 based on direct disabling CTLs to form immune synapses through Spike protein binding to ACE2. This mechanism could contribute to the failure of the immune system to control SARS-CoV-2 infection.
Keywords: SARS-Co-2, immune synapse, CTL, ACE2, immune evasion
Original paper: rupress.org/je...