Optimal Level Of Uric Acid For Health | Dr David Perlmutter Series Ep 2
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- Опубліковано 14 лип 2024
- In this video Dr Perlmutter discusses the optimal level of uric acid and how to measure. He also covers how uric acid levels change with age and fasting.
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Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
www.drperlmutter.com/
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#UricAcid #DrPerlmutter #DropAcid - Наука та технологія
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interviewer asks good, brief questions, and then allows the guest to provide a detailed, uninterrupted, answer-- refreshing ftom so many other channels.
Interesting comment - at your annual physical, if your doctor doesn't already test Uric Acid levels, just ask them to. I've had some bouts of gout and kidney stones over the past 8 years. Asked my doctor to test for Uric Acid on blood work in the past and the response was, why test it, we know it's high. You have gout. I'm presently reading Drop Acid and it is giving me numerous insights that I'm confident will improve my overall health going forward. Thank you so much!
Thanks for that video, it resonates well with my experiences.
I had hyperuricemia my self for 25 years including occasional (1...2 per year) gout flares. For those not having them: they can be extremely painful. I was told to lose weight, tried it and got gout from fasting - so I experienced that part myself. This led me to the idea to measure my urine pH, since fasting can lead to urinary ketone excertion which acidify the urine. I found that my urine was - on a std. western diet -always below pH 6, and especially acidic with fasting - as expected. I took alkaline supplements (potassium and magnesium citrate) which increase urine pH and reduced gout in frequency and severity. I found a paper in pubmed describing exactely that: "Urine alkalization facilitates uric acid excretion", Kanbara et al., Nutr. J., 2010. Increasing urine pH from 5.5 to 7 doubles the uric acid excretion.
For me the model ist very simple (most likely much too simple), based on the chemistry law of mass action. Any technical reverse osmosis system - and kidneys are exactly that - would behave like that. It it harder to up-concentrate acids into an ever increasing acid solution. The osmotic back-pressure would stop the up-concentration- On the other side the acids would flow freely into an alkaline solution.
So a simple method to reduce blood uric acid is to keep the urine around pH 7.0 by means of nutrition (foods and/or supplements).
The second step for me was going low carb, this limits fruits to occasional low-fructose types and succrose at all. Since than I had'nt any gout flare and my blood uric acid (home-tested since a year with such a device as shown in the video) is fine now.
Unfortuneatly non of the doctors I have seen in the 25 years on the topic of gout and hyperuricemia has told me anything of this. I was prescribed allopurinol and that's it. The physiology is widely unknown in the practicing medical community.
Thank you for the information so accurate, greetings from Buenos Aires.
How to keep urine around 7 pH
Did the allpurinal help
Note that there are two perspectives on time-restricted eating. The most common interpretation is that the actual delay is the important thing. The alternative explanation is that it is not the size of the eating window, but rather the number of calories you move earlier in the day that is the magic ingredient. If you can avoid calorically dense foods late in the evening you get better sleep, avoid weight storage, and are more likely to have your calories contribute to a strong metabolism.
Hi Jeff, thanks for sharing. There does seem to be debate over this and I have not seen a definitive answer. Dr. Stanfield quoted a Cochrane report saying the TRE, when adjusted for calories, was not effective. Certainly eating shortly before sleep is not good for the reasons that you mention. I also find that having a shorter eating window makes it easier to eat less calories overall which is also positive.
@@ModernHealthspan Less calories overall... I always forget that one.
Thank u so much Dr. Perlmutter for sharing all your knowledge!! You are an angel:)
I have smothies with frozen strawberries and blueberries, Moringa powder, organic brussel sprouts, organic Chia SEED POWDER, and organic Reishi mushroom powders every morning I add coconut sugar, an avocado sometimes.
Excellent really congrats.
Hi Francois, thanks!
Please do an episode on how to regulate hormones with PCOS.
MAn is brilliant read dropping acid. Onto grain brain working on getting my levels down. Im at 10.4 changed my eating doing the supplements
Really I’m sick to death of that evaluation of reference range. I want optimal on all my labs. But it’s so biased unless one searches the internet for optimal suggestions it’s nearly impossible to get a straight answer from my PCP which is PAID to help me with better health!
Example if A1c is 7 - which is horrible- there’s no reaction. I want at least to strive for optimal which is closer to 5.4. Currently I’m at 5.9 but it doesn’t concern my doc in the least. THAT is wrong!
I know someone that has gout, but insists upon consuming 5 tablespoons of brewer's yeast every morning, and has done so for the last 20 years. Yeast are very high in purines resulting in high uric acid numbers. I have warned him based upon my internet research ... but to no avail. He does listen to specialists and a word from you might get through to him.
Bought that exact tester (now sold out at Amazon) and my numbers are scary. I bought his book. Wish he had put the recommendations in the front end and talk theory in the back half. Just learned (from the Internet) that a high fat diet can hinder the expulsion of uric acid. I had been sucking down the mixed nuts, also daily cod liver oil (for Omega-3's) or olive oil. Tossed the nuts and plan on reducing the oils. Also this week I'm doing Fisetin and quercetin (1st week of every month) so I was wondering if a senolitic might cause a spike. And, I just finished my 2nd, two-week CGM (Levels) and my glucose is perfect so I'm not sure if glucose really tracks uric acid all that well.
Hi Scott, thanks for sharing. Interesting point about the high fat diet inhibiting uric acid expulsion, because those seem like healthy fats. Maybe it is like Dr. Lustgarten found, improving one biomarker may have a negative impact on another. With respect to quercetin Dr. Perlmutter mentions it as a supplement to decrease uric acid.
Link?
Yep i bought that
I just got a uric acid meter. Mine 5.6 and I had a craft beer last night.
Had first ever gout attack 3 weeks ago. I am keto fat adapted no fructos etc. I think it is from proton pump inhibiter omeprazol started Nov 2021. Or I make my own fructose due to insulin resistance.
You needs druuuuggz
It was the beer.
Greetings! Please do both you and your wife's NMN update, including daily feelings, changes?
What are the beneficial effects of allopurinol? Do you recommend it for people with high uric acid but no gout? . Does Basis raise uric acid?
Will allopurinol mitigate the potential damage?
Very informative, learnt a lot, thank you!
Is apple cider vinegar good for diminishing uric acid?
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Uric acid is well known as the #1 antioxidant in the body.
Thought that was glutathione?
Is there a better time of day to check your uric acid. I would think checking it an hour after eating 3 pounds of liver washed down with a 6 pack of beer would not be good. I am on an 18-6 time restricted eating plan (for years now). Should I check it just before my first meal?
I found #1 in the AM as this represents the longest period of bady stability. Time is in the formula for all crystal formation chemistry. Body UA levels move around similr to blood glucose depending on activity, food intake diet choices, hydration, mascle strain etc etc.
Is taking urine PH test the same as what you say about taking uric acid test that should be 5.5 or less (not 7 for gout)?
No where accurate enough. PH of urine contains lots of other things acidic than just uric acid. They are just color chip referenced litmus strips. No Dr. uses them for uric acid gout.
Mine is 3.6 mg/dL, n lab paperwork flagged as to low… is it really a bad thing?? The lab had Norma 3.8-8.4 , thanks
Drink some beer 😂
I couldn’t lower my levels no matter what I did’ I was hitting 11 but usually around 9.5 then I starting taking probenecid. In 3 weeks I measured 6.3. No side effects.
it is time for med intervention. Take Allopurinol. Check it out.
Mine is 3.2.
Mine came in at 3.4. Did your doc suggest that might be an issue being lower than 4.0?
@@Rickenaround No. I think it is great.
I have Uric acid test of 5.35 and still have gout symptoms and sore feet ! WHY
Because it takes years tonlosere the symptoms. Keep UA low.
Because blood has no nerve endings. Because pain/inflammation is centered at the site of long ago formed UA crystals. You can have gout flares day or night, winter/summer with high or low blood UA levels. Read up on the dynmics of UA gout. Pain is just a smoke alarm. Find the fire.
My levels were 11.6 im only 43. .😢😢
But, bears don't live 75 years...
72 hours is hardly enough time for the average person to run through the stored calories to the point it will start to "break down body tissue for fuel". Most of us have about 21-30 days of it before this happens. A 3day fast will not raise uric acid.
Your statment is incconsistent with my experience: I have done a uric acid test after a 3-day fast many times. My uric acid level is always 3 to 5 point higher than my normal level after the fast.
@@vmx0000 What happens when you complete the fast? Biomarkers will almost always change during a period of hormesis. It's usually always temporary as it's supposed to be.
@@StarvingMyselfToLIFE after the fast, when I resume regualr eating, my uric acid will drop 3 to 5 points. I am pretty lean, so i assume not much fat storage. I am also on keto diet, so in ketosis most of the time.
4.9....only deviate from ketovore with some chocolate now and again. Hate fruit anyway....
Those Uric acid meters are highlly inaccurate.
I was looking for those devises . Dr said a tape measure around your waist at min 10:43 question .
Searching for that tape measure . Couldn’t find it
How is it possible that the optimal uric acid level is
The average person eats garbage
Do you know just how small 0.1 mg/dl really is? The difference is rather moot as UA levels are always a moving target taken as a non-average.
Go carnivore and forget your ua level!
I have a very low level thats why I came here, dr explained nothing to me.
Go and look for a video about low uric acid levels then..
There is none
Mine is below normal range too. I'm not a vegetarian n I do eat red meat n purine rich food. I wonder why. My level is 0.14mmol/l .. should I be concern about low uric acid level. Some reading suggest low uric vid level link to disease too😢. Will be thankful if someone can share some light. Thanks