So. C15:0 makes up 1.2% of cow milk fat. One tablespoon of butter has 12 g of cow milk fat. 12 × 1.2% =144 mg of C15:0. In 1 tbsp of butter. It's pretty safe to eat one tablespoon of butter a day. Eat it and chill.
@TheVisserPodcast why are you saying it? What is "enough" to you? Daily Fatty15 pill has 100 mg as much as or less in a tablespoon of butter, or a very small piece of meat. Humans are not deficient in c15. Dolphins, maybe.
@@TheVisserPodcasthow many milligrams would you take? They claim 100 - 300 mg is enough. It's hard to imagine a non-vegan who wouldn't take that much already, just with food. C15 is abundant in a lot of foods.
C16 saturated fat, or Palmitic acid, is a common marker for inflammation, but C16 levels in the body are not based on C16 consumption. 16-carbon Palmitic acid (and the monounsaturated version, Palmitoleic acid) are what the liver turns excess circulating carbohydrates into, in insulin resistant people. This is an association, not a causal arrow of Palmitic consumption. A person who does not eat too much carbohydrates and does not develop insulin resistance has no issues promptly using Palmitic acid as a clean fuel, and it should not cause inflammation, AFAIK.
If your total daily fat content is high, you will not have high levels of C15 due to type of microbiota in the gut. It’s the gut bacteria that synthesize the C15. A few studies show this. One test compared 5% dietary fat with 35% dietary fat and 70% dietary fat (plus they use different types of fat). Result: “the concentration of C15:0 decreases as the dietary total-fat content increases (p < 0.05); a ~30% increase in dietary total-fat resulted in a ~35% decrease in circulating C15:0 concentration.” It didn’t matter what type of fat used. As the total daily fat content rises - the less C15 synthesized. We need the correct gut bacteria to break it down, where it is then usable. Total fat intake (when high) disrupts the individual fatty acids. By using cheese to get your C15, you end up with less if you’re eating high fat throughout the rest of the day (from other foods).
@@TheVisserPodcast So you find a isolated animal single study, and you are suggesting to ignore all randomized long term studies and the consequences of SFA because of this study? 😂 Flat earthers this days...
To be honest , i never saw someone having strokes or dying from diabetes while eating animal fat. The contrary is applied to ppl that love to buck up on seed oils , i look at my grandparents , my grandfather is 78 , he literally eats melted pork fat/butter with bread like 2 times a day , hes still functioning , he still does farming around the house and stuff , my grandmother is 75 , she is a lifelong lover of seed oils and likes to cook all sorts of veggies with seed oils and stuff like that , she is overweight , she has several chronic diseases , she is pre diabetic , she barely can walk 100 meters a day and the list goes on , while my grandfather is up and running even occasionally drinking and smoking , i don't mean to say that its only because of dietary fat choice , but i mean it , i dumped all the seed oils from my diet too and i could never feel better.
Great observation and comments, its hard for me to make an assessment on your grandparents without seeing them myself, however here are a couple of things to think about: 1. There are genetic differences between the two “the Churchill effect” smoked and drank like a fish his whole life, without any issues (strong genetics) someone else would have developed chronic disease, fatty liver disease, metabolic syndrome, diabetis and cancer. 2. Your grand father seemed to be doing heavy work on the land most of his life, this gives him strength, muscle and a higher VO2 max - these are the most important keys to longevity bar none! 3. Just off the top of my head, good genetics combined with the most potent elixir for longevity endurance and strength, will beat out smoking drinking and a poor diet in genetically strong people
@@TheVisserPodcast actually not its vice versa :D my grandfather have a pretty bad lineage , his mother died at 61 while father died at 55 one was morbidly obese while other was heavy smoker and drinker he could literally drink up to 10 liters of wine per day, also my grandfather has 3 dead brothers and 5 alive , 3 of them died before 65 hearth strokes. On the contrary on my grandmother side her mother died at 71 from breast cancer it was late 80 we didnt have access to advanced medicine over there , while her father died at 91 but he was ww 2 veteran he was shot like 6 times he had his legs burnt and they they somehow healed back and yeah i never saw him running out of butter in his home , like at all , he was even frying potatoes and other veggies with butter, he was a slave for the most part of his youth and he told me that sunflower oil was used by rich ppl to cut down costs for candles that's all , no one back in 1920 was using sunflower oil to cook or stuff like that , they all used pork fat or sheep/cow butter to cook. And yeah he died cause he had like 4 parts of a grenade left in his legs and they started to rotten and the doctors said that its impossible to do anything. Same stuff with his children , all of them are over 70 or near 70 5 out of 7 are quite heavy packing on vegetable oils and they all are overweight , and i mean it 100 kg at an average height of 155cm ~40% body fat and 2 of them are normal weight , and guess what , the 2 out of 7 are ppl that eat the most animal foods out of them and don't pack up on vegetable oils. This is just my observation im not trying to be scientifically accurate im just saying :)
Me too. Fermented dairy reduces most of the problems, lactose sugar has been eaten by bacteria. I ferment goats' milk so it's just clabbered. You probably wouldn't like the taste but it's very good for working out. Indian wrestlers used it a lot and turned into monsters.. 😂
Wow, your video nailed it. I've been trying to get a handle on this fatty 15. Found the dolphin dr giving too much technical info and it was just confusing. Your summary is awesome. I ordered it months ago. Very tiny capsules. It says to take with meals where there is low fat, so this fat doesn't compete for absorption with other fats.
I wonder why that study paper by Stephanie Venn-Watson doesn't mention that she is co-founder and CEO of Fatty15 (the only company that I could find that sells C15:0 pentadecanoic acid supplements).
You’ve got a valid point there, however there is more research on this topic that supports her case. I agree though its like the issue we have with Sinclair from Harvard
@@donalkinsella4380 - Ha, ha. Just eat what the heathy dolphins were eating, e.g., a fatty fish. I'm thinking sardines might be the most easily accessible for humans.
@@donalkinsella4380 the bottlenose dolphins eat fish that consume seaweed…so the real source is from plants (same way fatty15 company creates their product - it’s vegan).
my grandad ate almost a pound of butter per week, smoke and drank quite heavily, lived until he was 85. if not recommend the smoking or drinking but as far as he was concerned fat was the cornerstone of the diet. its taken me a long time to realise that saturated fats are key to health. i’ve looked at some old photos of myself when depriving myself of fat on some ridiculous type of diet, and i looked pale, practically no healthy glow in my face
I am taking the C15 supplement but now also eating the best sources of C15. Aged Goats Cheese is an excellent source. So is Aged Goats mild ghee. I bought some aged goats cheese recently and it tastes fine - I was worried I wouldn't like it.
These are exactly the people we look at and research, however our lifestyle has changed drastically so now a days we need alternatives to get there, based on the teachings of our elders
These food specialists should just shut the hell up, they put people on diets that exclude stuff and then it's found to be good for you. I am 69, healthy, exercise with weights 3 times a week. I grow my own veggies in my back yard in a spread out strange way for a reason. On top of that I use a slow harvest, letting the veggies recover for 24 hours before the next harvest. My grand father, farmer, carried a pocket knife that he used to skin his apples before eating them, he knew that the poisons sprayed on fruit penetrate thin skinned fruit. In nature if a giraffe eats on a tree, the tree releases tannins and oxalates into it's leaves so the giraffe moves up wind to the next tree as these chemicals "talk" to the down wind trees. I believe that veggies also "talk" to one another this way so that is why I use spread out planting and slow harvest. I eat anything I want to, but 17/7 fasting as a life style choice. Then if I decide to have pasta for an evening meal,I do so on a rest day so the next morning I burn it out with my exercise.
I have been taking it and haven’t experienced any symptoms of course these are dose dependent and we are all different and we have diverse sensitivities so it’s good to monitor and report these
My mom and I tried it for 4 months and saw no changes. Only one company selling it (the founder) and you have to buy 3 months worth of caps. I guess it's not for everybody.
It’s great to get this feedback, the human studies are promising but not conclusive, so we have to wait a bit for this one to pan out. For now we have to go by our own experience
If i had to pick one i would pick a high qualtiy high dose omega 3 fish oil. They take part in so many biologically essential role in every cell for making many proto hormones like prostaglandins involved in immune functions and inflammation. Have been taking it for 20 years and have no chronic disease and don’t take any medicines in my senior years. Other than relying on good nutrition and not eating processed carbs based on grains. Though have a family history of diabetes, high blood pressure, cardiovascular and arthritis. If one wants to boost your C15 i understand some sheep cheese have a good amount. More studies on C15 seem to be on animals so far.
Omega 3 DHA and EPA marine source are essential, but I would put vit D with K2 and Magnesium up there next to the Omega’s. Staying strong and fit is by far the key to wellbeing and longevity, keep up the good work
Avoid drama if you can . Eat foods that are organic and eat produce from grass fed animals like cows . Before the ww2 we didn’t have all these chemicals in and on our food . Moderation and walk more , laugh often .
@@TheVisserPodcast indeed. i swim twice a week and lifting weight 3x a week including squat. I also do African jump during weight training 1 minute for 5 reps.
C:15 is made by the microbiome from the fermentation of fiber-producing SCFA's, in particular propionic acid, which is then converted to C:15 in the liver. This is how it ends up in dairy fat, via a cow consuming grass: fiber>SCFA propionate>C:15 - the exact same pathway in humans. No dietary Saturated Fat is required to produce it. (cows don't consume hardly any Saturated fat). The issue is that for 10's of thousands of years, early humans consumed far more fiber than modern humans do now. Studies on early homo sapiens fossilized poop, shows that they consumed 100-225g of fiber per day on average: Coprolite research (fossilized human poop) reveals that prehistoric populations relied heavily on plants in their diet for over 10,000 years. Africa - 120g of fiber per day N. America - Mexico 150-225g of fiber per day S. America - Peru 100g per day Australia - over 100g of fiber per day Modern Americans consume about 10-15g of fiber per day on average. So humans were eating 10-20 TIMES more plant fiber than modern humans. 2017 Study: Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. The American Journal of Clinical Nutrition "Conclusions: Our data show that gut-derived propionate is used for the hepatic synthesis of OCFAs in humans. The association of OCFAs with a decreased risk of type 2 diabetes may therefore also relate to dietary fiber intake and not only dairy fat." Also BCAAs (Valine) are also used by the human body for endogenous production of both OCFAs C:15 and C:17: Study: The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism “Our data clearly show that valine supplementation in vivo contributes to C15:0 and C17:0 formation via these two described pathways. This is corroborated by our in vitro studies, showing that Valine treatment leads to elevated OCFA levels with inductions of Ppara and Hacl1 in a dose dependent manner.” “Taken together, these data illustrate differential roles of the BCAA in lipid metabolism and provide preliminary evidence that exclusively valine contributes to the endogenous formation of OCFA which is important for a better understanding of these metabolites in metabolic health.”
Fiber is key in our diet no question, however if the gut is not ready for the fiber we have a problem, so starting with pre and probiotics and following this up with fermented foods is the only way to diversify the gut biome, only then can we effectively introduce fiber
What is Ferroptosis? - Ferroptosis is an iron-dependent process that results in the accumulation of toxic lipid peroxides and ROS, which ultimately leads to cell death. What Causes Ferroptosis? - Heme Iron Where does Heme Iron come from? Only found in animal flesh. Plants do not make Heme Iron. What Helps Prevent Ferroptosis? OCFA C:15 What is an “Essential” nutrient? - “An essential nutrient is a substance that the body can't make in sufficient quantities or at all, and therefore must be obtained from food in order to function properly.” Is C:15 an Essential Fatty Acid? - No, because the body makes it through multiple pathways. How is C:15 Made in the Human Body? From the SCFA Propionate How is SCFA Propionate Made in the Human Body? Gut microbiome fermentation of fiber Where does Fiber come from? Fiber only comes from plants (and fungi and algae). Animals do not make fiber. Why so much C:15 in Dairy? Cows eat very large amounts of fiber (grass), fermented into SCFA/Propionate and converted to the OCFA C:15
That guy has absolutely no idea what he is talking about. Ive been taking Fatty15 for about a year and feel AMAZING. I was always tired, my skin was dry with wrinkes and dark circles, no energy and my sleep was messed up. As soon as I started taking Fatty15 it all went away. Now I sleep great, wake up energized, have plenty of energy throughout the day, my skin looks better and is softer, wrinkles and dark circles are disappearing...I feel great. This guy can say whatever he wants results are results and I am not making this up. If it's BS then how can you explain this?
They call him Flipper, Flipper, faster than lightning, No-one you see, is smarter than he, And we know Flipper, lives in a world full of wonder, Flying there-under, under the sea! 🐬🐬🐬🐬🐬🎼🎶🎶
You mentioned that C15 is being produced in the body naturally but that we cannot produce enough of it I may be questioned that because when people eat like potatoes and rice and pasta and bread and all that kind of stuff they do not feed the body what it really needs naturally if we instead eat only vegetables like cooked spinach or maybe roasted and maybe a lot of other vegetables the Earth that kind and maybe some food and stuff natural stuff then maybe we can actually produce enough of it what is taking that?
If its made in a lab its more than likely synthetic containing alcohol which goes straight into the brain & may cause aggresive brain tumors, also never know what else has been added into it if its liposomal. Id be happy to get some and see whats inside it
Where's your practice or clinic? I'm 60 with an 8-year-old, and I need to figure out how to stay in the ring as long as possible. I've really noticed a drop in my energy levels the last few years.
I’m currently living in Istanbul Turkey, where I work with over 5000 doctors in Stem cell therapy and longevity - looking closely at regenerative medicine and how this will redefine age management
I’m with you on this, I currently live in Istanbul, Turkey Look at the rest of my podcasts and the longevity 9 road map. If you really want to get specific you can write me and we can do a call in or zoom drvisser@me.com
Research by Dr. Venn-Watson indicates that a 100-200mg daily dosage of C15:0 is ideal for reaching a target blood value of 10-30µM.5 Fatty15 hits the mark with its 100mg, once-daily supplement dosage. I take one capsule daily personally, I would start there
I was using the Sony ZV 1 but it overheated and even with the fan attached it was a nightmare - image quality was great I also use a native 20mm lens you could op for the 24mm or go with the all around 24-70 GM zoom
No, C15:0 is not a full-fat kefir. C15:0, also known as pentadecanoic acid, is a type of saturated fatty acid found in some full-fat dairy products like milk, butter, and certain animal fats. It is being studied for its potential health benefits, such as anti-inflammatory and metabolic effects. Full-fat kefir, on the other hand, is a fermented dairy product rich in probiotics, made from milk and kefir grains. While full-fat kefir may contain small amounts of C15:0 due to its dairy content, they are not the same thing.
Dolphins get it from WHOLE FISH, not the parts of fish that we usually eat. Asian and Mediterranean diets do use a lot of whole fish and fish sauces.. So, they are getting this, even if they are not using a lot of grass fed dairy. In our culture, this is a big deficiency.
hey Mr. NCS. You left out so much. What is this saturated fat made from - you mentioned whole milk but don't drink it... So what foods DO contain it? Where do we get C15? Next time before posting a video can you please have someone with common sense review it and go over what you left out. thank you sir.
I take fatty 15, because I’m not doing Keto so I don’t consume enough dairy products, our fish doesn’t have enough our food unless you live on a farm and have access to farm to fork data, might not be clean enough to get your C-15 from But I will include a list of foods and how much C-15 you can expect to get from the products
Just make sure you analyze the “farm to fork” track, because it could affect your health negatively I’m talking about how they were fed, their environment, anti-biotic usage etc etc all this could be detrimental to our health. Times have changed and not always for the better
No... there is not any considerable C15 in the parts of fish that most of us eat, in the western diet. You need to consume WHOLE fish.. which is common in Asian and Mediterranean diets. Even if they do not eat a lot of dairy. And, very very few people consume GRASS FED dairy. That is key factor. Grain fed cows do not produce nearly that amount of C15.
So far I haven't heard one person say how it changed their life... so I am out on this one for now... I have tried so many supplements in my life that didn't make a difference and I am tired of it...
It’s a subtle improvement felt after time, the biggest impact you can make on health far and above fine tuning your supplement regime is: Optimizing your weight, Resistance training and improving your VO2 max nothing else and i mean nothing else comes close
If your total daily fat content is high, you will not have high levels of C15 due to type of microbiota in the gut. It’s the gut bacteria that synthesize the C15. A few studies show this. One test compared 5% dietary fat with 35% dietary fat and 70% dietary fat (plus they use different types of fat). Result: “the concentration of C15:0 decreases as the dietary total-fat content increases (p < 0.05); a ~30% increase in dietary total-fat resulted in a ~35% decrease in circulating C15:0 concentration.” It didn’t matter what type of fat used. As the total daily fat content rises - the less C15 synthesized. We need the correct gut bacteria to break it down, where it is then usable. Total fat intake (when high) disrupts the individual fatty acids. By using cheese to get your C15, you end up with less if you’re eating high fat throughout the rest of the day (from other foods). That’s why a low fat plant-based diet is the best (with very small amounts of cheese, meat and eggs) and animal based foods can be used as ‘condiments’.
Have to strongly disagree with that, protein is king for longevity, vegetables snd fruits are important and the giber is also vital - if you want to go vegan or close to it you will really have to supplement your protein intake and make sure you’re not coming short on the essentials - its doable but way more work and calculating
@@TheVisserPodcastNo, all blue zones style of eating is NOT high protein. It is always plant based, but also not vegan or vegetarian (except Linda Loma). They eat a bit of everything. Italy, Greece, Spain eat much less butter than other fats like olive oil. They eat hard and soft cheeses though. Anyway it is diet with less protein then Northern Europe and Asia or Americas.
Snake oil, this study has been so bias. Yeah I am going to take a drug from a study done by the owner who profits from it. Just eat whole food with animal meats. This is for vegans.
Luckily there are now countless independent studies that are confirming the findings. I also know that when you are researching non-pharma as in supplements funding is hard to come by.
I had overheating issues with my ZV-e1 so when I send it out to editing a piece got repeated 😅 yeah will do better - I really had had it with the camara so I traded it in out of frustration
OK, here is a more detailed explanation of my comment. This dude is talking about using pharmaceuticals to enhance longevity and promote better health. He’s also discussing the use of single compounds and how they might affect the physiology of the human body. Start with this is a great example of reductionism, which is an extremely flawed methodology. Secondly, while some pharmaceuticals have their place in the reduction of pathology symptoms, the idea that you’re going to use a pharmaceutical like Metformin to enhance your health and longevity is total nonsense. Simply allows cells to shove more glucose into them, exacerbating the underlying problem of glucose regulation in the first place. I.e., don’t eat so many damn carbohydrates. This guys dunning Kruger is stunning. His understanding of biochemistry is so lacking, I doubt he has even the slightest understanding of the physics as well. Like I said, the worst video ever.
Obviously you haven’t really seen the whole episode or episodes building up to this one where i go over Metformin, the ongoing human trails and that up to this point the research doesn’t show an advantage for healthy people, only those that are diabetic or pre- diabetic. In this episode we are comparing C15:0 to these compounds that are current being used in the longevity space by researchers such as David St Claire of Harvard and dr Peter Attia to name just two There is no reductionism here
@@TheVisserPodcast hahaha, there are people on this thread stating that they are ordering c15 because of this video. Why don’t you try diving into the quantum biology before trying to muddle around into the bio chemistry? It is extremely reductionist to attribute single compounds to any physiological response, positive or negative. Metformin does not “help” people with diabetes, it merely delays their neuropathy.
Your video is horrible. All over the map, full of needless diversions and distractions and badly edited. Full of irrelevant information. You have important information that needs to be communicated much more succinctly and in much less time. Redo it and keep it at 5 minutes max.
So. C15:0 makes up 1.2% of cow milk fat. One tablespoon of butter has 12 g of cow milk fat. 12 × 1.2% =144 mg of C15:0. In 1 tbsp of butter. It's pretty safe to eat one tablespoon of butter a day. Eat it and chill.
Yeah but to get the real benefit you’ll have to take the supplement, the foods won’t get you enough
@TheVisserPodcast why are you saying it? What is "enough" to you? Daily Fatty15 pill has 100 mg as much as or less in a tablespoon of butter, or a very small piece of meat. Humans are not deficient in c15. Dolphins, maybe.
Not enough to get the benefits, still need to supplement
@@TheVisserPodcasthow many milligrams would you take? They claim 100 - 300 mg is enough. It's hard to imagine a non-vegan who wouldn't take that much already, just with food. C15 is abundant in a lot of foods.
@@TheVisserPodcast
144mg isn't enough?
C16 saturated fat, or Palmitic acid, is a common marker for inflammation, but C16 levels in the body are not based on C16 consumption. 16-carbon Palmitic acid (and the monounsaturated version, Palmitoleic acid) are what the liver turns excess circulating carbohydrates into, in insulin resistant people. This is an association, not a causal arrow of Palmitic consumption. A person who does not eat too much carbohydrates and does not develop insulin resistance has no issues promptly using Palmitic acid as a clean fuel, and it should not cause inflammation, AFAIK.
Thank you for the feedback, and I will look into this
It all depends on your state of health and your genetic pre- deposition
If your total daily fat content is high, you will not have high levels of C15 due to type of microbiota in the gut. It’s the gut bacteria that synthesize the C15. A few studies show this. One test compared 5% dietary fat with 35% dietary fat and 70% dietary fat (plus they use different types of fat).
Result: “the concentration of C15:0 decreases as the dietary total-fat content increases (p < 0.05); a ~30% increase in dietary total-fat resulted in a ~35% decrease in circulating C15:0 concentration.”
It didn’t matter what type of fat used. As the total daily fat content rises - the less C15 synthesized. We need the correct gut bacteria to break it down, where it is then usable.
Total fat intake (when high) disrupts the individual fatty acids.
By using cheese to get your C15, you end up with less if you’re eating high fat throughout the rest of the day (from other foods).
@@TheVisserPodcast So you find a isolated animal single study, and you are suggesting to ignore all randomized long term studies and the consequences of SFA because of this study? 😂
Flat earthers this days...
To be honest , i never saw someone having strokes or dying from diabetes while eating animal fat. The contrary is applied to ppl that love to buck up on seed oils , i look at my grandparents , my grandfather is 78 , he literally eats melted pork fat/butter with bread like 2 times a day , hes still functioning , he still does farming around the house and stuff , my grandmother is 75 , she is a lifelong lover of seed oils and likes to cook all sorts of veggies with seed oils and stuff like that , she is overweight , she has several chronic diseases , she is pre diabetic , she barely can walk 100 meters a day and the list goes on , while my grandfather is up and running even occasionally drinking and smoking , i don't mean to say that its only because of dietary fat choice , but i mean it , i dumped all the seed oils from my diet too and i could never feel better.
Great observation and comments, its hard for me to make an assessment on your grandparents without seeing them myself, however here are a couple of things to think about: 1. There are genetic differences between the two “the Churchill effect” smoked and drank like a fish his whole life, without any issues (strong genetics) someone else would have developed chronic disease, fatty liver disease, metabolic syndrome, diabetis and cancer.
2. Your grand father seemed to be doing heavy work on the land most of his life, this gives him strength, muscle and a higher VO2 max - these are the most important keys to longevity bar none!
3. Just off the top of my head, good genetics combined with the most potent elixir for longevity endurance and strength, will beat out smoking drinking and a poor diet in genetically strong people
@@TheVisserPodcast actually not its vice versa :D my grandfather have a pretty bad lineage , his mother died at 61 while father died at 55 one was morbidly obese while other was heavy smoker and drinker he could literally drink up to 10 liters of wine per day, also my grandfather has 3 dead brothers and 5 alive , 3 of them died before 65 hearth strokes. On the contrary on my grandmother side her mother died at 71 from breast cancer it was late 80 we didnt have access to advanced medicine over there , while her father died at 91 but he was ww 2 veteran he was shot like 6 times he had his legs burnt and they they somehow healed back and yeah i never saw him running out of butter in his home , like at all , he was even frying potatoes and other veggies with butter, he was a slave for the most part of his youth and he told me that sunflower oil was used by rich ppl to cut down costs for candles that's all , no one back in 1920 was using sunflower oil to cook or stuff like that , they all used pork fat or sheep/cow butter to cook. And yeah he died cause he had like 4 parts of a grenade left in his legs and they started to rotten and the doctors said that its impossible to do anything. Same stuff with his children , all of them are over 70 or near 70 5 out of 7 are quite heavy packing on vegetable oils and they all are overweight , and i mean it 100 kg at an average height of 155cm ~40% body fat and 2 of them are normal weight , and guess what , the 2 out of 7 are ppl that eat the most animal foods out of them and don't pack up on vegetable oils. This is just my observation im not trying to be scientifically accurate im just saying :)
Yeah, I remember Flipper, the hero of my childhood ..
i eat butter and ghee and hard cheeses everyday and I feel amazing!
Me too. Fermented dairy reduces most of the problems, lactose sugar has been eaten by bacteria. I ferment goats' milk so it's just clabbered. You probably wouldn't like the taste but it's very good for working out. Indian wrestlers used it a lot and turned into monsters.. 😂
We're in the minority. Most people avoid high fat dairy due to 40 years of bad press
Wow, your video nailed it. I've been trying to get a handle on this fatty 15. Found the dolphin dr giving too much technical info and it was just confusing. Your summary is awesome. I ordered it months ago. Very tiny capsules. It says to take with meals where there is low fat, so this fat doesn't compete for absorption with other fats.
Thank you so much
I wonder why that study paper by Stephanie Venn-Watson doesn't mention that she is co-founder and CEO of Fatty15 (the only company that I could find that sells C15:0 pentadecanoic acid supplements).
You’ve got a valid point there, however there is more research on this topic that supports her case. I agree though its like the issue we have with Sinclair from Harvard
@@TheVisserPodcast I'm actually really close to getting some of this supp, but I have some other stuff in queue to trial first.
Lol
@@donalkinsella4380 - Ha, ha. Just eat what the heathy dolphins were eating, e.g., a fatty fish. I'm thinking sardines might be the most easily accessible for humans.
@@donalkinsella4380 the bottlenose dolphins eat fish that consume seaweed…so the real source is from plants (same way fatty15 company creates their product - it’s vegan).
Perfect, thank you Doctor.
I'm a new follower Dr - Love your style
I started C-15 this past week for blood sugar control.
do you see any effects?
Please don't cut corners some of us really are interested thank you
Noted
my grandad ate almost a pound of butter per week, smoke and drank quite heavily, lived until he was 85. if not recommend the smoking or drinking but as far as he was concerned fat was the cornerstone of the diet. its taken me a long time to realise that saturated fats are key to health. i’ve looked at some old photos of myself when depriving myself of fat on some ridiculous type of diet, and i looked pale, practically no healthy glow in my face
Great but I want to get you past 90 and fit
@@TheVisserPodcastSounds great to me 😎
FLIPPER, DANIEL BOONE, MY FAV MARTIAN, MR. ED, LASSIE❤❤
Drink whole fat raw milk. Grass fed. C15 abundance
Not enough
Off the subject, just want to let you know that your microphone sounds really good, even the music.👍
Great presentation style will be interesting to see how things pan out with this molecule
Next week will do an update on where they are with the human trails
I am taking the C15 supplement but now also eating the best sources of C15. Aged Goats Cheese is an excellent source. So is Aged Goats mild ghee. I bought some aged goats cheese recently and it tastes fine - I was worried I wouldn't like it.
Good stuff
My grandmother was a longevity expert.She lived until 103 and worked in the fields until 100.
When you can claim that then you may be taken seriously.
These are exactly the people we look at and research, however our lifestyle has changed drastically so now a days we need alternatives to get there, based on the teachings of our elders
Including our work and food sources
These food specialists should just shut the hell up, they put people on diets that exclude stuff and then it's found to be good for you. I am 69, healthy, exercise with weights 3 times a week. I grow my own veggies in my back yard in a spread out strange way for a reason. On top of that I use a slow harvest, letting the veggies recover for 24 hours before the next harvest. My grand father, farmer, carried a pocket knife that he used to skin his apples before eating them, he knew that the poisons sprayed on fruit penetrate thin skinned fruit. In nature if a giraffe eats on a tree, the tree releases tannins and oxalates into it's leaves so the giraffe moves up wind to the next tree as these chemicals "talk" to the down wind trees. I believe that veggies also "talk" to one another this way so that is why I use spread out planting and slow harvest. I eat anything I want to, but 17/7 fasting as a life style choice. Then if I decide to have pasta for an evening meal,I do so on a rest day so the next morning I burn it out with my exercise.
Awesome next level
In a controlled laboratory setting, pentadecylic acid (C15:0) can be synthesized through permanganate oxidation of 1-hexadecene (CH3(CH2)13CH=CH2).
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
I have been taking it and haven’t experienced any symptoms of course these are dose dependent and we are all different and we have diverse sensitivities so it’s good to monitor and report these
Video Production 🔥🔥🔥
My mom and I tried it for 4 months and saw no changes. Only one company selling it (the founder) and you have to buy 3 months worth of caps. I guess it's not for everybody.
It’s great to get this feedback, the human studies are promising but not conclusive, so we have to wait a bit for this one to pan out. For now we have to go by our own experience
Great post- easy to understand (Stop moving the camera- its better when he's looking directly at us)
If i had to pick one i would pick a high qualtiy high dose omega 3 fish oil. They take part in so many biologically essential role in every cell for making many proto hormones like prostaglandins involved in immune functions and inflammation. Have been taking it for 20 years and have no chronic disease and don’t take any medicines in my senior years. Other than relying on good nutrition and not eating processed carbs based on grains. Though have a family history of diabetes, high blood pressure, cardiovascular and arthritis. If one wants to boost your C15 i understand some sheep cheese have a good amount.
More studies on C15 seem to be on animals so far.
Omega 3 DHA and EPA marine source are essential, but I would put vit D with K2 and Magnesium up there next to the Omega’s.
Staying strong and fit is by far the key to wellbeing and longevity, keep up the good work
where can i get a C15 supplement that does not cost an arm and leg
Look up fatty 15
Great podcast. Who would you recommend I buy it from?
There isn’t much choice currently I get Fatty 15
Online look for Fatty 15
The only one I know of and that I use is Fatty 15
@@TheVisserPodcastit's extremely expensive as I see
Avoid drama if you can . Eat foods that are organic and eat produce from grass fed animals like cows .
Before the ww2 we didn’t have all these chemicals in and on our food . Moderation and walk more , laugh often .
That for sure
Lift weights keep your bones, and muscles healthy
@@TheVisserPodcast indeed. i swim twice a week and lifting weight 3x a week including squat. I also do African jump during weight training 1 minute for 5 reps.
C:15 is made by the microbiome from the fermentation of fiber-producing SCFA's, in particular propionic acid, which is then converted to C:15 in the liver. This is how it ends up in dairy fat, via a cow consuming grass: fiber>SCFA propionate>C:15 - the exact same pathway in humans. No dietary Saturated Fat is required to produce it. (cows don't consume hardly any Saturated fat).
The issue is that for 10's of thousands of years, early humans consumed far more fiber than modern humans do now.
Studies on early homo sapiens fossilized poop, shows that they consumed 100-225g of fiber per day on average:
Coprolite research (fossilized human poop) reveals that prehistoric populations relied heavily on plants in their diet for over 10,000 years.
Africa - 120g of fiber per day
N. America - Mexico 150-225g of fiber per day
S. America - Peru 100g per day
Australia - over 100g of fiber per day
Modern Americans consume about 10-15g of fiber per day on average. So humans were eating 10-20 TIMES more plant fiber than modern humans.
2017 Study: Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. The American Journal of Clinical Nutrition
"Conclusions: Our data show that gut-derived propionate is used for the hepatic synthesis of OCFAs in humans. The association of OCFAs with a decreased risk of type 2 diabetes may therefore also relate to dietary fiber intake and not only dairy fat."
Also BCAAs (Valine) are also used by the human body for endogenous production of both OCFAs C:15 and C:17:
Study: The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism
“Our data clearly show that valine supplementation in vivo contributes to C15:0 and C17:0 formation via these two described pathways. This is corroborated by our in vitro studies, showing that Valine treatment leads to elevated OCFA levels with inductions of Ppara and Hacl1 in a dose dependent manner.”
“Taken together, these data illustrate differential roles of the BCAA in lipid metabolism and provide preliminary evidence that exclusively valine contributes to the endogenous formation of OCFA which is important for a better understanding of these metabolites in metabolic health.”
Fiber is key in our diet no question, however if the gut is not ready for the fiber we have a problem, so starting with pre and probiotics and following this up with fermented foods is the only way to diversify the gut biome, only then can we effectively introduce fiber
What is Ferroptosis? - Ferroptosis is an iron-dependent process that results in the accumulation of toxic lipid peroxides and ROS, which ultimately leads to cell death.
What Causes Ferroptosis? - Heme Iron
Where does Heme Iron come from? Only found in animal flesh. Plants do not make Heme Iron.
What Helps Prevent Ferroptosis? OCFA C:15
What is an “Essential” nutrient? - “An essential nutrient is a substance that the body can't make in sufficient quantities or at all, and therefore must be obtained from food in order to function properly.”
Is C:15 an Essential Fatty Acid? - No, because the body makes it through multiple pathways.
How is C:15 Made in the Human Body? From the SCFA Propionate
How is SCFA Propionate Made in the Human Body? Gut microbiome fermentation of fiber
Where does Fiber come from? Fiber only comes from plants (and fungi and algae). Animals do not make fiber.
Why so much C:15 in Dairy? Cows eat very large amounts of fiber (grass), fermented into SCFA/Propionate and converted to the OCFA C:15
I can't find fatty15 on amazon. Do you have a link? I'm missing something perhaps.
fatty15.com/
People who suffer greatly become great
Dr. Brad Stanfield in his video "Exposed! The Dangerous Truth About Supplements" said that C15:0 is BS.
That guy has absolutely no idea what he is talking about. Ive been taking Fatty15 for about a year and feel AMAZING. I was always tired, my skin was dry with wrinkes and dark circles, no energy and my sleep was messed up. As soon as I started taking Fatty15 it all went away. Now I sleep great, wake up energized, have plenty of energy throughout the day, my skin looks better and is softer, wrinkles and dark circles are disappearing...I feel great. This guy can say whatever he wants results are results and I am not making this up. If it's BS then how can you explain this?
They call him Flipper, Flipper, faster than lightning,
No-one you see, is smarter than he,
And we know Flipper, lives in a world full of wonder,
Flying there-under, under the sea! 🐬🐬🐬🐬🐬🎼🎶🎶
roflmao! This CHEMICAL they're selling is TRASH
Answer: 6-12 months, tops. Question: hwo long before the info about C-15 gets at least somewhat debunked.
You mention it helps with Copd? Can you elaborate?
Great question here you go: pubmed.ncbi.nlm.nih.gov/30661707/
Have you looked into Mullein?
You mentioned that C15 is being produced in the body naturally but that we cannot produce enough of it I may be questioned that because when people eat like potatoes and rice and pasta and bread and all that kind of stuff they do not feed the body what it really needs naturally if we instead eat only vegetables like cooked spinach or maybe roasted and maybe a lot of other vegetables the Earth that kind and maybe some food and stuff natural stuff then maybe we can actually produce enough of it what is taking that?
We’d have to eat raw dairy full fat but that just isn’t an option these days with all the processing going on the feed for the cows etc
It's not the C16 you consume that's inflammatory. The C16 in your blood as an inflammatory marker is made endogenously, not consumed exogenously.
www.ncbi.nlm.nih.gov/pmc/articles/PMC5867544/
Please let me see the research
100g of butter = 50mg to 100mg of fatty15. That's a lot of butter, but totally feasible if you're on a keto diet.
If its made in a lab its more than likely synthetic containing alcohol which goes straight into the brain & may cause aggresive brain tumors, also never know what else has been added into it if its liposomal. Id be happy to get some and see whats inside it
It’s a supplement like any other we take daily, so I wouldn’t be too concerned
Where's your practice or clinic? I'm 60 with an 8-year-old, and I need to figure out how to stay in the ring as long as possible. I've really noticed a drop in my energy levels the last few years.
I’m currently living in Istanbul Turkey, where I work with over 5000 doctors in Stem cell therapy and longevity - looking closely at regenerative medicine and how this will redefine age management
I’m with you on this, I currently live in Istanbul, Turkey
Look at the rest of my podcasts and the longevity 9 road map.
If you really want to get specific you can write me and we can do a call in or zoom
drvisser@me.com
What would you consider an effective therapeutic dose of fatty15?
Research by Dr. Venn-Watson indicates that a 100-200mg daily dosage of C15:0 is ideal for reaching a target blood value of 10-30µM.5 Fatty15 hits the mark with its 100mg, once-daily supplement dosage.
I take one capsule daily personally, I would start there
I now take 2 per day and my results are even more pronounced. Energy, better mood.
Hey doc, which camera do you use? Wanna get the same one for my YT channel :)
Great video btw!
I use a Sony Fx3 as my main
@@TheVisserPodcast Thank you very much sir
I was using the Sony ZV 1 but it overheated and even with the fan attached it was a nightmare - image quality was great
I also use a native 20mm lens you could op for the 24mm or go with the all around 24-70 GM zoom
where do you get the supplement from?
Fatty 15 is what I use 100mg a day
Have you looked at IL-11 antibodies yet? Looks like it beats c-15 . Both to see 150yrs?
Will look into it. Thank you for the feedback
good
excellent!!! just subscribed to your channel . we shroud talk. looking forward to. ore videos. I'd like to see your charts. any chance on that one?
Where to source C-15 from food or as a supplement???
Supplement
Supplement
Ghee butter its cheaper
Doesnt C15, fatty15 do the same job as spirluna for mitochondria
Yes and much more by strengthening the cell walls amongst other things
you said C15 triggers mTOR? do you mean C15:0 activates AMPK and INHIBITS mTOR?
My bad: C15:0 activates AMPK and inhibits mTOR, both of which are core components of the human longevity pathway
Where can we get c15 supplements ? I already eat grass fed cheddar cheese but I don’t know if I get enough of c15.
Online is the only place I’m able to get it, look for fatty 15
One ounce of cheddar cheese contains 90 mg of pentadecanoic acid (C15:0), almost the daily dose of those pills.
Which brand is recommended?
Fatty 15 is the only one I know
Is C15 in Full Fat Kiefer?
No, C15:0 is not a full-fat kefir. C15:0, also known as pentadecanoic acid, is a type of saturated fatty acid found in some full-fat dairy products like milk, butter, and certain animal fats. It is being studied for its potential health benefits, such as anti-inflammatory and metabolic effects.
Full-fat kefir, on the other hand, is a fermented dairy product rich in probiotics, made from milk and kefir grains. While full-fat kefir may contain small amounts of C15:0 due to its dairy content, they are not the same thing.
Where to get it?
Online Fatty 15
Tell me how to get C15
Eat moderate dairy fats and supplement with fatty15
Just wondering what kind of Milk or Butter do Dolphins eat?
Dolphins get it from WHOLE FISH, not the parts of fish that we usually eat.
Asian and Mediterranean diets do use a lot of whole fish and fish sauces.. So, they are getting this, even if they are not using a lot of grass fed dairy.
In our culture, this is a big deficiency.
Thanks, so what is best way to get it if you’re plant based whole food?
Correct and what we are seeing is that the fish are becoming smaller and have less and less C15:0 I
I am using the Fatty 15 supplement 100mg daily
Is butter better than Ghee? how can i increase my C15 intake?
I would take the supplement just to be sure
Sour cream too
I eat raw goat and sheep milk cheese and it is also in there.
Yea you are correct, but not enough
Aren't most goat and sheep gras fed... where our dairy farms, and beef, is grain fed.
This could make a real difference.
What about muscle wasting with metformin ?
That is exactly the problem with taking Metformin if you are not pre- or full diabetic
Not as much the waisting, but more waisted workouts
How about dairy cream or butter from organically grass fed cows?
Great but it won’t get you to desired levels
Yes on the right track
hey Mr. NCS. You left out so much. What is this saturated fat made from - you mentioned whole milk but don't drink it... So what foods DO contain it? Where do we get C15? Next time before posting a video can you please have someone with common sense review it and go over what you left out. thank you sir.
I take fatty 15, because I’m not doing Keto so I don’t consume enough dairy products, our fish doesn’t have enough our food unless you live on a farm and have access to farm to fork data, might not be clean enough to get your C-15 from
But I will include a list of foods and how much C-15 you can expect to get from the products
@@TheVisserPodcast thanks, you're the best!
I heard 1/2 ounce of pecorino Romano cheese gives a daily supply of C 15. Yes? No?
Too many variables one of em is bioavailabity
@@TheVisserPodcast I only recently heard of C 15. What would you suggest to get the MDR of C 15. Thanks.
So what food is highest in c15?
As far as the research suggest we need the supplement to get enough of C15
Need to supplement
@@TheVisserPodcast, butter will do the trick.
Just eat fatty meat and fish, we evolved eating this stuff.
Just make sure you analyze the “farm to fork” track, because it could affect your health negatively
I’m talking about how they were fed, their environment, anti-biotic usage etc etc all this could be detrimental to our health.
Times have changed and not always for the better
No... there is not any considerable C15 in the parts of fish that most of us eat, in the western diet.
You need to consume WHOLE fish.. which is common in Asian and Mediterranean diets. Even if they do not eat a lot of dairy.
And, very very few people consume GRASS FED dairy. That is key factor. Grain fed cows do not produce nearly that amount of C15.
So far I haven't heard one person say how it changed their life... so I am out on this one for now... I have tried so many supplements in my life that didn't make a difference and I am tired of it...
It’s a subtle improvement felt after time, the biggest impact you can make on health far and above fine tuning your supplement regime is: Optimizing your weight, Resistance training and improving your VO2 max nothing else and i mean nothing else comes close
1 spoon of grassfed ghee. Who would have thought it?
Not that simple - You have to look at the bioavailability of Ghee; It’s a good start
is it not same as vitamin b5
No it’s not these are two different things
If your total daily fat content is high, you will not have high levels of C15 due to type of microbiota in the gut. It’s the gut bacteria that synthesize the C15. A few studies show this. One test compared 5% dietary fat with 35% dietary fat and 70% dietary fat (plus they use different types of fat).
Result: “the concentration of C15:0 decreases as the dietary total-fat content increases (p < 0.05); a ~30% increase in dietary total-fat resulted in a ~35% decrease in circulating C15:0 concentration.”
It didn’t matter what type of fat used. As the total daily fat content rises - the less C15 synthesized. We need the correct gut bacteria to break it down, where it is then usable.
Total fat intake (when high) disrupts the individual fatty acids.
By using cheese to get your C15, you end up with less if you’re eating high fat throughout the rest of the day (from other foods).
That’s why a low fat plant-based diet is the best (with very small amounts of cheese, meat and eggs) and animal based foods can be used as ‘condiments’.
Have to strongly disagree with that, protein is king for longevity, vegetables snd fruits are important and the giber is also vital - if you want to go vegan or close to it you will really have to supplement your protein intake and make sure you’re not coming short on the essentials - its doable but way more work and calculating
"concentration of C15:0 decreases " does not mean total C15:0 decreases
@@TheVisserPodcastNo, all blue zones style of eating is NOT high protein. It is always plant based, but also not vegan or vegetarian (except Linda Loma). They eat a bit of everything. Italy, Greece, Spain eat much less butter than other fats like olive oil. They eat hard and soft cheeses though. Anyway it is diet with less protein then Northern Europe and Asia or Americas.
Snake oil, this study has been so bias. Yeah I am going to take a drug from a study done by the owner who profits from it. Just eat whole food with animal meats. This is for vegans.
Luckily there are now countless independent studies that are confirming the findings. I also know that when you are researching non-pharma as in supplements funding is hard to come by.
"You need to take more than 5 mg per mililiter"...? No sense at all.
fatty15.com/blogs/news/healthy-fats
All these youtubers trying to hawk questionable animal studies (dolphins, rats and cows) as if those things translate to humans!
Stick around I’ll be discussing the human studies next
Wow! This guy managed to condense a whole 2 minutes worth of information into a mere 12:53. 😴
Thanks for the engagement :)
Gen X’r maybe that explains it for you
❤
Thanks for informing us old man. Just kidding. Take your c-15 and chill!
😂
Eat more butter
UA-camR DR. ERIC BERG RETIRED AMERICAN CHIROPRACTOR HAS @ 13 MILLION SUBSCRIBERS.
C4😂😂❤😂
Dude, you are dating yourself
😂
Visser 3
Why is this video repeating 😂
I had overheating issues with my ZV-e1 so when I send it out to editing a piece got repeated 😅 yeah will do better - I really had had it with the camara so I traded it in out of frustration
OMG… soo many words and still so low contant. 🙄 What a waste of time.
Contant: meaning cash money in the Dutch language - episode was made on a low budget you are correct 😂
absolutely the worst podcast ever.
So it was impactful 😂
Worst video ever
You might try to think about giving a reason for your comment!
It seems a little incomplete as it is.
Otherwise, it will be the worst comment ever!
OK, here is a more detailed explanation of my comment. This dude is talking about using pharmaceuticals to enhance longevity and promote better health. He’s also discussing the use of single compounds and how they might affect the physiology of the human body. Start with this is a great example of reductionism, which is an extremely flawed methodology. Secondly, while some pharmaceuticals have their place in the reduction of pathology symptoms, the idea that you’re going to use a pharmaceutical like Metformin to enhance your health and longevity is total nonsense. Simply allows cells to shove more glucose into them, exacerbating the underlying problem of glucose regulation in the first place. I.e., don’t eat so many damn carbohydrates. This guys dunning Kruger is stunning. His understanding of biochemistry is so lacking, I doubt he has even the slightest understanding of the physics as well. Like I said, the worst video ever.
Obviously you haven’t really seen the whole episode or episodes building up to this one where i go over Metformin, the ongoing human trails and that up to this point the research doesn’t show an advantage for healthy people, only those that are diabetic or pre- diabetic. In this episode we are comparing C15:0 to these compounds that are current being used in the longevity space by researchers such as David St Claire of Harvard and dr Peter Attia to name just two
There is no reductionism here
@@TheVisserPodcast hahaha, there are people on this thread stating that they are ordering c15 because of this video. Why don’t you try diving into the quantum biology before trying to muddle around into the bio chemistry? It is extremely reductionist to attribute single compounds to any physiological response, positive or negative. Metformin does not “help” people with diabetes, it merely delays their neuropathy.
Will work on it, thanks
Your video is horrible. All over the map, full of needless diversions and distractions and badly edited. Full of irrelevant information. You have important information that needs to be communicated much more succinctly and in much less time. Redo it and keep it at 5 minutes max.
Thanks for the feedback, thank you for taking the time. I will keep your suggestions in mind
Thank you for your information and effort！😇🙏🦭
You are so welcome