C15 A Longevity Game Changer? | The Studies Reviewed
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- Опубліковано 9 кві 2024
- C15 or Pentadecanoic acid, also known as Fatty 15 may be an essential fatty acid and we may not be getting enough of it. Here we go through the science of C15, its benefits and natural sources.
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🌐Links in this video
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Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
www.ncbi.nlm.nih.gov/pmc/arti...
Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds
www.ncbi.nlm.nih.gov/pmc/arti...
Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?
www.ncbi.nlm.nih.gov/pmc/arti...
The lipidomic correlates of epigenetic aging across the adult lifespan: A population-based study
onlinelibrary.wiley.com/doi/1...
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#C15 #fatty15 #fattyacids - Наука та технологія
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To further improve health and mitigate damage to mitochondria, the RDA is insufficient. Increasing dairy consumption would also increase the even-chained, inflammation causing acids/fats and caloric intake. C-15 supplementation would offer swifter resolution for health issues. I suppose if you aren’t worried about aging or health issues, the RDA would be fine..
A healthy source for C15 is Ghee. It is a high smoke point fat extracted from cows milk which is used in Indian cooking and for many other purposes.
Thank you for the recommendation of 100 grams of C15 per day, the approximate amount in one tablespoon (12 grams) of butter. Easy enough to add to my day. Thank you so much, Richard!
Hi V, thanks for your comment. Cool! Sounds good.
@@ModernHealthspan hi I recently just emailed you about the chemical cocktail from harvard that I heard about I got a response in the email saying please type your reply above this line what line are you talking about
@@eman1989z I believe it was a mistyping error. I think it was meant that there is about 100mg C15 in 12 grams of butter. That jives with a couple sources I've found that put the C15 content of butter fat at ~1%. Use real cream in your coffee and real butter on your veggies and you're getting more than the postulated 100mg/day.
Is fatty15 the only company that produces this? $40-$45 per month depending if you elect for the subscription. $30-$35 maybe, But $40-$45 a month equals nearly $500 a year. From my understanding they take c14 from plants (abundant source) and add one carbon? (Whatever it is I don’t know!) the point is, it seems a little overpriced for what it is. I want to take it, but sheesh, that’s quite a financial investment on the consumer’s part…
Nice to see you adding biochemical commentary from your expanding knowledge,,, love the evolution of the channel as such....
Unless you're a vegan or otherwise don't eat dairy, it would seem relatively easy to get more than the recommended amount through food with small amount Dairy fat.
How much is that?
@@eman1989z 100mg of c15. Supposedly 1 ounce of cheese contains that amount.
@@eman1989z apparently you need 100 mg.
100 grams butter= 830 mg of C15
100 grams of full fat cream= 450 mg
100 grams cheddar cheese = 390 mg
A great and timely video. Thank you for this Richard.
Hi Lars, thanks!
If one tablespoon of butter makes the recommendation then there are millions of people around the world that are getting this amount of c15. Dr Venn-Watson in one of her presentations on the internet mentioned that she had started menopause (with all problems) and doubled her dose with good results. This leads me to wonder if this is one of those molecules that gets less and less as we age. Anyway an incredible analysis and review Richard...
Really enjoyable; appreciate the work
Ha, all the foods we eat since we embarked on the proper human diet, labeled the Carnivore diet but really it's a way of eating rather than a 'diet'. Loads of info on YT, but Dr Ken Berry is a good starting point.
Thank you for this insightful
Very nice deep dive. Stearic acid (C18:0) is kind of magical, also, and has dropped dramatically in Western diets due to the general fear of fats. Since it didn't fall in consumption simultaneously in the same way across all cultures (France, for instance, continued having stearic acid as part of their diets well after the United States had all but eliminated it), however, there's interesting evidence out there that suggests that the correlation of the fall in stearic acid consumption with the increase in cardiovascular and other problems is not merely coincidental.
Hi Scott, thanks for sharing. Interesting, based on the reading I did I would have thought that an even chained fat would have a negative impact on health - though there did not seem to be a mechanistic explanation for this. I do think eliminating nearly all fats is not a good idea. I did see that Dr Venn-Watson also highlighted the correlation of lower dairy fat and increased CVD as being possibly related to lower C15. There have been many changes in the diet over the last 40 years so difficult to pull it apart after the fact!
Odd number fats like c15 are better than even number fats like c18.
You look young Richard, thank you for this presentation.
Hi Ben, thanks! I hope that you found the video helpful.
Thank you Richard.
Hi Ron, thank you!
Thanks for this video. I just ordered C15 from the company in San Diego.
Amazing Supplement!!!
Thanks
Hi Mike, thanks!
I tried taking C15 (aka commercially as "Fatty 15") for a couple of weeks. I had negative neurological symptoms that started, including tingling and numbness in extremities and a psychological sense of unreality and a generalized feeling of being way off. It was frightening. I'm not going to try taking it again,
Hi Thanks for sharing. Can I ask did you reach out to the vendor? Also, do you eat dairy products? If you do, you would probably have similar levels of C15 in the blood.
@@ModernHealthspan I did not contact the company yet. It's the company founded by Venn-Watson, the scientist who did the dolphin studies. I did some subsequent research on C15:0. It is actually one of the fatty acids that is HIGHER in people with MS, a neurological condition. There is actually good research on this. So, the idea that C15:0 is some sort of panacea is not completely accurate--- there are diseases associated with higher levels of C15:0. Omega-3 fatty acids have been shown to help people with MS, which is also interesting. Omega-3 fatty acids make cell walls more flexible, C15:0 makes them more stiff. (BTW, I DO eat butter, a lot of it.)
@@ModernHealthspanThere must be other Areas in ones Body Blocking absorption of this newly discovered c. 15.. or everyone who eats sufficient dairy and Red meat, Would have a Normal Insulin level!
ESPECIALLY IF one has Methylation issues. Which apparently 40% of people do have. OR more!
No wonder. So many people have high Insulin!
Thank you soo interesting! 🎉👏🏻🎉
Eat real butter. Problem solved.
@@LloydsofRochester C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
I thought dairy products causes inflammation. So adding cheese butter dairy are good fats. Why take a $50 supplement if you get it from your diet?.
Because there's lot more C16 in dairy than C15, and that's inflamatory
C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
The trouble with getting C15:0 from food is that it is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb. For this reason C15:0 absorption from only food has not been studied in depth on humans. What we do know is this- natural C15:0 levels started decreasing when the "Low Fat" movement happened in the 80's and 90's.
That said, C15:0 is found in some foods. This means that we all have some baseline level of C15:0. What fatty15 is expected to do is to raise this level to achieve the desired circulating C15:0 concentrations of 10 to 20 uM needed to attain key benefits.
I know when I took this product it did nothing for me so I stopped taking it but glad maybe it was just the amount that I did not get enough of.
Is there a reason to take it as a supplement? I've seen other places say that you can get plenty by eating a little butter or cheese.
Hi thanks for the question. As the slide with the availability in foods shows, it is certainly possible to get the required amount from food sources. You could consider pure C15 as being more healthy as it does not contain the even chained fatty acids that come with butter and cheese.
C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
Looking at the fatty acids in Sphingolipids, it looks like they might be about 15 carbons long. I also don't understand how we're not making any, if it's in beef and butter. Perhaps it's a fermentation byproduct?
Hi Thanks for comment. The papers did address that humans do not make it but did not talk about where it was originally produced and I cannot find an answer.
High amounts in high oleic sunflower oils
I have several reasons to stick with butter and away from seed oils. But thanks for the feedback !
I put ghee in my coffee. I hope it has the recommended amount of c15!
nope~! there is one hour special done by Thomas DeLauer. not enough. whatever is left is destroyed by the liver if i remember right.
you should watch the visser podcast
Is C-15 increased or modified by fermenting milk?
If true that we're not making any but ruminants do... that's a legit question.
Hi thanks for your question. I don't have an answer for that, but looking at this table (wholefoodcatalog.info/nutrient/pentadecanoic_acid/foods/high/) it seems that fermenting does not seem to reduce the level by much. It is an interesting question as to how it gets into the milk. Whether the cows make it or get it from their diet.
@@ModernHealthspan Thanks Richard.
If you can get c15 from cheese, then fermenting should be fine. In the Netherlands, a woman was trying to sell us tourists some cheese and attributed her young looks to eating cheese. I took it with a grain of salt but she may be right!
@@marnold2791 The ratio of C:15 to other saturated fats is 1 to 100 in dairy products, so it is not obvious that eating them is worth it. She said in another video that grain fed cows have lower C:15 so it might be better to chose organic dairies.
I'd be curious to know how animals like cows make C:15 and if we could emulate that one way or another in a way that doesn't create other saturated fats at the same time.
What about ghee ?
I tried this product for 3 months. Did nothing. In fact. My HS- CRP increased from 1.5 to 2.4 mg/ L. Scam
This is not good point
@@antonisfoteinos1796 why not. Their literally say it will lower inflammation and to check your HS CRP after 3 months So I did.
Just 1 ounce of cheese per day gives you the recommended amount. Unless you're a vegan or otherwise avoid dairy, why consider a supplement?
Where are you getting “recommended amount” from?
@@cactuscanine3531 The video references 100mg as being recommended by the Researcher cited in the video.
This is one of the many problems of a plant-based diet, particulary a plant-exclusive diet. When such diets are studied, they are almost always compared against a standard American diet (SAD). Ironically, SAD is described as animal-based, even though it's 70% plant foods. What never gets included in such studies is a diet that is 70-100% animal foods, especially not one that is whole foods, nose-to-tail, organic, and pasture-raised. Or rather such research is typically only found in Asia where higher meat intake is correlated to better health and longer longevity.
@@MarmaladeINFP Well, there are several people that live past 100 on exclusive plant based diets, so at least certain people can thrive on them Now are these people genetic longevity freaks that would live long on any diet, maybe, maybe not.
Hi Jack, thanks for your comment. I would think that that is correct. The downside is that you get the other saturated fats too, but if you are eating full fat dairy then you have already decided that you are OK with this. As well as vegans, you could see if people are lactose intolerant it would be helpful.
I poop out c15 it is
Why not stearic acid?
Hi thanks for your question, however, I am not clear as to your meaning. The video is not about a supplement but about C15, the fatty acid and the benefits that it has. Stearic acid does not seem to have the negative effects of the other even chained saturated fats and it is available in common food sources. I am not sure if it would be a substitute or not.
@@ModernHealthspan It is cheap even if you ate it as a cosmetic grade powder supplement melted into food, it has mitochondrial fusion effects and it is the slowest to reach fat cells and it directly fights visceral fat and ectopic organ fat (palmitic acid has some of these benefits but not all of them). the main benefit of MCT fats would be driving BCAA catabolism.
Way over priced and riding the "latest great thing" wave. Just take a daily dose of Mega-3 three times a day.
You are confused. This literally blows away your Mega-3
All the more reason to be on carnivore diet
Anyone who cites Dr Steven Gundry approvingly should immediately be assumed to be profit-driven bunk prone. PS Does the guy happen to be selling this nonsense?
PS Oh, right. Yup. The guy is flogging stuff. Not a researcher. Not a clinician. Just a marketer.
Thanks
Hi Thanks!