Edit: For everyone commenting that I forgot exercise…you might enjoy this video: ua-cam.com/video/9H40yatCwo0/v-deo.html :) If you just want the lowdown on a specific drug…check out the video chapters! 00:46 Rapamycin 02:34 Senolytics 04:49 Metformin 06:18 Taurine 07:24 Statins And, if you want to know more about these and many more longevity drugs, you might enjoy my book, _Ageless_ ageless.link/ or my playlist of aging biology videos ua-cam.com/play/PLg0VbZ0kyCHmO8iGdXdg_FudrWauf48BT.html
@@DrAndrewSteele Thanks, Andrew... In humans, walking circulates lymph from the gut to the lymph nodes. This carries nutrition out of the gut. It's good for you because, otherwise, parasitic gut bacteria can eat your protein groceries. Note: parasitic bacteria don't eat fatty acids ...which explains your middle. My work (patents pending) seem to suggest that parasitic gut bacteria are also behind the protein loss associated with aging.
Here hoping real progress is developed here. The case that ageing is one of the most pressing human causes of suffering and death, especially in wealthy societies where easier problems have been solved, has convinced me.
I only wish I could put any trust in these companies at all after what happened after 2O2O. I doubt I'd even try these things and I expect they'll have plenty of the list long negtveffects
Problem with statins as anti-aging: although statins do reduce ldl cholesterol, the hypothesis that ldl cholesterol is the cause of heart disease has been falsified. In fact people with high ldl tend to live longer than people with low ldl, because ldl appears to have immune system functions protecting against infection and cancer.
I agree that statins really don't improve longevity, it's more about inflammation than the level of cholesterol. However 'people with high LDL tend to live longer'? really?? Point me to the meta analysis that backs up that huge claim. thanks
@@stevo5000, although some meta analyses establish a high cholesterol association with CVD deaths, the challenges to those interpretations are substantial, as detailed in "Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review". Also, look up the following: "Towards a Paradigm Shift in Cholesterol Treatment. A Re-examination of the Cholesterol Issue in Japan", "Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure", "Is a high serum cholesterol level associated with longer survival in elderly hypertensives?", "The low cholesterol-mortality association in a national cohort".
Wild that there are so many anti-statin comments popping up, and especially this claim that LDL improves health. Tell that to people with a PCSK9 mutation who have rock-bottom LDL throughout their lives and don’t have any major differences health-wise except vastly reduced heart disease!
@Ge1Ri4- Incorrect. The PESA study conclusively proved that lowering LDL to a level at least 60 will prevent the development of CAD, that is atherosclerosis.
Statins are the most prescribed drug in the world, it’s also the most lucrative by amounts prescribed. In fact I think it’s over prescribed. Cholesterol is very necessary for body functions. Our brain is about 30% cholesterol. Just say no and control it by diet.
Great question! But sadly I find it hard to get very excited about NMN/NAD boosters generally… As I said in the video, the ITP found that NR didn’t increase mouse lifespan, which isn’t ideal! And all the human studies are small and somewhat inconclusive because they’re in very specific populations, only show very small effects, and so on. They may find a niche treating specific diseases, but for ageing generally I think there are much more promising approaches out there.
Alpha-Ketoglutarate appears to be a promising anti-aging drug (it has increased lifespan in studies on worms and mice). Another is the combination of the amino acids glycine and n-acetyl cysteine (often referred to as GlyNAC), which increases levels of endogenous glutathione. I would welcome your thoughts on these in a future video.
@@DrAndrewSteele Thanks. I forgot to also mention glucosamine sulfate, which has extended lifespan in nematodes and mice, appears to be associated with reduced mortality in a human study, and is thought to induce autophagy.
Taurine had great effect on my brother. I suppose we are all diffrent . He also take all other supplements you mentiond but first when He added Taurine he saw a big change. Anyway i think Exosomes research is the only real longevity methode with real visual effects on humans. Like the researcher that treated His 80 year old hand and after 4 days it looks like a 40 year old hand.
As a statin user from age of 17 until now 29.5 and hardly research that thing I would advice you to check the negatives of statins on humans who take them for a long period. I take it because I have to but I wouldn't touch it otherwise
Exactly. If you need to take them, it's one thing. I haven't seen anything about statins for people who don't need them for anti-aging. Also, there are so many criticisms about the Tame study but apparently the kind doctor is not aware of and that's why that study didn't get the funding (yet, maybe it will never will).
*Why would anyone want to live longer??* 😮 I can't wait to tap out. I am 63, healthy and have seen it all. If my demise comes knocking tomorrow, I'll leave with a smile. 😊
Thanks for the vid, Dr Steele! Suggestion for the future topic is eating related interventions for longevity, as far as I saw, you didn’t cover it on your channel. Complete fasting for multiple days vs intermittent fasting vs longterm low calorie diet vs fasting mimicking diet vs keto diet vs macronutrients manipulations etc. There are many proponents for each of these strategies, but I didn’t saw any deep enough comparison.
@@DrAndrewSteele I find it curious that you choose 3. to comment on, maybe because exercise and it's affects are the most traceable and quantifiable. Question: which of these do you believe to be more favorable to a longer life? a. A lifestyle of optimal exercise plus high stress. b. A lifestyle of optimal stress plus low exercise.
@@dfgaJK I don’t think we know the answer, and it’s a bit of a meaningless question since exercise reduces stress anyway. :) But I did choose to comment on that because the evidence is far stronger-there haven’t been any good RCTs on happiness, stress, or mindfulness.
@@DrAndrewSteeleMaybe I phrased it wrong. My intent was for the question options to be the total level of exercise and stress within one's lifestyle irrespective of how they would have contributed to each other to achieve the final stated level.
The much insulted method of intermittent fasting removes senescent cells through autophagy and doesn't involve taking drugs. You also lose weight, lower blood pressure and sugar, as well as a load of other improvements. "Take a pill for it" should be a last resort.
@@Tommo0706 Buzz word? Is that a new way of saying 'disinformation'? Intermittent fasting is a way of reducing energy input (or calories as you put it, what a charm to hear such an old fashioned concept brought up as an argument). Autophagy can very clearly be demonstrated to be a result of IF, or 'calorie defect' (meaning, I suspect, calory deficit). IF is a much easier way of doing it, which you evidently haven't tried.
IMF 18-6 works best for me. Have been on this fasting diet for over 2 years. No sugars whatsoever. 100-200 grams per day max of complex carbohydrates ( Brown rice, multi grain -Schwartz Brot, whole grain pasta). Semi - Keto diet. Fish, seafood, eggs- pescatarian. Almost 63 yrs young. Perfect health! No pills whatsoever. Low glucose, normal colesterol, low blood pressure, low heart rate. Also, 15 minute HIIT every morning . ❤
I couldn’t believe what I was hearing. First time here. Statins have caused small blood vessel disease for me. They shut down and interrupt signals in the brain. I can’t cite you a study since I am only a nurse. But I have researched this for years. They have to keep us sick to make money $$. No respect
For dementia in particular what do you think of low dose lithium (~150mg). Bipolar patients usually have terrible death and dementia rates in older age but some studies have shown those on long term lithium to have equivalent rates to the general population. Obviously even in low doses not for anyone with kidney problems. Might it be possible to get the same benefits with doses even lower than are produced for medical use
Hi Andrew, thanks for doing this video! Two questions: 1) Due to the dietary sources of Taurine, do you think that considering Taurine supplementation may be especially interesting for strict vegans (like myself)? 2) What is your take on (taking) Alpha-Ketoglutarate?
You’re welcome, glad you enjoyed it! Great questions too: 1) Yeah, interesting! Given that the authors’ hypothesis is that they’re topping up taurine to more youthful levels, perhaps we should be basing supplementation on blood tests rather than age? And then vegans, or anyone whose taurine is low for whatever reason, might be advised to supplement… More research is needed but it’s a plausible idea! 2) I need to look into it some more but it’s definitely promising-might even have made this video’s list on a different day of the week haha. But with the same caveats as the other things here, we need a proper human RCT. :)
Humans and all mammals need taurine. It's just that humans, other primates, and many others can make our own assuming your pancreas is working as it should. Cats, being carnivores, get so much in their natural diet that the synthesis pathway lost its function, sort of like the missing eyes in cave fish. The same is true of why most primates can't produce our own vit. C even though many animals can. The early monkeys were eating a lot of fruit and thus had no need to produce their own vit C.
Have any studies shown that berberine can be used in the place of Metformin? I realize that Metformin has been established to exhibit anti-aging properties because it is synthetic and money can be made on Metformin. Berberine on the other does have similar properties but is a natural compound found in a number of plant species. Therefore there is little incentive to make any money on the sales of berberine which is available OTC. It does exhibit less side effects than Metformin according to reports in the literature. I generally take berberine in a formulation combined with medium chain sized fatty acid oils. Please comment if you know of more information about berberine. Thank you.
Could you please look into peptides. I had problems with pain in my shoulder and hip for 1.5 years, trying everything, nothings worked. I ordered the peptide bcp 157 in tablet form. I took them for a month, and the pain is gone. I would be very interesting to hear what you think about peptides.
There was a recent paper from Harvard labs regarding drugs that activate cellular reprogramming. One of those compounds was a molecule CAKG what about a deep dive into that one ??
Pills can help, but nothing can replace good ol' sleeping cold, HIT exceecise, maintaining endurance fitness at old age, diversifying sources of protein intake, and eating more micronutrient & antioxidants-rich foods.
@@mysticm1543 literally sleeping with the thermostat turned down a couple degrees. Doing workouts and sports outside during fall & winter as well as cold showers, Ice baths, Jogging or climbing up a mountain in nothing but shorts like Wim Hof works too.
Hi, thanks. I was looking for an oral thrombolytic agent, plasminogen for intermittent use for the prevention of approximately of 87% strokes. Still looking...
Good point! Most strokes are from clots and not bleeds. All ischemic heart attacks are from clots. All pulmonary embolisms are from clots. Risk of death from clots is high but bleeding deaths do occur.
Today I discovered I've been saying quercetin incorrectly for years... My LDL has been consistently below 60mg/dl for years so I wasn't convinced of the value of a statin for me. The extra effects of statins mentioned seem remarkable though. If they are still there when controlling for cholesterol levels I may have to start downing big macs to get a prescription (joke). Overall senolytics seem the most enticing. Not having to take them chronically makes them much more appealing for the average person along with the immediate improvement rather than just slowing deterioration.
Haha don’t bet on it-the last video’s commenters were asking about my pronunciation of ‘citation’ aaaand…they were right. D‘oh. :) And yeah, the other effects of statins are very interesting. If they do indeed do that, perhaps we can find other non-cholesterol-lowering drugs for you lucky people which have the same effect!
Studies with humans would have to take a very long time to prove that these substances are actually effective. I suspect that very old, cheap and easily available substances could be equally effective: e.g. creatine, vitamin D or ginseng. Calorie reduction, a mostly vegan diet plus fish and certainly exercise might also be effective. If I had to choose one substance it would be creatine. The evidence is high that it maintains muscle strength. This is really essential for old age.
Thanks for sharing your top 5. I'm curious about your "it's too early, wait and see" approach. Sure for someone in their 30s that's fine and dandy but if you were in that older , deteriorating bracket of 60+ don't you think the risk of trying some of these safer ones now outweighs the risks of aging itself? If older people, who need it the most, sit on the sidelines and wait, they won't even be around when many of these officially get the green light. And when I talk about safer ones I mean taking them under a doctor's supervision.
It’s a really tough one, I agree-I actually don’t know what I’d do myself, let alone advise someone else to do! It frustrates me that there isn’t an experimental path available to people where they can be sure they’re getting the right drug in the right dose and their data can contribute to future understanding…and, in the absence of that, it’s really hard to know what to do. Even the supervision of a doctor may not be enough just because your average doctor probably doesn’t know much about using these drugs off-label for longevity! Sorry for the non-answer…but I really don’t know…
It is definitely hard to trust the typical doctor. For example, I have raging tinnitus due to the neglect of one in whom I placed undeserved trust. Shame on me. I also have a funny shaped front tooth, and thus a wonky smile, because I didn't voice my expectations prior to letting a dentist "grind down a chipped tooth to prevent further shearing" and said dentist didn't explain properly what he was about to do... A dermatologist that was going to remove a lipoma, but refused to align the scar to my wishes, for no reason other than it's what he wanted. I stopped that procedure before I got cut open... But enough of my personal experience with mediocre professionals... Vastly, it seems too many docs don't feel the need for life long research/study to stay at the top of the game... Not to mention the bigotted doctors that practice personal opinion in contradiction of established science... For longevity.. IMHO a good "functional nutritionist" who stays on top of established AND emerging research data, with a good head to analyze the findings and apply them individually, through personal patient testing for optimal outcomes, without crossing contraindications is the best bet. I'd add Glycine, N-acetylcysteine ester, methylene blue, melatonin, collagen, and absolutely creatine to adjunct your list of longevity substances... and copious amounts of microgreens, especially broccoli... Lastly, I'm considering nitro glycerine to boost vascular nitric oxide, but I haven't finished my research on it yet, so I haven't made a final decision. Hopefully my word salad 👆 wasn't too swellheaded to tollerate.. Ya'll have a good day.
I don't see much problem with taurine. I'm in my later 60's, and take taurine. I also take a statin that was prescribed. I have used senolytics, and will in the future. They are typically used for a couple days, with a long break in between uses. Dasatinib is technically a chemotherapeutic, since it is used against a (very specific) cancer, but it is nothing like the "chemotherapy" drugs that everyone is familiar with. It doesn't harm cells. It inhibits a single enzyme that is broken in a certain type of cancer. The same enzyme is broken in senescent cells. The dose used in senolytic therapy is only somewhat smaller than in therapy for the particular cancer that it's used for.
I think there is a lot of focus on supplements - which is fine if you already have your sleep, exercise and diet in order. Not many of us are exercising 2+ hours a day, sleeping 8 hours a night and have a great diet. Once that's in order then the risk of supplements is a personal one
I will forgive you. Very good attempt to a summary. Not easy since we are at the beginning of testing, so we are all guinea pigs. However i have to totally disagree total with statins and the LDL cholesterol. First plaques are not caused by LDL. Why you may say. LDL makes up less than 1% of the debris in plaques. Why would we blame LDL for 100% of the damage. Maybe you should look at fibrinogen, red blood cells, platelets and other stuff. Young and old people usually have heart attacks or strokes because of blood /plasma flow imbalance created by creating an injury to endothelial cells. Studies have produced conflicting results for statins and older people are not advised to use statins past 70 yrs. I have worked 40 yrs in pharma, so dont believe all the benefits of drugs. Another question for you. If LDL is present in your blood thru all your body, why do we have 90% of plaques in large artery close to the heart? For blood/plasma references you can check Dr Sloop on youtube or Researchgate. Thanks for entertaining video.
Nice overview but I disagree with metformin and statins. It strongly depends on your diet and lifestyle. But althrough its not wrong to say: just lean back and wait a few more years. Its the safest way. There is 1 drug I am actually taking and 1 Im experimenting with but Im not convinced. Its Rapa(1st) and Taurine(2nd). Overdosing taurine is quite easy. Take care if you are a labratory mice like me...
And yes, few years more or less is a marginal factor- we die, no matter if it is 70, 90, 200...we humans always want more. If you suffer, fear not, just accept and go and get a new body. Now that's a solution we all have agreed on long ago.
Blue Zones. Their diets. The foods that contain the more beneficial compounds. I've got COPD and just a couple months ago I was coughing every morning for about an hour. I started chewing on clones and taking a little tumeric with black pepper. It helped a lot. I since added ashawaganda and NAC. I just ordered some glycine. Hopefully it will help.
Long clinical trails on large groups of humans would be nice, but won't be funded if the drug is cheap or already exists and can't be patented, and need to last decades to track long term effects. If you are 60 now, you will be 120 when the final results are published. Reling on short incomplete trails and animal test is the name of the game until then.
You don't need any drugs- movement, herbs, fasting, clean eating and god will take you a long way. I personally met a gentleman in Varanasi India in 2018, he was 122 at the time. He's still alive and in good shape, doing yoga everyday.
@@annabarker7686 Yes, I sat down and ate with him. All he basically ate was dahl, chapatis, rice & veg.. so, very simple and probably not suitable for most people. He does not even eat fruit.
Who the hell wants longevity in this F-upped world? I've had enough, although I'll keep going for a while, but I'm not afraid of non-being. I suspect in comes as a relief unless of course you're still young enough to have some optimism, or at least a few delusions.
I think anecdotal evidence needs to be looked at more seriously with longevity drugs. My mother is pre-diabetic and has been taking Metformin for a few years now. She says she feels great now. I take NMN and I feel like I did when I was younger is the best way to describe its effect. This pans out in generic athletic stamina along with day to day energy. I was taking berberdine as well which was like a little boost on top of how NMN makes me feel.
U need to upgrade your information... as Metformin, and statins are now found to be not useful, and actually quite the opposite for longevity. Especially Statins. There are a numerous herbs for thinning your blood, that don't have the side effects like statins do. One such herb is Gingko. Which can be purchased in ground leaf's and made into tea. Which also helps with your memory.
Nope, Statins are not healthy for "healthy" people. My experience on statin prescription are far from good, even on low dose. Ar you another Ancel Keys offshoot?
Well put-together list, I would agree with that. Also like glycine maybe as 6th place. The only different thinking I generally have is that we are all aging every year when doing nothing. So if you don't take any anti-aging drugs because you are concerned about the risks, you should also know that not taking anything has a clear risk as well, i.e. aging one year every year. I've decided for myself that I am fine with risk here, because risk-free is an illusion.
@pierrejeanes Taurine and quercetin... also not "drugs," yet they made the top list of "promising REAL anti-aging drugs" Let food be thy medicine and medicine be thy food. Good day.
@Lennythewinner I'm actually good with calling these substances drugs. Frankly, Pierre is being overly narrow in his mindset.. Previously, I should have pushed back, rather than point out that by Pierre's methodology, neither were other things from the OP list... My philosophy, which is an echo of the expert's reasoning, is the following... An amino acid is generally considered to be a food, but if that amino acid is marketed/used as a remedy for sleep disorders, depression, premenstrual syndrome, and other medical conditions, then it would be classified as a drug. Glycine and N-acetylcysteine ester, being supplemented copiously, as I do, for the purpose of the restoration of youthful glutathione levels (I'm over 50). AND To improve oxidative stress, mitochondrial dysfunction, inflammation, aging hallmarks, metabolic defects, muscle strength, cognitive decline, and body composition: all implications for healthy aging. Certainly qualifies for the title of drug. I hope your weekend is going great!
Could it be that those people who take metformin and statins, which is usually the same group risk, are the ones who also aware and cautious of their diet and lifestyle. The researches published are of correlative type. Here is more factor; stress, socioeconomics and yes attitude towards life and a belief system.
@@DrAndrewSteele If you notice moderate or severe muscle aches after starting to take a statin, contact your doctor. If you have signs and symptoms of rhabdomyolysis, stop taking your statin medication immediately and seek medical treatment right away. If necessary, your doctor may take steps to help prevent kidney damage and other complications. Francisco Lopez-Jimenez, M.D.
@@ananovak1275 Agreed, if you experience problems, consult your doctor. Some patients do experience muscle pain, and everyone on statins needs their liver function monitoring. This is normal, but only problematic in a minority of patients. :)
Why just prescription drugs. What about natural substances like Fisetin, which is thought of as Senolytic, and it's natural. Just wondering if there is any data on this one..😊
New data just dropped on fisetin this week! It didn’t extend lifespan in mice in the ITP, unfortunately… twitter.com/statto/status/1731636952753897802 And rapamycin, taurine and quercetin (half of the senolytic cocktail I mentioned) are ‘natural’… Nature is often the source of inspiration for drugs, so I’m not sure it makes sense to draw a hard distinction.
I wonder if quercetin might not be just acting as a good supplement: in a population of burger-eaters, not getting enough fruit and veg, a flavinoid might just be making up for some of what's missing.
There is a doctor in New England who has been prescribing it for several years and I understand people are flying in from all over the world for it. I am presently not interested in the drug so my info is several years old. You should be able to find him on line but I will say be sure you understand what you are taking.
Edit: For everyone commenting that I forgot exercise…you might enjoy this video: ua-cam.com/video/9H40yatCwo0/v-deo.html :)
If you just want the lowdown on a specific drug…check out the video chapters!
00:46 Rapamycin
02:34 Senolytics
04:49 Metformin
06:18 Taurine
07:24 Statins
And, if you want to know more about these and many more longevity drugs, you might enjoy my book, _Ageless_ ageless.link/ or my playlist of aging biology videos ua-cam.com/play/PLg0VbZ0kyCHmO8iGdXdg_FudrWauf48BT.html
You forgot the number one intervention with the most powerful, and proven, effect: Exercise.
I’ve added a link to a video in the comment above for you, and others who have asked this below!
@@DrAndrewSteele Thanks, Andrew... In humans, walking circulates lymph from the gut to the lymph nodes. This carries nutrition out of the gut. It's good for you because, otherwise, parasitic gut bacteria can eat your protein groceries. Note: parasitic bacteria don't eat fatty acids ...which explains your middle. My work (patents pending) seem to suggest that parasitic gut bacteria are also behind the protein loss associated with aging.
When u send in market all drugs I m from India
Hello dr I m from India I need your all drugs in India when u send to India please talk to Indian prime minister Modi ji
This is very exciting because I am a mouse
They may not work on really, really big mice.
Fun fact: Andrew is 103 years old.
Well, you joke, but he's actually 64. Looks pretty damn young!
really?@@yourbrain8700
@@yourbrain8700he's 28?
LOL
LOL !
Here hoping real progress is developed here. The case that ageing is one of the most pressing human causes of suffering and death, especially in wealthy societies where easier problems have been solved, has convinced me.
I only wish I could put any trust in these companies at all after what happened after 2O2O. I doubt I'd even try these things and I expect they'll have plenty of the list long negtveffects
Problem with statins as anti-aging: although statins do reduce ldl cholesterol, the hypothesis that ldl cholesterol is the cause of heart disease has been falsified. In fact people with high ldl tend to live longer than people with low ldl, because ldl appears to have immune system functions protecting against infection and cancer.
I agree that statins really don't improve longevity, it's more about inflammation than the level of cholesterol. However 'people with high LDL tend to live longer'? really?? Point me to the meta analysis that backs up that huge claim. thanks
@@stevo5000, although some meta analyses establish a high cholesterol association with CVD deaths, the challenges to those interpretations are substantial, as detailed in "Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review". Also, look up the following: "Towards a Paradigm Shift in Cholesterol Treatment. A Re-examination of the Cholesterol Issue in Japan", "Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure", "Is a high serum cholesterol level associated with longer survival in elderly hypertensives?", "The low cholesterol-mortality association in a national cohort".
Wild that there are so many anti-statin comments popping up, and especially this claim that LDL improves health. Tell that to people with a PCSK9 mutation who have rock-bottom LDL throughout their lives and don’t have any major differences health-wise except vastly reduced heart disease!
@@DrAndrewSteele And what about low carb diets which prevents LDL to be glycated / oxidized ? Isn't this form of LDL that is harmful ?
@Ge1Ri4- Incorrect. The PESA study conclusively proved that lowering LDL to a level at least 60 will prevent the development of CAD, that is atherosclerosis.
What are your thoughts on resveratrol?
Horrible on joints and muscles
statins prevent absorption of vit k which is very important to accompany vit d.
@@lizinawe which vit K?
K1 or K2 melaquinoine?
Statins are the most prescribed drug in the world, it’s also the most lucrative by amounts prescribed. In fact I think it’s over prescribed. Cholesterol is very necessary for body functions. Our brain is about 30% cholesterol. Just say no and control it by diet.
Nattokinase,aka Natto beans,Mk7 , Serapeptase, Testosterone, TRT after 60 to name a few
@DrAndrewSteele what about NAD+ drugs and the like, are they not considered top anti-aging drugs?
Great question! But sadly I find it hard to get very excited about NMN/NAD boosters generally… As I said in the video, the ITP found that NR didn’t increase mouse lifespan, which isn’t ideal! And all the human studies are small and somewhat inconclusive because they’re in very specific populations, only show very small effects, and so on. They may find a niche treating specific diseases, but for ageing generally I think there are much more promising approaches out there.
Thanks for the answer!
@@Ramong Glad to be of service! :)
Statins are your best bet at the moment. Then taurine. The rest is hit and miss.
With all these mice doing so well in longevity studies, maybe we should start eating mice.
In Carbon 60 clinical trials, the unhealthiest rats lived 9x as long!!!! Would that be worth consideration?
Bucky Balls FTW 🙂
Oh right you exist. I had forgotten. Well, let's see what the man has to say.
Awesome as always Doc
Thank you!
Broccoli sprouts? Cloves? Watercress?
Dried Parsley .. has much to recommend it!
Ditch sugar, secondary sugars....ditch bread and processed dairy.go raw.
Definitely Epithilon
What is this?
i lost you with the "statin" part........you must be kidding!
Acarbose?
Old stuff lol
Such BigPharma BS
Exercise. Exercise is the best thing for antiaging.
It is, just make sure not to over train, i.e like a professional sports player or Olympic athlete. Overtraining speeds up aging. 😅
1. Beer
2. Tequila
3. Vodka
4. Whiskey
5. and a splash of Red Wine for good measure!
Alpha-Ketoglutarate appears to be a promising anti-aging drug (it has increased lifespan in studies on worms and mice). Another is the combination of the amino acids glycine and n-acetyl cysteine (often referred to as GlyNAC), which increases levels of endogenous glutathione. I would welcome your thoughts on these in a future video.
I’ve definitely got my eye on those, I’ll have to look into them some more! :)
@@DrAndrewSteele Thanks. I forgot to also mention glucosamine sulfate, which has extended lifespan in nematodes and mice, appears to be associated with reduced mortality in a human study, and is thought to induce autophagy.
@@DrAndrewSteele what about Resveratrol
NAC has been shown to promote tumor growth in the lungs.
Taurine had great effect on my brother. I suppose we are all diffrent . He also take all other supplements you mentiond but first when He added Taurine he saw a big change. Anyway i think Exosomes research is the only real longevity methode with real visual effects on humans. Like the researcher that treated His 80 year old hand and after 4 days it looks like a 40 year old hand.
As a statin user from age of 17 until now 29.5 and hardly research that thing I would advice you to check the negatives of statins on humans who take them for a long period. I take it because I have to but I wouldn't touch it otherwise
Exactly. If you need to take them, it's one thing. I haven't seen anything about statins for people who don't need them for anti-aging. Also, there are so many criticisms about the Tame study but apparently the kind doctor is not aware of and that's why that study didn't get the funding (yet, maybe it will never will).
Stations can cause arthritis and damaged joints. Not worth it.
*Why would anyone want to live longer??* 😮
I can't wait to tap out. I am 63, healthy and have seen it all. If my demise comes knocking tomorrow, I'll leave with a smile. 😊
Gimme the cocktail please. Time is running out.
Thanks for the vid, Dr Steele! Suggestion for the future topic is eating related interventions for longevity, as far as I saw, you didn’t cover it on your channel. Complete fasting for multiple days vs intermittent fasting vs longterm low calorie diet vs fasting mimicking diet vs keto diet vs macronutrients manipulations etc. There are many proponents for each of these strategies, but I didn’t saw any deep enough comparison.
Thanks! I get asked this a lot so it would definitely make for a good video topic!
My top 5 would be:
1. Pursue happiness
2. Alleviate Stress
3. Exercise
4. Eat Healthy
5. Being Mindful
Doctors joke that if exercise were a pill, everyone would be queuing up to take it… :)
@@DrAndrewSteele I find it curious that you choose 3. to comment on, maybe because exercise and it's affects are the most traceable and quantifiable.
Question: which of these do you believe to be more favorable to a longer life?
a. A lifestyle of optimal exercise plus high stress.
b. A lifestyle of optimal stress plus low exercise.
add "prioritize sleep" to this and i will 100% sign to this.. way above all other anti aging hacks like supplements and such
@@dfgaJK I don’t think we know the answer, and it’s a bit of a meaningless question since exercise reduces stress anyway. :) But I did choose to comment on that because the evidence is far stronger-there haven’t been any good RCTs on happiness, stress, or mindfulness.
@@DrAndrewSteeleMaybe I phrased it wrong. My intent was for the question options to be the total level of exercise and stress within one's lifestyle irrespective of how they would have contributed to each other to achieve the final stated level.
The much insulted method of intermittent fasting removes senescent cells through autophagy and doesn't involve taking drugs. You also lose weight, lower blood pressure and sugar, as well as a load of other improvements. "Take a pill for it" should be a last resort.
Exercise also does this. I do both.
Autophagy is a buzzword, your body does it anyway if you’re in a calorie defect, so that’s correlation not causation
@@Tommo0706 Buzz word? Is that a new way of saying 'disinformation'? Intermittent fasting is a way of reducing energy input (or calories as you put it, what a charm to hear such an old fashioned concept brought up as an argument). Autophagy can very clearly be demonstrated to be a result of IF, or 'calorie defect' (meaning, I suspect, calory deficit). IF is a much easier way of doing it, which you evidently haven't tried.
I see pills more like supliments
Not enough scientific evidence. Sorry.
IMF 18-6 works best for me. Have been on this fasting diet for over 2 years. No sugars whatsoever. 100-200 grams per day max of complex carbohydrates ( Brown rice, multi grain -Schwartz Brot, whole grain pasta). Semi - Keto diet. Fish, seafood, eggs- pescatarian. Almost 63 yrs young. Perfect health! No pills whatsoever. Low glucose, normal colesterol, low blood pressure, low heart rate. Also, 15 minute HIIT every morning . ❤
Wouldn't touch metformin,statins taurine might be interesting 😮
I couldn’t believe what I was hearing. First time here. Statins have caused small blood vessel disease for me. They shut down and interrupt signals in the brain. I can’t cite you a study since I am only a nurse. But I have researched this for years. They have to keep us sick to make money $$. No respect
I would like your thoughts on both Omega 3's, as well as Omega 3's paired with a B complex like what Elysium Health markets.
For dementia in particular what do you think of low dose lithium (~150mg). Bipolar patients usually have terrible death and dementia rates in older age but some studies have shown those on long term lithium to have equivalent rates to the general population. Obviously even in low doses not for anyone with kidney problems. Might it be possible to get the same benefits with doses even lower than are produced for medical use
Hi Andrew, thanks for doing this video! Two questions:
1) Due to the dietary sources of Taurine, do you think that considering Taurine supplementation may be especially interesting for strict vegans (like myself)?
2) What is your take on (taking) Alpha-Ketoglutarate?
You’re welcome, glad you enjoyed it!
Great questions too:
1) Yeah, interesting! Given that the authors’ hypothesis is that they’re topping up taurine to more youthful levels, perhaps we should be basing supplementation on blood tests rather than age? And then vegans, or anyone whose taurine is low for whatever reason, might be advised to supplement… More research is needed but it’s a plausible idea!
2) I need to look into it some more but it’s definitely promising-might even have made this video’s list on a different day of the week haha. But with the same caveats as the other things here, we need a proper human RCT. :)
Thanks for your replies, Andrew!
Glad to be of service!
ps: I really enjoyed your long podcast episode with Simon Hill a few months ago!
Oh, thanks for listening in! That one was fun :)
I had only heard of taurine as what cats need to keep their heart healthy. Interesting that it helps other animals.
Mammalian physiology
Taurine is not drug your body makes it also
Doesn’t taurine stimulate mtor?
Humans and all mammals need taurine. It's just that humans, other primates, and many others can make our own assuming your pancreas is working as it should. Cats, being carnivores, get so much in their natural diet that the synthesis pathway lost its function, sort of like the missing eyes in cave fish. The same is true of why most primates can't produce our own vit. C even though many animals can. The early monkeys were eating a lot of fruit and thus had no need to produce their own vit C.
Have any studies shown that berberine can be used in the place of Metformin? I realize that Metformin has been established to exhibit anti-aging properties because it is synthetic and money can be made on Metformin. Berberine on the other does have similar properties but is a natural compound found in a number of plant species. Therefore there is little incentive to make any money on the sales of berberine which is available OTC. It does exhibit less side effects than Metformin according to reports in the literature. I generally take berberine in a formulation combined with medium chain sized fatty acid oils. Please comment if you know of more information about berberine. Thank you.
Could you please look into peptides. I had problems with pain in my shoulder and hip for 1.5 years, trying everything, nothings worked. I ordered the peptide bcp 157 in tablet form. I took them for a month, and the pain is gone. I would be very interesting to hear what you think about peptides.
I had heard that nicotine divorced from inhalation and smoke seems to have anti-dementia effects, perhaps you could look into that?
There was a recent paper from Harvard labs regarding drugs that activate cellular reprogramming. One of those compounds was a molecule CAKG what about a deep dive into that one ??
I’ll take a look into it! I’m planning on making a video about reprogramming generally, so… :)
Pills can help, but nothing can replace good ol' sleeping cold, HIT exceecise, maintaining endurance fitness at old age, diversifying sources of protein intake, and eating more micronutrient & antioxidants-rich foods.
WHat is sleeping cold?
@@mysticm1543 literally sleeping with the thermostat turned down a couple degrees.
Doing workouts and sports outside during fall & winter as well as cold showers, Ice baths, Jogging or climbing up a mountain in nothing but shorts like Wim Hof works too.
well I guess sleeping without air-conditioning in a hot room is not so beneficial for sleep. @@handlemonium
Hi, thanks. I was looking for an oral thrombolytic agent, plasminogen for intermittent use for the prevention of approximately of 87% strokes. Still looking...
Good point! Most strokes are from clots and not bleeds. All ischemic heart attacks are from clots. All pulmonary embolisms are from clots. Risk of death from clots is high but bleeding deaths do occur.
Today I discovered I've been saying quercetin incorrectly for years...
My LDL has been consistently below 60mg/dl for years so I wasn't convinced of the value of a statin for me. The extra effects of statins mentioned seem remarkable though. If they are still there when controlling for cholesterol levels I may have to start downing big macs to get a prescription (joke).
Overall senolytics seem the most enticing. Not having to take them chronically makes them much more appealing for the average person along with the immediate improvement rather than just slowing deterioration.
Haha don’t bet on it-the last video’s commenters were asking about my pronunciation of ‘citation’ aaaand…they were right. D‘oh. :)
And yeah, the other effects of statins are very interesting. If they do indeed do that, perhaps we can find other non-cholesterol-lowering drugs for you lucky people which have the same effect!
Doctors don't even all pronounce duodenum the same way. English spelling is a curse.
@@therabbithatand colloquial, regional pronunciation variations are the norm..
The most common pronunciation of quercetin that I've encountered is KWER seh tin
Studies with humans would have to take a very long time to prove that these substances are actually effective. I suspect that very old, cheap and easily available substances could be equally effective: e.g. creatine, vitamin D or ginseng. Calorie reduction, a mostly vegan diet plus fish and certainly exercise might also be effective. If I had to choose one substance it would be creatine. The evidence is high that it maintains muscle strength. This is really essential for old age.
Video suggestion: 5 effective anti-age suplemments available in the market now.
I really hope anti aging is a think within the next 10 years. Mostly because of my parents, i want them to live for a long time and be healty.
The one time I'm lucky to have cholesterol/heart problems, lmao. Wahoo.
Hahaha congratulations!
Wow, I'm going to be addicted! ;)
How to quickly boost NAD + in the blood plz? Niacin+Nicotinamide?
Well every single drug that is out there has sight effects ; natural ways exist to prolong healthy body / mind in balance .
Thanks for sharing your top 5. I'm curious about your "it's too early, wait and see" approach. Sure for someone in their 30s that's fine and dandy but if you were in that older , deteriorating bracket of 60+ don't you think the risk of trying some of these safer ones now outweighs the risks of aging itself? If older people, who need it the most, sit on the sidelines and wait, they won't even be around when many of these officially get the green light. And when I talk about safer ones I mean taking them under a doctor's supervision.
It’s a really tough one, I agree-I actually don’t know what I’d do myself, let alone advise someone else to do! It frustrates me that there isn’t an experimental path available to people where they can be sure they’re getting the right drug in the right dose and their data can contribute to future understanding…and, in the absence of that, it’s really hard to know what to do. Even the supervision of a doctor may not be enough just because your average doctor probably doesn’t know much about using these drugs off-label for longevity! Sorry for the non-answer…but I really don’t know…
It is definitely hard to trust the typical doctor.
For example, I have raging tinnitus due to the neglect of one in whom I placed undeserved trust. Shame on me.
I also have a funny shaped front tooth, and thus a wonky smile, because I didn't voice my expectations prior to letting a dentist "grind down a chipped tooth to prevent further shearing"
and said dentist didn't explain properly what he was about to do...
A dermatologist that was going to remove a lipoma, but refused to align the scar to my wishes, for no reason other than it's what he wanted. I stopped that procedure before I got cut open...
But enough of my personal experience with mediocre professionals...
Vastly, it seems too many docs don't feel the need for life long research/study to stay at the top of the game...
Not to mention the bigotted doctors that practice personal opinion in contradiction of established science...
For longevity.. IMHO a good "functional nutritionist" who stays on top of established AND emerging research data, with a good head to analyze the findings and apply them individually, through personal patient testing for optimal outcomes, without crossing contraindications is the best bet.
I'd add Glycine, N-acetylcysteine ester, methylene blue, melatonin, collagen, and absolutely creatine to adjunct your list of longevity substances...
and copious amounts of microgreens, especially broccoli...
Lastly, I'm considering nitro glycerine to boost vascular nitric oxide, but I haven't finished my research on it yet, so I haven't made a final decision.
Hopefully my word salad 👆 wasn't too swellheaded to tollerate..
Ya'll have a good day.
😊
I don't see much problem with taurine. I'm in my later 60's, and take taurine. I also take a statin that was prescribed. I have used senolytics, and will in the future. They are typically used for a couple days, with a long break in between uses. Dasatinib is technically a chemotherapeutic, since it is used against a (very specific) cancer, but it is nothing like the "chemotherapy" drugs that everyone is familiar with. It doesn't harm cells. It inhibits a single enzyme that is broken in a certain type of cancer. The same enzyme is broken in senescent cells. The dose used in senolytic therapy is only somewhat smaller than in therapy for the particular cancer that it's used for.
I think there is a lot of focus on supplements - which is fine if you already have your sleep, exercise and diet in order. Not many of us are exercising 2+ hours a day, sleeping 8 hours a night and have a great diet. Once that's in order then the risk of supplements is a personal one
Absolute wrong track for anti ageing
I will forgive you. Very good attempt to a summary. Not easy since we are at the beginning of testing, so we are all guinea pigs. However i have to totally disagree total with statins and the LDL cholesterol. First plaques are not caused by LDL. Why you may say. LDL makes up less than 1% of the debris in plaques. Why would we blame LDL for 100% of the damage. Maybe you should look at fibrinogen, red blood cells, platelets and other stuff. Young and old people usually have heart attacks or strokes because of blood /plasma flow imbalance created by creating an injury to endothelial cells. Studies have produced conflicting results for statins and older people are not advised to use statins past 70 yrs. I have worked 40 yrs in pharma, so dont believe all the benefits of drugs. Another question for you. If LDL is present in your blood thru all your body, why do we have 90% of plaques in large artery close to the heart? For blood/plasma references you can check Dr Sloop on youtube or Researchgate. Thanks for entertaining video.
Arsenic makes up less than 1% of this soup. Why would we blame it for 100% of the fact the person who drank the soup is dead?
🙌💯
Nice overview but I disagree with metformin and statins. It strongly depends on your diet and lifestyle. But althrough its not wrong to say: just lean back and wait a few more years. Its the safest way.
There is 1 drug I am actually taking and 1 Im experimenting with but Im not convinced. Its Rapa(1st) and Taurine(2nd). Overdosing taurine is quite easy. Take care if you are a labratory mice like me...
And yes, few years more or less is a marginal factor- we die, no matter if it is 70, 90, 200...we humans always want more. If you suffer, fear not, just accept and go and get a new body. Now that's a solution we all have agreed on long ago.
How could you skip Resveratrol and NMN which is recommended by David Sinclair, the number one in the field of life extension?
I can’t take metformin because of intestinal problems. I don’t see reversitrol which is not sill in trail or prescription released.
Blue Zones. Their diets. The foods that contain the more beneficial compounds.
I've got COPD and just a couple months ago I was coughing every morning for about an hour. I started chewing on clones and taking a little tumeric with black pepper. It helped a lot. I since added ashawaganda and NAC. I just ordered some glycine.
Hopefully it will help.
Long clinical trails on large groups of humans would be nice, but won't be funded if the drug is cheap or already exists and can't be patented, and need to last decades to track long term effects. If you are 60 now, you will be 120 when the final results are published. Reling on short incomplete trails and animal test is the name of the game until then.
You don't need any drugs- movement, herbs, fasting, clean eating and god will take you a long way. I personally met a gentleman in Varanasi India in 2018, he was 122 at the time. He's still alive and in good shape, doing yoga everyday.
@@annabarker7686
Yes, I sat down and ate with him. All he basically ate was dahl, chapatis, rice & veg.. so, very simple and probably not suitable for most people. He does not even eat fruit.
Wolf in sheep’s clothing.
Who the hell wants longevity in this F-upped world? I've had enough, although I'll keep going for a while, but I'm not afraid of non-being. I suspect in comes as a relief unless of course you're still young enough to have some optimism, or at least a few delusions.
Rapamycin is too expensive 200mg: 150€
Metformin and Statins have too many side effects.
Selenium and Q10 are far better options.
I think anecdotal evidence needs to be looked at more seriously with longevity drugs.
My mother is pre-diabetic and has been taking Metformin for a few years now. She says she feels great now.
I take NMN and I feel like I did when I was younger is the best way to describe its effect.
This pans out in generic athletic stamina along with day to day
energy.
I was taking berberdine as well which was like a little boost on top of how NMN makes me feel.
U need to upgrade your information... as Metformin, and statins are now found to be not useful, and actually quite the opposite for longevity. Especially Statins. There are a numerous herbs for thinning your blood, that don't have the side effects like statins do. One such herb is Gingko. Which can be purchased in ground leaf's and made into tea. Which also helps with your memory.
Please talk about VC6TF, other similar compound, and LSD1 inhibitor
Hi Andrew, what are your thoughts about alpha-keto-glutarate?
Nope, Statins are not healthy for "healthy" people. My experience on statin prescription are far from good, even on low dose. Ar you another Ancel Keys offshoot?
I was with you until you talked about statins. At that point, I cut you off. The downsides statins negate any positive effects.
Statin dugs - Lower CoQ10, and by the way no libido! Be radical, live, don't die longer...
I'll only take them if they're highly addictive and have appalling side effects.
As a 48 year old white European male with the chance to score some dasatinib:
Should I do D&Q?
Well put-together list, I would agree with that. Also like glycine maybe as 6th place. The only different thinking I generally have is that we are all aging every year when doing nothing. So if you don't take any anti-aging drugs because you are concerned about the risks, you should also know that not taking anything has a clear risk as well, i.e. aging one year every year. I've decided for myself that I am fine with risk here, because risk-free is an illusion.
Are you combining N-acetylcysteine ester with your glycine?
It is reported as a good tandem.
Glycine is not drug
@pierrejeanes Taurine and quercetin... also not "drugs," yet they made the top list of "promising REAL anti-aging drugs"
Let food be thy medicine and medicine be thy food.
Good day.
@@jadabaudelaire118 Indeed; perhaps the word "substance" would be more appropriate.😊
@Lennythewinner I'm actually good with calling these substances drugs.
Frankly, Pierre is being overly narrow in his mindset..
Previously, I should have pushed back, rather than point out that by Pierre's methodology, neither were other things from the OP list...
My philosophy, which is an echo of the expert's reasoning, is the following...
An amino acid is generally considered to be a food, but if that amino acid is marketed/used as a remedy for sleep disorders, depression, premenstrual syndrome, and other medical conditions, then it would be classified as a drug.
Glycine and N-acetylcysteine ester, being supplemented copiously, as I do, for the purpose of the restoration of youthful glutathione levels (I'm over 50).
AND
To improve oxidative stress, mitochondrial dysfunction, inflammation, aging hallmarks, metabolic defects, muscle strength, cognitive decline, and body composition: all implications for healthy aging.
Certainly qualifies for the title of drug.
I hope your weekend is going great!
I recommend you look over the way you speak. It's strange and takes away from the message. All love! (you have my sub!!!)
Won't doing a 36-72 water fast eliminate those senescent cells?
mention side effects man
I’m nearly 70, so I don’t feel that I have a lot of time!…I did find time to read ‘Ageless’ though! Very interesting…
Thanks for finding the time! Really glad you enjoyed it :)
Please.. no. Don't want to live in the first place... Geez ... Be alive forever would be so boring.
why do you say "might be able to slow down " ? why are you scared of being Definite ?
Could it be that those people who take metformin and statins, which is usually the same group risk, are the ones who also aware and cautious of their diet and lifestyle. The researches published are of correlative type. Here is more factor; stress, socioeconomics and yes attitude towards life and a belief system.
Hello Andrew, thx for the video. Can you please cover minocycline in one of your next videos?
I’ll look into it!
This man is 10 years behind lol.
A video on nootropics ("smart drugs") would be interesting...
1. calorie restriction [ keeping a good weight ] 2. adequate sleep, low stress 3. Aspirin 10mg 3x a week 4. low dose stain twice a week, Crestor 5. Metformin daily 6. Jardiance daily
Those prescriptions... not good.
What good is any of this when everyday that goes by the earth is becoming more and more inhospitable?
Aging is different from longevity, short term health is different from long term health, etc
I am 75 years old and haven't been to a doctor since 1969. I believe you need a prescription for Metformin so I take berberine.
@@JimmyJapan Grab your Bud Light and photo of Dylan Mulvaney and day dream.
@JimmyJapan why??
This feels a bit like wishing for flying cars.
I’d suggest watching some of my other videos or reading my book-it sounds like sci-fi, but this is real science!
I have a Mthfr gene mutation and can't take Metformin 😢
What about muscle pain and dementia when on statins?
No evidence of dementia risk increase, and muscle pain is almost as bad with placebo…
@@DrAndrewSteele If you notice moderate or severe muscle aches after starting to take a statin, contact your doctor. If you have signs and symptoms of rhabdomyolysis, stop taking your statin medication immediately and seek medical treatment right away. If necessary, your doctor may take steps to help prevent kidney damage and other complications.
Francisco Lopez-Jimenez, M.D.
@@ananovak1275 Agreed, if you experience problems, consult your doctor. Some patients do experience muscle pain, and everyone on statins needs their liver function monitoring. This is normal, but only problematic in a minority of patients. :)
Eating fermented NATTO cleans the arteries ( k2 )
Red Yeast Rice is a natural statin used to lower red yeast rice to lower cholesterol
Why just prescription drugs. What about natural substances like Fisetin, which is thought of as Senolytic, and it's natural. Just wondering if there is any data on this one..😊
New data just dropped on fisetin this week! It didn’t extend lifespan in mice in the ITP, unfortunately… twitter.com/statto/status/1731636952753897802
And rapamycin, taurine and quercetin (half of the senolytic cocktail I mentioned) are ‘natural’… Nature is often the source of inspiration for drugs, so I’m not sure it makes sense to draw a hard distinction.
No doctor wants to give me these 😢drugs.
Lost me at statins....those are slow metabolic poisons imo.
I wonder if quercetin might not be just acting as a good supplement: in a population of burger-eaters, not getting enough fruit and veg, a flavinoid might just be making up for some of what's missing.
The mice in these experiments aren’t fed burgers though!
All those drugs have bad side-effects.
Is there any information on the recommended human dose of rapamycin or is it still under preliminary study?
We just don’t know without a human trial for longevity purposes :)
There is a doctor in New England who has been prescribing it for several years and I understand people are flying in from all over the world for it. I am presently not interested in the drug so my info is several years old. You should be able to find him on line but I will say be sure you understand what you are taking.
Surprise he didn't mention Acarbose. That seems to be well ahead of statins and even taurine at this point.
That's jus to prevent carb digestion, which I agree also helps prevent Age related glycation