Antiviral game changer
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- Опубліковано 3 чер 2024
- Is this antiviral a game changer, Oral Antiviral, molnupiravir
www.merck.com/news/merck-and-...
Merck and Ridgeback
Oral Antiviral, molnupiravir (MK-4482, EIDD-2801)
Positive Interim Analysis of Phase 3 Study
Significantly reduced the risk of hospitalization or death
During day 1 to 5 to 29 days
Phase 3 MOVe-OUT trial
At risk, non-hospitalized adults with mild-to-moderate COVID-19
A global Phase 3, randomized, placebo-controlled, double-blind, multi-site study
of non-hospitalized adult patients
Brazil, Canada, Chile, Colombia, Egypt, France, Germany, Guatemala, Israel, Italy, Japan, Mexico, Philippines, Poland, Russia, South Africa, Spain, Sweden, Taiwan, Ukraine, the United Kingdom and the United States
Eligibility criteria
Laboratory-confirmed mild-to-moderate COVID-19
With symptom onset within 5 days of study randomization
All patients were required to have at least one risk factor
Molnupiravir group
Hospitalization or dead, 7.3% of patients
28 out of 385
No deaths
Placebo group
Hospitalization or dead, 14.1% of patients
53 out of 377
P is 0.0012
8 deaths
Data Monitoring Committee in consultation with Food and Drug Administration
Recruitment into the study stopped early
Due to these positive results
Merck, application for Emergency Use
Authorization in US
Other regulatory bodies worldwide
About the Results of the Planned Interim Analysis
Evaluated data n = 775
Recruitment 90% of 1,550 the intended sample
Molnupiravir reduced the risk of hospitalization and/or death across all key subgroups;
Efficacy was not affected by timing of symptom onset or underlying risk factor
About 40% of participants had sequencing data
Molnupiravir demonstrated consistent efficacy across viral variants Gamma, Delta, and Mu
Incidence of adverse event between groups
Molnupiravir group
Incidence of any adverse event, 35%
Drug-related adverse events, 12%
Subjects discontinued study therapy due to an adverse event, 1.3%
Placebo groups
Incidence of any adverse event, 40%
Drug-related adverse events, 11%
Subjects discontinued study therapy due to an adverse event, 3.4%
Merck has said data shows molnupiravir is not capable of inducing genetic changes in human cells,
but men enrolled in its trials had to abstain from intercourse or agree to use contraception.
Women of child-bearing age in the study could (not) be pregnant and also had to use birth control.
www.reuters.com/business/heal...
About Merck’s Efforts to Enable Access to Molnupiravir, if it is Granted EUA or Approval
Merck has been producing molnupiravir at risk.
Merck expects to produce 10 million courses of treatment by the end of 2021
Existing procurement agreement with the U.S. Government
Merck will supply approximately 1.7 million courses of molnupiravir to the U.S. government upon EAU
$700 per 5 day course (2 doses per day)
$1.2 billion purchase agreement for the
1.7 million 5-day treatment courses of molnupiravir
MOVe-AHEAD
A global, multicenter, randomized, double-blind, placebo-controlled Phase 3 study,
evaluating the efficacy and safety of molnupiravir in preventing the spread of COVID-19 within households
My cynicism level towards big pharma has now gone beyond $700.
As well as the world governments who kept Ivermectin from their people. It's shameful and disgusting.
Mine beyond 1. 7 billion
@@antd8667 👍
@@craigphillips6308 NOT PARTS OF INDIA THOUGH!!!
New episode!
Project Veritas.. Pfizer scientists exposed part 4: ua-cam.com/video/On5RYFbcxWY/v-deo.html
The level of corruption exposed by this pandemic is stomach churning
Right! I can’t believe it either!! It does churn my stomach!!!
President Donald J Trump said time to clean the swamp up. Well, none of us would of thought the corruption was this huge. It’s not a swamp it’s an ocean.
It’s devastating, and as a cancer patient I have to wonder - is there a cure that was bypassed.
@@kimfletcher584 'time to clean up the swamp' and then added to it.
Aaww c'maawn guys, the dirt poor humanitarian and philantropist guys are asking for ONLY 700 bucks a box for the wonder pills... Who else would have done such a good hearted next-to-free welfare act to humanity but pharma ?
It's easy to see how someone becomes a domestic terrorist...
Now we know why Merck was opposed Ivermectin.
I googled it and it's true, what are they doing?
@@timothyhubert2305 Molnupiravir is Ivermectin with an NSAID mixed in and then split into a 5-day regimen.
A money grab.
Nothing more.
@@wayneparke554 where is there evidence of this? Genuinely curious.
now? knew 18 months ago. your late
@@wayneparke554 No it isn't.
It's funny how something that will make big pharma loads of cash is better than something (ivermectin) that won't make them loads of cash. These past 2 years have made me very wary of trusting any health professionals.
Yes
It's funny how Merck makes both ivermectin and the new drug, let's see a list of ingredients and patents on both lol I'm just wondering if they changed it just enough to get a new patent 700$ for 5 days vs like under 5$ a pill for ivermectin
I agree. From now on, I'm going to avoid doctors as much as I can and hope that my life will end in a sudden manner so I don't ever have to deal with what seems like a bunch of corrupt people.
If you think an animal dewormer is your answer to anything. I'm worried about YOU!
@@TheJimprez ivermectin is a antiviral and antiparasitic. A Dr won a nobel prize for inventing the drug you don't get that for inventing a animal dewormer
Branding opportunity gone missing. “I can’t believe it’s not Ivermectin” was a better name.
Ha ha ha!
😂
Brilliant!
🤣🤣
Or Ivermectavir (Needs the vir to indicate antiviral)
Funny that Merck could figure out that giving treatment early in the sickness is the most effective method, but our medical establishment can’t seem to figure that out. They send them away with a “Come back if your symptoms get severe”.
I am a doctor and was listening to a talk on Remdisvir from an academic lab with no financial ties on the topic. He discussed how the issue with a lot of the immediate treatments (viral phase) require a doctor to administer and a pill treatment is desperately needed that can be prescribed immediately.
MSD is not a medical establishment. There is also a Move-In trial which tested the drug on hospitalised patients where the drug was not as good.
@@rc8929 Ivermectin ?
Don't Merck also make ivermectin?
@@MM-ig3qy Ssshhhh! They don't want you to know that! Don't tell!
Interesting that Merck, the owner of the Ivermectin patent before expiration, who denounced it's use and safety as a COVID anti-viral, now has a billions backed, patented, COVID anti-viral pill. The Meta-Analysis of Ivermectin reviewed here a few months ago showed "probably reduces deaths %62 and transmission by %86".
What is also very suspect is coming up with such an effective antiviral so fast when it seemed virtually impossible to do so prior to C19
The marketing strategy is way too transparent for big pharma to survive. everyone is catching on. it's just too obvious, especially if you read the patents and patent history of pharma trying to get patents on manmade caronaviruses, it's in the literature if you care to read it.
I don't suppose you noticed that the largest study in that meta-analysis had to be withdrawn due to evidence of fraud.
Who told you that was the largest study ?Yes , MSM and you quote it without checking. That was the fourth largest study and excluding that the overall efficacy by meta analysis is 62% ( meaning saving 2 out of 3 ) and early treatment efficacy is 86%.
@@misstangentina8552 indeed!
Ivermerctin finally! About time they got a patented over priced version of a generic drug. It's not safe unless it's patented folks!
So its like ivermectin but less effective and no safety history, but very expensive.... sounds like it will get approved instantly!
On the plus side, you get to take 8 pills each day, a whopping 800 mg, so for your money that's a good deal. I mean a good meal.
The real doc would have a number starting +44
Merck, of course, is chasing money.
@@theconstitutionalist6305 I don't understand these statements. What does any company chase? Isn't that the point of a company? It's not like companies chasing money is in any way unusual or surprising.
Racist!!!!
During this comedic tragedy more brains got washed than hands.
@Will R Thomson Not many brains left to wash.
Very true
Be open minded, but not so open minded that your brains fall out.
Groucho Marx. Not his best quote but the message is there.
I appreciate the humour.
The government policy is now printed on every shampoo bottle as an easy reference.
Half the efficacy and 70 times the cost of ivermectin...unbelievably evil.
Has the world always been this corrupt? I guess I’ve just been blind. If this study is all they need to approve this then I will never ever listen to a public health official again.
Yes it has been !!!
Uttar prudesh did great with “that which can’t be named”
I wouldn't trust the numbers coming out of Uttar Pradesh. The chief minister yogi adityanath is corrupt.
@@ramindersingh1360 The numbers for the whole of India are pretty telling, not just one part of it. So much so that the (Indian) Chief Scientist to the WHO is in deep legal water with the Indian Bar association having lodged papers over her role in the misinformation campaign.
Someone help me here I'm looking for the numbers from India and Its hard to find. The only thing I get to see is BBC reports showing cremations going on.
Did the use the PCR test to determine cases in Uttar prudesh ?
The home medical kit included like 8 other elements, so how has it been confirmed that ivm was the key thing that did the job? What about the restrictions, curfew, twice daily check ins for confirmed cases isolating at home, citizen compliance with the rules...????? Soooooooo many confounding factors, but suuuuuuure, it was ivm. lol
This answers the question as to why so many including governments and Merck have discredited ivermectin.
Too many smal, low quality trials, too many trials withdrawn. Too many meta analyses which contained these withdrawn (Egypt and Argentina) studies.
@@SAFETYfull Meta analysis is not based on those studies but rather based on empirical data collected in the real world.
@@SAFETYfull like India right
Makes sense now. They had this money maker up their sleeves. How disgusting what's happening in this world these days.
@@buntafujiwara3586 stick to what you do best and make tofu, leave the science to the corporations
"We've always dreamed of an antiviral". That's exactly what Ivermectin is. That's why the US has criticized Ivermectin, because the drug companies wanted to profit.
You nailed it!!
Ivermectin is an antiparasitic that has shown some antiviral action IN VITRO. But at levels that would be toxic IN VIVO.
What works in agar culture doesn't always work the same way in a living organism.
@@keysrat46 Coffin nails?
@@TheBarkinFrog Ivermectin stops viral replication, which snuffs the virus completely out if taken as first symptom arise. In a study with 3500 medical student, it was also proven as a prophylactic, when the students on placebo were 53% positive for the virus but the ones with IVM were virus free.
Right? Why hasn't the FDA approved several attempts of tried and true vaccines that were both mRNA and DNA viruses, but somehow those didn't pass the FDA approval for decades? Then comes the Covid-19 vaccine. In 12 months, the miracle vaccine "Pfizer" is created and passed. The FDA also approves GMO'S and cigarettes. But for years, marijuana was evil and bad for your health. Even growing your own plant. 👎👎👎👎👎👎
As an unjabbed person I've been adhering to strict PPE while waiting for more therapeutics. Kind of figures that a pharmaceutical company would come out with their version of ivermectin, at 700 times the cost.
If your Vitamin D status is fine and you take vitamin C with zinc - you have no fear from covid. Stop hiding like a coward and get out there - protest for your freedom back.
@@LondonSteveLee I respect this serious virus, and I am not impositioned by protecting my lungs from it from wearing an n95 mask, nor do I feel like it's "taking my freedoms". If anything it's the virus that can take my freedoms away. But thanks for the pep talk since you think you know what I think and feel. You come across as a complete d:k.
@@tuffstuff2U How are you protecting yourself by inhaling all the toxins your body is trying to excrete from your lungs? How is an untrained person slapping a dirty abused petri dish over their airways good for them? And how is it there can be a "serious" virus and yet the overall death stats for 2020 (UK peak pandemic) is only the 59th most deadly year since 1946? You've been had - now go back behind the sofa if that's where you want to be. Leave retaining your freedom to real men. "Tuff"? hahaha!
@@LondonSteveLee I use a new n95 everyday when I go to work, just like they do in hospitals. I guess doctors and nurses are fools too? Again great pep talk - you're an amazing speaker, so full of wisdom and deep thought intelligence. I can see how you influence so many to do what you tell them to do ///.
Bye-bye now 👋🙄
@@tuffstuff2U A new one everyday? Gee - just like surgeon! Not.
If only there were a cheaper, readily available drug which produced similar or better outcomes and had been demonstrated as being safe for decades. Sigh.
Ivermectin?
But US officials have already told us that there is no such thing and that we should be very careful. It in fact, it would be very dangerous for us to take anything not approved by the US government officials... 🥴 ... #AnonAplusOfficial
😉 Yes, if only...
You're all ridiculous
So how is Merck’s fancy new high priced antiviral chemically related to their out of patent much less expensive antiviral with much better success rate (85%) of keeping pts out of hospital?
In the mean time Delhi, India has dropped to 97% covid free by giving covid kits with the very safe, I-mek tin in every kit. The kits cost nearly nothing compared to a new, rushed pill.
Exactly
Merck is manufacturing all the new drug in India. Do I smell corruption and fall from grace of invermectin in India?
Indian data is about as true as Chinese data
@@sundariann9161 Indian data is more trustworthy than U.S. data. It's been corrupt since March 2020 when "probable deaths" counted as COVID deaths and the CARES Act gave financial incentives for COVID cases to hospitals.
@@sundariann9161 It does not take an epidemiologists to understand 4 things….
1-what India is giving millions of citizens
2-the case numbers
3-the death numbers
And 4- If #2 and #3 were out of control, the mainstream media would be in it like flies on 💩! That’s a fact for you….. because a different treatment than Fauxchi and the NIH protocols aren’t working, the media and Biden administration just gaslight another topic for distraction
Be honest Dr. John, is this just Ivermectin in a new dress? Afterall, it was Merck that brought Ivermectin to market many years ago.
Be honest?? He is not a medical doctor!!!!
I'd like to see the how much the chemical structure resembles Ivermectin.
Look on wonkypedia, different structure. But if you also look at the entry for Ivermectin, you'll see that this new one seems to be effective against a couple of viral diseases in common with ivermectin. Its also worth noting that they've been working on this new product since 2014, so its hardly been developed with covid in mind, but just happens to maybe work with it, just as Ivermectin maybe works with it.
A lot of these preparations turn out to have alternate uses, Thalidomide for example, excellent for Leprosy and oral cancers, not so good during pregnancy.
They want us to pay them as they ... well, they want us gone
I won't trust big pharm any more
It doesn't at all. It's an RNA analog, nothing to do with ivermectin
@@Fanakapan222 oh and you believe them when they say that we've been working on it since 2014?
Top secret information. 🤐
Why are heroin dealers punished and pharmaceutical companies aren't?
Set and setting.
Heroin dealers don't make campaign contributions.
In today’s world that question makes a whole lot of sense! Truth can be a funny thing..
In a way big pharm are like heroin dealers, I mean some of those opioids the dish out are just as additive.
@@peacepuffz big pharma created heroin. In fact bayer pharmaceuticals own the patin and created the name haroin. It was used as a cough syrup for kids back in the 1800’s
"it would be unethical to carry on giving a placebo"
Interesting, cut the studies short, just like they did with IVM, except those were criticized for being "incomplete".
Does this make anyone else sick to their stomach?
To bad Ivermectin isn’t that effective in that phase of disease 🦠
exactly! IVM is off patent, no money for big pharma, no approval for dying patients. IVM has decades proven safety profile, this has what, maybe 2 minute safety profile? Heinous, I pray they ROT in hell!
And too bad that there is evidence of systematic data fraud in the initial "poster child" study supposedly proving the effectiveness of IVM.
It does make me sick especially the $700.00 price tag for a course of treatment! Merck would never lie about another off patent highly effective drug now would they??? Not much they wouldn't!
I agree 💯. And, yes. It IS absolutely sickening.
Should have been a huge international role out with the old ivermectin a year ago!!!!!
How many lives would have been saved?
Yes. This would have been low cost, also. Natural immunity with herd immunity achieved would have likely ended an epidemic early. Think of the suffering, deaths, and massive economic cost that was achieved through corruption and the push for totalitarian control. The mainstream media and politicians (notice the governors and mayors) pushed fear mongering for control and cash. Hospitals and big pharma received bonus cash.
@@theconstitutionalist6305 And now thousands are loosing their jobs and we had a cure all along.
@@Robert-lw2tt So true! This was governments out of control. Reduce government in size and power. The people who suffered belonged to all parties, races, nationalities, etc. Begin with the principle of a small government For the People, the wisdom of the Constitution.
Check the bank accounts of ALL politicians worldwide, then you will see why it was banned in many countries, like Australia.
It's based on hydroxy!
I suspect they've rebranded/ tweaked a very cheap hydroxychloriquine or ivermectin, given it a fancy new name and hefty pricetag.
Great if it works but this is about money!!!! Remember what Merck said about ivermectin. Don't be fooled
Glad I’ve had my effective and 40 years proven safe IVM for 18 months. It saved 4 family members and 2 friends who got COVID. Fast complete recoveries for 3 of them who had very serious symptoms.
Yes I've taken the apple flavored anti-covid drug - only side effect was a shiny mane. No need to wait for any more experimental jabs or expenses. I'm set.
@@jandeligans2834 we took the human version … plus 3 doses of Pfizer. Try that instead. The horse paste is perfectly safe and effective for humans but tastes bad. And get a life, bumpkin.
You all got done for. I just ate my body weight of vitamin C in a single day, problem solved for 10 years straight. Would rate the flavour 9/10, although more like 4/10 by the final few kg's
@@binkaboi5865 so funny 😃😂
I'm with you. I have a two year supply of Ivermectin, which I procured from a pharmacy in India...all for a whopping $75. And yes, it's the real thing.
But they wouldn't run Ivermectin thru the same study. Could have been completed already. Oh, that's right, there isn't enough income potential to for a trial and a EUA for Ivermectin. The needs of the corporation outweigh the needs of the many.
More studies will be done on the “non money making” treatments just as soon as we are past this initial phase. Once it’s no longer a concern and most profits have already been made the smaller studies will start coming out. Ones that hopefully include some herbs.
The Ivermectin study would be much faster because the safety is already proven. I could prove it works in less than a week. Most people are cured in several days if taken early. It is criminal this test has not been done and the FDA claims they do not have enough data. Trivially fast and cheap to prove.
$700 for 10 tablets folks. Gets your wallets out 😆
@@politics4816 The tests are being done and they take months. Ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings. The study started in June this year.
I think the only reason Ivermectin was not studied was because Trump mentioned it. It is a very useful drug.
It is not going to be a "game-changer" if most people can't afford to get it!!!
You don't need to get people to buy it. That's why you sell to governments and people would pay the cost through taxes. Sad, but seemingly so. The people should have a say on a purchase like that.
Subsidy? Most medications you buy daily is not affordable without subsidy. If it is essential, it will be subsidised.
The only way they can make ivermectin pay it's way is to rework ivermectin into another shape with a massive price.. New expensive ivermectin
It' works by the same interference principle as ivermectin does but at a thousand times the price tag
Did you not catch the part about the pricing being tiered based on how poor or wealthy a country was? And voluntary licensing for third party generic producers?
I agree it's a rip off at $700, but let's face it, in the western world, that's the price of a cheap TV, to potentially save your life.
Game changer? Recently you did a vid on the fantastic results achieved in parts of India using IVM. That's the game changer, but there is no money any more in that perfectly safe Merck invention. So let's go for the $700 per course new Merck new wonder drug. Governments should be funding research into IVM rather than spending billions on this new " game changer "
I think he's allowing you to put two and two together here. If he mentions the "I" word, his video would likely get taken down.
If it quacks like a duck and it walks like a duck and it looks like a duck. Then there is a very good chance it is a $700 duck.
😆😆😆😆
🦆 $700 please
$700 for a 50% chance rather than just a couple of $ for a 90+% chance (as shown in the Indian states of Delhi and Uttar Pradesh).
I rather have the 'horse de-wormer', thank you.
Well didn’t Merck produce ivermectin sure they do repackage ivermectin and Collett something else so they can patent it and yada yada yada
@@bensengng as long as it stays on the market.
Ivermectin outperforms this new concoction at a fraction of the cost, and has an excellent safety record built up over decades.
Money talks - loudly.
if theres greed to vacuum up they're gonna suck that shit up like a golfball through a straw.
@Dr. John Campbell is this the real one
Finally someone stating that ivermectin outperforms molnupiravir. The only problem is that ivermectin outperformers molnupiravir at a different medical task. But that is to be expected since one is an antiparasitic and the other an antiviral, and are entirely different chemically. .
Ivermectin has insufficient evidence.
@@braintree7502 The posts here are from a scammer, not the real Dr John Campbell.
Would love to see a trial study of Merck's original Ivermectin vs their new Ivermectin and see if the difference between the two is zero significance.
The only thing positive about Ivermectin is You grow a horse tail 🐴 to swat away the flies on your ass. 🤣🤣🤣🤣😭😭 Ivermectin, It’s only pushed in Third World countries go figure.
@@FDT000 You guys just don't know when to give up do you?
@@Scepticalasfuk yeah, we should just shut tf up & let nature take it's course.
No money to be made so no one will fund an Iver study.
Thank you for going over this new study for us. Here in Australia we have just been told of this tablet to come, however it is still yet to be approved here. This sounds fantastic.
Interesting how 'other' less expensive protocols have an even better result in lowering hospitalisation and death..
Oh, really? Name one. Give us a link to a peer reviewed article that proves its better results.
Dr. Shankara Chetty of South Africa has huge experience with ivermectin....great results.
@@SpectatorAlius I get where you are coming from, but answer me this: does peer review actually MAKE said a outcome, or just confirm it? Confirm, obviously, yes?
So you agree that something could be true and not been peer reviewed? Quite true. So ignore signals and don’t investigate?
You are truly a fool if you shrug your shoulders at the obvious coordinated attacks on ivermectin and the Blatant disregard for dozens of countries ( and their health bodies) saying it works.
The fact the MSM went after this amazingly safe, Nobel prize winning drug used millions of times by humans.. calling it horse dewormer. Says it all. It was never given a chance, only citing lack of proper studies.
Run a study on it then.. come on.
Oh no$$$ in it… follow the $$
But where is profit in that cheap medications? You lost the point of american medical system.
@@jeffm5271 Great. Only I know of a woman, who was taking a lot of these things and still got it so bad to die from (not with) Covid-19.
It will work for most, but there are no guaranties.
Molnupiravir $700 US? for the course... vs $2.75 Ivermectin kit in Uttar Prudesh! Go figure.
Have you been to Uttar Pradesh?
Well said brother. India is where my Ivermectin came from. 200 12 mg tablets for a whopping $60 plus shipping. The greed of these pharmaceutical companies makes me sick.
@@dummgelauft can't even go if I wanted to.
@@paulkelly412 you are missing nothing. It'd pure, unadulterated shithole, ruled over by a fascist Hindu terrorist organisation called RSS
" I can't believe it's not Ivermectin " $ 700.00 vs. Horse dewormer ( Ivermectin ) $ 7.00 . Hope an independent double blind clinical study for comparison happens.
Dr Campbell's assumption about Merck, that they will have done all to assure a strong and valid test, seems naïve given all we know about how drug companies design their tests for success and the number of drugs that have subsequently had to be recalled for ill effects.
Reduced risk by 50%. Didn't that meta study show Ivermectin reduced risk by around 60%? So now we see why Merck advised WHO and Governments not to use Ivermectin, they had something else brewing.
Deaths went from 8 in the placebo group to 0.
The problem is that the "studies" in that meta study were extremely poorly designed and controlled. It could all just be publication bias and confounding issues. There are better, larger studies under way that will show the effect of Ivermectin either way, but it doesn't look good so far.
No, the reduced risk was much higher for ivermectin. like reduced risks of 74% in one trial and 85% in another trial.
It’s like a gut punch from Merck.
Follow the money. I’m worried about humanity. 😢
Who do you think is putting out ivermectin and telling u it works... Merck.. you conspiracy theorists are just part of mercks counter narrative to sell you something else. 🤣
You guys see all the angles right? How do you not see that obvious angle.
No offense but with a few changes here and there (change to nucleoside ring to a purine and hydrolyze the amine side ring) molnupiravir is very similar to quinine and shares a common precursor hydroxycytidine. Problem: the changes in Merck-quine though will make it less effective than the original quinine. It will be interesting to see the dosing regimen for this "game changer".
@@jeffsteyn7174 Well ... I'm not sure if I've fully grasped what you mean, but the thing is Ivermectin no longer belongs to Merck and it isn't making them any money. The patent expired in 1996 and that's why it's cheap, dirt cheap.
That's why Merck put out a statement encouraging NOT to take it.
@@michaelpimentel3002 40 pills. 8 pills a day for 5 days. Eeeek
@@bigcat2520 Vs it's parent compound which is 1 pill a day for 7 days.
Can you please have a debate with Tess Lawry from BIRD group on a MERCK vs Ivermectin review? So why give EUA for this when Ivermectin has a longer safety record?
Hey John, this seems to work as a protease inhibitor. Ivermectin has a pretty high Moldock score, any reason that this would be more effective than Ivermectin? Or at least close?
I wonder if the world leaders that are ignoring Ivermectin sleep well at night? I hope they have nightmares forever of all the people they could have saved.
They don't really care about anyone but themselves
Could have saved? They down right MURDERED them for the ALMIGHTY $$.
Amen!
Even the makers say IT DOSENT WORK
You can bet even Lord Fauci hits the horse paste.
John speaking about the study: "And it was carried out basically all over the place...." Lots of countries listed, but thats strange, India not involved. Hmm, oh I remember, they were already far ahead of the game using some fifty cent drug called Ivermectin. Come now John, that's what I call a remarkable and real "...game changer"
Also only one african country and black people are being severely affected by covid and being pressured to take the vaccine and we will not be bullied. Provide the evidence its safe and effective for us and our obesity and hypertension or it's a No
@@chelseagalloway6913 Lose weight. Vaccine or drug won't save you from diabetes or heart problems brought on by obesity.
@@peterc.1419 I've known several obese patients,and after taking Ivermectin..they were fine. STOP shaming people
@@debicaron6046 nobody said that ivermectin causes more side effects in fat people than in not fat ones. I suppose fatness may even protect one from mucosal lining irritation and pooping your guts out
Ivermection gross price is globally 3.95$ per tablet. So if you get it for 50 cent, you have government founds involved. Ivermectin is hardly a cheap pill compared to 2 doses of vaccine.
Excellent examination of the trials. I was reading them while you were speaking and was going to comment on the abstinence requirements right before you went over it.
Dr. Campbell, I appreciate very much your daily talks. Helps keep some sanity into what seems to have become an insane society. This whole thing shows that there is a power in this world fueled by greed. But in the end, your excellent counsel based on the data and facts will keep us on the straight...and give us faith!
Just imagine if there were such a generic antiviral...
Might have saved millions of lives. Shame really, if corrupt financial interests were able to cover up the existence of such a life changing miracle.
I noticed you posted as link somewhere. Unfortunately links get removed. You have to break it up into parts. Even pub med can't be one word.
Too early to tell how effective this one will be. Don't get too excited.
There is also risk of viral resistance. Vaccines are still better. As you know HIV treated with single drug gets resistant fast. It was sad to see people die on AZT monotherapy in the late 90s. But that's all we had. Prof Francois Balloux tweeted about this the other day on Twitter. It's not a panacea. Vaccination is the best deal.
It's such a shame that the Indian medical bar is suing the WHO over it.
@@kyron42 That's maddening. Why on earth would they block links to NIH studies and PUBMED on a podcast about medicine during a pandemic?
The studies I linked to were responses to Blaine's assertion that Ivermectin is an Anti-Helminthic. They were studies of its effective use in also acting to block binding as a protease inhibitor.
Sounds like Merck is reinventing the wheel and at a very high cost to boot.
And the wheel they just created here is very inferior to the OTC drug given to humans for 45 years around the world with a shocking safety profile despite 3.4 Billion doses given.
@@chuckbecker8735: The existing drug is very good if you've got _intestinal parasites._ COVID is a viral infection, not a parasitic infection.
@@resourcedragon Water is a fire retardant. Why would you drink a fire retardant?
@@peetiegonzalez1845 You're all stupid. Ivermectin has been shown to be effective in a bunch of trials, so yes, it is questionable that they haven't given it emergency approval, but molnupiravir is even more effective according to the trial, so it also makes sense to roll it out first.
And not nearly as effective as the 'other' wheel they invented 4 decades ago.
Seems like Merck have just invented a very expensive Ivermectine 700 dollars for a 5 day course as opposed to around 2 dollars for the original.
They should take away their Nobel prize
I stumbled across one of your video's several weeks ago and have since subscribed. I am keeping current with your video's and going back and watching ones from past I have not seen yet. Thank you for the no nonsense way of providing info to us. Can you consider doing a video on "antibody testing"? Thank you.
They knock Ivermectin treatment information because docs don’t want to have the placebo group suffer, but it’s OK when it would hold up profits to conclude the study.
That's not why they stopped it. It was stopped by an independent watch group because when something works this well, it's unethical to give continue giving the control group a placebo. Ivermectin has never demonstrated data this good in a multicentered RCT with a placebo control. All the Ivermectin studies are low quality highly biased CRAP
@@oldmedstudent1750 Merck even stated that any science made below the Equator means nothing.
Ivermectin blocks an Ion channel, it is essentially a nerve poison/gas against parasites. Molnupiravir is a decoy Nucleotide that sabotages RNA Virus replication. I leave you to figure out which one has a better chance of working against an RNA virus...
@@oldmedstudent1750 How much is Merck paying you for these posts?
@@williamolenchenko5772 as usual, the Ivermectin shills accuse everyone who opposes Ivermectin as working for "Big Pharma".
Funny how Merck happened to come up with an all new (expensive) anti-viral after hiding their own cheap Ivermectin in the cupboard.
That will be a big winner third world countries where have no money .
There are many effective anti-virals. But they are not patentable and don’t stand to make one company tons of money, in fact, many simply grow out of the ground. And for some reason, no-one has the interest (money) to conduct “impeccable”, large, global studies on their efficacy. I wonder why?
They didn't. It was invented by Emory University in a not for profit company. They licenced it to Ridgeback who later linked to Merk as the manufacturer. It was originally published in Oct 2019 before anyone knew about covid or anyone had thought of using ivermectin.
@@beachdancer So why is it so expensive .
There putting the brand new labels on the pills as we speak.
Great news Dr John - let the scientific community keep researching - what ever the initial cost, the reflection, if it is proved that it helps to prevent deaths, the reflection in history will confirm that lessons are being learned and the more companies invest in this type of research all the better. A good positive step forward. Thank You for you continued informed presentations - they are excellent
Dr. Campbell, you are one of the few that are unbiased actually looking out for the public!
This study is smaller than the Ivermectin studies which they told us was insuficient.
That is not true and it's also not just about size but about the quality of studies and the drug in question. There were multiple unsuccessful studies with Ivermectin as well as some "successful" ones, but all were poorly designed and controlled. Plus, there is no explanation why Ivermectin should be able to stop a virus at all.
Yes, pretty big sample size in India eg uttar pradesh 240m pop now covid free for example. Gotta love real world cf blah
@Hooch Smeeth do you have any reference linking this method of action to Ivermectin and Sars-Cov-2? Any experimental data? At best this is deeply buried and indirectly linked. It is a fact that there is no significant evidence of Ivermectin being effective against Covid-19 at all. Several studies are under way trying to finally prove this one way or another.
I would donate to a head to head clinical trial of Ivermectin vs molnupiravir.
lookup BIRD - u can support IVM there.
I would join ;)
I suspect that a comparative study between IVM and MOL would be counter to Merk interests, but I also suspect that it will be done in India or some other place, eventually.
So u want the old stock vs the new relabeled stock what
For those of you who are unjabbed, do not take Merck either. Whatever they release for your “benefit,” is almost certainly for your destruction.,
You really are a happy person.
Who else here remembers Roche and the Tamiflu fiasco? These pharmaceutical companies are often dishonest with regards to their clinical trials, as shown by the Cochrane Collaboration.
Dr Pierre Kory tweeted this a few days ago:
#pharmageddon on IVM occurred to protect profits. Merck's news is great since patients will have early Rx but also sad given the high cost and lives lost compared to IVM. Molnupiravir=47% reduction in hospitalization/death while IVM=88% reduction.
d3=78%
@@esecallum which will be the right level of d3?
i read that this will cost $700 per patient
@@luzysombra5291 have you still not seen THAT graph?
Vitamin D versus Covid Death Rate Graph
on whytube
Yeah and that Merck stands to make $7 billion plus. Making Molnupiravir potentially one of the top 10 most profitable drugs ever. Hey... we can say Molnupiravir without being censored woo! PS Have a look at Merck's stock price chart.
$700 to put little "molnupiravir" stickers over "ivermectin" on the boxes? Cha-ching!
maybe because HDQ, zinc and z pack is only $20.
Sadly true, I'm trying to compare the chemical formula
$700 for 10 tablets folks. Gets your wallets out 😆
@@airvicemarshalsirgeorgemas2083 > I'm trying to compare the chemical formula
We are told that molnupiravir is a ribonucleoside. Ivermectin is not, it is a larger, far more complex molecule, from what I can see. Very different. It's really daft to speculate (based on nothing) that it is the same thing - it just ain't.
@@airvicemarshalsirgeorgemas2083 give me the source for the chemical formula.
I can't believe you still have not realised what is going on doc. Come on we need you!
Great to hear, thanks. I wish you could boot your volume. Can barely hear you with my volume up full.
Has there been the same type of study on Ivermectin? I’d like to see a comparative study.
Not yet. Result are (hopefully) imminent however.
There are many peer-reviewed studies on ivermectin. UA-cam will insta-delete comments that try to link them. [Eye-vee-em meta (all one word) dot you-know] if you want to read up.
No money in it.
New episode!
Project Veritas. Pfizer scientists exposed part 4: ua-cam.com/video/On5RYFbcxWY/v-deo.html
@@chaosinfusion8127 I've had UA-cam insta-delete comments with links even to official pro-vax gov domains. I don't think it's censorship, I think they're just a little spooked by links outside of UA-cam in general
For everyone that asked why Merck would shoot down their own medicine (i.e. Ivermectin), you now have your answer.
ATTN DR. CAMPBELL; Need to do a special on body produced enzymes and how both starting and long covid affect the production of body produced enzymes. I got covid 19 early on, a form of it and have suffered from the after-effects of this virus. I'm noticing now that it seems the full functioning of some enzymes have been slightly off. This might diminish with daily body renewal metabolic or other functioning cycles? Would like to see a special vid on this. Thanks, Dan
This is a major breakthrough! This is data demonstrates that Merck had a solid protocol. Keeping it out of the reproductive cycle is an excellent demonstration of prudent caution. As for the cost, 13 years ago Vioxx, an oral medication used to treat MRSA cost was $100.00 per capsule. An initial 14 day treatment cost $14,000. Thank You Dr. Campbell for educating and keeping us up to date.
I wouldn't trust Merck due to their past and present contracdictory attitude towards Ivermectin. It's understandable that their current stance would be to not support IVM!
But then people like you don't trust "Big Pharma"
Next time you need surgery or dental work, be sure to reject medication. Same with headaches---tough it out. No help from nasty big pharma.
@@alan4sure We ALL have the right to choose for ourselves and our families the degree of drugs and "big pharma" we consume. I highly doubt that @raidermanuk came here to solicit medical advice from YT armchair experts.
I have a feeling they didn't want to use Ivermectin because of the stigma as it being developed originally as a horse dewormer. I truly believe this new anti-viral drug is the same thing as ivermectin without a doubt.
This is CLEAR proof they don't want you taking anything that isn't putting money in their pocket.
straight up GREED so strong the devil smiles.
@@alan4sure oh whenever there is money involved people should be hesitant. And there is much reason to be. Your Condescending remark is childish and unnecessary. Grow up.
Hi John,
Thanks for the analysis of the Merck press release. A transcription inhibitor that kills ribosomes? ! Sorry, I feel Ivermectin is a far safer early intervention : don’t you?
Kind regards,
Dr. Beth Dyer
Any long term animal studies?
One small study and it is half as effective as ivermectin meanwhile at a hundred times the cost… and no long term safety data.
I believe the ivermectin evidence is clear now. Nurse with my own stethoscope here. 😆 check out the latest DOD report on the pentagon page. Clear problem we have w the vaxxed getting sick.
@@sachabarlow9483
THIS is based on A PRESS RELEASE. That is ADVERTISING not SCIENCE. Shame on John for this erosion of the scientific method of discussing the SCIENCE not the manufacturer's MARKETING.
Of course.. But its past its money making curve... Sadly! Will be blocked by our new world leaders... Big Pharma!
John, I'm astonished at your confidence in Merck.
John, what are your thoughts on the sample size for the study? I almost expected thousands of participants with your introduction of the study but was surpised it was less than 1000. Just wondered what your opinion is on this matter ( I realized you said they stopped recruiting because the results were promising but with the all the differing opinions regarding Covid and it's prevention/treatment, I would have expected a larger number).
This drug is bloody expensive. I'd only use it on race winning horses tbh.
Just like Ivermectin? Can't be dangerous if they give it to million dollar racehorses.
Ok, now that was funny🤣🤣🤣
What if it wasn't a racehorse, but you?
Need to ask Mike Pellegrino....he has plenty of horses, and uses Ivermectin very much...but refuses to take it himself. I'm sure Mike will like this new expensive stuff.Oh, Mike...wherefore art thou, Mike?
It would probably be effective if used off-label to combat river blindness and scabies.
It also shows promise as an equine anti-parasitic.
Lol.
In studies, molnupiravir has demonstrated broad-spectrum activity against other viruses such as influenza, Ebola, and Venezuelan Equine Encephalitis virus, although molnupiravir has not been approved by the FDA for treatment of these diseases.
😂😂🤣
Post a link the minute you read about someone giving it to a multi million dollar race horse. We ll wait.
@@andieb8230
You can't post links on Screwyoutube anymore unless it's a link to another Screwyoutube link
Surely Ivermectin works just as well as an antiviral and is much cheaper? Why would they stop the study early if to continue would save lives of half of the participants? I assume they didn’t give the antiviral to all of the remaining participants; but that would be the only justification to end the study?! They could still give an interim analysis and report.
I'd like to commend you Dr. John Campbell for your distribution on studies and facts, most Doctors on YT just follow the established narrative, as do you to the letter, but with out omission of any fact or study. Respect.
This is not FDA PRESS RELEASE. This is "marketing" before the facts presented."
Medicine show. 🤐
Been taking Ivermectin front line worker never felt better all my colleagues are going off sick, I haven't had one sick day, during this whole time.
Has a long half life so don't take the full dose everyday generally the first dose is 12 mg and then after that it's 3 mg or less. People that accidentally take 12 mg every day get quite a build up and by the time 5 days comes around they are overdosed!
@@tetech2 thanks yes I'm only taking a small dose and forget at times.
Hi! Can you please comment on the MSD MPP document on Mulnopiravir? Thank you
I like that they had to have a Co-morbidity factor added for subjects, cause they knew that if it was random then too many people would recover with no significate difference between test and placebo group.
My guess is that this being in the pipeline is the MAIN reason why there has been so much effort to discredit Ivermectin and the people proposing it. If people use this new treatment, Merck makes tonnes of money while if people use Ivermectin Merck loses out.
ivermectin doesn't work, and that is that
@@franciscomap75 I bow to your medical knowledge, experience and ability to read what you see online
@@franciscomap75 you base that statement on what, you pharma shill?
@@franciscomap75 - Tell that to India and Japan, both of whom are using it to great positive effect.
Merck has fought Ivermectin because is so cheap and they couldn’t make enough profit!
And they developed and slid it while on license. This is so transparent
I am already taking Ivermectin with Zinc I am ok and i have been with people who have had covid with no affect on me I am Immune thanks to Ivermectin,
Its not cheap and hard to get
You are a genius Paula, You figured it all out in about 5 seconds with no effort at all. Who needs to put in the work, when you can come up with your own half assed conclusion?
@@Freedomfred939
It's dirt cheap!!
A few dollars per tablet
It's hard to get because people are buying it on mass
In some countries they try and ban it
Guess they needed a way to charge more for a drug with the same efficacy as Ivermectin (which their patent has expired on)
Ivermectin is being prescribed in India and has been for months. Hydroxychlorequine has been stockpiled in the UK since April 2020. MSM/Govt remain silent.
Another “Ivermectin” with I’m sure a completely different price tag.
Yep, $700 for a course of 5 days, 8 times a day...
Big bucks springs to mind Cheryl good comment best from Glasgow scotland
Yep another ivermectin. Well...... Except for this few decades of safety record as opposed to stopping the study before safety is addressed in order to rush drug to market problem..... These are not the droids you're looking for. Nothing here to see. Move along. Move along.
This is only half as effective as Ivermectin and has side effects
@@DavidMiller-yc5ol I smell a rat David it's all to do with profit not people's health best wishes David from Glasgow scotland stay safe 👍
Isn't it amazing what can be studied when there's a dollar involved?
Ivermectin though? Not enough study been done to be confident it's safe/effective.
One big trial just finished from Canada , the Oxford trial on going , two big American trials ongoing. So ivermectin is indeed being studied.
3.7 billion doses and 16 deaths isn't to bad of a run.
I assume you're being sarcastic.😁
OR the studies didn’t show efficacy.
It's been studied before and seems to indicate some benefit while being very safe unlike remdesivir which was the opposite but somehow that one was approved for use. Welcome to the world of the upside down.
Thank you, Dr. Campbell.
Thank you Dr. Campbell. Your astonishing. Appreciate all your information and clarity so much.
I might just wait for independent review. Sounds more like a gamechanger for Merck profits. If only they'd acted that quickly with advising vitamin D.
And Ivermectin.
Say it loud
The key word here being "Independent". Right now I trust nobody but myself using a 25p daily dose of Quercetin, Magnesium, Zinc, C and D3
@@lagunafishing I have been using several prophylactics and haven’t even had a sniffle in 18 months. I’ve been around Coof positive people indoors and an elderly relative(regularly without masks, hand washing etc).
I’m definitely healthier now than before all this all started.
NAC and Echinacea are both effective and safe (probably why NAC was banned in the land of the free recently).
Ivermectin.
I remember a survey of doctors early in the pandemic where more doctors preferred to have antivirals over vaccines for covid...perhaps because vaccines were a long way off (or so they thought), but also because they knew this could be a long pandemic
I prefer and took the vaccine over antivirals. The doctors doing vaccine trials all vaccinated their families.
I also remember when they promised that vaccines were years away and that Trump was making things up. I also remember seeing interviews of doctors who thought people could get reinfected not even a month apart, when the good Doctor Campbell here explained the simple science of why PCR tests give false positives. Not all smart people are equally smart.
@@jeffweingrad4658 PCR tests don't always give false positives. Most of the tests are done correctly. Of the patient's I've tested I've seen percentages which were not high. My own PCRs also always came back negative. In my ICU we've had patients who had negative PCR tests but had COVID-19. They had 3 neg tests in a row, but the CT chest imaging and clinical picture was pure C19. I am sure Campbell would not diss other colleagues as he's an old guy and the Brits believe in collegiality among physicians, plus GMC would kick him out and it also would not be true what you said anyhow. YT videos are not a substitute for medical education.
@@peterc.1419 Yeah right.
@@peterc.1419 If you're going to make statements like that, you had better be prepared to provide proof because it would appear that more and more doctors are coming forward to say the current experimental vaccines are potentially more dangerous than the viruses and I can provide proof of that.
John great video. I was wondering if you might like to do a video on the N-Acetyl-Cysteine (NAC) supplement as a prophylaxis and as an antiviral for Covid 19 & in general.
$700USD is amazingly cheap compared to a single day in the ICU, probably comparable to a single day on O2 in the non-critical wards.
Oxygen consentrators are a cheap solution. No oxygen tanks needed:
In a study of astronomers working in Chile at 5050 m, oxygen concentrators increased the level of oxygen concentration by almost 30 percent (that is, from 21 percent to 27 percent). This resulted in increased worker productivity, less fatigue, and improved sleep.[38]
Merck was the patten holder of ivermectin but it’s off label so they can’t make much money
The Big med farm are only interested in helping you IF they can make money. And they're very good at it
It would be funny if the new pill is mostly lvermectin and a bit of a placebo in the form of an antiviral. No one could tell then which part is working.
You realise a patten is a clog?
Any price multiplied by millions is big money. I don't buy the conspiracy theory about big pharma withholding effective drugs because they're less profitable.
@@pensiveintrovert4318 It isn't. It's completely different and unlike IVM proven to be effective.
$70 dollars a pill, 2 pills a day = $140 a day and John says with a straight face it can act as a prophylactic. Yeah, right.
Zinc + ionophore = cheap antiviral
Ivermectin = cheap antiviral.
Ionophores- Quercetin and green tea extract.
I also take Lysine in addition to C, D, Zinc, Quercetin.
Gee, imagine how much damage could have been avoided if they had just identified a safe antiviral earlier in the pandemic. Oh Shucks I guess all those people had to die.
hi dr John campbell .. i have a concern .. about this new pill .. does it has enzyme reverse transcriptase in it ?
Antiviral must be given in first 5 days; UK IVM trial given upto 14 days after symptoms. US 14 days. Both given without zinc. Stop treatment at day 3. UK/US trials designed to fail/obscure effectiveness of IVM to protect profits.
"UK/US trials designed to fail/obscure effectiveness of IVM to protect profits."
But then they couldn't force the vac mandate....
Same as the WHO trial for HCQ which administered toxic doses without zinc (the whole point of HCQ was to open the cells to zinc) not only poisoning the patients already in late stage covid - but helping covid infect more cells!
$700 per course of molnupiravir vs. pennies for Ivermectin. Wonder how many health officials have a conflict of interest with respect to the anticipated cash cow of new anti-virals that are in development or already in clinical trials. Could this be why Merck refused to acknowledge the safety of Ivermectin for treatment of COVID-19 despite having donated millions of doses of Ivermectin to developing countries for treatment of endemic parasitic diseases?
Hydroxyzine and its otc active metabolite Cetirizine is under a dollar per treatment.
Yes
Come on people! Let's dip into our savings accounts! $70 dollars per tablet - 2 per day is only $140 dollars a day. In the UK thats only around £100 per day. Come on....it's not that much is it really?
there is no "conflict of interests", there is only interest in milking the people who they were supposed to serve. Dark immoral ages are upon us...
Do a double-blind worldwide study on the efficacy and risks of ivermectin, and then let's see what you end up charging for it to recoup your investment (provided it actually proves safe and effective).
HI Dr. Campbell
I noticed on the mayo clinic's website under long term covid effects, they list under brain
Brain. Even in young people, COVID-19 can cause strokes, seizures and Guillain-Barre syndrome - a condition that causes temporary paralysis. COVID-19 may also increase the risk of developing Parkinson's disease and Alzheimer's disease.
Would you happen to know where they get the data for Parkinsons and Alzheimers and where I could find it?
My friend developed guillain-barre following the AstraZeneca vaccine. That was 8 months ago still unable to work
“Catch it early” is the key
I'm not feeling it ....
It seems many others in the comments section are not feeling it either..
It should really be for non profit in this type of situation, big pharma makes plenty of $sss on other drugs..
It is very hard to trust these people ..
Yeah - seems perfect timing to come up with this just as almost everyone's already had the jab. Nothing was going to be allowed to get in the way of the vaccine programme.
All drugs are for profit. You think anti cancer drugs are free or anti-HIV drugs or what about high blood pressure drugs. Someone had to develop them and pay for them.
Lol anti-socialism and anti-communism until someone offers you a treatment for a disease then it should be free. :) These people I swear.
I don't trust them at all. They are pure evil.
@@peterc.1419 yes I understand they cost to produce, it just seems in this case it wouldn't hurt to do it for cost price, not for free or even reduced profit.
“We produce the “other” medicine but that’s patent free, so we needed time to come up with one we can patent. You know, for real money.”
$700 for 10 tablets folks. Gets your wallets out 😆
Saw this coming ages ago.
BINGO!
I get your point, but to be fair. They started creating this medicine back in 2014, wasn’t like it was just started last year.
@@RabJ208 #1 cut and paste troll.
Why do you never reply, publicly or individually? I'd love a chat with you. Your resilince to this raises suspicions.
Just when I thought I had reached the depths of my cynicism, this .... the comments below and their "thumbs up" tell quite a story 🤑