COVID-19 Pill | Molnupiravir: Efficacy and Safety Concerns
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- Опубліковано 21 тра 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Molnupiravir. This drug has been developed by Merck and is indicated for patients with mild to moderate COVID-19 to be taken orally. During this lecture we will be discussing the mechanism of action (MOA) and pharmacology for Molnupiravir, intended population, efficacy and safety concerns. We hope you enjoy this lecture and be sure to support us below!
COVID-19 Pill | Molnupiravir References:
docs.google.com/document/d/1x...
Table of Contents:
0:00 Lab
0:08 Molnupiravir Introduction
1:49 Mechanism of Action (MOA)
7:31 Molnupiravir Pharmacology
12:02 Population Targeted
13:48 Efficacy
17:45 Safety Concerns
32:40 Comment, Like, SUBSCRIBE!
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#ninjanerd #Molnupiravir #COVID19
I got COVID and took Molnupiravir. Thanks for clearing up my fears about the cancer risks of this pill.
They refused to prescribe you Paxlovid too, huh? 😕
I am honoured that had a chance to be up to date due to this video. Above all is your hard work. MILLION thank you!!!
New subscriber. Great presentation. I am taking my last dose of this medication tonight. I do think it has helped me a lot. My fever dropped and generally improving, still have some chest congestion. But I felt less “toxic”. I was in the target population. Aged 68, heart disease, overweight. This really helped me understand the mode of action.
Yassss! Thank you over an Infinite Number of times❣️❣️🙏🏽❣️So blessed with all the hard work and research you all have done on this channel to present this info to us in such a succinct and quickly digestible format. APPRECIATED!!!
Thank you for this clear, concise, right to the point video. You are amazing.
Can’t wait to hear all the details !
Wow this work of presentation is perfect I’ve never encountered before. Wanna know more about this. Thanks, doctor.
Thank you for delivering an outstanding presentation.
First video I ever watch. You are a phenomenal professor! Like I’m in shock how well spoken you are and how amazing your videos are. You are an incredible teacher! Thank you for sharing your knowledge with us. Your videos are wonderful!!
im leaving the comment on the day it is published. im a fan of ninja nerd.thanks for sharing
Excellent presentation
Looking forward to being enlightened on this
I've been waiting for you to review Molnupiravir, perfect explanation as expected! Thank you so much, love from Turkish physicians
Awesome stuff (as always)!!
what an outstanding video! amazing
Thank you sensei for pointing out on the last figure. It was an interesting point!
Awesome. Thank you
So waiting for this one
Thank you so much 🙏🏻🙏🏻
Thank you sir 😊
Great review 👍🏻
Thank you so much ❤❤🥰🥰🥰
Thanks Zack
Can't wait for your Omnicron video... :)
Wonderful
The living legend sir
Thanks bro for your effort in collecting those new data..
Awesome 😍
Wow!
Nice work!
Now we need a video about covid vaccine side-effects, with data analysis and updated info!
Thankd
I juste love your way to make it easy 😍😍😍😍❤❤ plz more video about **microbiology*
Nice a video on this novel antiviral drug for covid popped up!
very interested
How can this drug differ and don't harm the DNA dependent RNA polymerase replication?
Waiting⏳
I don't know what to say, just thank you for being this good
I like this video but I hope you will make a series of videos on pharmacokinetics
I can't wait to hear the comparison withIVM.
There is none.
IVM is protease inhibitor
molnupiravir mechanism of action is straight up targeting the nucleic acid of the viral replication process.
You can see clear as day which one is potentially more risky long term.
@@Misaka-gt5yj thank you. They quit talking about it all of a sudden.
I am taking it now!
How did it work for you
Zac, anyone, please how do you make good quality videos like these and still manage to reduce its size so efficiently?
I have tried using my phone to make videos but the size is usually too huge to share on UA-cam.
Help me with info please.
1st thank you for yet another great and informative video!
2nd; the first and biggest concern I got while watching this was; how big are the risks that we actually accidentally create a more potent form of the virus, while changing the RNA strands and creating mutations?
According to the Nov 30, 2021 FDA Antimicrobial Drugs Advisory Committee Meeting, it's a low risk but with the caveat of given how many people are going to take it, the risk will be significantly higher.
I’m in Australia and started treatment with this antiviral today.
How did it go? I just started this treatment as well.
starting on this today, I have many health issues regarding psoriatic Arthritis, diabetes, I also had covsars2 Antibodies, this looks like omicron I have, wife son both positive to yet no symptoms, on the 4th day I was struggling, felt ok after 4 capsules, hope this works,
Could you please do a video on the Johnson and Johnson and the Novavax vaccine please. Thank you.
Thanks. A good VDO and rare to here anyone talking about the African green monkey study. The only point which has been made in some earlier studies is that there is a ‘random’ effect too that isn’t captured in increasing the concentrations of NHC to a a level that clearly damages all or most host cells (one study suggested that only one does could be enough although it might be 1/1000). In conclusion, It is unknown what the actual level might be before there are random or odd mutations to our DNA although we known from the monkeys what the level is for mass cell mutations - however, agreed that the chance rises with higher doses.
I have long covid symptoms, and I am doing the dumm thing now, and read about antihistamines helping, so I started it, and it worked like magic. I would say avoid it because it can be dangerous for kidney and liver, but man I am on 90% instead of about 30-40%. Soar throat, dry cough, some muscle pain, brain fog, I felt like waves of heat and cold but never had fever, and all that is gone... mostly. I was never tested positive for covid, but there was a period of time when I felt like a very mild cold. I have 3 Pfizer shots, but I"ve read that long-covid can happen even with asymptomatic infection. So... could you elaborate on this in a video?
Hi sir!
can you please make a video about Hereditary Fructose Intolerance (HFI).
Remember 30kb is a really really long RNA and it might be questionable whether it could continue endemically.
Any chance for future updates on the drug? Would you get your blood checked every 6 months for concerns? I am a very healthy active older male. Three months later I feel weakness in my joints/knees/ribs. I regret taking it now.
How long does it take to start working
I just got covid this week. Tested positive yesterday, and started molnupiravir last night. I have asthma, so I qualified for the drug. I'm vaccinated and overall pretty healthy outside of having asthma, so I would have probably been fine without it, but my city had a plentiful stock so they gave me some anyways. I've had two doses already and so far no weird side effects.
It's a probable carcinogen that Drs tried to ban but Big Pharma pushed. Look it up; not here to scare you just provide you with information and urge you to do your own independent research. However, you also took the inoculation shots. You swallowed the propaganda but it's over. If I was you, I'd be watching my health very closely and doing a lot of bloodwork. If you want, I'll send you links. Godspeed
@@pragmaticparadox5981 Haha idk if I'd call it propaganda or inoculation, but I did stop taking the medicine at 2 or 3 doses because I was starting to feel better anyways and figured it wasn't very necessary at that point
Any side effects that you have noticed? I stopped taking the medication today at my third dose because of everything ive been reading on it.
@@jesusromo547 why did you stop taking it? We’re you feeling better after taking it the 3 days?
I started it today and researching it
@@mistismith4498 i did stop taking it because I was advised to do so by my primary care physician, hence I was prescribed the medicine by the ER. I only took three doses of it so 12 pills total. I feel completely fine! No side affects no nothing. STOP TAKING THIS MEDICINE IF YOU FEEL IT WONT BENEFIT YOU BUT FIRST SPEAK TO YOUR PRIMARY CARE!!!!! If your covid symptoms are too bad I wouldnt see why you need to take this nasty drug.
My physician said it is a horrible drug and advised me to stop which is why I stopped immediately.
Hello Ninja, thought I'd ask if you could do a video on ivermectin. As there is a lot of controversy regarding that particular agent. I read studies and anecdotes of people getting clinically better and not getting sick as a prophylaxis, and then I read that it is not a good agent at all. If you can look into the mechanism of action on how it operates that would be a awesome (although the youtube gods might try to take it down). Thanks!
I'm curious too since ivermectin is technically for helminths infections. How it can help with viral infections? Having the info without politics would be nice :)
If you do a search using the terms “mechanism of action” for a given medication, you can find articles about it. One of the proposed mechanisms is that it binds to some of the channels on the surface of a cell where proteins can enter; it makes the invader proteins less able to get inside the cells to replicate. This is why it is also proposed if it’s already replicated a bunch it may not be as effective. There are lots of molecular pathways in the body, and that can make it tricky to determine what is going on specifically.
Wait a sec... so it leads to a ton of lethal mutagenesis, and even if some of the mutations would be beneficial /rule of the big numbers/, the translation of those would also end up in lethal mutagenesis, right? But is that means that this drug has to be taken like antibiotics, so until the immunne system eradicates the virus?
we now kinda need another video about Pfizer's paxlovid combo with Ritonavir. it's proposed to be much better ...
Or you could take a drug that actually works. But hey take whatever you want. ps ….
NARRATIVE COLLAPSE: CDC admits there is no record of an unvaccinated person spreading COVID after recovering.
🎉
Would be interesting to see what the drug is actually made of, probably sea salt and magnesium
One BIG question not being ask is; how long does this wonder drug stay in your system?
Please make a video on Omicron variant
It is interesting that there is a line of inquiry into whether such a mutative drug has not had the effect, here in SA, during its trial study that ended up developing the highly mutated Omicron variant. It is a fascinating thought experiment that fiddling with the genetic code of anything can have the effect of killing the thing but also the effect of allowing mutation when the drug is given at various doses in its trial whereby facilitating supercharged mutation. Will be interesting to see the results of that study as it will be a huge warning to further drug developers to be very cautious in dealing with genetic code. Clearly there are other lines of inquiry. for example that Omicron was brewed up within a sadly very immuno-compromised patient or that it has been through a cycle of animal-human-animal-human transmission which has allowed such vast mutation. Both also equally viable options are this point, as far as I understand it.
Please give some information about omicrone varient 😀
Merck published that MOV doesn't reduce virus levels in the first 3 days. So patients will be shedding mutated virus for 3 days, which may or may not be immunoevasive (1:10k-1:100k chance according to FDA Antimicrobial Drugs Advisory Committee Meeting).
I got sars covid 2 whilst travelling in thailand 2 days ago thai docs gave me this told me to take 8 pill per day. 4 in the morning and 4 in the evening i took about 12 pills so far then I fully stopped although I was told by doc to take it for 6 days, have I caused damage by taking this drug? Is the mutagenisis reversibile?
The fox Merrick in the hen house says don’t worry I’m just sleeping in the hen house you can trust me 🤮
WHY is it so expensive though? Outrageous.
Patent protection, something Ivermectin doesn't have
Because they can. ¯\_(ツ)_/¯
@@Noodles.FreeUkraine And they're sure as hell taking advantage of that fact, aren't they...
I am currently taking it now and the us govt. Pays for it, there is no charge. It is however finding a pharmacy that has it, i finally found it in a walmart pharmacy.
Sir, if its so safe then how come it can cause bone and cartilage damaged within just 5 days? Also, pl suggest that if its taken for 2 days and patient has recovered from symptoms like fever, cough etc then will there be any harm if its discontinued after 2 days?
Yes same with me. Doc prescribed me though maybe it was not required as i have got vaccinated twice, no other health issues. And fever subsided just after 1 dose which probably was due to natural immune response. Now its 3 days and i want to discontinue it.. Can some1 advice asap.
there is possibility it will not kill the virus. i dont know, .. i finished whole dose of it, but then i started reading about it, now if i can go back i wouldnt have taken it,. i mean, it killed the virus, but i wont know if my body would have killed it anyway, without molnupiravir...as i said, its russian rullet, in terms of will it have some longterm sideeffect on me, i can only hope and pray it wont. btw, doctor gave it to me, because im not vaccinated. p.s. another thing about it i dont like, its because its made in England : D
Did u discontinue it?
@@Maria-qq4tv Yes, after 3.5 days.
@@sidjor9587 did your symptoms come back? Or you had fully recovered? I discontinued after a day and a half
Thank You for detailed explanation. I am looking forward to have another option besides vaccine to control and test that virus . Have healthy and good new year 🙏🏻🤗
Typo: to treat that virus 😀
Anyone eat that pills? My doctor give it for me but i scared to use it, i dont want to get any mutations or cancer. Please help me, it is really safe? i dont die?
Is it true that Molnupiravir is a re-named drug should not be taken by women thinking about childbirth or Pregnancy? as it may cause birth defects? Because of its mutagenicity have young ladies in mind just asking
Oh so that's why they stopped the study early, because it was working so good, not because a longer study may have shown genetic defects.
The GMO pill Molnupiravir which the FDA granted EUA have studies are up to 29 days only. One of the most influential leaders in biotech professor at Harvard Medical School biochemical pharmacology works include antivirals, cancer wrote that the FDA needs to tread very carefully with molnupiravir, potential for mutagenicity, birth defects, cancer and supercharge SARS-COV2 mutations.
There has been evidence of bone marrow toxicity in dogs and growth plate toxicity in rats and embryotetal toxicity in rats and rabbits. There has been talk about damage to DNA/RNA leading to cell death possible cancer.
@@rebeccat5994 your response matches what I've come to learn. My wife's doctor recommended this medicine when she had a positive test. I told her skip this med. She had a rough go for a 2 weeks but recovered nicely without it.
@@rebeccat5994 name of the professor pls??
@@genrichyagoda715 William A. Haseltine
Could any mutant be a gain of function?
I fully trust anything governments wish to mandate into our bodies ❤️ They would never harm anyone purposely, I know my history well.
@anglovirtual I surely hope so
Haven’t watched it yet but excellent video!
Ivermectin is easier to pronounce.
Similar to Uranium 235
Please pfizer with gonade femelle
So Ivermectin really cured Joe Rogan?
Harmful