Plasminogen and Plasmin (Fibrinolysis)

😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/me...
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►👨‍🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Tissue plasminogen activator (tPA) converts plasminogen into plasmin, then plasmin will dissolve the fibrin clot into degradation produts “i.e. fibrinolysis”.
This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding).
There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc). If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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I love this guy!! His lame humour is helping me through my degree😁

[@MedicosisPerfectionalis]

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[@Alexx-ke8be]

I feel like the genie from Aladdin is teaching me fibrinolysis... and I am not mad.

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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you know, this is the one of the few channels that makes me pause the video to laugh

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Awesome 👏
Thanks a ton!

[@qaisdinho1999]

You actually explain better than my hematology course instructor, Thank you !

[@MedicosisPerfectionalis]

My pleasure 😇

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[@MedicosisPerfectionalis]

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...not to mention, also introducing the possibility of saving our lives.!

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[@MedicosisPerfectionalis]

Thank you so much ☺️

[@UristMcFarmer]

I really like the flow charts and color coding, they help me pick this stuff up. However, these videos were not designed to be binge watched. Have you made, or do you play on making, a version of these videos that are longer and where if you need to review you're expected to watch the previous videos?

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OMG I CAN'T THANK YOU ENOUGH I didn't skip the ad .... YOU ARE MY SUPER HERO

[@MedicosisPerfectionalis]

Thank you so much, friend!

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Very nicely explained...thank you

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I like the Einstein relative glasses joke!

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You are AWESOME!

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[@MedicosisPerfectionalis]

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[@ianrjm969]

So if someone has Peyronie's Disease, they should take more proelytic enzymes to produce plasmin and then that plasmin can destroy the fibrin/plaque formation?

[@Floodland-bn3ol]

what can we do to trigger fibrinolysis?

[@vaishnavimannekunduri4090]

U r video's r not boring. I appreciate ur hard work hope u get more subscribe rs

[@fersonjames9793]

if Lp(a) is a homologus competitor of plasminogen how will high and low levels change coagulation as u see it?

[@alexandranicolelazaro3873]

total life saver!!!!!!!!

[@MedicosisPerfectionalis]

Thank you so much, Alexandra!

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"Who is your daddy" got me weak

[@MedicosisPerfectionalis]

:)

[@zarakhanzarak2714]

Howanu days taken by primary and sec hemostasis to be takes place

[@Enpsychclopedia]

That's exactly right hunny

[@QassamAlaa]

Factor XII is amplified indirectly by plasmin too 🤔 I'm confused

[@krasivaqdevochka9680]

Thank you so much! It is a great and fun explanation ♥️♥️

[@MedicosisPerfectionalis]

Thank you 🙏

[@laluhasan5165]

amazing, thousand thanks for you!!!!!!!

[@MedicosisPerfectionalis]

My pleasure...Thank you! Can you-please-share my videos with others? It really helps me.

[@laluhasan5165]

@@MedicosisPerfectionalis Done

[@MedicosisPerfectionalis]

Thanks a ton!

[@VDRO]

How can I get Plasmin to activate?

[@danielj.6647]

awesome video, I didn't understand the importance of fibrinolysis in sepsis :)

[@MedicosisPerfectionalis]

It’s not an importance, it’s a statistical significance “i.e. correlation”

[@ionictotalwar6389]

I am recommending you to all my classmates.

[@MedicosisPerfectionalis]

Thank you so much 😊

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Best teacher i came across ever .. what u teach just fits in mind Nd i never forget...

[@MedicosisPerfectionalis]

Awesome 👏
Thanks a lot

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Pure genius..

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Well explained 👏👏 thank you😊❤

[@MedicosisPerfectionalis]

You're welcome 😊

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Thank you so much for explening hema for me even better than my college professor❤️

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Thank you so much. Although I am not good at English , I feel this lecture be very great.

[@MedicosisPerfectionalis]

Thank you 🙏

[@danbui4473]

After watching this video, I understand many things and one of them is that my prof doesn't understand hemostasis well enough ahaha

[@MedicosisPerfectionalis]

Haha 😂
I appreciate you so much, Dan!

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you are awesome 😭😭💕💕

[@fdr.nazileguliyeva46]

great work ))

[@MedicosisPerfectionalis]

Thank you 😊

[@frailpel]

Sooooo what supplements should one take if they have blood clots, let’s say in their leg(s)?

[@MedicosisPerfectionalis]

They should dissolve the clots ASAP using anticoagulants.

[@frailpel]

@@MedicosisPerfectionalis thank u

[@NicolaNyawasha]

thank you💙

[@MedicosisPerfectionalis]

My pleasure!

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bahaahaah...because it's relative. You slay me sire

[@hanifabashir2002]

Perfectionist ❤

[@MedicosisPerfectionalis]

Thank you!

[@leteasilence8288]

pov youre a German high schooler just trying to make a powerpoint slide about plasmin--

[@MedicosisPerfectionalis]

Thank you for watching!

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Well said .... From india

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That's Right, Too much of everything is bad... But your Lectures :P

[@MedicosisPerfectionalis]

Haha 😂
Thank you so much 😊

[@annaelizabeth3525]

I like the way you say plasmin

[@MedicosisPerfectionalis]

Is it pronounced differently? 😂

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Wow super

[@MedicosisPerfectionalis]

Thanks 🙏

[@Javabox04]

Thanks

[@MedicosisPerfectionalis]

My pleasure!

[@noconintended]

QUESTION…in the hope you can answer… can I increase my fibrin from food? …cause I have big clots in portal vein and the polycythemia Vera mutation

[@MedicosisPerfectionalis]

I haven’t heard of a diet that was shown to help with polycythemia vera.

[@noconintended]

@@MedicosisPerfectionalis thank you for responding.

[@MedicosisPerfectionalis]

Anytime!

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funny plus perfect

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[@MedicosisPerfectionalis]

Thank you 🙏

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THAAAAAAANK YOOOUUU

[@paulhetherington3854]

Swedish-- words! PLASM--PSASMZ-- Personally Swedish, AYE! I'am this! MZ- Egypt as, well!

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Its relative🤣🤣🤣

[@MedicosisPerfectionalis]

Haha 😂

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i would literally pay for your sessions

[@MedicosisPerfectionalis]

Thank you so much, dear :)
Your kind and encouraging words are infinitely more valuable than money.
Thanks 😊

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[@MedicosisPerfectionalis]

Thanks 😂

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love your sense of humor :)

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

??

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you are too fast though
but you are understandable

[@MedicosisPerfectionalis]

Thank you so much for your honest feedback

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some areas he's talking real fast bc they were already discussed on other videos, so he's just making a recap.

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[@MedicosisPerfectionalis]

Is this a good thing or a bad thing 🧐🤔?

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Elaborate

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9:43-9:53 hahahahahaha

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[@MedicosisPerfectionalis]

Thanks a ton, dear!

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[@paulhetherington3854]

FIBAR-- Friendly, AYE! B-- past tense, I am-- AYE! Swedish! Funny he, used hemzo! Usually, means: Lots of hatred! Hawaii-- homosexuals.

[@amandaellsworth9254]

"If you haven't read Shakespeare, this is no hope for you. Keep reading your Kaplan medical."
#triggered

[@MedicosisPerfectionalis]

I am sorry 😭

[@amandaellsworth9254]

@@MedicosisPerfectionalis It's okay, I read plenty of Shakespeare in high school before I got old and went back to medical school in my almost 30s. 😂