Clinical Uses of Tissue Plasminogen Activator (tPA)
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- Опубліковано 6 тра 2019
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►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Tissue plasminogen activator (tPA) converts plasminogen into plasmin, then plasmin will dissolve the fibrin clot into degradation produts “i.e. fibrinolysis”.
This is known as thrombolytic therapy, useful for myocardial infarction and ischemic strokes, but contraindicated in hemorrhagic strokes (due to increased risk of bleeding).
There are absolute contraindications as well as relative contraindications to fibrinolytic therapy (tPA, alteplase, streptokinase,...etc).
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I am old enough to have used both Streptokinase and TPA for acute myocardial infarction. Probably treated 20 plus before angioplasty took over. You had to use Streptokinase right. 1.5 million units over 30 minutes, instead of 60 minutes...this was rock and roll Strepto from protocols developed in New Zealand. The guys would groan, " I feel terrible " , roll onto their sides, vomit, and... reperfuse. I loved it, much more dramatic than the slow TPA protocol. Being in a community hospital about 60 miles from tertiery centers, I still drill with the TPA protocols because sometimes the choppers don't fly and on those days ground transport ain't humming either! Cheers!
شكرا كتير انت سبب نجاحي بامتحان الascp بعد انقطاع ١١سنه
I am so glad to hear that...Way to go 👏...Please consider sharing my videos with others... Thanks 🙏
ألف مبروك
im watching all 121 videos rn for USMLE
Wow 🤩
I appreciate it!
what other intravenous medication for the stroke except TPA please ?
NCLEX-RN tip: contraindication of tPA starts at 13:48
Thank you so much 😊
Great job , thank you ⭐️
My pleasure
Why we lysis fibrin by plasmin but on otherhand we need fibrin for cloting
Thank you! 🌻
My pleasure 😇
@MedicosisPerfectionalis can plasmin break chronic blood clots which has organized or calcified in artery?
great videos thank you
My pleasure 😇
"uh- we have another hour to.." "s-h-u-t. u-p." LOLLLLLLL!!!!!!!!!!!!!
Haha 😂
Yes, let’s have tea!
Excellent 👌
Thank you 🙏
Where can i find your video on stroke ?
In my Neurology playlist (and in my Emergency Medicine playlist).
So here's a question for you, if Pharmaceutical companies don't increase prices to 'what the market will bear', why do patented drugs in Europe cost only about 20% of what they cost in the USA? Even drugs off patent are about half as expensive in Europe. Answer... Because the pharmaceutical companies are limited in how much they can charge in Europe and other countries too. Not so in the USA, where they raise the prices to what the market will bear, lol... I do appreciate your point though about why localized fibrinogen drugs are more expensive!
Hey 👋 Andy,
Have you read “Applied Economics” by Dr. Thomas Sowell? There’s a whole chapter addressing this issue!
I hope you like it!
Thank you!
NEUROLOGY 😭
Why you talk so fast