The Clotting Cascade EXPLAINED!
Вставка
- Опубліковано 2 чер 2024
- Discussing the complex clotting cascade. 📝 Free Quiz: adv.icu/3Px3yXI
💲✂️ 10% off EACH Month @ My Mastery Nursing membership: 👉🏼 adv.icu/mastery
❤️🙏🏼 Show your support with an ICU Advantage Sticker HERE 👉🏼 adv.icu/support
When bleeding is present, our blood needs to transform from a liquid to a gel in an attempt to slow and stop the bleeding. This process of hemostasis is a complex one and the most complex part of this is what we refer to as the clotting cascade. The cascade allows the rapid conversion of Fibrinogen to Fibrin, a crucial component to forming a stable clot. The cascade involves multiple steps and enlists multiple helpers to "cascade" into a large volume of fibrin. We have both the Intrinsic and Extrinsic Pathways that both feed into the Common Pathway and result in clot formation.
----------
🤔 Curious how you can show your support? AND get extra content such as the notes for each lesson!
Consider supporting ICU Advantage....
- on UA-cam channel membership head over to: adv.icu/ym
- on Patreon head over to: adv.icu/pm
If not, no worries, as you watching videos here, liking them, commenting and sharing them also really help to support the channel! 😍
________________________________________________________
🧠🤓 ACCELERATE YOUR LEARNING
🔹Critical Care Academy (CCRN Review): adv.icu/cca
---------
👕 $20 towards Figs Scrubs! adv.icu/figs 🤑
---------
📚📖BOOKS I RECOMMEND
✔️Barron’s CCRN Exam: amzn.to/2MFWIkH
✔️Pass CCRN!: amzn.to/36apxgN
✔️AACN Essentials of Critical Care Nursing: amzn.to/2F5riQs
✔️Kaplan Adult CCRN Review: amzn.to/37igv1t
✔️Marino’s The ICU Book: amzn.to/2ZzKP4Y
🩺🏥🖊SOME OF MY FAVORITE NURSING GEAR
✔️3M Littmann Master Cardiology Stethoscope: amzn.to/2sn0wR5
✔️Rip Shears - Trauma Shears: amzn.to/35diZwR
✔️Leatherman - Raptor Shears: amzn.to/2MGF801
✔️Stethoscope Tape Holder: amzn.to/2snWkAy
✔️Pilot FriXion Erasable Pens: amzn.to/2Qw9pQg
💻🎙GEAR THAT I USE TO MAKE THESE VIDEOS
✔️Apple Pencil: amzn.to/368qS83
✔️iPad Pro 12.9”: amzn.to/367s2QV
✔️Blue Yeti Mic: amzn.to/2Q7vrK9
✔️MacBook Pro 15”: amzn.to/2tcDegM
👍🏼👍🏼👍🏼
If you enjoyed this video or found it useful, please hit the like button as this greatly helps the channel out! Also make sure and subscribe, hit the bell icon and select all notifications to stay up to date on our latest videos!
🙏🙏 A Special THANK YOU to UA-cam and Patreon Members!!! 🙏🙏
🏆 Patreon Code Team: John, Tsz, Dajana, Selena, Anita, Amelie, Dominic, April, Laura, Dina, Lydia, Lindsay, Daisy, Jennifer, Shaun, and Nilam!
⚠️⚠️ DISCLAIMER: Links included in this description are affiliate links. If you purchase a product or service with the links that I provide I may receive a small commission. There is no additional charge to you!
❗️❗️PLEASE NOTE: ICU Advantage medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider. The information is present here to give you a starting place to further look in to the proper treatments and recommendations for the care of your patient.
0:00 Intro
1:32 Hemostasis
4:51 The Cascade
12:46 Extrinsic Pathway
14:33 Intrinsic Pathway
16:53 Entire Cascade
19:29 Wrap up
#ICUAdvantage #ClottingCascade #Hemostasis
❤ Show your support with an ICU Advantage sticker! 👉🏼 adv.icu/support
💲 10% off EACH Month @ Nurisng Mastery membership: 👉🏼 adv.icu/mastery
NOTES for this lesson (and all previous lessons) are availably only to UA-cam and Patreon members. Links to join both here ⬇
► UA-cam: adv.icu/ym | ► Patreon: adv.icu/pm
❤
As a Clinical Hematology Professor, I approve! Love your videos!!!
Awesome! So cool to hear this. Thanks so much Luis and glad you enjoy them.
You really approve that calcium is needed for conversion of fibrinogen to fibrin? And that platelet phospholipids are not needed for prothrombinase formation?
You are exceptionally well spoken: you speak very clear and explain very nicely.
It is very desirable.
I don't know why school teachers can't explain vividly and briefly like this. Thank you man. Keep up the good work 👏 🙌 👍 👌 💪
Thanks so much for that. Really glad I was able to convey the info so it made sense.
U mean medical schools?:)
@@malikasha yes med school,.all my doctor teachers know is to make med school a hell life.
@@fredoxychannel923 haha I see, dont give up
Because they don’t actually know it
Some tips to help remember :
PT = tennis (played inside) = intrinsic pathway versus aPTT = table tennis (ping-pong, played outside) = extrinsic pathway
Common pathway = 10, 5, 2, 1 = like $ currency
Intrinsic = numbers 8 through 12 (except 10)
Thank you so much ICU Advantage! You have greatly helped this pharmacist prep for hospital residency!
Thanks for sharing that! I really like the currency part! And you are very welcome. Truly happy to know I'm able to help!
Forgive my ignorance, but I thought tennis is played outside and table tennis is played inside?
@@bonniehuang8696 oops! True, I meant the opposite :(
I am also teaching from time to time and really can´t get my mind wrapped around this cascade. Great Job wrapping this thing up.
Nice! Happy to help Igor!
“All bleeding stops eventually”, is my favorite one liner
Haha yes and it’s so true!
Woah, clear and concise thank you!
Thanks so much for making this video! I was just looking into learning more about this topic the other day. I definitely have a better understanding of it now
Watched and read many things trying to understand this, and this video was what put it all together for me.
I particularly enjoyed this presentation!
Very logical and good explanation, thanks
I absolutely love your lectures.
Thank you so much Rose!
Great lecture
This is awesome.❤ Thanks a lot
thanks it really helped!!!
Thank you so much sir.❤
Thank you sir 😢
Thanks !
Thank you
Love your videos!! Thank you!
Thank you Faith! ❤️
Loved it. Thank you so much 😊
Glad to hear it!
Incredibly easy to follow lesson... thank you
So great to hear this Ken!
I finally understand this!!
😊 🙏 thank you so much!!
Woohoo!! Happy to help!
Your the best !
Very helpful in developing my understanding of my factor VII deficiency hemophilia on a mechanistic level
thank you so much!
You’re welcome!
Thabk you so much!
This helps very very much!
Glad it helped!
Started scribing in a heme/onc clinic and this video is gonna help a ton
Glad you liked it!
thanks for explaining something pretty complex...
You’re welcome and glad I was able to do so in a way that made sense!
This is excellent, from a University College London Professor of biochemistry, I also approve.
Thank you ❤❤❤❤
You're welcome 😊
🤩thanks
Pretty complicated but explained well❤
Great to hear! And yes, it is quite complicated!
Hello!
love your videos I've been struggling with this topic for a long time. So thank you!
I just have a quick (and rather dumb) question: When you were explaining the intrinsic pathway you said activated factor 12 and 11 activate factor 7 which activates the extrinsic pathway, but you drew the arrow from activated factor 9. Which one is it?😅🙈
Ahh this was my bad! It took me a minute to try and make sense of what was being asked, but once I realized my mistake it all makes sense now. I did draw it correctly, but I completely misread IX as 11 instead of 9. It is activated 9 that activates 7, along with many others. Sorry for the confusion!
@@ICUAdvantage Thank you so much!!!
One question, with txa it stops the process of fibrinolysis by binding with plasminogen. Why during a massive hemorrhage is the body trying to breakdown its own clots? Something I could never understand. Great videos!!
Coagulation is much faster than fibrinolysis. Normally, the clot is being lysed after the vessel is regenerated. In massive hemorrhages fibrinolysis does not play big role
❤
My head hurts 😂
Hahaha yeaaahhh...... this will do that!
Where can I find the notes please??? ❤
Hey Larysa! First off, thanks so much for your support!
Unfortunately UA-cam doesn't make it very clear. If you go to the main "ICU Advantage" UA-cam page, then at the top look for "Community" and that is where you will find the link to the notes and the current months password.
Let me know if you have any issues and feel free to shoot me an email if you still do! Thank you! -Eddie
Notes?
Every time I teach this pathway, I run out of blackboard space.
Hahaha I could see that!
Flabbergasted
Holy craps...that's why EDDIE WATSON is the GOAT. Complex indeed
Thanks !!!!!
Yw!!