Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, LOX,Prostaglandin, LTNs

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  • Опубліковано 2 лют 2025

КОМЕНТАРІ • 444

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  6 років тому +8

    👨‍🏫 💊 Cardiac Pharmacology Lectures: www.medicosisperfectionalis.com/ 💊🦠 Antibiotics Lectures: www.medicosisperfectionalis.com/

  • @joshdudeguy2830
    @joshdudeguy2830 Рік тому +40

    Me *comes to video knowing absolutely NOTHING about the arichidonic acid pathway*
    MP *makes 18 minute video full of freaking magic*
    Me *leaves at end of video feeling like a subject matter expert*
    I know this is a 4 year old video but still. You do incredibly important work here, man! Thank you!

  • @Mandh223
    @Mandh223 5 років тому +77

    Whoever you are, you’re just absolutely an amazing teacher! God bless you

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому

      😊😊😊

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +5

      Please consider sharing my videos with others...Thanks in advance!

    • @samuelwaithira
      @samuelwaithira 2 роки тому +1

      A comedy pharmacology class, you have made my day, in autocoids am now good.

    • @something93565
      @something93565 2 роки тому

      @@MedicosisPerfectionalis always do!!! your dry sense of humor makes it all even better! made in egypt vibes ;) love it.

  • @moonprincess1992
    @moonprincess1992 4 роки тому +99

    My professor didn't even attempt to teach this, just gave us a chart to memorize. So thank you for explaining everything so well!!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 роки тому +10

      You’re very welcome 😊
      Good luck 🍀
      Let me know if you have any questions!

    • @yes7855
      @yes7855 3 роки тому +1

      Same here hahah. And these vids are great! :)

    • @yui870
      @yui870 Рік тому

      yeah my doctors too .. never told me diz (in my campus there's no proffesor, just doctors until doctorate degree)

    • @mariamlatif5095
      @mariamlatif5095 Рік тому

      Share kardein chart

    • @tauqeerahmadsafi8522
      @tauqeerahmadsafi8522 9 місяців тому

      You are lucky to have a professor 😅

  • @Deepayan00
    @Deepayan00 4 роки тому +25

    I am rewriting an article on "arachidonic acid, inflammation and mental health" and needed to know the whole mechanism. This video gave me a head start to decode the overly densed wiki article on arachidonic acid and saved my mental health. :D

    • @mariansmith9685
      @mariansmith9685 2 роки тому +2

      Where can I read your findings? I'm really excited to see your work!

  • @mossaybo
    @mossaybo 5 років тому +41

    15:21 to 16:10 was the best explanation of the pharmacology behind Aspirin , since it's invention !

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +3

      Thanks, dear!

    • @mossaybo
      @mossaybo 5 років тому +6

      @@MedicosisPerfectionalis I'm the one who should thank you , I'd love to know , when you're learning about a new subject , how do you approach it ? .. reading different textbooks , sticking with one book , reading research papers about it ? because you have an amazing big picture and you make smart connections between things , I'd appreciate it if you'd teach us how to fish

  • @miradl
    @miradl 4 роки тому +9

    This truly made my night! Who knows learning the AA pathway (that I've been dying to defy since medschool) can be fun?! 7 years later and this made sense

  • @MrNakedWizard
    @MrNakedWizard 5 років тому +16

    Thank you, banging my head against a wall to learn this and your style of repetition and humour was wonderful and refreshing, thank you again

  • @ameerahal-sadi9596
    @ameerahal-sadi9596 5 років тому +12

    Love love love your teaching style!! You're making immuno more doable!

  • @wcomsa
    @wcomsa Місяць тому +1

    This is the best explanation, I watched before for my presentation preparation and now I'm watching it again for my final exam. I'm so grateful thank you

  • @alibuknan193
    @alibuknan193 6 років тому +61

    Thank you so much, you got me laughing while watching this and learn :)

  • @sharonkende4774
    @sharonkende4774 2 роки тому +2

    Thank you so much. I am a nutrition student but hearing how meds work made the information so much more retainable. the difference between teaching vs teaching and the student learning is timing and ways to engage (showing connections between things and even adding humor). It makes all the difference.

  • @abcgames4454
    @abcgames4454 4 роки тому +28

    The most doubt clearing video I have ever seen. A must for every medical student. Love from India! 🇮🇳👩‍⚕️

  • @dh1147
    @dh1147 3 роки тому +4

    Holy moly, I “learned” this in nutritional biochemistry and in pathophysiology and after watching your video, I finally get it!!!! Thank you, subbed and saved! Thank you you are amazing!

  • @dge.
    @dge. 5 років тому +9

    Came across your video while studying for Pharmacology. I am so glad I did! Not only did you make it so simple, but I was laughing throughout the video, too!
    Ps I'm surprised at how low the view count for this is. Honestly this is better than Khan Academy. It uses a white background and u managed to inject bouts of humor (which I think is so hard to do for topics like these) I hope you continue on making videos, my good sir! You have made a medical student's week 😊 I wish all of my lecturers were like you.... SUBBED!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому

      Thanks a ton!
      I am honored...You’re such a kind person.
      Can you please help me by sharing my videos with your friends?

    • @dge.
      @dge. 5 років тому

      Do you have any videos on anticonvulsants? 😄 also, I've sent this video to a ton of my classmates! They loved it!!!

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  Рік тому +1

    💊 Pharmacology Playlist: ua-cam.com/play/PLYcLrRDaR8_d5RzuEJprW-NWXTK22ByVC.html&si=MGlX4_a2LlLOo6Ed

  • @Guidus125
    @Guidus125 4 роки тому +6

    where has this channel been my whole life

  • @nfa861
    @nfa861 5 місяців тому +1

    thank you sir you are essential to humanity and deserve a nobel prize 🏆

  • @snehasha6891
    @snehasha6891 6 місяців тому

    This is HANDS DOWN THE BEST video on arachidonic acid pathway

  • @fionacole7811
    @fionacole7811 11 місяців тому +1

    Thank you so much❤❤ i have a biochem exam tomorrow on this and you just about saved my life (gpa)

  • @FlowRXOXOXO
    @FlowRXOXOXO Рік тому +1

    Love the sense of humor with the teachings!

  • @colbertoise
    @colbertoise 4 роки тому +3

    I wish there was a way to like and subscribe 1000x times srsly u have the BEST Hematology lectures eveeeeer thank you so much and GOD bless you

  • @eduardocarvalho7810
    @eduardocarvalho7810 3 роки тому +4

    I don't generelly make comments, but this lecture was AMAZING. Very clear and engaging explanation, congrats and THANK YOU!

  • @charlemagnebaguio3734
    @charlemagnebaguio3734 3 роки тому +4

    Been sharing this golden content to my friends! Thank you for this and thank you for being a great teacher.

  • @BitseatGetaneh
    @BitseatGetaneh 4 місяці тому

    aren't you the best??? wow!!!! YOU MADE ME UNDERTSTAND THIS IN AN EASY AND DIGESTABLE WAYYY! Love how you repeat it as well to make us remember

  • @mehdiazaz7669
    @mehdiazaz7669 3 роки тому +1

    the best professor I've ever seen, good job !

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  6 років тому +6

    From the arachidonic acid pathway, can you mention some side effects of Acetyl-Salicylic Acid (ASA)?

    • @ricardobaroni1714
      @ricardobaroni1714 5 років тому +3

      Bleeding, peptic ulcer (decreases production of mucus)

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +1

      Good...and why does it decrease production of mucus?

    • @ricardobaroni1714
      @ricardobaroni1714 5 років тому +6

      @@MedicosisPerfectionalis Because ASA inhibits the COX pathway, consequentely inhibits the production of prostaglandins, wich are responsable for the production of mucus. Sorry for my english, I am still learning haha

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +4

      You’re excellent 👍

  • @ieorj4080
    @ieorj4080 2 роки тому +1

    This is the BEST video I have seen on this topic. Thank you kind sir.

  • @KazokuMugiwara
    @KazokuMugiwara 4 роки тому +2

    Thanks for the video. It went more in depth than my dental pharmacology textbook and helps me picture this action.

  • @laibasheikh137
    @laibasheikh137 8 місяців тому

    This was explained 10x better than it was at my university. Thank you so much!

  • @LisaClarkmedicalillustrator
    @LisaClarkmedicalillustrator 2 роки тому +1

    I couldn't love your teaching style more! Fantastic.

  • @akaakram1347
    @akaakram1347 3 роки тому +1

    I am starting to lern with love&fun our medical lectures than i just find this masterpiece..thank god and may the god bless you 🫀

  • @lorena6020
    @lorena6020 Рік тому +1

    Who are you? You are too good! I have to study for my periodontology exam but this is way better! Thank you!

  • @chiahead52
    @chiahead52 3 роки тому +1

    You speak my language MP! Acronyms and association helps better memory retention. Thank you

  • @rimshaabdullah8373
    @rimshaabdullah8373 3 роки тому +1

    You proved that.. yes I am medicosis perfectionalis love your method of teaching you are best 💗

  • @shubhampatil4496
    @shubhampatil4496 10 місяців тому

    I never understood this in my second prof ..And the fear of this topic stayed with me for too long.Thankyou for such simple easy explanations

  • @partomeraji3084
    @partomeraji3084 3 роки тому +1

    every single time I cry with happiness... Medicosis you are a gift from God

  • @drtahirakhtar2485
    @drtahirakhtar2485 2 роки тому +5

    Thank you so much for this masterpiece, this is really helpful for medical students and I am sure no body will deny this fact, 💯

  • @alibaldiwala1604
    @alibaldiwala1604 10 місяців тому

    THIS IS A CRIMINALLY COOL EXPLANATION! Thank you so much!🤯❤

  • @NightWiitchh
    @NightWiitchh 2 роки тому +1

    Absolutely loved the video!!! It was wonderful and not confusing at all. I am currently in Pharmacology and everything makes since now!!

  • @agyadmohd1395
    @agyadmohd1395 3 роки тому +1

    You are so freaking genius!!! Can’t say how much u make medicine interesting and logic 🥺🧡🧡

  • @sxvioux
    @sxvioux Рік тому +1

    Wow I never knew Studying these mechanism will be a lot of fun, its so colourful and I love how u throw jokes sometimes. Keep up the amazing work. 💙💙🥺

  • @j.sbhandari8813
    @j.sbhandari8813 4 роки тому +2

    what an explanation, PERFECT MAN! thank you so much and God bless!

  • @CeliaHH1
    @CeliaHH1 4 роки тому +3

    Thank you so much! Many greetings from Germany!

  • @a_a_n_i
    @a_a_n_i Рік тому +1

    Gosh your explanation was amazing!!! The way you made every single step funny was just cute and helped me memorize them easily, i'm preparing a presentation about arachidonic acid derivatives and was very worried where to find information cuz there isn't much to find, your video is the best, couldn't be better, thank you! 😭

  • @swally1206
    @swally1206 4 роки тому +3

    I love the way you make life easier, that was incredible and so helpful, thank you so much.🤩😁🙏🏻 I wish you were my Doctor at Uni😅

  • @shadysid5570
    @shadysid5570 3 роки тому +1

    Best education channel on UA-cam

  • @shyamagrawal36
    @shyamagrawal36 5 років тому +1

    First time ever I could understand the exact mechanism by this video.. Thanks

  • @YusraAli313
    @YusraAli313 4 роки тому +2

    I actually Love you, you are so entertaining it's not funny! haha Education on another level. Thank you doctor xxxxx

  • @farhinsiddeka
    @farhinsiddeka 4 роки тому +1

    This really is the most beautiful thorough explanation! Thank You!

  • @parishaykhan8139
    @parishaykhan8139 5 років тому +9

    We need more lectures on pharmacology plz upload ...waiting ...God bless you

  • @SaraMicallef
    @SaraMicallef 2 роки тому +1

    This textbook chapter traumatised me. Thanks for undoing the damage :)

  • @aboodmoghraby4647
    @aboodmoghraby4647 2 роки тому +1

    When a young guy beats our professors
    Great respect for you bro🌺

  • @lisameller1
    @lisameller1 2 роки тому +1

    Thanks for making this easier to understand!

  • @afsa2973
    @afsa2973 3 роки тому

    Thank you for the wonderful lecture . Love from India 🇮🇳.

  • @becky5950
    @becky5950 4 роки тому +1

    This made everything so crystal clear, thank you!

  • @wafaeltaief723
    @wafaeltaief723 4 роки тому +2

    Looooove this one it makes sence in an amazing way , may god bless you medicosis 🥰

  • @rizz1088
    @rizz1088 2 роки тому +1

    The way you teach is similar with my biochemistry teacher in medschool. ❤

  • @SW-fk3rb
    @SW-fk3rb 3 роки тому +1

    You are funny!! Really enjoyed this, so delighted I found your channel.

  • @mdam1543
    @mdam1543 4 роки тому +6

    Me when I watch other educational vids: *nods* yeah okay. Thank you
    Me while i watch medicosis perfectionalis: *smiles* *chuckles* haha yeah. I understand better now✨ thank you 🥺💕

  • @osayamenogiugo3864
    @osayamenogiugo3864 3 роки тому +1

    Thank you! Thoroughly enjoyed learning.🙌🏾

  • @ishaqureshi402
    @ishaqureshi402 Рік тому +2

    I was emotional cuz I watched sth emotional just before starting this lecture. My tears still hadn't dried up when he talked about Aristotle's deduction followed by 'Buhahah' which cracked me up. Thank you. I am back.

  • @kharboze_asmr
    @kharboze_asmr 4 роки тому

    I love how easy it seems when u explain it. Tnx so much 🌹🙏

  • @daingfirdaus7951
    @daingfirdaus7951 4 роки тому

    The explanation is crazy yet understandable

  • @mennanabil9680
    @mennanabil9680 3 роки тому +1

    This looks like heaven thanx from Egypt

  • @tyrhere
    @tyrhere 5 років тому +3

    My life would have been smooth af in freshman year if these existed, DANG. So glad I stumbled upon this

  • @josephbanoub8392
    @josephbanoub8392 3 роки тому +1

    Excellent presentation and I am really impressed how you could simplify the science
    Thanks

  • @qusai1437
    @qusai1437 4 роки тому +2

    I CANT THANK YOU ENOUGH !!!!!!

  • @masoomafatimah
    @masoomafatimah 4 роки тому +1

    The best explanation!
    Bravo 👏🏻

  • @radojemarkovic5290
    @radojemarkovic5290 3 роки тому +1

    Man. This is masterpiece

  • @lostSempaiWissame
    @lostSempaiWissame 3 роки тому +1

    Your laugh always cracks me up .. thanks a bunch

  • @garrett_jp
    @garrett_jp Рік тому +1

    Loved this, very helpful. Thank you!

  • @keurinrin16
    @keurinrin16 3 роки тому +1

    Thank you for making medicine fun!🤗🤌

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 роки тому

      My pleasure 😇

    • @keurinrin16
      @keurinrin16 3 роки тому +1

      It would be nice if we could have a pdf form of your notes hehehe because it is much understandable than reading books lol

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 роки тому

      I do actually...Here: www.medicosisperfectionalis.com/products/illustrated-notes-pdfs/

  • @mohamedafifi955
    @mohamedafifi955 6 років тому +2

    This is genius as always .. thanks doc. Bless you

  • @nishaanbhagwandin9394
    @nishaanbhagwandin9394 2 роки тому +1

    Thank you ,your explanations are just awesome 👌

  • @haseraaaopi3433
    @haseraaaopi3433 3 роки тому

    i m about to sit for my Professional Exam in 5 days and this playlist makes my 5yrs in medsch into sense 🤧🤯

  • @swngstr
    @swngstr 5 років тому +2

    Wow. Great job. I like how you think. This works for me!

  • @subeshsaurav8046
    @subeshsaurav8046 4 роки тому +1

    You are simply EXCELLENT!!!

  • @احمدعبدالعزيزسلامه-ه4ك

    God bless you ,indeed I benefit alot from you Sir

  • @angis8505
    @angis8505 5 років тому +1

    Great video!! Love your ironic sense of humor!!!🤓😂

  • @radojemarkovic5290
    @radojemarkovic5290 3 роки тому +1

    Man, I I'll post another same comment. This i s masterpiece. Now I understand corticosteroidss and aspirin use( never knew why would drug which inhibit inflammation inhibit trombs) .

  • @manbirsandhu1492
    @manbirsandhu1492 2 роки тому +1

    This was amazing, thank you so much!!

  • @elenamirova7990
    @elenamirova7990 3 роки тому +4

    Thank you for the great explanation and the great content you put out regularly! Your videos are of great help when preparing for exams :D
    About the anti-platelet activity of aspirin, despite its inhibition on prostacyclin synthesis, I found this piece of information in Voet's Principles of Biochemistry: "Vascular endothelial cells are not so drastically affected, since, for the most part, they are far from the site where aspirin is absorbed, are exposed to lesser concentrations of aspirin and, in any case, can synthesize additional PGH2 synthase".

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  3 роки тому +1

      Excellent!
      Thank you so much 😊

    • @nikolamarkovic4845
      @nikolamarkovic4845 3 роки тому

      i dont understand. how are endothelial cell far from aspirin ? endotleh covers all of blood vessels, so ist it all around the body?

    • @erykahbrown9239
      @erykahbrown9239 3 роки тому

      Additionally, as I've now learned in my hematology course, since epithelial cells have nuclei they have the ability to regenerate cyclooxygenase whereas platelets, being only cell fragments have no nucleus and lack this ability

  • @fazalwahid9950
    @fazalwahid9950 2 роки тому

    Excellent easy and clear vision 👌
    Thanks dear you are doing a good job. Please keep it up

  • @parthagrawal6254
    @parthagrawal6254 2 місяці тому

    You have got my respect dude. ❤

  • @ricardobaroni1714
    @ricardobaroni1714 5 років тому +1

    Hello from Brazil... this channel is amazing, please keep the good work!

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 років тому +1

      Thanks, brother, for your encouragement 👍

    • @ricardobaroni1714
      @ricardobaroni1714 5 років тому

      @@MedicosisPerfectionalis I am very grateful for this channel You really left the content fun and didactic.

  • @danielnaranjodelpino7895
    @danielnaranjodelpino7895 3 місяці тому

    Hermano se te fue la manoooo! Muy buen video. Excelente. al fin entendi esto!!

  • @dianareyna8889
    @dianareyna8889 4 роки тому +1

    You are right, best explanation!

  • @DR22711
    @DR22711 10 місяців тому

    I respect you effort Sir
    Nice explanation ❤❤

  • @edthoreum7625
    @edthoreum7625 2 роки тому +1

    4:35
    5:40
    7:20 platelets as H2O pump
    13:48 aspirin

  • @sammay4063
    @sammay4063 5 років тому +1

    A very helpful and clear video

  • @drneelagiriparameshwar4219
    @drneelagiriparameshwar4219 Рік тому +1

    That was smooth 👍💓

  • @ahmedassadi9227
    @ahmedassadi9227 2 роки тому

    Ive always been a fan and you've saved my ass since year 1 till the 3rd I'm in rn, 3 more to go :D

  • @thathaw7769
    @thathaw7769 3 роки тому

    Indeed the best explanation! Thank you!

  • @thelmataonga5211
    @thelmataonga5211 4 роки тому +1

    Best explanation 👏 thanks not only for the best explanation but for making me laugh too😍😍

  • @hajare4522
    @hajare4522 Рік тому +1

    This ssssssssso great explanation 😮❤❤❤❤❤❤

  • @gayanms
    @gayanms 3 роки тому +1

    You are the best! Thank you.

  • @tashreeqa_ek
    @tashreeqa_ek Рік тому +1

    Absolute lifesaver

  • @hananemess8696
    @hananemess8696 Рік тому +1

    You are my Savior ! Thank you ❤️

  • @MrSaloha
    @MrSaloha 5 років тому

    Please make neurology Medicine series like hemiplegia and para... Again you’re the best...