Adrenopause, Low DHEA & Low Testosterone: Facts You Should Know
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- Опубліковано 14 лип 2024
- Adrenopause is when your adrenals go into a state of decline, which happens with age but appears to be happening earlier and earlier for people, leading to low
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----------------------------------------Show Notes-------------------------------------
0:00 Intro
0:10 Adrenopause is when your adrenals go into a state of decline.
0:30 About 75% of estrogens and androgens come from adrenals in post-menopausal women.
1:00 Adrenopause can appear as low DHEA, low cortisol, low cortisol awakening response, and low libido.
1:40 The adrenal medulla is the innermost portion of the adrenal gland.
1:45 Adrenal glands make epinephrine and norepinephrine.
02:00 The zona reticularis and zona fasciculata are where cortisol and other corticosteroids are released.
02:50 Cortisol should be high in the morning and lower at night.
03:30 Atrophy of portions of the adrenal glands can lead to adrenopause, which is linked with sub-optimal testosterone, poor immunologic responses, aberrant changes in estrogen and vaginal dryness.
05:40 DHEA is metabolized into testosterone, dihydrotestosterone, and estrogen, as well as affect immunologic health, brain tissue and other aspects of physiology.
07:10 Men should test DHEA before considering HRT.
08:10 You can test serum DHEA sulfate, the storage form of DHEA.
08:50 The DUTCH plus complete tests your cortisol awakening response, DHEA, melatonin, estrogen metabolites and progesterone.
09:45 Supplement timing: You may supplement adrenal glandulars and thyroid extracts in the morning and DHEA in the evening.
11:10 General dosing: men - 10 mg/decade of life, women - 2.5mg/decade of life
11:45 Insulin resistance can increase levels of androgens with DHEA supplementation.
12:20 Exposure to morning sunlight and evening sunlight can stimulate your cortisol awakening response.
12:45 The amplitude and intensity of your circadian clock system becomes muted as you age.
I'm not against supplementing but to me it seems like you often gain much more from retracting and replacing negative stuff and habits rather than add somethign on top of the old.
dealing with depression, hair loss low sex drive, foggy brain during peri menopause, i have found supplementation to be an essential tool in my arsenal to maintain my sanity. life changing. to each her own but certainly don’t assume that what you are doing/ experiencing in life is appropriate for all bodies
To each his own. If you have negative stuff you can identify to get rid of them yea go for it. But if not, supplement and see if it works
We are all different.
Thank you so much. I already took DHEA but taking it at night has been a game changer for my sleep. I’m even dreaming which I never do, or at least remember. I don’t wake up as much and if I do, I go right back to sleep. I’m so appreciative and happy I listened to this episode
How long did it take to work??
I’ve been taking Life Extension’s DHEA for several months now and I have noticed that I have more energy. DHEA is critical!
Concise, clear, relevant and helpful as always. Thanks High Intensity Health.
Keep making these videos! The people who care about doing better for their body will watch and appreciate all that you do. Thank you!
Great Info. Thanks for posting!
I’ll move my DHEA from the AM to the PM based on this and see how it impacts me. Thanks!
So interesting Mike! Thanks
Thanks for this. I just started taking DHEA after researching and this is definitely helping me. I have a history of chronic stress, chronic fatigue, and had adrenal fatigue a few times in my life. Once fairly severe. The one thing, I would never take it at night because it gives me energy, if I took it at night I'd never sleep. I do notice that it has stopped my waking up at 4:00 a.m. and it also has stopped my 4:00 p.m. slumps, which are classic chronic fatigue adrenal insufficiency symptoms. I've also read it's better to take it topically because in that form it can cross the blood-brain barrier.
Great content!
Agree with some comments here. Been off and on DHEA 25mg a day. 58 old male 5 days a week in gym. Test blood every 4 to 6 months. DHEA is a hit or miss. Sometimes I feel great and lately sluggish. Just tested last week waiting for results. The best advice is test before then after and frequently. Also keep in mind that this is a hormone that can throw off other hormones. Life extension has their annual blood tests sale going on right now. I would take advantage of it. Also functional doctors can help guide you through this; your regular doctor has no clue. UPDATE: Just received my blood test results. My Testosterone was 532 from 360. My estridiol went up to 28.7 from 27.4. But my DHEA was 73.9! I expected this to be like 200 to 300. My last readings including DHEA back in November 2021 was 298. Bad reading or did fasting 12 hours before test affect the outcome? Well im going to kick up DHEA to 50mg a day see what that does.
Update?
DHEA can convert into other hormones. That's why it was low and your other hormones higher.
DHEA is broken down to testosterone. Your body’s doing a more efficient job breaking it down.
Thank you for everything 💥
Thanks for the help
Great answer to that argument about “if this happens naturally, why supplement or intervene”
This was a great resource. Thank you I just had my labs drawn for the symptoms of fatigue and tiredness and low and behold my DHEA was low. My total testosterone was above average but my free testosterone was on the lower side. I’m going to talk to my clinic tomorrow and if they only recommend testosterone replacement therapy then I know they’re not truly a good clinic to be at because in reality they should try the DHEA supplementation first
How low?
I was on a sustained releasing DHEA from a compounding pharmacy that seemed to help with cortisol later.
I’m 38 yr old female n just got back my female hormone test. My dhea is suppose to be in the range 2-19 at my age. Mine came up as .2. On a journey to figure stuff out. Being a women is not easy.
Excellent video Mike… hubby & I live a healthy lifestyle… I’m on DHEA thanks to your past videos 👍. Hubby 60, awakens at 12:30 🕧 & can’t get back to sleep. Retired now so no stress… would you suggest DHEA for him as well? Thanks so much . Could you do a video on TRT for both sexes as we age? 👍
Thank you
Been there and it was so severe my hair looked fried, I had no energy physically, but mind was active. Started on DHEA, 50mg/day, and that reversed it for years, but had to stop because I felt I needed to get back my normal production. C19 caused more hair loss so working on that. Divorce helped.
divorce always helps :-). That's an upstream solution.
Years ago it was found that my Test was low. I was put on Androgel. My Dr swore that it would fix my levels and refused to double check to make sure. When it looked like he was going to lose his license I switched doctors. The new one tested my levels and found no improvement so he switched me to an injectable. At best, my levels were low normal. Ended up eventually going to a fertility doctor and they put me on Clomiphene. That seemed to help some. In October I went keto and incorporated IF. I had my levels tested in March and my levels were high. The lesson I learned is that diet can have a much larger impact than pharmaceuticals can.
Good story, but one point about your conclusion...
Yes, diet itself can have a huge impact on stuff like hormone levels, etc. But so can other factors, such as bodyweight, BMI etc...
And I'm gonna go ahead and guess that if you started doing keto AND IF from October to mid March (5+ months?) you probably lost at least a few pounds during that time, unless you were already at an ideal / low body weight...
And losing weight is a well known method of increasing testosterone levels.
Just saying...
That being said, IF has all kinds of other benefits, from everything I've heard...
@@aaronmerrill4730 I'm not convinced that losing weight impacted my testosterone levels. The reason I say this is that I had mild success in losing weight before and after a 20 lb weight loss, my test levels went down. I agree that body fat itself can mess with hormones but my experience is that diet is much more important. My diet may have been low fat at that point which could have also tanked my levels. Either way, the choice to go keto and do IF resulted in increased test as well as improving a lot of other issues.
I've been taking clomiphene for two months already. Raised my TT from 253 to 582 ng/dl. But my libido is zero. Nada.
@@LuisGonzalez-gb4uh check your "Free" testosterone not just overall test. Also consider taking Primave Shilajit and Shoden Ashwagandha (cycle it) from nootropicsdepot.
Just got my blood results back after being in keto for about 5 months straight. My dhea-sulfate was 630 lol. Very high end of normal. Can't tell if it's bad because I've never tested it before but I feel great. I've read as long as your estradiol (e2), dht, etc. is normal then you're good since dhea can be converted into all that.
Were cholestol through the roof too ? That happened to me on keto, but it took about 9 months to get out of control. But dang keto is playing with fire 🔥
I think I am doing pretty good... I am already past menopause and generally I have a lot of energy. My calves are 12.5 inches around and oddly enough so is my neck! Coincidence?? No idea. But I do have a small body frame & wear XS clothes. I do a lot of walking & carry my groceries home from the store for several miles (which is mostly grass fed meat). I do wake up a few times during the night but I believe that is common for someone who has autism + EDS. Oh and I ride horses, do yoga, mudras and meditate too. No problem walking a half marathon on a regular basis. I like doing the farmer's walk too. But due to the connective tissue disorder I cannot lift much but I do have small arm muscles from the farmer's walk.
Interesting on the adding berberine to DHEA supplementation if insulin resistant. I was hesitant before at taking DHEA because of this as well as how it can also fuel estrogen. I was thinking more DIM + DHEA but if berberine is sufficient I already take that (plus exercise, diet and IF)
Lol “I can’t under emphasize this enough”
Thanks for this stuff, mike, really appreciated. Started taking DHEA about a month ago (left comments under another Video of yours how to get the stuff in Europe) and so far its very promising, i feel pretty good, substantially increased mood, higher activity levels, increased libido ... and that could very well be the DHEA (or spring, who knows, haha).
I understand I'm a bit late with that question, but: does taking external DHEA affect the glands? Do they shut down even more, like it happens with external Testosterone? Thanks in advance, greetings from Germany 🙂
I dont understand Europe, why is so much stuff banned? Who the h3ll gets to decide? Why do you let government pricks treat you like children? I have DHEA at a store down the street, the same place I buy my chocolate bars and Red Bull. Of course last week I also bought a gorgous lever action 357 rifle so... I think you Europeans need to vote your governments and whole lot less power and a whole lot more freedom for yourselves. You are a democracy, right?
@@BenMJay with DHEA, the explanation is quite simple: drugs need approval, there must be studies that prove the efficacy, look for side effects, etc. And that hasn't happened with DHEA (yet), there's probably not enough money in it, it's not a patentable super drug that you can sell to people for a lot of money. It's not a patentable super drug that can be sold for a lot of money. It's also not a bad idea that companies are monitored during production, that they are forced to enforce a certain level of quality management, etc.
That there is a lot of bureaucracy, a lot of officials who introduce some wild regulations is clear ... where do you come from that this is better with you?
@pfote65 Can you share here where you got it from?
Just wondering if you can give advice for those of us who have to work third shift. What are ways we can optimize our health, what supplements would be beneficial and how we can have good sleep hygiene?
Yeah, I get up at 3am and telling me to get morning sun has become a very unfunny joke.
Switched things up a few weeks ago. Stopped taking all my supplements that have Bio-Perines in them, and added in Creatine & Tong-Kat Ali. Feeling a little better and more energized. Hopefully I will see more muscle mass soon. Might cycle DHEA back in again. It's been a good long while.
Quit the 20z. can of White Claw every night, and I'm sleeping much better with D3/K2 & Magnesium after dinner. Now, if I can just kick the coffee habit...
Coffee is the last weakness for me, too. I have no problems with cravings for carbs. But that coffee man......
haha was doing coffee every single morning - I'm on day 3 without it today. no headaches or anything so that's good and I really just forget about it once it gets to lunch time so not bad
Don't Drop the Coffee, just do Intensity Training with it for the DHT, than do Tong Kat with Pine Pollen or Pine Nuts, but Cycle that Pine stuff... I would say 5 days on, 2 Off, 5 Weeks on, 2 off, 5 Months on, 2 off, at most...
I am 5 weeks on decaf, looking forward to being off it entirely in the next 2 weeks!
thank for this because I have a doctor who is so against this and I know this and it's hard to find a doctor in my city who will treat this exact problem. Are you a naturopath?? can we talk. I appreciate this very much.
Google Functional Medicine doctor in your area or find someone who can see you virtually.
Is adrenal pause also known as adrenal fatigue?
Been watching you for awhile. 2yrs ago DHEA-S was 184. Been take DHEA supplement for over a year DHEA-S now 432. Should I be concerned? Thanks, Mike
My morning cortisol is very high but my DHEA is as well as my testosterone. Oh and my estradiol is very high.
Should we consider Adrenal cortex extract instead?
Any thoughts on Tongkat Ali?
Hey Mike, what do you think about some of these studies and people who are saying that saunas are destructive to sperm count and quality
Prolonged high heat is not good for the sack
So both products in your “alpha stack” are bedtime items now?
All 3 elements and am Cortisol were found to be low on me. Shocked because I’m a good eater and I work out 6 days a week. Age 60. I cannot wake up in the am and if feels like I’m on a sleeping pill after 8 hrs of sleep. Sweating!! Weight gain. Lightheaded, dizzy. I’m wondering how much getting black out curtains impacts the morning light issue.
I had my right kidney was removed at 17 due to kidney stone damage caused by a hereditary disease, I don't digest cystine, I am now 60 a female, i have no sex drive haven't for years, is it because I am missing one of my adrenal glands? The last 10 years I have been good with my diet and get good exercise, do you recommend any supplements that could help? My biggest problem is sleep, I usually fall asleep easy but have a hard time sleeping, really good night is 6 hours and usually very broken up, lost most muscle tone, 5'7" and 145 pounds.
If you have low cortisol and high estradiol is it okay to supplement with dhea?
I did the DUTCH test and its flawed for sure. I did serum tests prior and after and serum test were low on male hormones both times and dutch test says im high on male hormones.
Can we increase DHEA naturally?
If we take DHEA will it lower our own production?
My cortisol is too high in the morning. My melatonin is also high in the morning. My ACTH is too low. Any suggestions?
I take 10 mg daily in the morning so far im feeling better with my menopause im 52 the only thing is my insomnia
Is there anything that I can do, or a supplement, which stimulates/supports more production of DHEA? Instead of simply replacing with DHEA with a DHEA supplement??
should DHEA be cycled? one week on one week off or some other time frame?
If glandulars are all bovine based, what alternatives are there?
Scientists come up with (sometimes) with the funniest names for conditions haha
Dhea supplement seemed to make my low libido worse. Is it raising estrogen or progesterone levels?😮
If people were sick of your videos haha they wouldn't make it far enough to have heard you quote them hahahaha I don't think I share any other channel's videos as much as I do yours
The problem is that the DHEA pathway has been shown to be erratic and there is no good consistent literature on use and dosing of DHEA. The literature gives undertones that supplementation should therefore be with caution. Please advise.
There's good literature on dosing, but it's best to ensure people test and not whimsically take.
While you're kind of wrong I told my endocrinologist what you said that taking DHEA will raise a woman's testosterone she told me it's fine to take a small dose of DHEA but she also sent a prescription for compounded testosterone a very low dose because my free testosterone is low she said DHEA will not get my testosterone to a good level. So it's best to get blood test find out what your low on and consult a professional she did say 5 to 10 mg of DHEA for a woman is fine
👍
Perfect. I just had to make my doc order me tests. Both low. But estrogen high.
I do 25mg in the morning and 25mg at night. Will that work ?
There is evidence that suggests a predominantly plant-based diet may help regulate DHEA as well as other hormones. A controlled experimental diet study found that plasma levels of DHEA were higher in the subjects who consumed a vegetarian diet than those who consumed a diet of meat-based protein.Sep 27, 2021
Lol give it a rest
Taking DHEA has been linked to prostate cancers?
Do you have any info on PMDD? I
Do you think testosterone is indicated in PMDD? I have PMDD and my estrogen and progesterone are normal but low dhea and testosterone. I feel great just before ovulating and noticed on my dutch test testosterone rises then. Wondering if the PMDD is low testosterone in relation to E and P during that time of the cycle
my DHEAS is 8.5 umol/L is that good or bad??? I'm 36 years old and suffer with brain fog and fatigue.
Doesn't Pregnenolone (the true "Mother Hormone") go on "pause?" Why not replace Pregnenolone?
Do lifestyle things like coffee, which raise one's cortisol affect adrenal glands / adrenopause?
Chronic stress, poor sleep and circadian rhythm dysfunction is the issue with adrenals IMO
@@Highintensityhealth Thanks!
I'm 36 years old, last year was a really rough one for me. I already live with Generalized Anxiety. And after my rough year, I felt like my antidepressant wasn't working. My doctor changed my antidepressant. I felt good for like 3 months until it drops so bad. He changed my dose. Dind't do nothing. I went for check, for my hormones. Progesterone was low, testosterone was low, DHEA-S was low, my Cortisol was ''ok'', Vitamin D was not really high, too. Now, I'm treated for Progesterone, and I see an improvment but not a biiiig one. This week, I'm going to be treated for my DHEA and Testosterone. Do you think I could also add Adrenal Glandulars, too??? Thank you for your answer!
update?
I take 30 mg of Prenenolone (the "grandmother of ALL hormones") time release 2 hours before bed 3 days a week on workout days.
My understanding is it will then convert into the other hormones my body needs with excercose, sleep, healthy nutrishtion, etc.
I'm slleping better, stress is managed, focus and brain functions have improved, energy and improved sence of wellbeling.
Please comment...Thanks
Just got my saliva cortisol plus DHEA levels back; paid out of pocket. DHEA is on the low normal side 2.2; ref range 2-23. Morning cortisol 7.8 morning (range: 3.7-9.5; noon: 1.8 (range: 1.2-3.0); 5pm: 0.8 (range: 0.6-1.9); and bedtime: 0.5 (range: 0.4-1.0). I have the most energy during the morning, and fatigue sets in around noon. I used to have insomnia. ACTH was tested a year ago, showing 7 without stimulation. I’m 44.
Gosh. You look so young!
@@King311___ Thanks. I’m 45 but ppl think I’m in my 20s. They, also, think my 16yr old daughter is my sister.
I already have low testosterone & low cortisol :/ Im 28... But my dhea is super super high (i have pcos)
I heard the dutch test was a scam..is it or is it not🤔😣
Taking 200mg of Dhea supplements an my test results still in lower part of test range , trying to figure out why it won't increase my Dhea levels
Ps cortisol is high and testosterone low
Any ideas?
I'm a female, nearly 54, and have been dealing with debilitating adrenal fatigue/ chronic fatigue, whatever it is, for 4 years now. I have no quality of life, zero capacity to do anything I.e. a shower completely exhausts me.
I am well through menopause. My body broke down 6 months after a nervous breakdown and developing c-ptsd.
My dhea levels have been very low for years and my gp can't get them up. We've tried dhea troches, no improvement. Pregnenolone, which is meant to work with dhea in a different way? No improvement.
I've avoided specialists till now because I think mainstream think dismisses too much, but I really need to get my health sorted and I need to get my life back, and the various supplements aren't cutting it.
My understanding is an endocrinologist looks at this area. Is that who you'd recomend for an official diagnoses of what's wrong with me?
My thoughts are get a diagnosis, and then go and see a functional medicine team and get their help fixing the prob, rather than have a standard doctor just shove drugs at me.
Can women with low estrogen and women w low testosterone take DHEA? Or pregnenolon?
yes, the body will convert it into what it needs.
I got immediate high blood pressure when I took DHEA supplement, is this common?
research it....
@@annaburns5382 thanks mom
I take 25 mg of dhea, I'm 66 and work with a "keto-doc" - specialist in integrative medicine
......7Keto being a safer form of DHEA. DHEA is a banned item here in Canada so we are forced to use DHEA's precursor Pregnenolone which is doing the job quite well.
Dosing for women in menopause or after menopause question I wasn't clear if you is there if you were advocating 25% of the man's dose or 25% less than the man's dose
25% LESS than the man's dose. Women peri or post start at 5 mg or 10 mg. Go slow.
55 yo male, just started taking 30m dhea per day. Feel like my mood and energy is a little better but it is being negated by my sleep being affected. I find my mind is more active at night and I'm having crazy dreams, so waking up feeling tired. Anyone have a similar experience with dhea?
He said 10 mg per decade so you could try 50-60 mg. If you take in am, take at night. If you take at night, try in the morning. I am glad to hear you say you're getting dreams because I never dream. Usually a sign of getting deeper sleep but if you feel less rested, that doesn't sound good. Maybe taken 12 hours earlier or later, the dreams aren't so tiring.
I have very high / out of range DHEA, but slightly low testosterone? Does that make any sense. What could be going on?
This isn’t common but I do see it. Are you male/female and what’s age?
@@Highintensityhealth I'm male, 32 years old. I've been unwell with a strange issue with extreme thirst, dehydration and fatigue for a few years. I do not have diabetes. All bloods are normal other than high DHEA, intermittently low testosterone, and slightly high creatinine (probably because I'm dehydrated no matter what I drink).
@@swamphawk6227 That's what was suspected initially but I've multiple tests for that and even tried Desmopressin the replacement hormone. It's not Central DI or Nephrogenic DI.
check e2 and free t.
@@friedux2065 e2?
What are your thoughts on 7 Keto DHEA? 100 mg BID 63 years old active lifestyle like 20k steps a day abs 30 minutes of HIIT daily with body weight and various weights. I feel great often but I occasionally crash. Hard. I often experience the inverted cortisol response you have described
Hi Tim! Not a fan of 7 Keto DHEA...IMO probably best at your age to just hit 100 mg in the evening of a micronized DHEA. My 2 cents.
You’re overtraining… that’s the main reason
Dhea gives me terrible acne and mood swings. Tried a lower dose and there is no work around.
Interesting, what's your gender and age?
Take it with DIM
I don't know what's worse. Dry thanksgiving turkey or vaginal dryness.
Agree, neither one is good!!
Chicken is better, a dry vagina is no bueno
I am turning 70 does that mean I take 70 mg
Correct, try 50mg first. DHEA is sold in 25mg, 50mg and 100mg
Mike I challenge you, Do you even understand the correct kind of DHEA to supplement? I don't think you do?