Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes, Obesity & Chronic Disease
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- Опубліковано 24 вер 2024
- About the guest: Robert Lustig, MD is a physician-researcher and expert of metabolic health. He is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF), specializing in neuroendocrinology with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes.
Episode summary: Nick and Dr. Lustig discuss the true causes of obesity and metabolic discussion; how the in utero environment during pregnancy leads to multigenerational effects on health; different forms of sugar like fructose vs. glucose; different dietary fats like omega-6 and omega-3 PUFAs, and saturated fat; oxidative stress & mitochondria biology; how temperature, altitude & oxygen affect obesity; processed foods and how industry influences public perception; body positivity & public education; insulin, diabetes & fatty liver disease; statins & cardiovascular health; and more.
*My content is never meant to serve as medical advice.
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#metabolism #fasting #science #biology #medicine #food #health #exercise #stress #podcast #obesity #diabetes #fat #sugar #disease #inflammation
0:00:25 Intro
0:05:21 Placenta's role in fetal development & exposure to environmental toxins
0:10:20 Fructose & obesity
0:16:21 The browning reaction and its impact on health.
0:21:16 Fructose and glucose metabolism, addiction & obesity
0:26:40 Omega-6 fatty acids & health.
0:33:04 Saturated fats
0:39:00 Saturated fat & cardiovascular health
0:46:56 Statins
0:52:11 Diet & growth, with a focus on type 2 diabetes and statins
0:58:31 Food & obesogens, with a focus on fruit & diabetes
1:02:40 Obesogens in the environment
1:07:18 Environmental toxins & Estrogens
1:12:47 Nutrition & health
1:21:01 Obesity & the unholy alliance of special interests
1:25:51 Improving school meals & education
1:32:05 Limitations of energy balance model of obesity
1:36:43 The role of calories in weight gain and health
1:43:07 Insulin & weight gain in children with brain tumors
1:46:55 Obesity & energy metabolism, with a focus on reactive oxygen species and mitochondria
1:53:49 Mitochondria and metabolic health
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Thanks!
Love this info! It's saving my life!🎉
This is the best of the many online interviews I’ve seen of Dr. Lustig. The interviewer doesn’t trample over him like so many others do. He instead asks pointed questions that allow Dr. Lustig to fully expound on the wide range of his ideas while clarifying matters for the viewer. It is notable for its scope, depth, and pace. Kudos.
Dr Lustig is an American 🇺🇸 hero. His book Metabolical should be required reading for doctors and frankly all Americans who care about their health.
Thanks!
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
No, he is an obese liar.
Such an intelligent, passionate and lovely man. He is so clear that he makes everything easy to understand. Thanks Dr Lustig
Thanks!
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
Dr. Lustig improved my life for the better, more than any other! Truly the GOAT in nutritional education! Long live Dr. Robert Lustig!
Great to hear!
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
Thank you Dr. Lustig for your sustained heroic efforts to educate us about the dangers of ultraprocessed foods and the obesogens in our enviornment. You are making a difference.
Thanks!
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
I've been following the work of Dr. Lustig for 12ish years. I continue to learn from his books, interviews, and talks.
I've given his books to quite a few people and send links to interviews like this often.
He's had a major positive impact on my life.
Thanks for posting this interview.
Glad to hear it. Some of my other content on diet & metabolism may be of interest to you: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
@MindAndMatter Thanks, will do.
I'm always trying to separate the wheat from the chaff, so to speak :)
As a EE with 40 years as a software engineer, including quite a few years in biomedical, I'm fortunate to have the ability to grok complex systems across myriad domains for which I have little to no previous knowledge.
I have a deep appreciation for people like you, Dr. Lustig et al. who have the ability to communicate clearly to the layman as well as the most highly educated.
Thank you, Doctor Lusting for the real science and your humanitarian mission! The way how you explain complicated things is just brilliant! I wish you a long active life!
You maybe be interested in this written content, where I summarize this and other, related podcasts, and synthesize some of the key insights together: mindandmatter.substack.com/p/why-are-we-getting-fatter-part-i
One of the best podcast with dr. Robert Lustig, thank you! He is briljant and has amazing broad knowledge and memory.
What can I say . Just love listening to him over the last few years ❤x he makes so much sense.
Thanks!
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
Thank you. This is the best interview with the most detailed reasoning interview with Dr. Lustig.
Thanks!
mindandmatter.substack.com/
Have listened to many discussions with Dr Lustig, and this is by far my favourite. Thank you for the interesting, and relevant to many questions.
Thanks! You may also enjoy my written content: mindandmatter.substack.com/
Rob is a rockstar of his field.
Robert Lustig for US FDA chairman.
You may be interested in this written content, where I summarize this and other, related podcasts, and synthesize some of the key insights together: mindandmatter.substack.com/p/why-are-we-getting-fatter-part-i
Brilliant. Thanks. I've sent this to so many people to watch. Very much appreciated.
Thanks! mindandmatter.substack.com/
There is a remedy, well, there are two remedies. The holistic approach, which is diet, exercise, herbs and supplements, fasting, 😮saunas and cold plunges, etc.
The platinum approach is plasma exchange, which can even remove plastics. But it costs about as much as a new car.
In either case, you work to reduce your exposures by removing all unnecessary chemicals from your home, clean with baking soda and vinegar; get a water filter for your kitchen….cut down on plastic containers for food storage, get bags that aren’t plastic.
All of us should do everything we can to clean up our own space and share information about the problem.
Education is essential.
@ 44:00 talking about the LDL, My lipids improved dramatically after cutting carbs and replacing them with healthy fats (including saturated ones)
True, my LDL is high now, but mostly type A, compared to type B I’ve had before. And I’m insulin sensitive now, compared to insulin resistant before.
I run a Labcorp NMR blood test every so often to measure all of this. Oh and I lost weight too.
Are type B the small dense ldl .(and type B , the large bouyant )? .Even your minimal amount of type B will not Glycate or oxidise in your endithelia (artery walls) if you don't eat processed food (with seed oils/added sugars/refined carbs) .
It was an interesting and refreshing interview with Robert Lustig. Lots of things he's mentioned he mentioned elsewhere, but there were a few new ones, like he's recent work on the models of obesity. Thanks for having him.
Thanks have to go to the Mind matter podcast producers for an excellent interview❤
Thanks! mindandmatter.substack.com/
Thank you for the amount of great information provided! I Always learn something new by listening dr Lustig
Thanks! You may be interested in this written content, where I summarize this and other, related podcasts, and synthesize some of the key insights together: mindandmatter.substack.com/p/why-are-we-getting-fatter-part-i
"Do something about it ... VOTE ... this is a voting issue ". Just love this advice 👏🏽👏🏽👏🏽. There's plenty of other fabulous advice in the podcast too. THANK YOU!
Like AA I have to stand up introduce myself and say “I am a sugar addict” 71 years now! I have listened to Dr. Lustig several times working on absorbing the science. One question is he keeps talking about “ultra processed food” What about processed food? Is there a distinction he should be defining? What about phytoestrogens in soy aka tofu…Are they obesogens, breast developers?
Meanwhile I need to memorize and fully understand these fascinating metabolic mechanistic pathways and make the change as much as I can! Its righteous work and I love these interviews with him😅
In the last 2.5 years, I have been watching dr Lustig pretty much daily in order to learn and retain that he and other doctors are presenting. At some point, the light bulbs start turning on and it is a revelation indeed.
Single Ingredient foods are the least processed.
@@SharoPeikof Of course, my lightbulb is on bright, making the changes to lower insulin. I get single ingredient food low processed. My question is around frozen organic dinners in supermarket like amys or others that are mixed vegetables, tofu, cheese, chicken. I wanted to know if HE considers them “Ultra processed foods” as opposed to McD’s fast foods? Wished he would have discussed range of processed foods if any acceptable, or if HE feels only whole unprocessed foods Good 👍 luck
For 20 years dr Lustig has been trying to circumvent the establishment and pass on his extraordinary knowledge to us all. No one can boil down complicated information the way he does….,,example “if your triglycerides are high then your LDL is the wrong kind”. This man was a God Sent to us all - rich, poor or in between he is trying to educate anyone that will listen. That’s why I call him AMERICAS DOCTOR :)
robert lustig and i disagree on the role of government. the only purpose of government is to protect your rights. it isn't to regulate your existence.
In an idealistic world that would be true.
I believe the sugar industry paid for Ancel Keys grant to do that study. I could be wrong, but I believe they cover that in a documentary that is available to watch here on UA-cam for free.
The documentary is titled ‘sugarcoated ‘ and everyone should watch it. That’s how I found Dr Lustig. He is in the movie.
When I tell people that in my quest to become more metabolically healthy, I realized that fructose was one of the substances that was pushing me down the road to more and more pathology. Now I only consume sparing amounts of strawberries and blueberries. My over consumption of watermelons, melons, oranges, apples, dried raisins and cranberries etc are over. Thank God, I stumbled on low carb / ketogenic pathways when I did.
Great questions for us T2 diabetics. I'm always interested in what the recommendations are for us.
Thank you for the interview. You ask great quick to Dr Lustig. I will subscribe to your channel ❤😊
Thanks! mindandmatter.substack.com/
It's never ever been about calories. You cannot eat heat energy! It's all about Mass in mass out. Calories are mass less, and is only a term pertaining to closed systems. Humans are open systems. it has nothing at all to with calories...nothing at all. It's all about MASS IN MASS OUT...make sure you understand this....
Take a litre of boiling water and measure it on a set of scales...record its weight. Then let it cool down to room temp say 20 degrees celcius. Record its weight.
You will see that its weight has not changed yet its temp has by 80 degrees.
Therefore its lost 80kcal but kept its weight....it proves that calories have nothing to do with weight.
Secondly if you use the figures for protein, carbs and fat in terms of kcal
1gm of carb is 4.2kcal
1gm of protein is 4.2kcal
1gm of fat is 9kcal
But swapping it around you get
1kcal of carbs is 0.25gm
1kcal of protein is 0.25gm
1kcal of fat is 0.11gm
This explains why Low carb effectively works
Why?
If you are eg on a 2500 kcal daily intake using the "calorie" model on both low carb high fat and high carb low fat YOU ARE TAKING IN LESS MASS by swapping carbs for fat....so you will lose body fat. So Its MASS not CALORIES that matters...I hope you are clear on this. Obviously there are many other factors at play like insulin and grehlin among others but from the food intake perspective its MASS at play not CALORIES.
Each time we breathe out, we are releasing MASS into atmosphere along with water, tears, sweat, ketones, etc...poo..all have MASS.
Brilliant information that will take some time to sink in for all.
Thanks - you maybe be interested in this written content, where I summarize this and other, related podcasts, and synthesize some of the key insights together: mindandmatter.substack.com/p/why-are-we-getting-fatter-part-i
I see in this the fact that you cant convince most people against their WILL. BUT individual s will SAY. ME AND MY HAPPY GUT BIOME WILL LIVE MEDS FREE AS LONG AS POSSIBLE. Thanks to wonderful people like YOU. Thank you for doing GODS work.
I wish there was a way to KNOW if the olive oil I buy has been adulterated or not. I quit buying it because I have no way of knowing for sure and I keep hearing how all of our olive oil has been cut with cheaper oils here in the U.S. I absolutely do not trust our food system.
Yeah, I seen a podcast on it, don’t remember which. You may want to do a deep dive….
I am very diligent about pure unadulterated olive and avocado oils. I buy my oil from sources where I can return them and receive a refund if I find they are not pure. Once I purchase them, I pour about a half cup into a glass jar and place it in the refrigerator. If the oil remains liquified in 24 to 48 hours, it has been adulterated. I buy only extra virgin and first cold pressed. Unfiltered is acceptable but I prefer filtered. I buy many oil products from COSTCO because they vet their vendors and keep them honest by testing their oil content regularly. I also will call the manufacturer of the product and quiz them on their resources and processing techniques. But the refrigerator test is my best analysis for unadulterated avocado or EVOO. Hope this info helps.
@JulieRolhoff I am also weary of the EVOO, if they are altered or not. I have learned that single country or single farm origin are better and less altered. The fridge tip in this thread is also good
Your my hero you justify my liking to eat RAW NATURAL FOOD along with pescatarian benefits. in my omad or sometimes 2 mad diet. It suits me to be too lazy to cook evening meal and then suffer indigestion when sleeping. I sleep very WELL now. Since on this lifesyle I can now breath through my nose at night instead of waking dreaming I am smothering. All this thanks to doctors like you wonderful people. cheers from this 73 y old.
I grew up in the era of DDT and we did use the wonderfull teflon coated frypan. None of my familly got Cancer.
Excellent information.
Thanks. You may enjoy this written content: mindandmatter.substack.com/p/why-are-we-getting-fatter-part-i
Please moderate a debate between Dr. Lustig and Dr. Layne Norton. Layne has already put out a video debunking some of Lustig’s claims, but what I think needs to happen is a head to head confrontation or it’ll just be a back and forth, back and forth.
I've had LN pop up on my feed.
His creds aren't all that, but I'll check out his 'debunking ' video with an open mind.
Lame Norton is a joke. Got his phd from the back of a cereal box.
1:12:10 what paths for the public 1:14:50 Doctors, "who are you patients to lecture me" 1:19:23 what we laymen do ay home
1:45:10 insulin and obesity
1:56:05 other professionals worth reading about and listening to.
He’s right! The only candidate who is addressing this, is Kennedy….
obviously in my experience beetwix is the only cereal I will TRUST
1:46:00 😮 Energy Models: 1) Calories in Calories out 2) Carbohydrate Insulin Model 3) Redox Model 4) Obesogen Model -- Target ROS
Does the carbon-13 in corn and the kinetic isotope effect figure into how high fructose corn syrup affects metabolism?
Hypothesis: (1) Omega-6 fats are essential for humans in small amounts --> (2) Omega-6 fats were somewhat rare and/or seasonal in the diet 200+ years ago --> (3) Humans adapted by avoiding using Omega-6 fats as fuel, to preserve the valuable resource --> (4) Humans adapted further to store nearly all Omega-6 fats above the small required amount in body fat as a reserve source in times of shortage. The combination of hidden added factory seed oils and high fructose via added sugars, at 50% of the diet, seems to explain obesity for basically everyone who eats mostly processed food.
Spirulina and cholelia are algae and very good supply of omega 3 s I know of someone who ate only spirulina 3 times a day. He was superbly fit. and pumped iron. Spirulina is the algae the fish eat. We eat the fish which also gives protine
Can someone therefore tell me why sleep apnea is though to be a cause of mitochondrial dysfunction that causes cancer? Ref. Thomas Seyfried
Obstructive sleep apnea causes lack of oxygen that mitochondria need to produce energy. When oxygen is missing, mitochondria switch to anaerobic metabolism. Anaerobic metabolism is how cancer starts. Ref. Thomas Seyfried
Low oxygen and N.O.
I read body temperature came down because people have fewer chronic infections?!
Because people have poisoned mitochondria. That's why.
I used to take 20 mg. statin daily without having any heart attack event but I started having a very severe spondylitis and neck hardening for 2 years i dont know where this came from. I am regular gym goer . When I was reading articles on statin and found that statins give very back pain as side effect.I am taking only know 5 mg and I got rid of my back pains
Have you ever taken a fluroquinalone antibiotic like Cipro by chance? That drug has destroyed me but I’m working on healing with Dr. Lustig and other doctors’ advice.
Wondering if Lustig has low triglycerides high hdl ? curious because im on statins, because my ldl spikes without statins, even on a keto diet. trig 88 hdl 58 ldl 126 on 40mg statin
33:26 saturated fat is neutral, neither good nor bad; 40:00 2 types of saturated fats: red meat saturated fat (neutral) and dairy saturated fat (cardio protective), 52:31 type 2 diabetes
Lies
Now I have to modify my keto omad into 2 mad so I put a bit of weight back on. I built houses for 50 years eating good old beetwix and milk at 11 stone which I feel good at. So niw can anyone tell me what vegies for this pescatarian learner
Can we convert DHA to EPA?
we are betrayed by industrial greed
I have an issue here. My Total choles=200 mg/dl (more like 175 average of 20 yrs) , LDL=130mg/dL, Trig=47 mg, HDL~50 mg/dL. VLDL ~10 to 15 mg/dL all 20 yrs. Mostly veggie+oils+some dairy (very less trans all 20 yrs), D2M for 20 yrs but always A1C of 6 to 6.2%. NO MEAT, Why I have a CAC score of 3000 now? is it just the omega 6? I think most DOCS don't have any clue under what conditions, PLAQUE is formed in arteries other than in extreme conditions. I can't be considered as extreme under any circumstances. BMI always 23-21, BP 120/80 for ever.
Maybe carbs. Maybe not enough MK-4 given your diet
Suggest MK-4 MK-7 the western price foundation. And getting into actual ketosis with glucose Leone ratio less than 2 at least a couple of days a week based on what our ancestors likely did.
It's the insulin likely. So you have to reverse your diabetes pronto. Talk to Dr Ken Berry and Dr Ovadia
Seed oils cause heart damage
@PiujuqInuitArt
Probably using speech to text, but I'm sure it was meant to be Weston Price Foundation.
The saturated fat you didn't talk about was coconut. I'm confused by what I read and would have valued Dr Lustig's opinion on this
Coconut oil apparently has a lot of medium-chain saturated fatty acids compared to other sources of saturated fatty acids. These may have different effects on everything from cognition to lipid profiles compared to longer-chain SFAs. Here's one paper on the subject: www.ncbi.nlm.nih.gov/pmc/articles/PMC7766932/
"Most studies discovered an association with increased risk of CVD and long-chain saturated fatty acid intake, as well as a neutral (potentially beneficial) association with short- and medium-chain saturated fatty acids."
www.ncbi.nlm.nih.gov/pmc/articles/PMC9823926/
There is no mention of choline and leucine in red meat and their role in CVD. That's the reason red meat is an undesirable food. There is also no mention of vegetable protein and if its better than animal protein. Perhaps that can be a follow up video on the missing topics.
Animal protein is more absorbable and has an amino acid distribution closer to that of our tissues compared to plant protein: www.mdpi.com/2072-6643/11/8/1825
no amount of mental gymnastics can rationalize a vegan diet.
there is 0 evidence to suggest red meat is bad in any way shape or form.
there is 0 evidence to suggest red meat is bad in any way shape or form.
plant protein is still inferior. whether you like it or not.
there's no mention of it precisely because it's pure rubbish.
it's false.
Children eat what their parents bring home
Children eat food brought to the cafeteria from school
Kids eat what kids in TV commercials eat too
Children are children
If kids are fat who's fault?
Pescatarian diet is best middle middle ground for most people
What about mercury from polluted ocean water ?
@@kenadams5504 What about cadmium from cocoa, arsenic from rice, pesticides from vegetables and fruits, mycotocsins from grains and peanuts and PFAS from drinking water?
Yahusha bless you !!!
Dr list of please follow Dr Kahn n Dr Furhman Dr Gregors way of eating and you will be off your statins God bless
"dr" greger... (who's not even a doctor)... what a joke.
disappointed by his opinion on statins...
Get the mic further away from your mouth and more to the side. You can talk to the pop filter but set a greater distance between it and the mic.
01:53:36 -🖐🎤
Humpf ... 👁👄👁... 🕒 ...
I’m 😊😢😅😅😊 1:02:09 1:02:09
Keys was great scientist!
Fatty meat and water. It's simple. I can stick to it. It works. Love Roberts explanations of the mechanisms, if only I could remember 20% of it😊
Ha. Right?
You should live in a cave and eat bone marrow too.
@@truthseek3017 Bone Marrow yum😋 I eat it every week.
In love with Robert ❤️
You might enjoy my other content about diet/metabolism/nutrition: substack.com/search/diet%20metabolism?focusedPublicationId=513528&searching=focused_posts
Stellar advice…. I try to keep to it most of the time. 🫤. I love grapes. Real, fresh and juicy …. And also in the form of wine …