Dr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44
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- Опубліковано 1 лип 2024
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In this episode of The Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International Journal of Obesity, dissecting specific obesogens like bisphenol A, phthalates, and glyphosate, and examining how different foods and lifestyle choices can mitigate their effects. This episode is a must-listen for anyone interested in nutritional science, metabolic health, and the future of obesity research.
About Dr. Lustig
Robert H. Lustig, M.D., M.S.L. is Emeritus Professor of Pediatrics in the Division of Endocrinology, and Member of the Institute for Health Policy Studies at UCSF. Dr. Lustig is a neuroendocrinologist, with expertise in metabolism, obesity, and nutrition. To learn more about Dr. Lustig, please visit: robertlustig.com
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Referenced Papers:
Obesogens: a unifying theory for the global rise in obesity: www.nature.com/articles/s4136...
Do We Need a New Unifying Theory for Obesity?: academic.oup.com/endo/article...
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Dr. Robert is an encyclopedia of scientific facts and has no problem exposing the corrupted food industry and educating the curious.
I like both of you a lot but DUDE! You’re interviewing Dr. Lustig! Let him talk. Your interruptions are highly irritating.
They're not corrupt they're trying to make money. That's what companies do. If you want corrupt, look at the American Heart Association and the American Diabetes Association. They're supposed to be looking out for our health, but they're taking money from the food industry.
Dr Robert is more like the new MCAT's though in that now it's all about Critical Thinking and less of Memorizing Terms (Questions will often be defined in the Passage)
Once again you have presented a treasure trove of data points and critical information that each of us really do need. Thank you!
We're so glad you enjoyed the episode! Thanks for watching!
Thank you very much, Dr. Dom and Dr. LUSTIG for this insightful podcast. I can utilise the insights well in the case report I am writing about a man who after 10 years of battling,, overcame his obesity through lifestyle changes . Looking forward to your next podcast in which you both share your wisdom. Best wishes, miss Reimara
I want to put it out there that everything dr lustig says, explains nicely everything what i have been trying to figure out about autism for my patients. So many things that we are doing, are not just making adults sick but kids and even the unborn. We need to change the diet in pregnancy and the first 30months of life.
I'm very pleased to hear Dr.Lustig's comments on the carnivore diet. I was curious.
Another great discussion of metabolic health. Several years ago, there was several articles stressing the benefit of complex 2 vs complex 1 entry into the electron transport chain in the mitochondria, one benefit being less ROS formation when the complex 2 entry is predominant. This concept seems to have disappeared from the metabolic health discussion. Is the concept of improved metabolic health when complex 2 is predominant valid?
the biggest cause of oxid stress and ros is excess, unbound iron due to a lack of regulation and recycling from bio avail Cu, ceruloplasmin and ferroxidase
Question: Regarding infant average weight, do they take into consideration the number of surviving preemies today? If they exclude them, then the average weight is actually way higher than half a pound.
Very interesting and informative podcast, great guest! It was hard to follow for a lay person, but I managed to get some interesting information. Needless to say the story about NESTLE made my blood boiling.
Can we get to the point please?
Obesogens mentioned here are factoring into the obesity crisis. It is NOT clear to me of their magnitude, but some people seem more vulnerable. Importantly, food selection, exercise, and lifestyle choices can largely mitigate their effects.
Link to the Kevin Hall paper that's mentioned?
www.ncbi.nlm.nih.gov/pmc/articles/PMC7946062/
npc1 L1 what is this? Even R.Lustig as humble he is, told us ´I didn´t know this.´ Why so many interruptions by Dr. Dom?
NPC!L! causes cholesterol hyperabsorption ((target of Zetia) www.ncbi.nlm.nih.gov/gene/29881 Agree, rude on my end, should have let him speak more.
Would’ve been super interesting if Dr Lustig wasn’t interrupted that much. Sorry.
Can you let dokter Robert speak please! 😒
Apologies, rude of me, but appreciate the feedback
thx
Omg, stop man, let the guest speak!
Is it generally acknowledged that DAGE’s can pass the digestion system and become problematic regarding ROS/ redox processes?
Too many adds!
Only 15 minutes in and this podcast and i need to comment . You need alot more definitionof terms for the lay person listening. I have fairly strong science background and I am have ng trouble: what the heck is NNT????
Good feedback. We will work to define terms up front. NNT = number needed to treat
@@DominicDAgostino Thanks for definition of NNT. I should have known that but my brain doesn't do well with acronyms.
Imo, the time I stay on my ketogenic diet is directly proportional to how much my health symptoms disrupt my life ,when I stop keto/carnivore. (and I'm 21 months on a ketogenic diet.) Keto for a health condition is different to keto for weight loss etc. .Please don't hesitate to start keto if you have a health condition ,because you will find the motivation to sustain it when it helps significantly ....,I assure you.
should have spoken lesser and let robert speaks, so distracting
Really, Dr. Lustig? Nobody can sustain a ketogenic diet for more than two months unless they are doing it with medical supervision? With no qualifications at all of that statement? There are hundreds of thousands of who are doing just that, many of us not only without medical supervision but contrary to the advice of our clueless physicians.