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DHEA, The Often Neglected Hormone That Helps Against The Effects of Aging
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- Опубліковано 17 сер 2024
- I wanted to tell you a little bit about an often neglected hormone called DHEA. This is a hormone that can be important in aging, and it definitely declines as we age. Peak levels would be in your thirties and then they would begin to decline such that by about the age of 55, you've lost about 60% of your production of DHEA. It comes mostly out of the adrenal glands, although some of it is made in the ovaries in women and the testicles in men. DHEA is considered to be a neuro hormone, it mostly has effects supporting the brain, particularly with mood, memory, concentration, and multitasking. It also assists the metabolism and helps with fat burning to some degree.
For women after the menopause, it turns out that DHEA is the source of all of the sex hormones that your body is able to make now that the ovaries are no longer making them; that includes estrogen, progesterone, and testosterone. For men, DHEA does not convert directly to testosterone, but it certainly does help to support mood and memory.
There are very few side effects associated with supplementing DHEA. It could cause a little bit of oily skin or acne, even a little bit of facial hair growth and certainly if the level was too high, we could start to see becoming a little bit angry or irritable and short tempered, so getting the dose right is important.
This particular hormone is available over the counter as a supplement in the United States, but in Canada, Health Canada regulates DHEA because it can convert to testosterone in women so it is considered an anabolic steroid for women, which is why it's only offered by prescription in Canada.
My usual starting dose for women would be between 5 to 10 milligrams a day, whereas for men more like 50 to 100 milligrams a day. The testing of the levels of DHEA is usually not something that's covered by MSP insurance so be expected to pay a little bit for the blood test if you want it to have your levels checked. If they are low, consider talking to your doctor about going on some DHEA as a replacement to help you with some of the effects of aging.
I use 10 mg a day for my menopause and i love it and grateful i found it🙏🤗
She's works great in low doses for pain depression and energy. Also makes it easier to not gain weight great stuff. Take with amulti v Omega threes plus b complex and also melatonin plus magnesium. It works and will be worth it.
I agree, Michael, the dose is important: too much can make you feel agitated and angry! We track blood levels to avoid overdosing.
Hey thanks for writing this i also heard about these added supplements in addition to dhea im giving it a try but thus far my pjoint pain and mobility has been improving im so very grateful nothing else my Doc gave me worked.
BEEN TAKING 100 MGS DAILY FOR LIKE 4 YRS
New subscriber, starting back on dhea, took in the past, 77 yo male. I supplement & train a LOT.
You might notice a lift in mental performance with DHEA
@@pagdinhealth Thanks, I liked it before but no specific reason I stopped, good channel.
Well said and to the point. Thank you.
Wonderful info! Thank you! Can you tell me what the difference is between DHEA and 7-KETO DHEA supplements and which one you prefer?
DHEA is the “parent” hormone and can be converted into androgens and estrogen. The 7 Keto form does not convert, so I use it particularly in women who get unwanted side effects from DHEA like oily skin or acne. The 7 Keto avoids that.
I take 20 mg per day with a popular multivitamin and I can concentrate easily for 8 hours in conferences or when working by myself, used by itself or at seperate times from the multivitamin it seems not to do much... can't figure it out why. It just is ... so I take the two together.
Also there's a lot less squeaking in my knees when doing squats... I am 56 years. been taking DHEA for 7 years more or less daily, and eat anything I fancy with moderation. As for anti-aging, I look 45 (so I've been told)
As for the estrogen thing... I have noted that with exercise (weights and endurance) testosterone rises... failure to exercise estrogen markers jump way up within 3-4 days.
So I keep active, and the wife is happy. wink.!
I have been educating myself here on YT and the Internet in regards to DHEA supplementation. Side effects mentioned in various places, as to an increased chance of prostate cancer is scaring me off. Does anyone have any reliable information in regards to DHEA and Prostate cancer? Thanks (Ohio)
DHEA does not automatically convert to testosterone, your body decides how to "distribute " whats there.
There is a lot of wishy washy studies done on the correlation of dhea and prostate cancer.
Recent studies on the cancer show aggressive cancer in patients with LOW testosterone. But once a cancer is found blocking natural testosterone helps keep the cancer under control.
Remember. Some people smoke cigarettes all their life and others get lung cancer quickly! Luck of the draw.
@@LabRat6619 Thank you. I now see DHEA & DHEA-S forms available.
Is one form better than the other?
Pregnenolone is a DHEA precursor and is a safer option if you're concerned, you can raise your levels this way but Alzheimer's and other serious illnesses (like autoimmune disease) are associated with LOW DHEA, so it's a coin toss. Do yourself a favor and get tested @ a retail lab (like Ulta Labs, they have a $30 test) before getting started, you can track your levels if you can't find or afford a Functional Medicine doctor.
@@LeTrashPanda Thank you so much. I am on Ulta Labs site now.
Im 60 year man i been taking 100mg of dhea for 10 months i haven't had any side of & had two Dr. Told me to take that much he said it help you better than anything on the market i was considering taking trt he said it was too much of risk to take it gives me ton of energy this morning i missed taking & boom out nowhere a tons of energy it just really unrated supplement 🤯🤯😵💫😵💫
I like DHEA for mental performance, and I like TRT for physical performance. The key is to get your blood levels tested to make sure you are on target. Remember that in men, DHEA supplement makes very little difference to testosterone levels.
100 mg for like 4 yrs now
No side effect
I like to keep track of the blood levels to make sure the dose is correct. No reason not to supplement testosterone as well, if it’s needed, as they do quite different things
@@leelunk8235great - how are your blood levels?
@@pagdinhealth HAVEN'T CHECKED IN MANY YEARS, BEEN OFF DHEA FOR A GOOD MONTH, I HAVE TO REORDER, WOULD LIKE TO KNOW IF IT'S WORKING OR NOT
66 male, PSA was already at 5 for years, increased DHEA from 25mg to 50mg, PSA went to 8 in less than a year. Diagnosed recently with prostate cancer. Can’t say if DHEA contributed to the tumor growth or not.
No evidence for that in the medical literature
I have normal cortisol and sodium levels, but low dheas as 69.0 ug/dl and am 40 yrs old with reactive hypoglycemia
Here in Canada, we measure DHEAS in umol/dL so our range goes from 0.7 to 12.5 depending on age. Your normal range will be approx 30-300, so a level of 69 is fairly low. I am always aiming for the upper end of the normal range, as too much DHEA can have side effects like irritability
Thank you. I now see DHEA & DHEA-S forms available.
Is one form better than the other?
“S” is the form we measure in the blood. The capsules or tabs typically contain DHEA.
@@pagdinhealth Thank you sir. (Ohio).
Great video, I just found your channel. I know this video is old but what manufactures make a quality DHEA? I see so many brand’s it’s hard to choose. Should I select by cost of the product?
I do not have any affiliation with any manufacturers, but in general the better products will be slightly more expensive. I like Pure Encapsulations, Havasu, and Doublewood, but there are certainly other good-quality products out there. In Canada we have our capsules custom compounded since there are no licensed manufacturers here.
@@pagdinhealth thank you!
@@cscott0722 eric serrano along with mark gordon both mention douglas labs sublingual and pure encapsulations brand. i rotate between both of those aiming for 10mg per decade of age (i'm 49 and take 50mg daily). every twelve weeks when i get tested i hover right around the 500 mark.
DHEA!! --- it suppresses Cortisol, take it later in the day and definitely not before workouts.
Both hormones are produced by the adrenal glands. Some studies have suggested that supplementing DHEA will reduce cortisol but this has not been determined for sure. It is true that people with high cortisol levels often have low DHEA, and if they are able to reduce stress and improve (lower) their cortisol, the DHEA also improves (increases). I typically take DHEA first thing in AM.
@pagdinhealth I am post-menopausal I just received a Troche with Testosterone and DHEA , the Pharmacisist said to take it after dinner but the AM seems better so now I'm not sure when I should take it each day, what is best in this case Dr?
Why might someone's DHEA level be at the bottom of the range in their 30s?
Because DHEA is produced mainly by the adrenal glands, a lower production in your 30’s would be related to overall adrenal function. Supporting the adrenals may be all that’s required to get DHEA back on track.
High stress lifestyle, reliance on stimulants, burnout/not enough rest, etc.
If you have low Cortisollevels, DHEA is contraproductive.
Please check first your Cortisol.
Correct: both cortisol and DHEA are made in the adrenals, so if cortisol is low then supplementing with adrenal supports can help elevate both!
@@pagdinhealthsuplementing with adrenal support? What substance is that? DHEA?
@@olijfcadiz4231 adrenal supports include adaptogens, licorice root, and adrenal glandular extracts. Often, we find that supporting the adrenals in this way will lead to improvements in DHEA levels (because most of our DHEA production comes from the adrenals).
Im 28 but i take about 15mg-50mg before and then another after a intense workout. Helps keep cortisol at bay and great for recovery 👍🏾
ever check your blood levels? DHEA has a fairly short half-life, so it's best taken daily. Aim for a blood level at the top end of the normal range. Too much can make you feel irritable!
Hello, thank you for the great information.
Can you stack DHEA with Tongkat Ali or Fadogia?
What’s your opinion?
Thank you in advance for your assistance.
There is no reason these cannot be used together, as far as I know, as they each support different pathways
@Jtrain21 thanks
@@pagdinhealth thanks
I am a 57 year old BodyBuilder who just started taking DHEA supplement. 100mg per day. The Internet says "DO NOT take DHEA for more than two years" So what happens after two years? Just stop taking and never take it again? I want to take 50mg to 100mg per day for the rest of my life. So what is this two year limit, or you will get cancer? It seems silly to only be able to take it for only two years. Then what? Take a year off... then two years on again? Please, anyone help me with some advice. I want to take it for more than two years.
There is no truth to the rumor that you can only take DHEA for 2 years. I’ve been taking it for over 5 years, and I get my blood levels checked every 3-6 months to make sure the dose is appropriate. I’ve actually been able to reduce the dose over time so that I currently need just 25mg daily to keep my levels up.
@@pagdinhealth Thanks for the information. What blood test do I ask my doctor for to check for DHEA levels in my blood? I just had a full blood workup from my urologist but I don't know how to read the results or DHEA was tested for. What do I look for on the lab result? Thanks!!
The blood test is called DHEA-s (that stands for DHEA-sulfate)@@superdave1466
@@pagdinhealth Thanks!! I will make sure I a get checked for that for blood work labs.
Good question I’ve asked the same question, the only theory I can come up with is that maybe after two years the DHEA has reached its optimum in your body and you don’t need it until you feel it’s lowering again!!
Dear, can you let me know what is the best dhea? which brand?
In Canada our DHEA capsules have to be custom compounded, as we have no commercial manufacturers
Hello Dr, I am a 33 year old male who wants to experiment with 25mg of DHEA. I read that it can raise estrogen in males and that is something I am seeking to do, as my E2 is low. Would it be safe to take that dose, without doing any long term harm to hormone production?
The best way to know if the dose is right is to check your blood level of DHEAS. Aim for the top end of the normal range without going over. For me, the perfect dose is 25mg per day but everyone is different. I always keep track of blood levels and adjust dose accordingly. I have male patients on anywhere from 10 mg per day to 150 mg per day.
How much should i take being 31 doc I haven't been supplementing for very long like less then a Year i haven't got it checked but i supplement 25mg capsule a day I've just done some reading?
The best way to know how much to take is to have your levels tested, and aim for the upper half of the normal range. Starting with 25mg daily sounds like a good plan. That’s the dose I’m currently taking.
IVE TAKEN 100 MGS FOR 4 YRS STR8
Hi Dr.
I am perimenopause. I currently using progesterone ( 14 days per month)and DHEA 5 mg every day in cream on my skin. I feel good. Should I use less DHEA? Like 4 x a week instead every day?Please help .
Daily cream is fine. I usually recommend 2-3 consecutive days off each month just to give the skin receptors a little break.
Thank you so much!
how about having dhea in 20% of the range and testosterone in 95% of the range. does it make sense to supplement with DHEA in this case or I may overshoot my T?
For men, DHEA really does not convert to T. For women however the T level can double by going on DHEA!
How much of DHEA does turn into DHT (dihydrotestosterone) in men?
Virtually none, which is why it’s not really considered anabolic in men
Great stuff if you don't mind losing your hair. Both men and women.
It’s not DHEA that’s responsible for hair loss, it’s DHT - we have ways to control for that (zinc, progesterone, etc)
@@pagdinhealth Can you suggest a dosage on either of the above?
For zinc try 40-50 mg per day. Progesterone is by prescription and we usually start with 50 mg at bedtime
@@pagdinhealth Thank you.
My doctor said 25 mg I’m a women age 67 and my levels where low
The usual dose for my female patients is anywhere from 5mg to 40mg per day. I adjust the dose based on blood levels. Too much DHEA can make you feel irritable, and cause some androgenic side effects like oily skin and whiskers.
I was on 25 mg and it didn’t seem to work so I went up to 50
Is there a way to make sure DHEA converts to testosterone and not estrogen?
Yes, Jon. Thanks for your question. In men, very little of the DHEA turns into testosterone so it's not considered an anabolic supplement. To control estrogen levels I recommend a supplement of either I3C or DIM which helps to metabolize and excrete excess estrogen. For women however, there is often a substantial boost to testosterone levels associated with supplementing DHEA and it is considered anabolic for women. It is for this reason that DHEA is not available over-the -counter in Canada.
@@grantpagdin414 Thanks. How much DHEA and DIM would you recommend for a guy who's 71?
@@jonjanus5167 For DHEA I would start with 50mg daily, and for DIM start with 100mg daily. Have your levels checked in about 2-3 months and adjust accordingly.
@@grantpagdin414 One more question: Is there a best time to take these? I've heard DHEA in the morning and DIM at night but I'm not sure about anything.
Afaik Vitamin E reduces the response cell lines to estrogen. Boron helps to reduce the amount of estradiol, a type of estrogen and Zinc lowers estrogen levels by stopping an enzyme in fat tissue (called aromatase) from changing other hormones into estrogen. Grape seed extract will decrease plasma estrogen levels. DIM (Diindolylmethane) can possibly prevent the excess production of estrogen. But I don't know which of these are effective or what dosage you would need.
Whats the difference between regular and Micronized DHEA supplements?
That’s a good question to ask your compounding pharmacist!
Micronized is more potent n gives real results . Always use micronized if you wanna see some gains . 100mg + for muscle gain
Curious if i would benefit from dhea supplementation. I'm 42 and blood work done last month showed dhea at 149 and total test at 319...thinking of trying this before commiting to trt. Be interested to get your opinion thanks
I believe the upper limit of normal DHEA for men your age is around 500, and the upper limit of normal for total T around 900. I would look for ways to optimize both, but supplementing DHEA will not likely move your testosterone at all. A suggested dose for DHEA would be 50-75 mg daily to start, and recheck your level in 2-3 months. Optimizing your testosterone does not necessarily mean going on TRT - we have lots of other strategies for someone your age
@pagdinhealth thank you for the reply and advice. What are some suggestions for raising the test outside of trt? Feel like I've tried everything.
@@danielkunz2393 depending on the age of the patient, we like to try a stimulating cycle using hCG 500 units three times a week and Clomid 25 mg three times a week for cycles of 12 weeks at a time. Other important factors of course include reducing stress, getting proper sleep, optimizing a fitness routine , and a couple of nutritional supplements, including Tribulus, D-aspartate, and Tongkat
@pagdinhealth do you ever see cases where the tongkat ali has a reverse effect of lethargy and fatigue ? What does that mean?
Tried supplementing 400mg daily and had to stop because the fatigue
@@danielkunz2393 I typically use Tongkat if SHBG is too high, as a way to help improve the proportion of bioavailable testosterone. It is not likely to cause lethargy
Should dim be taken with dhea?
Great question, Mark. For men, DHEA does not substantially raise testosterone (or estrogen), so no need for DIM. For women, some of the DHEA can convert to testosterone as well as estrogen, but generally I don’t put women on DIM unless they have “estrogen dominance”
Will it supress my normal testosterone production
No, in appropriate doses it will not affect male testosterone levels
Sir my fsh level 15 and i want baby dr recommend dhea 25 mg for conceive
What is your DHEAS level? I would only supplement if you are at the lower end of the normal range, plus I would discontinue DHEA once you are pregnant
I took one capsul of DHEA supplement in a week, Doctor. Is that alright? I stopped it because its price is sky-high.
Amazon
Should be cheap, actually. I like Swanson brand, the cost means nothing as far as quality.
What about 4-DHEA?
4-DHEA is simply a pro-hormone of DHEA, meaning it gets directly converted into DHEA, so it offers no advantages over just using DHEA itself.
@@pagdinhealth I heard it converts to testosterone more than regular dhea?
Not true: you are thinking of 4-androstenedione
@@pagdinhealth well doesnt 4-dhea convert to 4 andro though? And then convert to testosterone so its a 2 step precursor to testosterone or am i wrong?
can i take dhea sir
I would only suggest taking it if your blood level is in the lower half of the range or below normal
@@pagdinhealth thanks sir is there any side effects
@@comedyvideos1659 yes there can be: there is no such thing as a perfectly safe hormone! Too much DHEA can make you feel edgy, irritable, or anxious, and in women can cause androgenic side effects like oily skin, acne, and whiskers
Made me feel like shit
Important to get the dose right and check your levels: too much can make you feel edgy and irritable
Will DHEA lower our semen volume?
DHEA supplementation for men should have no appreciable effect on testosterone levels or semen volume