THE GUT MICROBIOME AND THE BRAIN
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- Опубліковано 15 жов 2024
- The gut microbiome includes bacteria, bacteriophages, viruses, fungi, protozoa, and archaea, and this community of organisms is critical to the maintenance of human health, as well as in the pathophysiology of various diseases. The community in your gut is unique, much like your fingerprint. They began to colonize you the moment you were born and can change throughout your lifetime. Good bacteria in your gut help you absorb nutrients from your food. They also take up space and hog vital nutrients so harmful microorganisms are not able to colonize, and educate immune cells in the identification of harmful invaders.
However, did you know that your gut microbiome also affects your mental health? These tiny beings help you break down food traveling through your intestines, hence producing metabolites influencing all your cells - including those of your nervous system. Simultaneously, immune responses to harmful pathogens produce molecules that can also affect brain physiology. But that’s just scratching the surface.
A healthy and diverse microbiome is essential for normal cognitive and emotional processing. Your microbiome communicates with the central nervous system - aka the brain and spinal cord - through nervous, endocrine, and immune signaling mechanisms. We don’t yet have a good understanding of how the gut microbiome and central nervous system influence one another, but it’s been shown that changes in gut flora composition can result in increased intestinal permeability, allowing neuroactive compounds through and activating the inflammatory response. Yet other microbiota can produce compounds that affect gene expression in the nervous system. Research has shown that changes in microbiota can cause depression, change social interactions, protect from stress-induced changes to the immune system, and can cause physiological changes that are even transferable between species!
Our lifestyle has a major effect on the composition of our microbiome. What we eat, our stress levels, and our emotional state determine which organisms can live on in our gut. The human gut microbiota is generally fairly stable and resists change in community makeup. However, the brain can modulate the composition of our gut community by changing intestinal permeability and secretions, as well as through the release of hormones that affect microbial gene expression. Our gut flora composition can also be perturbed by changes in hormones or diet, antibiotics and stress. Reduction of the normal gut biota population - for instance while taking antibiotics - provides an opportunity for pathogens to colonize the gut epithelium.
It has been known for a while that the gastrointestinal system communicates with the brain. The enteric nervous system is a mesh-like set of 500 million neurons governing the gastrointestinal tract. That’s 5 times as many neurons as there are in your spinal cord - no wonder the enteric nervous system is sometimes called the second brain! The enteric nervous system CAN operate autonomously, however, it communicates with the central nervous system via the vagus nerve and prevertebral ganglia. This biochemical signalling between the gastrointestinal tract and central nervous system is called the gut-brain axis. However, it is only now being realized just how much of an affect the microbiome has on the brain. Hence, this bidirectional interaction between the microbiome and the central nervous system has been termed the microbiome-gut-brain axis.
The gut microbiome and central nervous system have bidirectional effects on one another. More research on this topic will help us get further insights into disorders of both the gut and the central nervous system. This is exciting news, because perhaps neuropsychiatric disorders will one day be treated through gut microbiota! Preclinical studies have identified plainly the powerful influence of gut microbiota on the central nervous system, but there are still issues with reproducibility, so we need continued improvement of experimental approaches. So what can you do to maintain the gut of your gut flora? Eat a healthy diet! Also, antibiotic resistance is no longer the only reason to not over-prescribe antibiotics.
THIS DESERVES SO MANY MORE VIEWS!!!! I LOVVVEEEE THE ANIMATION!! REALLLLLYYYYY INFORMATIVE AS WELL THANK YOU.💖
ua-cam.com/video/0COUZ7Zcm2w/v-deo.html I’d love to know your thoughts on this
I goofed up my life as much as you can. I decided to fix myself through the basics, starting with food. I learned how to fast and then I started eating strategically for a healthy gut biome. The results were profound physically, mentally, and emotionally. It didn't take long either. Please pay attention to this video and others like it. The Americans have a problem with their food. Our standard is great for business, not good for individual health. We have to rethink it with elements of this video in mind.
Couldn't agree more. I started a healthy diet and probiotics with microbiome support and it helped my anxiety by 70%. But it indeed took time for me I'd say 2 months.
So true both of you.
I’m holding out hope to do the same, but not sure how much longer I can hold on for.
Beautifully animated video,and commendably enlightening!Congratulations!
impressive, really appreciate the huge efforts you are doing guys, thanks a lot
May Al-Lah bless you with 72 virgins and a cup of wine. Amin! 🙏🕋☪️
Mice are the true heros here.
Mice are small rodents who, unbeknownst to the human race, are the most intelligent species on the planet Earth // The hitchhikers guide to the galaxy
The sad part is as a disabled veteran seeking help from VA hospital doctors no one took the time to explain anything or test for anything or offer anything to help me or give me a treatment plan so. I been spending enormous amounts of time to learn what I can and see if their is anything I can do for myself to control symptoms also informing myself of names of testing that I could request in order to know where I am at medically. Thanks for explaining things.
Thank you very much for your military service to the USA.
SUPERLATIVE, best cartoon I ever watched, much better than Bugs Bunny! Hoping you can do a take on SAD, "Sad American Diet" which I firmly believe is a slow motion train wreck to health & wellness, especially as we age aka superannuating. I'm sure that proper food combing at meals is an asset; eg: I cringe when I see people eating fruit with red meat proteins, eating sugary desserts right after a high protein/high fat meal; sugar slows down digestion resulting in putrification and fermentation of biome in the stomach. Hoping you can explain on all of the above, except for Bugs Bunny, I got him down pat!
Clear, concise, and really nice work on the animation. Subscribed
This is very interesting! Do you have, by any chance, some references rewarding the subject?
Hi, can I get the references to the research papers that were mentioned in the videos?
Thank you.
hi there! great informative video!
is there any way we can contribute with subtitles so it can be accessible to more people?
thanks so much!
Great video, however, citations would be nice. For example, m4:14. Were the fat calories from animal or plant source. It may not matter for the purview of this study, but would be interesting to know, as I am sure you are aware that seed oils are thought by many to be at least as big of a contributing factor than sugar, where as saturated fat intake is really not associated with obesity in clinical studies. Thanks.
Did you ever find the source?
clear info. but more has to be said. do ou guys have another updated video.
Such a great video 👏👏👏👏
Is there a reason why I feel food movement in my stomach?...is it maybe due to nerve inflammation?
U are amazing
Thank you I never understood why my grandma died beautiful with a big stomach some of the negative things they said about her she died at 42 in 2000 I was 11 now im having horrible stomach pains i started having seizures and emotional and mental issues my stomach is killing me I had a c section but my daughter stomach is big like my grandmother and she started having the seizures as well im skinny and cant gain weight and alot of people have diabetes in my family this video is what I think is wrong with me and I think this is why my grandmother died and I think this runs in my famiky
Have you started addressing your gut health yet?
@@lauralyon9629 yes i take 4 probiotics everyday eat yogurt and drink only water and homemade lemonade that I make with fresh lemons and I eat alot of okra and I pop 3 aloe vera and cactus pills daily.
You need to get the book 'Fiber fueled ' by Dr. B.....(hard name to spell)
@@1thinkboss don't forget about prebiotics. I had crazy neurological symptoms that would even cause me to twitch, convulse and have intermittent paralysis. Cleanses then, Prebiotics and probiotics are the key to gut and neuro health and no one is really talking about it. I literally have TREMORS 24/7 and on the days I take prebiotics I sleep 9 hrs and no tremors for at least 15hrs +. Prebiotics are associated with higher amounts of rem sleep and my sleep app tracks higher rem sleep on days I consume 6g of prebiotics. There are studies that show a large percentage of Parkinson patience have Sibo (small intestinal bacterial overgrowth) as well. Please do more videos on the gut microbiome - severe Neuro manifestations link.
@@Sara-worldProbiotics aren't good if you have sibo.
Cover Anhedonia and PSSD please.
I want to take probiotics but I can't because I got Sibo. And cant put more bacteria on top of already overgrown bacteria whether good or bad
If you have sibo you definitely need prebiotics. I have sibo too. Have you tried a detox senna tea then pre/probiotics?
How do you find out if you have sibo?
@@michellehydle a breath test
@@angela1981 at a regular doctor?
well, if you think about it, at the beginning of life on earth, there were just cells which eats little organism, so it's like a whole stomach organism fighting against other stomach organism
Can some viruses be harmful in the gut?
Why did the mice on the high fat diet gain more weight than the ones on the low fat diet? It is the opposite for humans. I'm guessing the mice on the low fat diet weren't given sugary foods like humans on low fat diets. In other words, those mice were given food that tastes like crap. Humans found that removing fat made food unappealing so they added sugar.
Guts are delicious