How your gut can change your mind | Professor John Cryan
Вставка
- Опубліковано 15 тра 2024
- In a lab in Ireland, a group of scientists stand around a stainless steel table. One is holding a device not unlike a small turkey baster. His free hand plunges into a box on the table and pulls out a mouse.
Using his device, he administers a brown solution rectally.
This mouse has just received a fecal microbiota transplant. And the donor was not another mouse, but a human being. And the person in question had symptoms of severe depression.
In this episode, Jonathan speaks with Prof. John Cryan, an author of the study, which showed a relationship between the gut and the brain. Listen in to learn more about his fascinating research, how microbes may affect our brains, and how to eat to appease your gut bugs.
John Cryan is a professor at University College Cork and a world-leading researcher into the relationship between our brain and our gut microbiome.
If you want to uncover the right foods for your body, head to joinZOE.com/podcast and get 10% off your personalized nutrition program.
Timecodes:
00:00 - Introduction
00:36 - Quickfire questions
02:05 - Are there links between the gut and the brain?
05:42 - The gut-brain axis
08:55 - How do gut bacteria affect our brains?
11:12 - Why does John call the microbiome “the chamber of secrets”?
15:10 - Does the microbiome explain drug side effects?
16:57 - Are there links between our microbiomes and mental health?
22:55 - If we improve our microbiome health can we improve our mental health?
27:53 - Can food help improve the microbiome and thus improve mental health?
32:20 - Microbiome’s effect on behavior
33:51 - Actionable advice
39:57 - Microbiome in adolescence
43:03 - Summary
44:15 - Goodbyes
44:38 - Outro
Episode transcripts are available here: joinzoe.com/learn/category/nu...
Follow John: / jfcryan
Follow ZOE on Instagram: / zoe
This podcast was produced by Fascinate Productions. - Наука та технологія
At the end of each Zoe conversation, Jonathan summarizes and I swear, every guest is impressed, if not amazed, and all they can think of to say is "Great summary!". You have a gift, Jonathan.
Yes, excellent summing up by The Wolf.
I want Jonathan's bacteria!
I really value Jonathan's summaries. I also think starting with yes/no answers to key questions helps grab the listener's attention .
‘Depression could be seen as a chronic inflammatory disorder’ 20.02: very interesting and thought provoking statement.
Fascinating! A lot of this makes so much sense to me. When my children were small, my friends were disinfecting just about EVERYTHING their children came into contact with, but (within reason) I let my sons experience the world without cleaning them off with a wet wipe every hour. They played in soil in the garden and we went for walks in the woods etc. They didn't get so many colds/bugs/etc. as other kids. They are both in their 30s now and pretty healthy. I'm really interested in how contact with the natural world - soil, trees, flowers etc. - affects our microbiome. Professor Cryan is a great speaker. I look forward to more videos with him. :)
I’ve often wondered about the diet offered to medical and psychiatric patients and prisoners and how this could be part of the treatment offered.
I eat Kefir. raspberry blue berries walnuts almond cashews flaxseed Apple pear banana avacado.
Organic oats. Most of the food I eat is organic. Need to make my own sourerkrut. Suffered from colitis for 3 year's. Now been in remission for 4 year's since I changed my diet.
Congratulations!
I did
Morning lovely people.... I'm loving my Zoe. Looking forward to my personal nutrition results. Im only a week in, but have been IF'ing now for 5 weeks, this has made me more fussy about what I eat in my eating window. But after listening to this...perhaps my gut was telling my brain something. I seem to just want to eat nutritious food. My biggest problem is not being able to eat all I buy whilst shopping, so I have had to find a way of storing my fresh diverse produce for longer. A pod cast on food storage I think would be great. Highly processed food has a longer shelf /fridge life making it easier to store and keep. I have started to buy frozen and tinned food ( Food for Life has helped me here). Im wondering, have I missed a podcast on food and storage? Anyway love Zoe , and happy annoying anyone who will listen about how it has improved my health, my energy, my sleep and my waistline. I even told my Doctor she should try it when i went for a thyroid medication for check up. ( I have a non functioning thyroid). I was staggered that a NHS GP knew nothing about Gut health, IF, and is health benefits. I gave her the link to Zoe. I would now like to go to my old Slimming World class and advise them all and meet new and pregnant mothers and teach them this from day one. 'Diversity rules' Michelle xx
I noticed your reference to Slimming World. Now I know the seriously bad effects artificial sweeteners have on gut microbiome I feel very uncomfortable when 'diet' drinks are promoted. I also dread to think about the damage Slimming World HiFi bars must do. They are not really food at all, just a collection of artificial additives combined to produce something resembling food.
My gut frequently changes my mind from eating salad to ice cream
The gut wants what the gut wants 🤷♀
@@joinZOE ml
Yeah, I got those particular microbes as well ?
Probably taste buds driving the change! !
Especially dopamine flavoured ice cream?
I'm interested to hear Professor Cryan say clearly that he believes artificial sweeteners are detrimental while the Zoe blog says there isn't enough evidence one way or the other. I do drink diet sodas so I'd like to know more about Professor Cryan's views on this. Thanks.
My mind was blown by how he likened probiotics to drugs, such that both are very broad concepts, but unlike drugs, we still don't know which probiotic works for specific types of illnesses. It made me realize how much we still don't know about this particular medical field.
Also, I love how he acknowledged democratizing and making available of mental health options to people of lower socioeconomic status and making gut and mental health accessible to people. Kudos to this really great interview!
Thanks soe amazing info mation
Excellent episode. This has such important implications for diet and nutrition in early years settings and schools and we need to be educating families Health visitors and School Nurses more about it. Over recent years whilst I’ve been working in education the number of children with emotional and behavioural needs has increased significantly. Diet must play a larger part than we realised.
Agreed. Most kids in our school eat grab bags of crisps. These are 8 year old. Plus energy drinks and a load of other crap in the lunchboxes 😢
I've noticed that food served in care homes can be high in refined carbohydrates and lacking in fibre rich foods. My mother who suffers from dementia was offered a chip butty for her evening meal! When she was being cared for by home carers I made sure there was always plenty of fresh and dried fruit and tinned fish available. She always ate wholemeal, seeded bread. Quick and easy to prepare, but so much better for health and wellbeing.
Reading John's book at the moment on psychobiotics. Excellent.
Fascinating indeed!! Thank you! 🙏🤍🙏
I'm 74, my gut score from Zoe was "excellent" have been feeding my microbiome for a year, have never felt so energetic, optimistic and full. .. no hunger pangs at all!!
Thank-you Zoe and Tim Spector for "Spoon-fed" it changed my life!
Was that volume of bacteria or the diversity?
How do you get your gut score please
@@Iris-lk9ig you do the Zoe progamme. It's one of the tests. Best google for info.
@@TillyFloss thanks
I'm 75 and find this so interesting as being in the Highlands buying anything that has not been pasturised is almost impossible
I did 😂
I'm slowly working my way through your videos. This discussion has to be one of my favourites, I found it absolutely, fascinating! I hope you are able to chat with Professor Cryan again soon. I learnt so much, thank you for posting... and, yes, I have subscribed ;o)
I'm very thankful for reminding me of eating diverse and the very best diet we should choose. It's so important for good health.
Absolutely fascinating! I think that having a pet and this leading to a better gut microbiome is brilliant news.
Thank you for doing the quick question and answer thing before delving deeper, that's very helpful!
I am eager to read his publications. Thanks for the actionable data. I am definitely upping my fermented foods.
First, I just adore this program and the topics you discuss with the leading scientists and how you translate the information into simple terms!!
Second, I've heard many times about various drugs negatively affecting the gut biome. I'm curious to know if that also applies to Bio Identical hormones that women take for menopause. And if so, is there any research being done regarding gut biome and menopause?
Many thanks!
Valuable information! Thank you so much! I am psychotherapist and clinical nutritionist. I bring food and lifestyle always into my work with clients.
Thank you! Fantastic interview!
I really enjoy your interviews. And really like that you summarize the info.
I like the synopses too!
love your jean claude and cristo tree wrap drawing, john🙏
A very well done episode.
And offering hope to those with mental health issues.
Love these Zoe vlogs really insightful and valuable. Thank you Zoe Team!
Very helpful.
Starting my ZOE testing after Thanksgiving.
Excited to see how these concepts affect me.
I love the Vegas reference, it's hilarious. The vagus nerve can even kill you when you are training too much, meaning training to have a bowel movement and you are pushing too much. I had many patients experiencing this.
Straining or training?
Straining
Straining, auto correct 😰
Very good interview. Thank you. X
Amazing channel!! I learn so much every single time I listen!!
What a fascinating conversation
Thank you, I will join the program.
i just discovered your channel and found it fascinating. thank you
These interviews are great! Thank you!
Absolutely fascinating … and so exciting!
Lots of wonderful insights in this - thank you! Would statins affect the microbiome?
I love ZOE ! Keep up the great work!!!!
Antibiotic wrecked my gut until I dosed up on friendly gut bacteria tablets and homemade yoghurt. Switched off the diarrea overnight!
Fabulously informative interview. What a coup to get John cryon on your youtube
I think Prof Cryan will be widely recognised as a pioneer in human health and wellbeing. His work is revealing the profound symbiosis between a human being and the microbes that live inside us. If the microbes aren't happy, the human isn't happy (or healthy). Promote the right microbes through appropriate nutrition and reap the long-term benefits.
Great episode, have sent it to family and friends. There seems to be 2 recent studies on ‘post-biotics’, with a focus on producing supplements. Do you have any insights into the foods that we can eat more of to produce these naturally?
Very good podcast. Thank you
Very fascinating and valuable once again 👏
Thank you, so interesting
I’m about 5/6 weeks in following Zoe I have already changed my energy levels are up my low mood has gone still hoping the sleep improves it’s better but can still be much improved. It’s not a quick fix you need to really focus and plan but now I’m on it it’s becoming second nature. The glucose alert at the beginning was too low at night I introduced slow release lentils and chick peas with supper and it disappeared. 🙏🏻I slept better what a relief the New Science is facinating it’s definitely The Future .
This is wonderful, Jilly. Keep going 🙌
It’s for life I’m amazed at the difference I feel, I only wish GPs would get more onboard they have failed me telling me my chronic tiredness is a result of age and RA medication for years. Thank goodness for research and Zoe 🙏🏻🙌❤️onward and upward 🚀
@@jillysharpe9112
💛
I have just come across this podcast, can you tell me a rough idea of what foods you are eating, it sounds lifechanging. I m nearly 56, suffer depression and anxiety and IBS, chronic fatigue and insomnia. Thank you. 😊
@@Bombabingbong66 But most importantly I forgot to say. We are all different, how I react to food will be totally different to you.
That’s what it’s all about .. your biology is unique to you.
So if you and I both eat the same apple we may have completely different responses in our blood sugar and fat reactions … listen to more of their podcasts it’s good stuff.
Very interesting. Thank you Jonathan and Prof Cryan. When I increased dietary diversity (adding rye and homemade saurkraut along with kefir) I developed problems with bloating and constipation. No previous diagnosis of Irritable Bowel and no pain. Changing to a low fodmap diet resolved the issue. Now I have to be careful about the types of high fibre/fermented foods that I can eat. It would be really great if one of your experts could look into this and tell us what the science says about the microbiome and fodmaps in our diet. Thanks
Go slow as you change things. A Zoe partner, Dr. Will Bulsiewiuz, a GI doctor, talks a lot about this. His book "Fiber Fueled" and the cookbook are very helpful explaining how best to evolve your diet.
Z$
Thank you
Thank you.
Great episode ! Thanks 🙏 Do you think the Zoe follow up will be available in Europe one day?
What about someone who has had their large colon removed. Do people with an ileostomy have no microbiome? I have looked for research into this but can't find anything
Thanks for these talks - love them. I recently started making seed sprouts and hoping it will improve my microbiomes!
It's a shame it had to involve so much animal testing I hope in future they find an alternative.
I'll be interested to see if others found their depression got much worse when doing the IF study, a few years ago a counselor told me about the gut producing more serotonin than the brain and to make sure I ate well/didn't skip meals, it wasn't until I tried to eat in the 10h window I realised just how right they were! (Luckily only took 2-3 days to go back to normal).
I hadn't really thought about what the various medications I am now reliant on do to my microbiome I'll have to look into it further to see if any of them or their fillers happen to have been studied yet (not that I have much choice but to take them unfortunately)
Are there any foods that can help children with Autism and ADHD? (Great discussion, thank you.)
One of the health pros said that people suffering from mental illness should not drink milk or milk products, I stopped it and my chronic cough stopped.
Wonderful discussion. In the philoppines we have Acharya made from green papaya and spice with peppers,carrots, blacknpepper,ginger,laurel leaf and choice of vinegar like coconut vinegar.thamk u
Thank you Zoe for yet another excellent podcast. I'm reading The Secret Body by Daniel M Davis, really fascinating, and have just reached the chapter on the brain, so I'll see if there are any links to this podcast.
So glad to hear you enjoyed it. Prof. John Cryan's work is fascinating 🤩
I read The Secret Body and found it fascinating.
Amazing and so interesting.
I accidentally found this out when I started to consume steel cut oats in the morning and found that I was able to cope and handle morning work stress easily. I was shocked.
One thing that we overlook here is that we got used to swallowing medication instead of pumping it directly into our blood through our veins. Now I don’t know if the reason is that we are all too scared of needles, if it just is easier for manufacturers to produce pills or if swallowing actually slows down the release of the compounds in our blood bringing some benefit, but if we only changed that one habit, our microbiome would definetely be healthier…
Does the microbiome control cravings like sugar, or is this moreso the need for fast energy? I have a full on addiction to sugar and affects my emotions in extreme ways but when I try to reduce the intake to 5 grams a day the withdrawals become overwhelming. I understand the glucose requirement and inducing response but my internal regulation is ridiculously sensitive so the classic "sugar begets sugar" becomes intense and the next thing I know I'm experiencing BPD traits.
So how do I get MY microbiome to talk nicer to my brain?? 😫
Whenever researchers talk about 'artificial sweeteners' I wish they'd clarify what they mean by that. Which ones? Aspartame, Cyclamate, Saccharin, Ace-K, Sucralose? All of them? Is Stevia and the sugar alcohols such as Xylitol, Mannitol, Erythitol and many others also labelled artificial sweeteners? Have they been tested, individually, too? Some sweeteners are more 'artificial', if you could call it that, than others and their chemical make up very different. Unless there's a common mechanism by which they all upset the gut microbiome, I really wish they'd name the sweeteners involved. Even on research papers it's often just stated, 'artificial sweetener' without stipulating which one (s) as if we all know what they mean. This lack of distinction seems to be a common problem in the diet discussion world.
I have been epileptic since 1965. My first consultant told me there was some connection between the gut and the brain causing fits but they hadn’t discovered what yet. Maybe we’re on the way to discovering??
Good, thanks
I had a gut feeling about the conclusions of this video
I think I eat the proper amount of plants but still have IBS and am trying to address it myself by eating more fermented foods, cutting back but not excluding lactose entirely. So the houseful of dogs at home in Scotland is going to be healthier than my flat and my cat and visiting pigeons in London? I speak to as many dogs as I see as I have always had them before moving to London, but, it makes me question how leaving Scotland and the dogs and horses maybe impacted my microbiome as I only got IBS since moving to London.
Maybe eat more real organic meat and organs of different animals, organic eggs from happy chickens. More animal fat. Fatty wild caught fish 2x a week.
Try eating locally made yoghurt? What you say is very interesting. Maybe the tap water is different,harder or softer than it was where you were previously?
Fantastic really interesting
I would like to know how do u define that mice is depressed.
Is cooking fermented food (cabbage, cucamber, reddish, wild mushrooms) changing the impact to our friendly bacterias? Or should we eat it only "raw"?
Whereas I'm normally pretty disciplined as far as food goes, and hardly ever feel hungry, I gave into temptation and had a triple choc cookie on Sunday afternoon when with friends. Was that my gut telling me what I needed? Later that day, still with friends and eating out at Cote, I really enjoyed the fish stew, but hadn't realised that there would be quite a number of new potatoes, which I ate, in and under the fish. Now was that my gut telling me that I needed something that I hadn't had for years, or was it my brain telling me not to leave them to one side?
Get informed to make right behavioral prognosis
Lots of interesting books out there- First one I read was Gut by Giulia Enders, very accessible. Plenty more nowadays, plus G plan diets to detox( really helped my sugar cravings although have passed so need to go back to it after Christmas!
A duodenal ulcer in my teens, took massive amounts of Tagamet. Now 71 Alcoholic dry, non smoker vegetarian. Suffer from Candida Albicans.
Depression, but have noticed when I pass stools, the depression abates, but inevitably builds up with eating. Nights are terrible, fear anxiety even to the point of suicide (but as it is regular) that is not going to occur. Has any reader any similar condition??
I heared someone that this all improved with adding a carnivore diet. Organic and fatty wild caught fish.
Sounds like H pylori, other issues also present. Find a functional medicine doctor that can do a work up on all aspects: stool, blood, gene profile. Best wishes,
@@karend.9218 Thank you Karen. I will pursue your suggestion.
Why some people cannot tolerate fermented food
What’s this about mitochondria being microbes on the loose and how key they are?
The evobio theory goes that mitochondria were microbes (archaea? I'm not sure) that entered into symbiotic relationships with eukaryotic cells, until eventually they became incorporated as organelles.
41:54 How can I tell if I have inflammation?
It hurts!
Arthritis, rheumatism, any immune system diseases, diabetes, blood pressure.... also check yr CRP results next time u have bood test . C-reactive protein is inflammation marker. Or get homocysteine levels checked. Depends what you're looking for tbh.
The gut bowl syndrome is very true when my gut bloats my blood pressure goes up
Is French kissing an effective transfer of microbial from one person to another?🤔🤔🤔
I’m sure fluid transfer during intimacy has a profound bacterial influence. My bacteria are pure ❤️ love.
Could the increase in mental health issues like anxiety etc be linked to children living in cleaner environments so have a less developed microbiome?
For example quetiapine has an antihistamine aspect which would affect inflammation
Probably agricultural chemicals and processed food.
Also living and interacting with the soil..
@@k8eekatt I’m keen to know if processed foods reduce the microbiome as well as restricting how complex it is
@@lorettabaquiran9540 so many of our antibiotics came from soil, I was a very muddy child 😂
Baked beans on wholemeal toast provides pretty much the same nutritional balance as steak and chips, and is packed with fibre.
However your body is unable to use the nutrients to the same degree.
Diversity fibre etc....thanks for posting
That may explain Dr JCambell’s 180 . too many burgers
Where does the HEART brain figure in this?
The relationship of HEAD- HEART-GUT brains are surely at the root of mental health issues and disorders. The VAGAS nerve is the superhighway between all three. The gut microbiome is one thing but the very neuro transmitters eg dopamine are extensively throughout the body and are also associated with the balance of the MIND.
Gut feeling... remember?
31;18.
This is why I really hate youtubers peddling probiotics. It's basically untested medication doing who knows what. There are bacteria you want to supportand some you want to suppress, and it won't be done by random shots.
Basically Ireland has a long way to go to meet its potential.
Say what?
Why does he need such a big complicated microphone?
I notice a big difference in sound quality between the “ big microphone” and the built in one on the laptop
I hope this doesn't fall into the hands of big pharma or big food. I thknk the possibility of misuse is immense .Get a patent. The vaccine experience makes me very wary.
𝕡𝐫ｏ𝕄ｏ𝔰𝓶 🤗