Hydrogen Sulfide SIBO Treatment: bismuth, Augmentin, Bactrim, oil of oregano, uva ursi, and more!
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- Опубліковано 7 лип 2024
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Time stamps:
0:00 Intro (important!)
6:05 bismuth
8:37 compounding bismuth
8:23 Augmentin (amoxi/clav)
10:09 Bactrim DS (trimethroprim/sulfamethoxazole)
12:04 oil of oregano
14:07 uva ursi
14:59 silver hydrosol
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Videos referenced:
• How I Treated My Hydro...
• Hydrogen Sulfide SIBO!...
Refs:
1. Leite, G.G.S., Weitsman, S., Parodi, G. et al. Mapping the Segmental Microbiomes in the Human Small Bowel in Comparison with Stool:
A REIMAGINE Study. Dig Dis Sci 65, 2595-2604 (2020).
2. • SIBO, IBS & The New 3-... 17 min 59 sec
3. Linden, D. R. (2014). Hydrogen sulfide signaling in the gastrointestinal tract. Antioxidants & redox signaling, 20(5), 818-830.
4. • #28 SIBO, Prokinetics ...
5. Shatalin, K., Shatalina, E., Mironov, A., & Nudler, E. (2011). H2S: a universal defense against antibiotics in bacteria. Science, 334(6058), 986-990.
6. Ohge, H., Furne, J. K., Springfield, J., Sueda, T., Madoff, R. D., & Levitt, M. D. (2003). The effect of antibiotics and bismuth on fecal hydrogen sulfide and sulfate-reducing bacteria in the rat. FEMS microbiology letters, 228(1), 137-142.
7. www.drweitz.com/2021/02/hydro...
8. drruscio.com/new-sibo-test-as...
9. Ouwehand, A. C., Tiihonen, K., Kettunen, H., Peuranen, S., Schulze, H., & Rautonen, N. (2010). In vitro effects of essential oils on potential pathogens and beneficial members of the normal microbiota. Veterinarni Medicina, 55(2), 71-78.
10. Van Den Brûle, S., Ambroise, J., Lecloux, H., Levard, C., Soulas, R., De Temmerman, P. J., ... & Lison, D. (2015). Dietary silver nanoparticles can disturb the gut microbiota in mice. Particle and fibre toxicology, 13(1), 1-16.
11. Wilding, L. A., Bassis, C. M., Walacavage, K., Hashway, S., Leroueil, P. R., Morishita, M., ... & Bergin, I. L. (2016). Repeated dose (28-day) administration of silver nanoparticles of varied size and coating does not significantly alter the indigenous murine gut microbiome. Nanotoxicology, 10(5), 513-520.
12. Bergin, I. L., Wilding, L. A., Morishita, M., Walacavage, K., Ault, A. P., Axson, J. L., ... & Philbert, M. A. (2016). Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model. Nanotoxicology, 10(3), 352-360.
13. Kovvuru, P., Mancilla, P. E., Shirode, A. B., Murray, T. M., Begley, T. J., & Reliene, R. (2015). Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues. Nanotoxicology, 9(2), 162-171.
14. Munger, M. A., Radwanski, P., Hadlock, G. C., Stoddard, G., Shaaban, A., Falconer, J., ... & Deering-Rice, C. E. (2014). In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 10(1), 1-9.
15. Kang, J., Dietz, M. J., Hughes, K., Xing, M., & Li, B. (2019). Silver nanoparticles present high intracellular and extracellular killing against Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 74(6), 1578-1585.
16. Sondi, I., & Salopek-Sondi, B. (2004). Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Journal of colloid and interface science, 275(1), 177-182.
17. Panáček, A., Kolář, M., Večeřová, R., Prucek, R., Soukupova, J., Kryštof, V., ... & Kvítek, L. (2009). Antifungal activity of silver nanoparticles against Candida spp. Biomaterials, 30(31), 6333-6340.
18. Wallace, J. L. (2008). Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?. Physiological reviews, 88(4), 1547-1565.
According to my lab work, the strongest binders to H2S are: bismuth, vit B12 (hydroxocobalamin) and molybdenum. Malva Sylvestris kills of sulfur reducing bacteria (SRB).
We don’t know yet how any of these can treat SIBO, IBS-D, colitis or Crohn’s disease, but we do know H2S and sulfur reducing bacteria can play an important role.
You seem to know a lot more than my science colleagues. Excellent work!
You are an amazing person. I simply want to say thank you for making the effort to educate the rest of us. I hope you can put these health problems behind you and focus your amazing energy and talents on whatever passions you have in life.
Also, for bismuth, take a look at Devrom
Thank you so much for your very nice comment! I can't wait until I am out of this bed too. My passion is making edutainment videos so hopefully one day I can make this my job when I feel better and can create more content ❤️ And thanks for the heads up on the Devrom! This is the first time I'm hearing about it
@@BartonellaBabe Keep the faith. I know how difficult it is to have ambition put on pause over these health issues. We embody the saying "the spirit is willing but the flesh is weak". But don't lose hope - what doesn't kill us makes us stronger (and more humble). After you get through this challenge (and you *will* get through this challenge) your depth of character will be profoundly deeper than it would have been otherwise and you will never take good health or life itself for granted. It won't be long before medical science catches up to our ailments - we are fortunate to live in this time when having such hope is perfectly reasonable. Perfect health is a simple mechanical problem from a certain perspective. I work in the pharmaceutical industry and I am watching amazing advances across the industry using artificial intelligence and very advanced modelling - I can not even imagine these problems will not be completely solved within the next decade or so. We are on the precipice of amazing advances in medical science that will make all of this seem like a bad dream. You'll see. ;) Hang in there.
Also wondering if you have run across Dr. Gregory Nigh for HS SIBO? Here is a link to one of his interviews: ua-cam.com/video/OzMU8GVzTko/v-deo.html He has recommended some other treatment protocols that have helped me, including molybdenum in the form of the product Mo-Zyme (sublingual) and various naturopathic remedies, such as lemongrass oil. It sounds like maybe HS SIBO is behind you for now with the Rifaximin + NAC treatment (I will try that next) but if it is still an issue I do think the molybdenum + bismuth approach is more effective than just bismuth for symptom control. My understanding is that the molybdenum plays a key role in sulfur metabolism as it is not just the side effects of hydrogen sulfide that can cause issues but also a sulfur deficiency since the bacteria is hoarding the sulfur before it can get to our cells. Another technique to test for that deficiency is epsom salt baths as you can absorb the sulfur in the epsom salt through your skin and bypass the GI tract. If that makes you feel significantly better then you may have a sulfur absorption issue. Hopefully all of this is moot if you already solved for HS SIBO, but putting it out there just in case. ;)
@@sebek12345She passed away. I am shocked and stunned… it’s so sad..
Your content is vital to my treatment journey. Thank you for your work.
Wow I’m so glad it has been so helpful to you and you are very welcome ❤️
Great job!
thank you!
Thank you!!!!
You’re welcome!
you are an icon!
An icon?!?! 😭❤️
Hi with your H2 S did you have trouble eating meat? I have had issues introducing meat. I haven’t tried the bismuth though I have tried all the anti-microbials. I seem to get better on a really high diet of fodmap. I use grapefruit seed extract for a lot of things. It’s great Meats just put me right back on diarrhea I was wondering if you had this happen at all I know we are all different but I thought I’d ask. Thank you for your videos beautiful ❤
I started using oil of oregano and it helps, and other people have said it helps.
Sorry if I totally missed this in your last video -- you mentioned taking compounded Bismuth in this video, but I thought you had used NAC (every 4 days) and food grade DE during your antibiotic? Was Bismuth part of the mix as well? Thank you!!
Thanks for the awesome video :) I just wanted to share that I wasn't able to do the trio test but i had a flatline in my breath test so my doctor suspected H2S sibo. I also had a stools test which showed that I had high levels of proteus and klebsiella and I was ultimately treated with Bactrim but I felt way worse than before and it has been a few months. I was wondering if you think that I still have H2S sibo or could it be something that is not being detected yet? Thanks
Thanks for watching! Are you able to do the trio smart test? If yes, I would do that. If not, I would say that it is entirely possible that you still have H2S SIBO after treating with Bactrim, especially if you were not on a prokinetic to maintain remission. The stool test showing Klebsiella and Proteus only show that it is in the stool and don't necessarily mean it's in the small intestine. According to Dr. Pimentel, the small and large bowel are two completely different worlds and he has shown this through his research
Which is better oregano oil or oregano tablets?
So cute
I brought up the possibility of SIBO with my functional medicine doctor as my medical history pointed at it. She didn't test me for it, but in my treatment program was uva ursa and oregano oil, so I guess she did listen to me on that one.
Oregano oild and urva ursi, should it be taken with food but what kind of food? Since we have sibo should it be sibo diet or eat anything so that it can work like antibiotics?
That’s such a good question and I’m not going to act like I know the answer. I have heard Pimentel say that he doesn’t have patients do any sort of diet while they are treating so that the microbes can “come out” and you can whack them with antibiotics. I can’t see how that would be any different with herbal antibiotics
So did you use 2 weeks rifaximin and NAC with bismuth? were you taking them all at the same time? I read that bismuth should be taken on an empty stomach.
Here is how I treated my hydrogen sulfide SIBO 🙂: ua-cam.com/video/Y4lNafhd8jU/v-deo.html
Hi Jake I'm suffering from constant nonstop foul smelling gas all day every day would hydrogen sulfide sibo maybe causing it would love to hear your feedback thank you in advance
I would recommend getting the trio smart breath test as that is the only way of diagnosing H2S SIBO. Foul smelling gas does not represent what is going on in the small intestine
Thank you for sharing all this information. I've had sibo for years but only diagnosed recently. The drs only tried 2 antibiotics and then have given up and are now saying they're not sure I have sibo because the rifaximin and doxycycline didn't work. A couple of years ago I had amoxicillin for a sinus infection and it was the best my stomach felt but drs are ignoring that and not willing to prescribe it. They also don't believe hydrogen sulphide sibo is a thing which is very frustrating!! I clearly have worse symptoms when I have higher suplhur foods
Also I had a positive breath test which had high hydrogen and a completely flatline of methane
well hopefully you can get the trio smart breath test because that will show you whether H2S SIBO is a problem for you or not!
@@BartonellaBabe We don't have the trio smart test here in the UK so they won't acknowledge sulfide sibo is even a thing. I also have candida issues which isn't helping but I don't hold out hope they will treat me for that. I've been trying different things out kinda like trial and error as I feel let down by the drs. I've had this hell for at least 10-15 years.
Hi Jake. I have read that the desulfovibrio bacteria and species that cause h2s sibo can produce beta lactam, that is, they are not sensitive to augmentin. I have read in many places. but why is augmentin recommended? When it comes to antibiotic resistance, I may only have one shot. and rifaximin didn't work. I’m so confused.
We actually don’t know yet which bacteria cause H2S SIBO. The hypotheses that it may be due to Desulfovibrio spp. are just hypotheses. I think Dr. Pimentel hinted the other week at what the bacteria are that cause H2S SIBO are on his Twitter but he has not yet published their findings on this topic, as far as I’m aware.
I took rifaximin once and it didn’t do anything for me either. When I used mucolytics with it, that’s what brought my H2S SIBO into remission
That's what the clavulanate is for. It's a becta-lactamase inhibitor, so when you combine it with amoxicillin (the two are in Augmentin) it allows amoxicillin to kill more of the bacteria that produce becta-lactamase.
New fan girl, here....... I had ecoli six months ago and am still struggling......Lost close to 30 pounds, reacting to EVERYTHING, and have belly pain, nausea, bloating, extreme fatigue, diarrhea daily.... My reactions now include vomiting and migraines. I am awaiting my GI mapping...... Appt is next week....
Hello new fan girl! 🙂Sorry to hear about your struggles. I hope your appointment next week is fruitful and that you can pursue a breath test for SIBO, if you have not done so already ❤️
I'm currently using silver spray to treat mold toxicity. Hope I don't turn blue lol
I hope you don’t turn blue either! But as I said it’s dose dependent and lots of stuff we take has toxicities. I mean Zantac was on the market for who knows how long with carcinogens in it! Oh what a wonderful world! Lol
When will pimentel tell us about h2s treatment?
Such a good question! I looked at his presentations at digestive disease week and it didn’t look like he was speaking on that topic specifically but I could have missed it. If you hear anything, let me know!
SIBO methane, what treatment if Rifaximin is not covered by insurance. My doc said Augmentin and i m allergic to amoxicillin....
I believe the standard of cafe is often metronidazole with neomycin but I’m not sure. I’m sure if you search around on Google you can find it. I also recommend joining a sibo support group on Facebook
@@BartonellaBabe thank you
Great podcast StillJake. Glanced at your shops, and I will spread the URLs around. I don't wear earrings myself, they clash with my faux leopard print muumuu, fuchsia hardhat and steel toes. :)
Thanks for spreading the word TR Savage. From the sound of your wardrobe, I want to be you when I grow up + my earrings
Hi Jake, Molybdenum is a mineral co-factor necessary for the enzyme Sulfite Oxidase. Two good seafood sources of molybdenum are Clams and Oysters. See what Elliot Overton says about it on his channel.
By the way, I hope that you come back to your channels and social media. After six months not posting, I feel that I'm worried for you. I hope that you are doing something so joyous and wonderful that you are just to busy to post. Cheers.
Well, your chronic illnesses haven't impacted your intelligence. That's for sure!!! If I could hire you to be my research physician, I definitely would! Keep these vids coming. I'm learning so much. 💕
Thank you so much! These days I have too much brain fog to work on my videos unfortunately. Looking forward to getting my brain back
So if stool tests aren’t an accurate way in determining h2s sibo is it just safe to say that symptoms are the only way of interpreting progress?..
Cyril is exactly right. They are hoping to get the machines to other countries so that the tests can be available there but idk when that is going to happen. So if you’re not in the US, you’re definitely without an important tool. Symptoms are a way to gauge but after I put mine in remission, I felt better but still had problems, which showed me I needed to look for more answers and that ended up being sulfur processing issues
@@BartonellaBabe I have already gotten a stool test showing disulfobrio but it may be wise to also do a breath test. For me epsom salts brought me to a different stage in the process but feel as if i plateaued with my treatment.
Yes breath test sounds wise!
So confusing im thinking i can only eat meat fish and eggs 😮
Just started working with Dr.Khangura and am so impressed with his knowledge!
I'm curious about the bismuth-- do you think that it turning the tongue black is a really good indicator of h2S? I don't remember that ever happening before all my gut issues, but when I take it now (and I def Have h2S) my tongue gets black.
No turning the tongue black isn’t an indicator that one has H2S SIBO. All humans create hydrogen sulfide from their own mammalian cells (in small quantities) so the tongue would turn black in those that don’t have SIBO. Also, the tongue is not indicative of what’s happening in the small intestine. The tongue turning black is just visual evidence that bismuth binds with hydrogen sulfide to create bismuth sulfide 🙂 it turns your stool black too but that still doesn’t mean you have hydrogen sulfide SIBO. Having hydrogen sulfide in the stool is normal and stool can’t tell you what’s going on in the small intestine
So glad to hear you’re working with Dr. Khangura and are having a positive experience with him! Here is to you kicking your gut issues 🥂
I just came across your you tube site and found it very informative. found you when I started searching why bismuth is used in combination with xifaxin. I I am on antibiotic for SIBO hydrogen. I was only tested one time and now I am taking xifaxin for the second time. I was watching Dr. Siebecker and host Shivan Sarna on a Zoom meeting and I am trying to digest all the current information on treating SIBO hydrogen. Can you tell me if there is two or three types of SIBO - I know of methane and hydrogen from my one test done. Is this Hydrogen Sulfide the third type? Can you tell me how to order the test you are referring about here? I feel that I should test when I finish the antibiotic because my gastoenterologist does not recommend a followup test. From listening to this I feel like I should take the bismuth and eat a regular diet while on the antibiotic. I find it hard to follow the FODMAP diet along with no sugar or dairy.
I would love to listen to a song about SIBO and pepto bismol from Caroline Konstnar featuring you. That would be the bathroomjoke haven. 😂 Your content is great by the way.
hahah I have never heard of her! I looked her up and it says she is 18. THANKS FOR MAKING ME FEEL OLD AF
@@BartonellaBabe I have no idea how old are you. 😅 You look way too young but you are way too smart and this totally confuses me. Please stop forcing my brain to figure out how old are you. By the way i feel young af and you better do so, stop being an estrogen dominatrix and get your sh*t together.🥬
@@davidbene9962 haha I look young because I make sure I have soft lighting so I look as good as possible lol. I am 28 and have a masters degree
@@BartonellaBabe My closest guess would have been 16-26 😂Im 28 too but they say i look like 38, im afraid lighting wont help me 😭. Im suffering from progressing seb derm for 14 years now and collecting knowledge about it eversince. Anyways, hope you get better and still share content with us.
Haha 16-26 is a big range. Well maybe if I didn’t wear toddler clips in my hair or hide my fine lines I wouldn’t look so young lol. So sorry to hear about the dermatitis! I like to watch Dr. Dray on UA-cam for skin advice. Don’t know if she has anything helpful for you