so thank you. I was so hard to understand this whole thing only reading the textbook, but now I completely understand by your nice, easily explained video!!
Can anyone let me know what causes the subsequent transcript of C-gamma to be not-sterile, but containing a start codon? Is it the start codon present upstream of V-h gene region?
Question: If a b cell only "needs" to produce IgM or IgD antibodies, does class switching simply not occur? Because in the scenario shown in the video, the regions for the m and d heavy chain were removed meaning the b cell couldn't produce anymore IgM or IgD antibodies..?
Class switching occurs only when some B cell clone recognizes its specific antigen and starts an immune reaction against that antigen. Depending on which class of the antibodies is the most effective against that particular antigen, follicular helper T cell will release different cytokines that will stimulate isotype switching in that activated B cell. For example if a follicular helper T cell releases interferon gamma the activated B cell will undergo class switching and start producing exclusively IgG2 antibodies and if follicular helper T cell releases interleukine 4 the activated B cell will also undergo class switching but it will start producing exclusively IgE antibodies, So they won't be able to produce IgM and IgD anymore. However all the other naive B cells which aren't specific for that particular antigen still express IgM and IgD antibodies because they didn't undergo class switching.
great video . now i totally understood the isotype switching
so thank you. I was so hard to understand this whole thing only reading the textbook, but now I completely understand by your nice, easily explained video!!
Vídeo incrível, didática excelente. Facilita muito a compreensão desse tema que não é trivial. Obrigada
Amazing Video! The animation is super helpful for understanding this fundamental immunology mechanism!
Thank you. THANK YOU SO VERY MUCH.
Best video on youtube for this topic. thanks
The best explanation!
BLESS UR SOUL
Great explanation!
This is really helpful.... thank youuuu 👍🏻👍🏻👍🏻👍🏻
Thank you! easily explained
thank you so much, that made everything so clear
Just WOW
Thank you!!!!
finally a good video that explains this thing!
Very very helpful, thanks!!!
Fantastic!
Wow...amazing
Excellent!!
I finally understand thank God
thank you queen!
thanks so much, amazing
Thank you very much
nice explanation Thanks ...
nicely explained.
Amazing video! You successed to make me understand isotype switching which my textbook failed haha
great video
Thank you
Well understanding ❤❤❤❤
wow!!! thanks so much!!
brilliant
amazing 😮😮😮😮😮
thanks
Can anyone let me know what causes the subsequent transcript of C-gamma to be not-sterile, but containing a start codon? Is it the start codon present upstream of V-h gene region?
great...:)
Question: If a b cell only "needs" to produce IgM or IgD antibodies, does class switching simply not occur? Because in the scenario shown in the video, the regions for the m and d heavy chain were removed meaning the b cell couldn't produce anymore IgM or IgD antibodies..?
Class switching occurs only when some B cell clone recognizes its specific antigen and starts an immune reaction against that antigen. Depending on which class of the antibodies is the most effective against that particular antigen, follicular helper T cell will release different cytokines that will stimulate isotype switching in that activated B cell. For example if a follicular helper T cell releases interferon gamma the activated B cell will undergo class switching and start producing exclusively IgG2 antibodies and if follicular helper T cell releases interleukine 4 the activated B cell will also undergo class switching but it will start producing exclusively IgE antibodies, So they won't be able to produce IgM and IgD anymore. However all the other naive B cells which aren't specific for that particular antigen still express IgM and IgD antibodies because they didn't undergo class switching.
So polymerase just functions to open the DNA and make a redundant piece of mRNA...
I can't tell if this is a robot voice or a real woman's voice lol.
😍😍😍