Brandl's Basics: Somatic hypermutation and class switch recombination

This video describes two processes that occur during B-cell differentiation in the germinal center: Somatic hypermutation and class switch recombination.

[@myspringatgate2007]

I learned more about VDJ recombination in this 5 minute video than I did in my first 2 years of med school... THANK YOU.

[@NincsTobNev]

This isn't VDJ recombination though....whoops....that's for the Light Chains & Heavy Chains, and that's for increasing the repertoire of antigen specificities, which happens in the Bone Marrow way way earlier. This happens in the Secondary Lymphoid Organs in the Follicles. Perhaps you noticed...the VDJ regions are NOT recombining.

[@SubashAdhikaridr]

This is one of the best videos around the topic.

[@yashan.b.8346]

Your video is the best! Love the content. Well explained.

[@elkhouh]

Beautifully made!

[@harrysmith2546]

Brilliantly explained, thank you!

[@jonahmj3228]

thank you for this lovely video..... i now understand the two pretty well

[@kannukandiddu]

very well explained. Helped a lot, thanks !

[@raanoooshh9296]

Thank you for explaining the difference!🙏

[@hamishbain4081]

This is fantastic! Thank you so much!

[@giuliocasalis5031]

very very well explained, great work. thank u!

[@saviourlives25]

Excellent explanation mam, Thank you 🙂

[@TragedyOfDarthPlagueis]

Thank you for this video - very good explanation 😊

[@hn2i]

Thanks so much for making this video!!

[@minileadja]

thank you very much for the very clear explanation!

[@stichymckelles1762]

Great explanation 👍🏻👍🏻👍🏻👍🏻 Beats having to go through a million reference books and going to lectures and falling asleep 😴🤣

[@TaiNguyen-tw1gp]

Very nice and clear explanation! Thank you! (:

[@MissLovertjee]

Thank you! This was really helpful!

[@busrakorkmaz8315]

Thanks a lot, I understood everything!!

[@monpotecreux2411]

Dr. Brandl🙌

[@kotob77]

I am grateful for your .

[@jollyghi]

Thanks you!
Very clear now

[@DrSanjayNatarajan]

Amazing lecture. Is Interleukin 5 also involved in promoting IgA production apart from TGF Beta?

[@chrislane2322]

Fantastic, thank you!

[@bnfu3428]

thank you. very helpful.

[@amiryakobson5640]

OMG really good! thank you!

[@jingxinfu4208]

helped a lot! thanks!

[@Sadia5646]

great video!! i get it now!!!!

[@drswetaruparel]

Very helpful !!! 👍

[@fadeskywards1245]

Why doesn't the cut-out part just be spliced as an intron in mRNA?

[@Ben__Hall]

Love this 🏆🏆

[@maudophelders8264]

life saver!

[@astroboy4610]

Madam, I have a question. Do the b cell always have to work as APC for the Th2 in the germinal centre, so it eventually get activated by it(Th2)?
Otherwise how could the b cell and Th2 cell directly interact with one another?

[@rahmacat3098]

thank you sooo much

[@fitinsan]

Excellent indeed

[@reemalzubaidy6037]

Thank you

[@MrAdoole1]

Thanks a lot...

[@asmarahman333]

THANKS!

[@rajghosh4485]

Amazing

[@holypain8152]

Thabk you so much

[@radhwanabdulla6806]

Thanks

[@GeorgeMatthews1]

can someone please help. At 4:40 she said "if we were infected with *somthing* in mucosal tissue" what is that something. Basically i want to know when the Tfh would secrete more IL-4 making IgE

[@katharinabrandl361]

The Th2 cell would make some extra IL-4 if the invader e.g. was a worm. As a consequence class switching would occur to IgE.Hope this helps. This is more detailed explained in this video: ua-cam.com/video/o7N7KfjeLAs/v-deo.html

[@rauhaaveljet2955]

it's "helminth", a type of worm-like (often parasitic) organisms

[@ibrshimnasser2001]

Thanks alot

[@viniciusdantas1521]

One question. Where this process take place?

[@katharinabrandl361]

Both processes (somatic hypermutation and class switch recombination) happen in the germinal center.

[@michaelramirez9186]

perfecttttttttt

[@sarabsoul323]

بحبك، شكرًا

[@ShaniAvraham]

I love you

[@trinatrina1746]

Where is AID in your explanation?

[@IcyEdits]

Is "somatic recombination" the same as "class switch recombination"?

[@seraphina4268]

no somatic recombination is before the antigen binds, but class switching is after the antigen binds

[@drids.]

@@seraphina4268wrong. Somatic hiper mutation happens on B cells already activated by antigen bound to BCR. They then do clonal expansion, form a dark zone in the germinal center and activate inside them the activation induced deaminase AID which introduces mutation that will refine the BCR specificity for the antigen. If this B cells interact with paracortical tcd4 helper T cells via cd40-Cd40L then they undergo class switching (which also employs AID as a recombinasse for changing the constant region of the heavy chain)

[@psandbergnz]

Confusing and completely over my head!

[@zhouwu]

Bis du Deutsch?

[@katharinabrandl361]

Ja ;-)

[@zhouwu]

Es ist sehr Toll! Ich habe im Hamburg gewohnt wenn ich war drei Jahre alt zum wenn ich war sechs Jahre alt. Ich liebe Frei HanseStadt!!!!!!

[@bibeksharma1767]

Thank you

[@drids.]

I love you