Summary/Transcribed: a. Initiated when C1 recognises a microbial surface directly or binds to antibodies already bound to a pathogen. b. Binding causes cross proteolysis and activation of C1r and C1s proteases -> Activated C1 c. Activated C1s cleaves C4 into C4a (acts as anaphylatoxin*) and C4b which covalently attaches to the surface of the pathogen. d. C2 coenzyme binds to C2b and is then cleaved by activated C1 releasing C2a, creating Protease C4bC2b** = C3 convertase e. C3 binds to C3 convertase and is then cleaved by it as well releasing another anaphylatoxin C3a while C3b binds covalently to Pathogen surface and associate with C4bC2b forming C4bC2bC3b = C3/C5 convertase f. Many molecules of C3 can be cleaved by C3/C5 convertase releasing many molecules of C3a and C3b (binds to surface of pathogen inducing phagocytosis). g. C3/C5 convertase also cleaves and activates C5 releasing C5a (potent anaphylatoxin and most important chemoattractant) and C5b which then acts to form the initiation of formation of the membrane attack complex (MAC). h. C5b (not membrane associated) assembles with C6 and C7 (membrane associated) and insert themselves in bacterial membrane i. C8 binds to C5bC6C7 complex and inserts as well into cell membrane forming C5bC6C7C8 complex j. Complex catalyses assembly of many C9 molecules creating cylindrical pore k. Pore disrupts cell balances and kills cell. *Play a role in inflammation, chemotaxis, and the activation of immune cells. **New nomenclature.
I had 4th stage Adenocarcinoma Lung Cancer with EGFR mutation, I have tried different methods of treatment to get rid of this disease but I could not, few months ago a friend told me about Dr. Sani's Herbal Medicine that Dr. Sani could cure me totally from pain with his herbal medicines and Cancer oil, when I heard about his good works from my friend I requested for the contact Information of this man, after some days passed as I was always praying to God for mercy, I said to myself that God could use this man to heal me totally, after giving myself this thought I Immediately contacted Dr. Sani on (perfectherbalcure@gmail.com) and I told him about my condition, he responded to me and told me not to worry that he was going to prepare his herbal medicine and cancer oil and send them to me that all I needed was to provide him my home address where he can send my medicine to, after some days of deal with Dr. Sani, I received a package from the courier service, while I was with this medicine I told Dr. Sani that I have received the medicine he sent to me, he gave me prescription on how to take the medicines, Today all I can share with you now Is that I have been cured permanently from my Cancer Disease. Is been 4 Months and I have not experience the symptoms again, God has used Dr. Sani to do some great works in my life, I'm a living testimony of Dr. Sani's cancer oil, Root and Herbs Medicine, Please contact him for help on (perfectherbalcure@gmail.com) This Man can help you cure no matter the Sickness you have, why not contact him now and start to live a healthy life again. Email: perfectherbalcure@gmail.com Whats-App: +2348118184266
forza Napoli
wow
¿Y la musica de Linkin Park?
The best explanation!
Well understanding ❤❤❤❤
Amazing video! You successed to make me understand isotype switching which my textbook failed haha
Good video 👌
the body is wild
Summary/Transcribed: a. Initiated when C1 recognises a microbial surface directly or binds to antibodies already bound to a pathogen. b. Binding causes cross proteolysis and activation of C1r and C1s proteases -> Activated C1 c. Activated C1s cleaves C4 into C4a (acts as anaphylatoxin*) and C4b which covalently attaches to the surface of the pathogen. d. C2 coenzyme binds to C2b and is then cleaved by activated C1 releasing C2a, creating Protease C4bC2b** = C3 convertase e. C3 binds to C3 convertase and is then cleaved by it as well releasing another anaphylatoxin C3a while C3b binds covalently to Pathogen surface and associate with C4bC2b forming C4bC2bC3b = C3/C5 convertase f. Many molecules of C3 can be cleaved by C3/C5 convertase releasing many molecules of C3a and C3b (binds to surface of pathogen inducing phagocytosis). g. C3/C5 convertase also cleaves and activates C5 releasing C5a (potent anaphylatoxin and most important chemoattractant) and C5b which then acts to form the initiation of formation of the membrane attack complex (MAC). h. C5b (not membrane associated) assembles with C6 and C7 (membrane associated) and insert themselves in bacterial membrane i. C8 binds to C5bC6C7 complex and inserts as well into cell membrane forming C5bC6C7C8 complex j. Complex catalyses assembly of many C9 molecules creating cylindrical pore k. Pore disrupts cell balances and kills cell. *Play a role in inflammation, chemotaxis, and the activation of immune cells. **New nomenclature.
Best video on UA-cam for Immunosupressent concept 👌 👏 🙌
Thanks for helping me pass MICRB410!
thanks
MIGUEL ÚTERO LENDÁRIO🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥 ESSE ÚTERO É FOGO, PARECE O DA MINHA PRIMA🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥
so what happens after the signalisation ?
Bem ilustrativo
what genes do it activate what happens to the T cell
Thank you very much
Abcisic acid
Tienen esto video en español?
Vídeo incrível, didática excelente. Facilita muito a compreensão desse tema que não é trivial. Obrigada
why did i apply to this major
So much better than a lot of the other videos on this topic. I wish this was top recommended when I first searched vdj recombination.
amazing 😮😮😮😮😮
Thank you
no habla ingles
Hablo un pocito espanol
Awesome
Nice video. just a thing: Ca++ doesn't come from external membrane but from IP3R in endoplasmatic reticulum;
perfect, simple explanation thanks
Great video, this cleared up my questions in A&P. THANK YOU
Clear, simple complete. Thanks
I had 4th stage Adenocarcinoma Lung Cancer with EGFR mutation, I have tried different methods of treatment to get rid of this disease but I could not, few months ago a friend told me about Dr. Sani's Herbal Medicine that Dr. Sani could cure me totally from pain with his herbal medicines and Cancer oil, when I heard about his good works from my friend I requested for the contact Information of this man, after some days passed as I was always praying to God for mercy, I said to myself that God could use this man to heal me totally, after giving myself this thought I Immediately contacted Dr. Sani on (perfectherbalcure@gmail.com) and I told him about my condition, he responded to me and told me not to worry that he was going to prepare his herbal medicine and cancer oil and send them to me that all I needed was to provide him my home address where he can send my medicine to, after some days of deal with Dr. Sani, I received a package from the courier service, while I was with this medicine I told Dr. Sani that I have received the medicine he sent to me, he gave me prescription on how to take the medicines, Today all I can share with you now Is that I have been cured permanently from my Cancer Disease. Is been 4 Months and I have not experience the symptoms again, God has used Dr. Sani to do some great works in my life, I'm a living testimony of Dr. Sani's cancer oil, Root and Herbs Medicine, Please contact him for help on (perfectherbalcure@gmail.com) This Man can help you cure no matter the Sickness you have, why not contact him now and start to live a healthy life again. Email: perfectherbalcure@gmail.com Whats-App: +2348118184266
owesome!!
thank you so much, that made everything so clear
😍😍😍
Where is the video from?
Sir, can you share me all videos of "Janeway's Immunologybiology" book ? Thanks so much !
There is no God but Allah
what does that have to do with TCR signaling?
@@mustafaal-ghezi1757 The religion of "peace", I mean, war and death.
@@mustafaal-ghezi1757 god created you and TCR signaling.
I finally understand thank God
Very very helpful, thanks!!!
Well explained! great job!
Amazing Video! The animation is super helpful for understanding this fundamental immunology mechanism!
Where is 6.2
Where is 6.2 video
You could say that his was a PYCARD maneuver :D
Ohhh my God thank u! Lol now I understand better 🙏
thank you queen!
Best video on youtube for this topic. thanks
Thanks for d video.. this helped me a lot
00:58 Better war scene than The War of Winterfell.
provide us more videos