NMN Improves Aerobic Capacity in Runners
Вставка
- Опубліковано 16 лип 2021
- Join us on Patreon! / michaellustgartenphd
Discount Links:
NAD+ Quantification: www.jinfiniti.com/intracellul...
Use Code: ConquerAging At Checkout
Green Tea: www.ochaandco.com/?ref=conque...
Oral Microbiome: www.bristlehealth.com/?ref=mi...
Epigenetic Testing: Trudiagnostic.pxf.io/R55XDv
Use Code: CONQUERAGING
At-Home Blood Testing: getquantify.io/mlustgarten
Diet Tracking: shareasale.com/r.cfm?b=139013...
If you'd like to support the channel, you can do that with the website, Buy Me A Coffee:
www.buymeacoffee.com/mlhnrca
Conquer Aging Or Die Trying Merch! my-store-d4e7df.creator-sprin...
__________________________________________________________________________________________________
Paper referenced in the video: pubmed.ncbi.nlm.nih.gov/34238... - Наука та технологія
It would have been useful to have niacinamide and niacin groups alongside the other groups. Those supplements are also forms of b3 and are inexpensive, so it probably would not have added much cost to the study.
Right, but who do you think paid for this study? NMN manufacturer.
@@ivanandreevich8568 Yep...yet another study in the cult of DS's NMN
Nicotinamide is a sirtuin inhibitor. It's been debated in the last decade if it was good to take it or not, especially high dosages. That's what's makes me hesitate about NMN, would it inhibit the sirtuins or not? It might be better to wait for another future NAD+ activator.
@@ivanandreevich8568
are you inventing a story here, or are you privy to data not in the article?
Department of Sports Medicine, Guangzhou Sport University, Guangzhou, 510150, China. bagen2015@163.com.
2 Guangdong Physical Fitness and Health Management Association, Guangzhou, 510310, China.
3 Department of Sports Medicine, Guangzhou Sport University, Guangzhou, 510150, China.
4 Guangzhou Institute of Sports Science, Guangzhou, 510620, China.
5 South China Normal University, Guangzhou, 510631, China.
# Contributed equally.
@@Battery-kf4vu The folks that manufacture Qualia mind argue that moderate doses of niacinamide do not inhibit sirtuins in vivo:
"One of the misunderstandings we see and hear frequently is the idea that NAM inhibits sirtuins. Sirtuins (SIRTs) are NAD+-consuming deacetylase enzymes, producing NAM as a byproduct. Some enzymes can be slowed down if the product they make builds up. This is called product inhibition. In vitro, NAM (a product of the sirtuin reaction) is a non-competitive sirtuin inhibitor at high concentrations,(72, 73) so shows some degree of product inhibition. But, because this inhibition can occur in cell cultures at high concentrations of NAM, does not mean it would occur in the body at cellular concentrations of NAM. And this inhibition doesn’t always occur in vitro. As an example, several studies using liver cells have found that niacinamide increased sirtuin activity.(42, 74)
In studies where moderate doses of NAM have been given to living animals, in contrast to the predicted in vitro results, NAM increases SIRT activity(61, 75, 76). The reason for the different in vitro and in vivo result is likely because, in our cells and tissues, NAM does not build up to the concentrations needed to inhibit SIRT activity."
See neurohacker.com/how-is-nad-made-salvage-pathway
Thanks. I would like to see a study that assessed gut barrier function and diet going into an 8 week trial, and during the trial period employ the simple dietary measures Michael has discussed to affect NAD+, such as reducing CD38, and increasing efficiency of NAD+ salvage pathway. I'm trying to steer clear of supplements to the extent I can (no NMN and stopped NR) and maintaining a healthy gut barrier function (good high fiber foods and no crap) seems like a no brainer, with many benefits besides potential positive impact on NAD+.
Any NMN benefits related to exercise capacity may be unrelated to NAD.
Nevertheless, I will comment on concentrating on the Salvage Pathway vs NR, NMN, Niaicin , Niacinamide supplementation in terms of NAD boosting.
It does not seem to me that NMN, NR, Niacin, or Niacinamide gave that much of a boost in NAD in mice muscle tissue in this study. See figure 1D, www.ncbi.nlm.nih.gov/pmc/articles/PMC3616313/
This may mean that supplements do not boost NAD levels in tissue in healthy individuals all that much.
I think I recall that Dr. Rhonda Patrick has either stated or implied that the salvage pathway had a much greater impact on NAD levels compared to NAD booster such as the ones mentioned above. Since diet and exercise appear to affect the salvage pathway, this may mean that exercise and diet may have a much greater effect on NAD muscle tissue levels compared to NR, NMN, Niacin etc. .
I focus on tissue levels in this commentary because I seem to recall Dr. Charles Brenner saying that tissue levels and not other measurements (e.g. blood, liver) are the important NAD measurements.
The article mentioned in the context of physical strength results, where only the 600mg group showed positive result: "In one study, it was reported that there was an overdose NAD+ precursor reduced skeletal muscle NAMPT content through negative feedback [43]."
I take a sublingual dose of 125 mg before my HIIT workout and think it helps me get a better workout. It's much more powerful when taken that way. This study used oral doses, but 90% or more will be converted into nicotinimide by the stomach and liver.
where do you get that information? could you give me the link?
Great talk Mike.Was the respiratory quotient compared in this study.
Thanks Leo, unfortunately they didn't measure RQ.
@@conqueragingordietrying1797 I'm guessing the supplement improved fat burning ie fatmax .The improvement in speed at VT1 conveyed that.
Hello Michael - looks like vo2max improved over control by a amount of 0.3. Sounds like not very much. Any way to know what this would very approximately improve a 5k race time if say now race time for a 5k is 20 minutes. Is this improvement a couple seconds or near a minute. This to help quantify if worth supplementing. Thanks for any thoughts.
Hey michael, VO2 max wasn't significantly increased in the NMN groups when compared with controls. See Table 3, T*D column.
Very interesting data, especially that NMN didn’t effect BMI. I take NR trying to be more cost effective so hopefully this data translates to that precursor. You don’t take either do you? How much does this data sway you towards/against taking NMN/NR?
I’m also only 27 so I hope more studies come out on younger people so I know it’s not a huge waste of money.
It doesn't for me, but I'm in the supplements as a last resort boat. Others may find value for it, though, which is why I made the video.
On another note, do you do any hot/cold exposure? I think it would be really interesting to track how things like saunas affect your blood markers.
Or RHR/HRV
@@MrGatward Nope, I don't track either
interesting thanks. i wonder if any of this translates into actual enhanced biological youth, which is the real point. i'm hoping one of these NAD boosters ends up really working out, but the results I've seen have been largely underwhelming so far.
i do not see any mention of age of the study participants, when talking nmn, older participants will see more benefit than the younger participants
It's in the middle of the screen, average age = 36y. Age range 27 - 50y.
Will the price of NMN come down anytime soon?
What time of day is best to take NMN?
@@ottoavila9895 The price of NMN supplements is going down already as more and more competition in this area.
"We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers."
alivebyscience.com/who-we-are-2/
@@ottoavila9895 I believe the best time to take NMN is in the morning.
Those RHR are atrocious. These people may be lean but they aren't fit
That was my thought as well.