Neutrophils, Lymphocytes, Monocytes: What’s Optimal For Health And Longevity?
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- Опубліковано 5 гру 2020
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White blood cells (WBCs) comprise many different cell types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Neutrophils, lymphocytes, and monocytes account for ~99% of WBCs, and accordingly, in the video I propose optimal ranges for these cell types in terms of health and longevity. - Наука та технологія
This puts more light/perspective in looking at the normal range for wbc. Again I’m learning so much from your channel. It all makes sense now. It seems that neutrophil level is associated with the level of inflammation. Leukocytes level is the state of readiness for viral infections. Monocytes level is related to parasitic infections. Eosinophils will only go up during allergic reactions. Generally. Pleased correct me if I’m off.
Appreciate this doc. My PCP said my last labs were low on WBC
(3.6 L) and Neutrophils (1361 L) .. 🔥🤙🏽 Perfect timing
Even with your neutrophils being lower than optimal, there is a path where it may not be suboptimal. Do you have data for CRP?
@@conqueragingordietrying1797 I don't believe so. Could it be listed under another name besides C reactive ?
I saw I would need that on your biological age video as well.
Is there a best practice to raising my Neutrophils? I'm currently taking CoQ10 and Astragalus
@@Calaman345 Even though < 2000 neutrophils is associated with an increased all-cause mortality risk, I wouldn't recommend any changes more data. What does the rest of your data look like-albumin, creatinine, lymphocytes, glucose, BUN, etc? Also, do you have other blood test results for neutrophils? this may be a 1-time test low.
Maybe CRP is listed under C-reactive protein?
@@conqueragingordietrying1797
Albumin: 4.0
Creatinine: 1.36
Lymphocytes: 44.6
A1C : 5.4
Glucose : 83
Bun : 23
Total cholesterol: 235
HDL : 70
Triglycerides: 84
LDL : 146
Testosterone: 750
Dhea: 97
Absolute Neutrophils
Feb 2019: 3959
August 2020 : 1361
@@Calaman345 Did you do anything different for your diet before Feb 2019 that you changed after that blood test?
Your albumin can be higher-5 is found in youth. Also, your kidney function doesn't look good-creatinine is very high, and so is BUN. I'd fix those 1st, neutrophils will likely fall into place as a result.
Glad to hear this, my WBC is at 3.6
Total WBCs within 3500-6000 is important, but a main point of the video is that the distribution of neutrophils, lymphocytes, and monocytes is important, too-what are their levels?
@@conqueragingordietrying1797 As always look forward to the next video.Many thanks Mike ,great summary as per usual
@@LeoShoSilva Thanks Leo!
Hi Dr, I've found another large study (n=478,259) on WBC count and ACM risk. Interestingly, Monocytes (~400) and Lymphocytes (~2000) were the same as you presented, but this study got a different optimal neutrophils count with nadir at 3.1-3.6 for men (and not 2000-3000). This also changed the optimal WBC count to 5.41-5.88. Would love to hear your thoughts about this study, Dr ("Association of Total and Differential Leukocyte Counts With Cardiovascular Disease and Mortality in the UK Biobank
").
Hi Obi Z, yes, I'm familiar with that study. I focused on the BLSA study in the video because it's a longitudinal study-data for the same subjects was collected for up to 40y. The data from the study that you cited isn't very different-WBCs are still within the 3.5-6 range which may be optimal. Also, neutrophils increase during aging, so lower is better, whether the range is 2000 - 3000, or 3100 - 3600. That said, I find the most value in looking at individual levels of neutrophils, lymphocytes and monocytes, rather than total WBCs, as the age-related decline for lymphocytes would get lost in only looking at total WBCs.
I haven't forgotten about your LDL paper, I've been buried in other stuff atm. I have the paper open in one of my tabs, so carefully looking at it is on my to-do list.
Also, it's getting harder to respond to all comments across social media. Patreon may be of interest, as I go there first above all other platforms.
@@conqueragingordietrying1797 Thank you so much, your'e my hero. No kidding.
Great vid, all parameters on optimal levels so far. Thanks for sharing all this content Michael!
WBC 5.08
Neutrophils 2.33
Lymphocytes 1.96
Monocytes 0.44
Can you do a video on cancer prevention and/or blood markers for it?
Thanks Omar, your WBCs and differentials look good! Now, the challenge is to keep them there for the next 50y+.
There are many cancers-do you have a preference? As a drawback, the cancer markers are not commonly measured for the chem panel+CBC, one has to ask their Dr to test them, which makes applicability of a video for those markers less popular. Similarly, there aren't commercially available biomarkers for Alzheimer's disease or they aren't commonly measured. Regardless, I'm open to making a cancer biomarker video...
@@conqueragingordietrying1797 I have read several cancer types are tied to inflammation markers life CR-P maybe something on those lines. Cancer is definitely something I would like to prevent either with diet, habits or supplements.
I think my genetical wealth is substantial since great grandparents live into their 90's some into the early 100's and grand parents are well into their 90's and late 80's, cancer does not seems to run in the family since only my grandfather has been diagnosed with a low grade prostate cancer when he was 79, he just turned 90 this year.
Any valuable insights on how to prevent it would be very much appreciated.
@@conqueragingordietrying1797 My family has had breast, pancreatic, liver and stomach cancer. If you are able to look at cancer, diets and lifestyle that reduce risk in addition to biomarkers it could help myself and my family. I'm looking currently at Valter Longo longevity diet if that is useful.
@@biogerontology7646 Having a younger biological age is associated with a lower cancer risk, so optimizing that may be important. See 5:26 of this video:
ua-cam.com/video/6Rc9xLvD2PU/v-deo.html
are these the levels they should be? I'm guessing 2.33 means 2330 neutrophils?
Wow thanks so much for this. I had a high mark on my Monocyte %, however my absolute numbers seem to be ideal, at 390 cells/uL.
Should I be concerned at all that my monocyte % is high? Once it was reported at 9% and that was outside the stated range.
I wouldn't worry about the %, as it's the absolute # of circulating monocytes that is associated with outcomes. What are your other values, including lymphocytes and neutrophils, for more context?
@@conqueragingordietrying1797 OK very good that is reassuring. Doctors said a high % could be an infection somewhere... but one that lasted a year? It's hard to find a great doctor in Hungary. Lymphocytes 164 and Neutrophils (Neutrophil granulocytes) at 301.
Hi Dr, my monocytes have increased from 400 to 500. Which foods are correlated with lower monocytes in your data? It seems very few published studies were done on this topic.
Hi Obi z, i over 17 blood tests that correspond to diet, the most significant correlation is for a higher turmeric intake with lower monocytes. Whether that would be true for you is unknown, though...The key is to track your own data, so that you can identify what may impact it for you!
@@conqueragingordietrying1797 Thank you, I'll try to add more to my food.
4:37 Ah yes, less pregnant women.
I'm teasing! Great video as always.
Aside from trying to stay in the optimal ranges for these biomarkers, do you have any tips for a 19-year old to maximize lifespan? Are there any supplements which are safe enough to recommend to someone my age?
Ha, you know what I meant, a lower proportion of pregnant women! I like preparing the slides and then talking off the top of my head, for better or worse, as that's more authentic than reading from a script like a robot. Sometimes I'll misspeak though!
See this post for factors that impart a 12 - 14 gain in life expectancy (michaellustgarten.com/2019/10/01/12-14-years-of-lifespan-extension-with-5-factors/).
But that amount isn't good enough for me. A higher level is tracking blood biomarkers 4-6x/year, tracking diet and fitness, and intervening when necessary through their combination to optimize the blood biomarkers. Aging and disease don't happen overnight, and by tracking circulating biomarkers, one can identify issues and intervene as soon as possible, thereby slowing aging and minimizing disease risk. Supplements are a last resort, if diet+exercise doesn't work. There's much more to say than this, but this is the abridged version!
@@conqueragingordietrying1797
While I certainly respect the benefits of having the fundamentals, it fells a little, well, fundamental.
To give an extreme example I have a single factor that can likely increase you lifespan even more: not being on end-of-life support. You see how that seems a bit off?
I'm definitely with you on tracking as many biological clocks as possible. Speaking of which, have you seen this hot new study? (does 6 months old count as "new" anymore?) www.biorxiv.org/content/10.1101/2020.05.07.082917v1
Apparently Katcher is patenting the intervention which he calls "elixir". There's an interesting writeup here (www.anti-agingfirewalls.com/2020/08/15/younging1-the-emerging-aging-reversal-strategy/) which focuses on H3K27me2/3 demethylators, specificaly via JMJD3 activators. Interesting tidbit: "IL-6 exuded by senescent cells is a necessary trigger for nearby normal cells in the same organ to start expressing the OSKM Yamanaka factors so they can epigenetically regress to becoming stem-cell like progenitor cells in the same lineage type, which can the differentiate to replace the senescent cells"
I'd love to see you do a video on the paper, which I suspect might be a bit of a teardown
I have fallen way too low at times likely due to fasting, NR, Fisetin, and a high plant based diet, all of which seem to knock down total WBC according to my anecdotal and scientific research. The last time I was measured, I improved to 3.3, slightly out of reference range. Now I only take Fisetin 5 days out of the month and have not fasted for more than 6 months. I was previously doing a 3 day fast once a quarter. Dropping daily fisetin and abstaining from Fasting increased total WBC from 2.4 to 3.3.
With low WBCs, the most important cell type to keep an eye on are lymphocytes. For optimal immunity, they should not be low, in contrast with neutrophils and monocytes, which increase during aging.
@@conqueragingordietrying1797 Thank you!
With no fasting for at least six months, I improved up to 3.7 total WBC, with neutrophils at 56%. which puts me at 2.07 neutrophils. lymphs at 28%, which put me at.1.036, monocytes at 14% at.518. I am in my 50s. . Being a vegetarian and exercising a lot (weights, running, sauna), I am on the lower side of protein intake, but I probably get slightly more than one half gram per pound of body weight. I am not really sure how one goes about increasing lymphs and reducing monocytes. One internet source suggested creatine, holy basil and reishi for raising lymphocytes. I will probably try low dose creatine. I already have it in the house and tried it a couple of times in the past and seem to quit it each time as I subjectively feel bulkier taking it.
@@jackbuaer3828 What's your hs-CRP, albumin? That plus your lymphocyte data can tell more of the story.
@@conqueragingordietrying1797 I stopped testing CRP since i have always been low. My last test was in 2018 and it was less than .2. Albumin has ranged from 4.5-4.9. I have not had Albumin tested for about a year. I think the last test, at 4.5, may have been lower than my previous tests to fasting near in time to the test. Though my carotenoid intake was likely already above average, I have increased carotenoids due to your albumin video. I eat a boiled carrot in the morning and full dehydated red pepper in my mixed green salad in the evening. I get plenty of lycopene daily and I also get carotenoids from several other sources. Thanks for your help!
What part does the NLR play ,and is this using a European cohort.Asians and Africans usually have lower N and L numbers etc
That's a video for another day, Leo, but the TL;DR is that a higher NLR is associated with worse outcomes:
michaellustgarten.com/2019/10/10/neutrophil-lymphocyte-ratio-and-survival/
What's your take on ratios? Specifically lymphocyte-to-monocyte ratios 5:1 and reciprocally 0.2?
Why the lymphocyte:monocyte ratio? Do you have some publications that suggest its importance?
Based on the optimal ranges in the video, somewhere around 5:1 would be expected to be optimal (lymphocytes, ~2000, monocytes ~400).
@@conqueragingordietrying1797 Hmm. It seems that YT doesn't approve of me posting links. Here are the titles:
"Monocyte-lymphocyte ratio is a valuable predictor for diabetic nephropathy in patients with type 2 diabetes" n=402
"Monocyte lymphocyte ratio predicts the new-onset of chronic kidney disease: A cohort study" n=11,280
🔴Video idea: Mean corpuscular hemoglobin and concentration🤔🤔🤔
Thanks Cal. Because that data is derived from MCV and hemoglobin, those biomarkers are more important, imo. I have a MCV video (ua-cam.com/video/_d0prokvH-s/v-deo.html),
and hemoglobin is discussed at 7:44 of this video:
ua-cam.com/video/_d0prokvH-s/v-deo.html
Actually, WBC 4.3 to 5.5 is optimal, but 3.6 to 6.0 is associated with longest survival--Absolute Neurophils should be between 2 and 3 and I'm at 2.4, and absolute monocytes should be between 4 and 5.5 and mine is at 5--Interesting that WBC should never be above 6, in this 43 yr study
Actually, it appears to me that 3.5-4.5 is associated with the longest survival
"Above the threshold of 3,500 WBC/mm3, the estimated mortality risk was 11% higher per each baseline additional increase of 1,000 WBC/mm3."
TWBC 5.5
Lymphocytes 0.60
Neutrophils 4.20
Monocytes 0.70
I'm 23 and now terrified
Hey Matt, are your lymphocytes chronically low, or is this an aberrant measurement? I'd retest sooner, rather than later.
how are you feeling?
None of these values are optimal for me. Lol.