I appreciate this course. I recently found out I have a mutation in the GAD1 gene that makes it hard for my body to convert glutamate into GABA. maybe that's why I've always been an anxious insomniac. I'm currently taking an SSRI which helped but I don't think it's helping as much as it could and now I understand why. I now at least have some ideas for what to try next. thank you!
Such a refreshing take to hear on this topic . I’ve seen so many people have problems from just being handed prescription meds. I work in the holistic /supplements industry and it’s awesome to see someone like yourself educate the public about GABA and its role in the brain. It helped me so much and I recommend it to customers often. I took high amounts in response to some crazy COVID stressors, but I would never recommend this. I only recommend much smaller doses to customers. Now with everything you explained here, I think I healed my brain after several years of heavy drinking. I stopped drinking entirely for about 2 years and during that time supplemented with the GABA. I rarely use gaba now and drink rarely and overall much more balanced and no longer anxious daily. GABA was a helpful little crutch but ultimately yoga, therapy, introspection , life changes, diet changes, and person growth were what solved my anxiety problems.
Thank you for sharing your experience. It's great to hear how GABA has played a positive role in your journey towards balance and reduced anxiety. I completely agree that while supplements can provide valuable support, a holistic approach encompassing lifestyle changes, therapy, and personal growth is crucial for long-term well-being. Your story highlights the importance of individualized care and the potential pitfalls of relying solely on prescription meds. Also, please feel free to share what you’ve found most useful from the video and, if you’re interested in learning more about neurotransmitters or to search for videos in the video library, don’t hesitate to use my AI: allceus.com/AskDocSnipes. Keep up the fantastic work in educating your customers and promoting a balanced, healthy lifestyle!
You’re most welcome. I am grateful to be of service. Also, I’d be grateful if you were to share what you found most useful from the video. Additionally, if you're interested in more tips on the topic or if you want to explore my video library, you can use my AI: allceus.com/AskDocSnipes.
You should make a video about BDNF and other anti-inflammatory nerve growth factors. If we're already entering the rabbit hole, then why not see it through to the end? SSRI/SNRI, altered GABA/glutamate signalling due to antidepressant treatment ultimately all translate to increased BDNF release and effects, which is in turn said to be the main mediator of treatment benefits. Sports, environmental enrichment, psychotherapy (and all other empirically proven treatments) facilitate that aswell, and it's thought that ketamine and psilocybine act rapidly, because they likewise lead to a very fast increase in BDNF release, instead of a delayed one that ramps up over a couple of weeks starting with treatment initiation (SSRI/SNRI). Neuroplasticity is everything!
Add Tinnutus on list of symtons of to little GABA in your system, with self (tone in your head 24hrs a day) reinforceingc by making you constantly overstressed. So far I am less into treatment of than a week into 2/3 tablespoon, twice a day, and got my Tinnutus down almost to almost totally gone. I shall see if makes my Tinnutus permanently gone or not. Tim Keating
I'm sorry to hear you're feeling this way. It's important to talk to a healthcare professional about your concerns regarding GABA and any symptoms you're experiencing. They can provide personalized advice and potential treatment options to help you feel better. Take care.
That’s a great question! If you have thyroid issues, it’s essential to be cautious with any supplements or substances that might affect your brain chemistry, like those influencing GABA and glutamate levels. It’s always best to consult with your healthcare provider or endocrinologist before making any changes, as they can provide guidance based on your specific condition and needs. Have you noticed any differences in how you feel when you adjust your diet or supplements with your thyroid condition?
What would one do for an abrupt cessation of Klonopin after 12 years? I have had akathisia constantly for over three years now my cognition is gone. I cannot think my anxiety is through the roof. It has given SI constantly. Seizures, hallucinations and I never even abused my prescription. The doctor just told me they didn’t want to prescribe it anymore. It’s like I have Parkinson’s now I can’t eat any glutamate food that makes it even 1 billion times worse. How are doctors an SSRI to calm down the nervous system when SSRI do not work the gather or glutamate system like a benzodiazepine manipulates the receptors? I would like to be able to live life. I have no quality of life all the doctors already tried all the antipsychotics and everything even ketamine none of it worked.i was also given cipro a month high dose my fear factors are now messed up i’m not scared of stuff. I should be scared of and scared of stuff that I should not like living in a house. I am totally not scared of tornadoes or other dangerous things now
Thank you for sharing what you’re going through-it sounds incredibly distressing, and I’m so sorry you’re experiencing this. Abrupt cessation of a medication like Klonopin, especially after long-term use, can lead to severe withdrawal symptoms, including akathisia, cognitive difficulties, and extreme anxiety, as you’ve described. The nervous system takes time to recalibrate after such a change, and symptoms can feel relentless during this period. The impact on GABA and glutamate balance is profound, as benzodiazepines directly interact with GABA receptors, so sudden withdrawal can disrupt this balance and heighten nervous system sensitivity. It’s understandable to feel frustrated, especially when treatments like SSRIs or antipsychotics don’t address the specific GABA-glutamate system changes caused by benzodiazepine withdrawal. Finding a doctor or psychiatrist experienced in benzo withdrawal syndrome may be helpful, as they can provide a tailored approach that acknowledges your history with the medication. It might also be worthwhile to explore gentle, supportive practices like mindfulness, grounding exercises, or breathing techniques to reduce nervous system activation, though I recognize that even these small steps can feel challenging in your current state. Please know you’re not alone, and there are professionals and communities who understand the depth of these struggles. Finding the right support can be difficult, but it is possible. Have you come across any techniques, even minor ones, that offer a little relief from the symptoms? Sometimes hearing what’s worked, even slightly, can help others going through similar challenges.
i have a vagus nerve stimulator. i have Petit mall seizures. I have noticed my seizures gets better if I drink omega 3 every day. Do you think I have some kind of deficiency? and what supplements do you think I can take? do you have any videos that addresses issues like this?
My overview about the topic is very limited, but there's some fatty acids that can theoretically have anti-seizure activity after metabolism. The one I'm specifically thinking about is arachidonic acid. When it gets metabolized to anandamide, it can increase the seizure threshold through similar mechanisms like THC. Fatty acids in general do also get incoorporated into cell membranes. The trend is the following: saturated fats -> more rigid membranes, unsaturated ones -> more fluid-like. This can in turn alter the activity of cation (excitatory) and anion (inhibitory) channels by altering their opening/closing patterns. When the net effect results in inhibitory signals getting enhanced, that could also play a role in anti-seizure effects. You could try supplementing some (no more than 400mg/d - talk to your doctor beforehand if you have kidney issues) magnesium, which serves the function of acting like a signal intensity filter in NMDA ligand gated ion channels (= ionotropic glutamate receptors of the NMDA type), which could also serve to reduce overexcitation of neurons.
I appreciate this course. I recently found out I have a mutation in the GAD1 gene that makes it hard for my body to convert glutamate into GABA. maybe that's why I've always been an anxious insomniac. I'm currently taking an SSRI which helped but I don't think it's helping as much as it could and now I understand why. I now at least have some ideas for what to try next. thank you!
Such a refreshing take to hear on this topic . I’ve seen so many people have problems from just being handed prescription meds. I work in the holistic /supplements industry and it’s awesome to see someone like yourself educate the public about GABA and its role in the brain. It helped me so much and I recommend it to customers often. I took high amounts in response to some crazy COVID stressors, but I would never recommend this. I only recommend much smaller doses to customers. Now with everything you explained here, I think I healed my brain after several years of heavy drinking. I stopped drinking entirely for about 2 years and during that time supplemented with the GABA. I rarely use gaba now and drink rarely and overall much more balanced and no longer anxious daily. GABA was a helpful little crutch but ultimately yoga, therapy, introspection , life changes, diet changes, and person growth were what solved my anxiety problems.
Thank you for sharing your experience. It's great to hear how GABA has played a positive role in your journey towards balance and reduced anxiety. I completely agree that while supplements can provide valuable support, a holistic approach encompassing lifestyle changes, therapy, and personal growth is crucial for long-term well-being. Your story highlights the importance of individualized care and the potential pitfalls of relying solely on prescription meds. Also, please feel free to share what you’ve found most useful from the video and, if you’re interested in learning more about neurotransmitters or to search for videos in the video library, don’t hesitate to use my AI: allceus.com/AskDocSnipes. Keep up the fantastic work in educating your customers and promoting a balanced, healthy lifestyle!
I am 53 on HRT since 3 years
Your Videos are pearls 💝Thanks blessings 😊💝
You are so welcome
Do you still take it
this was very insightful and applicable to real world daily life
Thank you
Good morning!
And a great day to you!😊
Hello!
I'm so grateful for this information!
You’re most welcome
Thank you!
You’re most welcome. I am grateful to be of service. Also, I’d be grateful if you were to share what you found most useful from the video. Additionally, if you're interested in more tips on the topic or if you want to explore my video library, you can use my AI: allceus.com/AskDocSnipes.
Thank you! Very informative.❤
You are so welcome!
thank you for this
You're very welcome!
You should make a video about BDNF and other anti-inflammatory nerve growth factors. If we're already entering the rabbit hole, then why not see it through to the end?
SSRI/SNRI, altered GABA/glutamate signalling due to antidepressant treatment ultimately all translate to increased BDNF release and effects, which is in turn said to be the main mediator of treatment benefits.
Sports, environmental enrichment, psychotherapy (and all other empirically proven treatments) facilitate that aswell, and it's thought that ketamine and psilocybine act rapidly, because they likewise lead to a very fast increase in BDNF release, instead of a delayed one that ramps up over a couple of weeks starting with treatment initiation (SSRI/SNRI). Neuroplasticity is everything!
Thanks for watching the video. I mention BDNF in this video on Intermittent Fasting: ua-cam.com/video/FAVQdw8Licw/v-deo.htmlsi=ketFjIPV2fm3Q7ZA
Add Tinnutus on list of symtons of to little GABA in your system, with self (tone in your head 24hrs a day) reinforceingc by making you constantly overstressed. So far I am less into treatment of than a week into 2/3 tablespoon, twice a day, and got my Tinnutus down almost to almost totally gone. I shall see if makes my Tinnutus permanently gone or not. Tim Keating
Thank you for watching the video
What are you taking?
I think I’ve ruined my gaba … just tuning in
I'm sorry to hear you're feeling this way. It's important to talk to a healthcare professional about your concerns regarding GABA and any symptoms you're experiencing. They can provide personalized advice and potential treatment options to help you feel better. Take care.
50:32 now i know why i loved dextromethorphan!!
Thanks for watching
@DocSnipes thanks for making this video!!! I once took a lot of GABA and had a panic attack where i couldnt breathe. I didnt understand, but now i do
What if you are extremely sensitive to glutamate? How to fix it?
What does your doctor say about that? Have you had a full assessment?
Can it be drunk with thyroid problems?
That’s a great question! If you have thyroid issues, it’s essential to be cautious with any supplements or substances that might affect your brain chemistry, like those influencing GABA and glutamate levels. It’s always best to consult with your healthcare provider or endocrinologist before making any changes, as they can provide guidance based on your specific condition and needs.
Have you noticed any differences in how you feel when you adjust your diet or supplements with your thyroid condition?
What would one do for an abrupt cessation of Klonopin after 12 years? I have had akathisia constantly for over three years now my cognition is gone. I cannot think my anxiety is through the roof. It has given SI constantly. Seizures, hallucinations and I never even abused my prescription. The doctor just told me they didn’t want to prescribe it anymore. It’s like I have Parkinson’s now I can’t eat any glutamate food that makes it even 1 billion times worse. How are doctors an SSRI to calm down the nervous system when SSRI do not work the gather or glutamate system like a benzodiazepine manipulates the receptors? I would like to be able to live life. I have no quality of life all the doctors already tried all the antipsychotics and everything even ketamine none of it worked.i was also given cipro a month high dose my fear factors are now messed up i’m not scared of stuff. I should be scared of and scared of stuff that I should not like living in a house. I am totally not scared of tornadoes or other dangerous things now
Thank you for sharing what you’re going through-it sounds incredibly distressing, and I’m so sorry you’re experiencing this. Abrupt cessation of a medication like Klonopin, especially after long-term use, can lead to severe withdrawal symptoms, including akathisia, cognitive difficulties, and extreme anxiety, as you’ve described. The nervous system takes time to recalibrate after such a change, and symptoms can feel relentless during this period. The impact on GABA and glutamate balance is profound, as benzodiazepines directly interact with GABA receptors, so sudden withdrawal can disrupt this balance and heighten nervous system sensitivity.
It’s understandable to feel frustrated, especially when treatments like SSRIs or antipsychotics don’t address the specific GABA-glutamate system changes caused by benzodiazepine withdrawal. Finding a doctor or psychiatrist experienced in benzo withdrawal syndrome may be helpful, as they can provide a tailored approach that acknowledges your history with the medication. It might also be worthwhile to explore gentle, supportive practices like mindfulness, grounding exercises, or breathing techniques to reduce nervous system activation, though I recognize that even these small steps can feel challenging in your current state.
Please know you’re not alone, and there are professionals and communities who understand the depth of these struggles. Finding the right support can be difficult, but it is possible.
Have you come across any techniques, even minor ones, that offer a little relief from the symptoms? Sometimes hearing what’s worked, even slightly, can help others going through similar challenges.
i have a vagus nerve stimulator. i have Petit mall seizures. I have noticed my seizures gets better if I drink omega 3 every day. Do you think I have some kind of deficiency? and what supplements do you think I can take? do you have any videos that addresses issues like this?
I am sorry you have seizures and I appreciate you watching the video. Your doctor is the only one who should recommend supplements
My overview about the topic is very limited, but there's some fatty acids that can theoretically have anti-seizure activity after metabolism. The one I'm specifically thinking about is arachidonic acid. When it gets metabolized to anandamide, it can increase the seizure threshold through similar mechanisms like THC.
Fatty acids in general do also get incoorporated into cell membranes. The trend is the following: saturated fats -> more rigid membranes, unsaturated ones -> more fluid-like. This can in turn alter the activity of cation (excitatory) and anion (inhibitory) channels by altering their opening/closing patterns.
When the net effect results in inhibitory signals getting enhanced, that could also play a role in anti-seizure effects.
You could try supplementing some (no more than 400mg/d - talk to your doctor beforehand if you have kidney issues) magnesium, which serves the function of acting like a signal intensity filter in NMDA ligand gated ion channels (= ionotropic glutamate receptors of the NMDA type), which could also serve to reduce overexcitation of neurons.
@@Psychx_ Thank you so much for this!!