Why Are Antidepressants So Difficult to Stop? A New Understanding of Drug Dysregulation Syndrome and
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- Опубліковано 22 вер 2024
- Many people who stop taking SSRI antidepressants experience what is often described as “protracted withdrawal syndrome.” In this webinar, David Healy presents a different understanding of the biology of this injury: people withdrawing from SSRIs are suffering a “dysregulation” of their sensory nervous system. He will tell of how drug companies knew of this hazard when they developed SSRIs, and how they sought to hide it from the public. As most of serotonin is found outside our brain, SSRIs primarily impact our “bodies”, especially our senses. The target effect of SSRIs is a sensory muting, but they may also cause a sensory irritation, giving rise to akathisia. Both muting and irritation can cause problems, especially on stopping.
As such, the drugs give rise to a “Drug Dysregulation Syndrome” affecting different systems, especially after extended exposure. These syndromes are not manifestations of psychological or physiological drug dependence. They are not linked to binding at the serotonin reuptake sites, and they are not caused by the speed of tapering. What we do know about managing these syndromes has come from people with lived experience with these problems.
This webinar will sketch a way forward for managing this "syndrome."
About the Guest Speaker
David Healy has worked on serotonin reuptake systems for 40 years, in the laboratory, as a consultant to pharmaceutical companies, as a clinician using SSRIs and recognizing the problems they cause, and, for over a decade, as a member of the RxISK.org team that collects reports on treatment-induced adverse reactions.
Amazingly inspiring talk.
I painted a grim picture of psychiatry as a med student, but these talks encourage me to become the psychiatrist the patients deserve.
Kudos!
It's Maddening in America that doctors generally don't much know about medication effects or cessation or even what they do and dismissing you when you say there's a problem with the meds.
It's not just America, in Ireland and the UK the standard is to put people on SSRIs and talk them out of coming off no matter how bad the side effects are. They have no idea what they are doing
It's the same all over the world, it's a mess.
psychiatry must be abolished and re founded.
“The last thing you want on this earth if you got a drug induced toxicity is a psychiatrist” David Healy
Wish I had known this when I first reacted to metroclopamide. I’d probably be healed by now.
"Don't do anything without consulting your doctor." 😥
Great webinar!
Thank you so much. Such a lot of information (which is a good thing). I had already discovered that doxycycline is a seriously bad antibiotic for me and ibuprofen is a no-no. I will now check carefully and use a lot of caution with any antibiotic or antihistamine!
I slowly tapered off of Zoloft over four months. I became extremely sick, flu like, bed ridden. I easily was able to get off opiates with no problems and I was prescribed enough to kill a horse. Modern medicine is good for some things but mental health is largely quackery. If drugging yourself into a disaffected apathetic state, it’s your choice. While I’m not perfect, I am feeling much better without it.
How are you now?
I’m doing far better than I was under pharmaceuticals. I feel more alive then a numbed shell of a person.
@@MisterMeow-vt8kl what dose did you take? Did you take Zoloft for depression?
Yes, MDD. 100 mg.
Me too. But different drug (mirtazapine). So glad you are free of Zoloft and feeling better.
I only recently found out about pharmacogenetics. I tried vairous SSRI at increasing doses (up to 40mg) in my younger years, for two decades. Only this year did I get a simple lab that tells me my genetics make me metabolize those drugs inefficiently and with toxic side effects the higher the dose. They were havoc on my liver but we didn't know, nobody checked. they just kept raising doses. Do they not screen clinical trial participants for genetic variation like this??? I feel super cheated like my 20s and 30s were just lost.
Same fricken thing happened to me. Except I caught on part way thru my 20s. I was started on all meds at 14. But I was put on SSRIs at 17. I’m 25 now I feel like I’ve woken up from an 8 year coma. All my friends graduated college. And I’m still only a few credits in. I’m getting my life back now tho; I am healing and have actually managed to get healthier than I ever was before. I view myself as a 14, 17, and 25 year old all in one body. So although I’ve lost so much time, mentally I still feel like a teenager and still have that spark and motivation to pick up where I left off at 14-17.
I hope one day you can interview Jordan Peterson. Regardless of his politics, his medication story is incredible and important. Because he is so smart and well spoken and clear, no one can get things mixed up and say his reaction was a mental problem, etc. He went through hell and talks about it so sanely.
Potassium boosts seretonin.
Very IMPORTANT info! I was tapered off Zoloft too fast by Dr. 17 year use (physical dependence, didn't need it). Sick housebound and disabled 1 year off.
I understand. I hope that the more time you have off Zoloft the better you will feel. Hang in there. It can be such a slow recovery. You got this!
Literally doesn't give a hard answer on Anthony for two hours
1 word BRAINDAMAGE
The last sentence or two is about the basic dynamic of capitalism.
For natural approaches...what about therapeutic ketogenic diet? Dr Palmer's book BRAIN ENERGY was eye opening.
Dr Georgia Ede as well
Now I wonder if my gluten problems are due to SSRIs that I took for nearly 5 years. I never had problems with bread before the drugs.
I can guarantee that it's related. Our homo sapien bodies have not evolved alongside these Pharmaceuticals for very long. These Pharmaceuticals are incredibly damaging on our bodies.
Help me someone, I'm near the end. Only hours left to live.. I dont want to die
What is your prpblem exactly?
@@jozefff7911 Damaged by Reglan and short term use of Lexapro. Severe symptoms, including akathisia. Help me!!!
Iam close to to you jrman413. It's sad. To be so close to end it all. I thought just two days ago im entering again the window and wave phase. But then again....its to much
All I can say and give you.....I send you a big warm hug. Hang in there.
such important work - amazing there is no much good information drowned out by the power of neoliberalism and its incentives.
Genuinely curious as to how neoliberalism is the issue (not disagreeing, I actually wanna know the reasoning behind this)
Do SNRI’s do the same thing coming off them?
Harris John Garcia Steven Rodriguez Donna
YT the sedation of nations. James Davies