Dr. Bruce Ames was talking about ergothioneine decades ago! He has a list of the most important compounds for health out there. Taurine was on there too.
Mice have approximately 97.5% of their working DNA in common with humans.........so you should not imply that you need to be a mouse to gain any benefit from this research
Don't black and red beans also have ergothioneine? I eat a ton of those. I only eat mushrooms like once a week or so. Maybe I need to eat more and look for these varieties.
@@rescuebabybirds Interesting, thank you very much!... "High levels of ET (up to 0.8 mg per g dry mass) were measured in cyanobacteria preparations sold as dietary supplements for humans and in fresh Scytonema and Oscillatoria cultures. Cyanobacteria contained as much ET as King Oyster mushrooms (Pleurotus eryngii). [...] Spirulina is a novel, safe, accessible, and affordable source of ergothioneine for humans."
Ergothioneine is an amino acid that is found mainly in mushrooms, as well as red and black beans. It is also found in animals that have eaten grasses containing ergothioneine. Ergothioneine is sometimes used as medicine.
@@gristlevonraben Molecular weight of Methylsulfonylmethane: 94.13 g/mol Taurine: 125.14 g/mol Cysteine (Taurine precursor): 121.16 g/mol Ergothioneine: 229.30 g/mol No, it does not
Wow, this is hectic, you made a complex scientific paper easy to understand in just over 12 minutes! Great work! ps I'll be back for the episode on pyruvate ;-)
Increasing respiratory rate artificially may have negative consequences, the vulcano plot clearly shows that there are severl metabolites that increase and decrease with exercise, all these metabolites change with exercise for a reason. So just supplementing ergothioneine may cause more harm than good. I would wait for a long-term study before considering this as a supplement.
I completely agree. This is one study that hasn't been peer reviewed, let alone replicated. One of my concerns is that if we increase mitochondrial respiration, we will also be increasing the production of free-radical species. We are only just scratching the surface here.
Visiting your channel for the first time. Good explanation. Normally I check whos talking first (phd in what, maybe publications etc). Id kept an eye on ergothioneine over the past months or so. Its getting more interesting but atm I will just eat my mushrooms on a daily basis (200g/d).
@@lonridgway2728 Glucose is broken down to pyruvate via glycolysis. The pyruvate is then metabolized is a chain of reactions that are termed the citric acid cycle (Krebs cycle)… I assumed you were asking a question based on the emoji, if it was a statement just ignore✨
I take NAC, am a vegetable consuming vegetarian, love and regularly eat oyster mushrooms. I exercise intensively and regularly. Have a low carb diet with a BMI od 22. Well muscled as well. I feel like crap most of the time. Ache all over.
Many supermarkets sell a 3 or 4 oz box of Oyster Mushrooms for 3 bucks to 4 bucks. Oyster Mushrooms are one of the highest grade source of ergothioneine and some strains of Pleurotus ostreatus (yellow oyster mushroom) can hit 11,000 mg / Kg or 11 mg / gram of wet uncooked mushroom. So a one ounce serving of common yellow oyster mushroom (28g) could be as much as 300 mg of ergothioneine for one buck for each days serving per person. Even if your oyster mushroom has the lower limit of only 1100 mg / Kg ergo, it is still a 30 mg serving per ounce of mushroom uncooked. Compare that to the claimed 5mg supplements sold on Amazon right now. I think the strain improvement of oyster mushrooms or the media they are grown on has just started and these little tasty guys may become a superfood dietary choice.
Fascinating in the context of Chronic Fatigue Syndrome and Long Covid, where mytochondrial dysfunction is suspected and yet exercise only makes the condition worse.
"uses more oxygen" is not alone a sign that it improves mito function. It could be, but it could also be that it stresses the mito, and it needs to work harder for the same outcomes. Too much guessing and assuming
@@mbmurphy777 Which likely also means more free-radical production, assuming that this non-peer reviewed study is successfully replicated (most initial positive studies fail on replication).
Anything that assists in enhancing the function and ability of the mitochondria is a potential tool to help in the treatment of cancer. Thanks for bringing this supplement to my attention!
The Oyster and Shiitake mushrooms are supposed to be very good sources of this aminoacid and some people claim they can improve workout performance and have antiaging properties. Does it make sense?
Ergothioneine was in my healing stack (arround 20 supps) 2 years ago. There was also reishi, chaga and all the antioksidantrs :D It cured my psoriasis. Tho as I said - 20 supps a same time - who knows what role Ergothioneine did there if any.
Methylene Blue increases mitochondria oxygen consumption around 30%, what happens when using both? Do you turn green and rip your clothes to shreds? How does oxygen concentration affect this process?
@@Mr_Penguins_Pet_Human If you don't mind, are your symptoms completely resolved? How much do you take, and how often? Do you have a recommended source? Thank you for your consideration!
Middle aged guy here. Well, I picked up _Life Extension L-Ergothioneine_ @ 5mg / day to see how effective it might be. There was one study from Blue California _(also makes this stuff)_ showing improved sleep. My sleep is notoriously bad, so if it improves, then maybe this product is perhaps also doing the other things this new study purports.
Seems promising. L-Ergothioneine seems to be available as caps with vague claims of beeing good for aging skin, is this the same stuff you think? We all could do our own n=1 study and see we notice anything in the gym :P
@@mballerI think ergo is a type of fungi and various types of mushrooms contain ergothienine. Though some contain more than others. I am not sure which type contains the most.
I process and track pretty accurate data for running and have had seen no additional improvement from NMN supplementation during my current base phase. I might try this one to look for a statistically significant increase in avg GAP times over the improvements I have seen in May.
@@MrJohnson57 It begins to break down chemically after 30-45 days. The bottle I purchased from Nutricost has no manufacturing date, but the expiration date on it says "02/2027". Which is about 3.8 years past 45 days to give you a good idea about how reliable these suppliers really are.
@@thepatternforms859 Recovery? Your mitochondria are going to recover by the next day. That's not what you are recovering from after a workout day in running (higher intensity). You have all of these waste products from burning glycogen in your fuel mix. Go to threshold and muscles are going to require at least another day to recover fully. That has nothing to do with mitochondria, though. You can go out next day to do a base run. Mitochondria still work fine as you stick around mainly in your aerobic system. The products are marketed as mitochondrial boosters -- and I saw no improvement over what I normally would have seen from training. Furthermore, I have discovered the chemical breaks down after about four weeks. The bottle I bought has an expiration date like four years from now.
Hmm... digging deeper on MPST: Dietary Supplements: While specific chemicals directly enhancing MPST production are less documented, supplements that support mitochondrial health, such as Coenzyme Q10 and alpha-lipoic acid, might have an indirect positive effect. Sulfur-Containing Compounds: Since MPST is involved in sulfur metabolism, dietary intake of sulfur-containing amino acids like cysteine and methionine might support its activity. (This is interesting because NAC is part of the GlyNAC duo that has been highlighted in another study for improving the hallmarks of aging.)
USC has discovered the protein humanin to play a significant role in the health of mt. Might be a good target for supplementation since its levels drop with age.
so our ancestors had it right?... work is necessary to live?... hummm. so sitting at a computer screen all day is not work in the sense that the body does not recognize it as work ? .... walking to school, walking to the store, walking up stairs not taking the elevator, .... ride a pedal bicycle not an electric bicycle... keep moving while you sit?.. answer : easy to do even if youre old disabled and cant drive, like i am. .... thanks❤
OK, so if ergothioneine increases, that suggests either (1) exercising mice eat more ergothioneine containing foods or (2) they biosynthesise more ergothioneine. However, there's no evidence animals can biosynthesise it themselves, and assuming food intake in the experiment was controlled... Where did it come from?
Hi, I am interested in learning more about HDL, specifically when it’s measured as “too high” (90). My doctor said she’s not worried because it’s the “good kind”.
I'm trying 10:1 extract of Cordyceps mushrooms instead of 5mg Ergothioneine, since it's way cheaper, and most supplements are just derived from that mushroom anyway (and listing 5mg Ergothioneine followed by the mushroom in large quantities).
When i saw your Astaxanthin clip I wanted to ask you to make one for Ergothioneine since it's becoming the next antioxidant trend in the market. I believe Quercetin till now is the most "proven" antioxidant when it comes to it's benefits. Now, is Ergothioneine really beneficial especially for skincare?
I’ve been getting daily ergothioneine in the form of beef kidney. It’s done wonders for my hormones, hair/skin/nails and overall happiness levels. Now this could also be due to the wide range of other cofactors, peptides and minerals present in the bovine kidney. Going on an animal based diet drastically reduced my need for most supplements, but when i do take them i love the food based ones such ans organs. They’re much easier to assimilate and breakdown for people with vulnerable digestive systems. Over time my body just totally rejects ultra processed supplements the same way it rejects ultra processed food
Safety first! "The Panel on Dietetic Products for the European Food Safety Authority reported safe daily limits of 2.82 mg/kg of body weight for infants, 3.39 mg/kg for small children, and 1.31 mg/kg for adults, including pregnant and breastfeeding women." source Wikipedia
Has anyone suggested a likely optimum dosage for humans? If these numbers are correct, it would seem that most adults would want to stay under 100mg. A lot of the supplements seem to have about 5mg.
According to the "volcano plot", it looks like pantothenic acid (aka vitamin B5) isn't far behind ergothioneine in exercise-vs-sedentary concentration.
Wow that MPST experiment was clever. Common dosage in supplements seems to 5 mg - I wondered if that would be enough, but a cup of Shitake mushrooms has nearly 25 mgs and would be much tastier
I watched another video you Made because I was taking lion. Main mushroom and what I got from, it was that it really didn't do much now that i've Tossed it Now after watching this, I went to Amazon looking for the supplement. I'm surprised to find lion's maine was one of them
Noticed cytochrome c oxidase and thought of a recent theory i had after considering a way to activate the mechanism naturally rather than through close proximity 600 nanometer red light therapy. While watching someone speak about how little known and studied the results are at the moment, i had recalled that there was a seemingly rare type of red fluorescent fluorite (due to elemental impurities and it's interaction with uv light); it was said to be found in two places, Mapami and another place i can't recall but feel free to ask and I'll check my saved research. Point is that I'm sure there are metal substrate flashlights and I'm assuming that any small electrical signal to the cell could prompt just enough of this light to elicit this response, maybe sent through the crystalline structure of some element. The ATP increase was 16 fold
As with all supplements - and everything else, for that matter - it all comes down to situation-specific dose. Too little and too much are both bad, and higher or lower levels of something can cause other mechanisms in the body to shift to counteract the change, over time. Evolution has tuned biology well. Increasing the speed of one part of an engine without doing the same to all the other meshing parts is not going to result in better performance. Odds are, like so many other single button changes, it’s not going to be what the public thinks it is. Instead, it’s science learning another part of the puzzle by pushing and pulling at another small piece to see how it fits.
Ergothioneine is icreased in mitochondria from exercise but the body doesn't make it. So more is transported to mitochondria do to exercise but also is increased by supplementation?
thank you I will make sure that my Magics have more Ergothioneine in the future🍄 ah yes this was recently in the news, what is your opinion on this ? "Fish oil supplements may increase the risk of someone developing a heart condition or stroke, but could reduce the risk for those who already have cardiovascular disease, according to study."😅
I know I'll get negative feedback on this. My Doc teaches all his patients to dowse (don't laugh) I've been dowsing for years which means I only take the supplements I get a "yes" to - works better and much more efficient - it means my daily vitamins are only being consumed when I know my body really needs them - economical and it works. It's really primitive to have a set list of stuff that you take religiously every day
The only thing that sort of scares me about supplements that improve cells...is not knowing if they'll be a nice performance enhancing drug for CANCER cells : /
Interesting.. Not only does it sound beneficial but it sounds like it can provide info regarding other aspects of my mitochondria that Ive been attempting to identify on my own without additional testing. Further research also suggests this is fantastic enough in a plethora of ways that I should probably be taking it regardless lol Taking a look at where it is naturally found further solidifies my thought that all the different branches of life that evolved prior to us contain something we need on a regular basis in order to maintain our mitochondria. Anywho. Ordered some 25mg capsules that'll be here Wednesday🤷♀️😂
It is interesting that erythrocytes having no mitochondria and cogito whether ergo they do accumulate ergothioneine.
5 місяців тому
a 100 kg man would need to consume approximately 1218.98 grams (or about 1.22 kg) of dried Shiitake mushroom per day to achieve a dose of 33.4 mg/kg of ergothioneine.
If this amino does in fact enhance “physical performance” like the study indicates, would supplementing with it be best done as a pre workout or post workout ?
@@baldwad Among the 14 evaluated mushroom species, Lentinula edodes (LE), shiitake mushroom contains the highest ergothioneine content and hence was used for the in-vitro studies. pubmed.ncbi.nlm.nih.gov/38036238/ Shiitake mushrooms are a very common dietary ingredient in (normally cooked) Asian food, and adverse reactions (from normally cooked mushrooms) are so rare they're practically unheard of in Asia.
This piruvate generate buy ergo and MP happens before the phosphorylative oxidation so in the Krebs cycle whos dont generate to much ATP as the phosphorylative oxidation and there complex 1 to 4. At least in theory i who possess a mitochondrial disease in the complex 3 will not work. I dont no exactly my issue but they found fat in my muscle biopsy so i presume some thing related to fat metabolism and answer why i do have fat in the faeces iam still waitibg the complete result for analysis of cyrochrome c oxidase that transport electrons to the complexes.
It’s so sad, they don’t even know if loading this substance is damaging when there is no physiological need for it. Always looking for results in a bottle, something to sell and make money.
![Does Glycine extend Lifespan? [Study 297 Study Analysis]](http://i.ytimg.com/vi/ovTdkYyrkWQ/mqdefault.jpg)
![Does Glycine extend Lifespan? [Study 297 Study Analysis]](/img/tr.png)
What a coincidence, we considered naming our son to Three Mercapto Pyruvate Sulfur Transferase but we went with Dexter instead.
Darn…
Elon?
Hey, I had dibs on that one! Good you didn't take it!
@😂kunalkashelani585
😂
Dr. Bruce Ames was talking about ergothioneine decades ago! He has a list of the most important compounds for health out there. Taurine was on there too.
Thank you for introducing me to Dr. Ames.
If only I had the body of a white lab mouse! I could breathe underwater, glow, regrow limbs, and probably time travel.
And everything will cure your baldness
Sign me up 😂
Mice have approximately 97.5% of their working DNA in common with humans.........so you should not imply that you need to be a mouse to gain any benefit from this research
This post made me laugh so hard it cleared a stuffy nose, thank you from the bottom of the piece of my heart I lost in bio 1, in Mendel we trust
And with an ear growing on your back, you could hear better, but only one directional.
Porcini mushrooms, and yellow oyster mushrooms generally contain the highest amounts of ergothioneine (and also a good amount of glutathione)...
And I am allergic to mushrooms.
@@dawnelder9046 You can purchase ergothioneine supplements, at fairly reasonable prices...
Don't black and red beans also have ergothioneine? I eat a ton of those.
I only eat mushrooms like once a week or so. Maybe I need to eat more and look for these varieties.
Decade’s trying to find the reason Mario grows when eating mushrooms
@@rescuebabybirds Interesting, thank you very much!...
"High levels of ET (up to 0.8 mg per g dry mass) were measured in cyanobacteria preparations sold as dietary supplements for humans and in fresh Scytonema and Oscillatoria cultures. Cyanobacteria contained as much ET as King Oyster mushrooms (Pleurotus eryngii). [...] Spirulina is a novel, safe, accessible, and affordable source of ergothioneine for humans."
Ergothioneine is an amino acid that is found mainly in mushrooms, as well as red and black beans. It is also found in animals that have eaten grasses containing ergothioneine. Ergothioneine is sometimes used as medicine.
Perfect I love my grass finish stake with mushrooms!
@@fantasticallyfit6030Stake? Meat dementia bro.
Bot
Taurine, (N-acetyl)cysteine, and ergothioneine. Sulfur-containing amino acids appear to have a similar effect in muscle tissue
Hmm. I'm taking taurine in the morning and NAC at night. I suppose mid-afternoon for ergothioneine then, and I have just run out.
i wonder if msm, methylsulfermethane breaks into these substances?
@@gristlevonraben
Molecular weight of Methylsulfonylmethane: 94.13 g/mol
Taurine: 125.14 g/mol
Cysteine (Taurine precursor): 121.16 g/mol
Ergothioneine: 229.30 g/mol
No, it does not
@@degusoap thank you!
@@mightbeanybodySIRT 6 Activator - look - do not age, company
Wow, this is hectic, you made a complex scientific paper easy to understand in just over 12 minutes!
Great work!
ps I'll be back for the episode on pyruvate ;-)
Experimental control design is the most important thing in science. These folks did a good job!
please talk about C15 or Fatty 15. It says its better than fish oil and help health metrics to a new level. also talk about INFRA RED LIGHT!!
+1000
Agreed. Would like to hear the data on C15.
C15 is scam sir - from what I have deducted
@@bartb1014 yeah i know this now. he made two videos about it and not enough evidence to support those claims
Increasing respiratory rate artificially may have negative consequences, the vulcano plot clearly shows that there are severl metabolites that increase and decrease with exercise, all these metabolites change with exercise for a reason. So just supplementing ergothioneine may cause more harm than good. I would wait for a long-term study before considering this as a supplement.
I completely agree. This is one study that hasn't been peer reviewed, let alone replicated. One of my concerns is that if we increase mitochondrial respiration, we will also be increasing the production of free-radical species.
We are only just scratching the surface here.
I stopped, increase my blood sugar
Visiting your channel for the first time.
Good explanation.
Normally I check whos talking first (phd in what, maybe publications etc).
Id kept an eye on ergothioneine over the past months or so. Its getting more interesting but atm I will just eat my mushrooms on a daily basis (200g/d).
I would thank you for your clear fluent expression
Soooo. Exercise is good. Got it!
Hearing “pyruvate” gave me Krebs cycle flashbacks 😂😂
Is this related to the recommendation to consume citric/acetic acid with our food?
pyruvate produced from glycolysis is consumed during citric acid cycle 🧐
@@lonridgway2728 Glucose is broken down to pyruvate via glycolysis. The pyruvate is then metabolized is a chain of reactions that are termed the citric acid cycle (Krebs cycle)… I assumed you were asking a question based on the emoji, if it was a statement just ignore✨
I take NAC, am a vegetable consuming vegetarian, love and regularly eat oyster mushrooms. I exercise intensively and regularly. Have a low carb diet with a BMI od 22. Well muscled as well. I feel like crap most of the time. Ache all over.
try ALL the things one at a time
Many supermarkets sell a 3 or 4 oz box of Oyster Mushrooms for 3 bucks to 4 bucks. Oyster Mushrooms are one of the highest grade source of ergothioneine and some strains of Pleurotus ostreatus (yellow oyster mushroom) can hit 11,000 mg / Kg or 11 mg / gram of wet uncooked mushroom. So a one ounce serving of common yellow oyster mushroom (28g) could be as much as 300 mg of ergothioneine for one buck for each days serving per person. Even if your oyster mushroom has the lower limit of only 1100 mg / Kg ergo, it is still a 30 mg serving per ounce of mushroom uncooked. Compare that to the claimed 5mg supplements sold on Amazon right now. I think the strain improvement of oyster mushrooms or the media they are grown on has just started and these little tasty guys may become a superfood dietary choice.
Yup!
I love this channel so much!
Me too❤
Fascinating in the context of Chronic Fatigue Syndrome and Long Covid, where mytochondrial dysfunction is suspected and yet exercise only makes the condition worse.
"uses more oxygen" is not alone a sign that it improves mito function. It could be, but it could also be that it stresses the mito, and it needs to work harder for the same outcomes. Too much guessing and assuming
Yes, that was my initial thought as well, but the mouse improvements suggest that energy production is increased along with the oxygen consumption
@@mbmurphy777 Which likely also means more free-radical production, assuming that this non-peer reviewed study is successfully replicated (most initial positive studies fail on replication).
Next time watch the whole video. They tested the mice on exercise performance later and found a 30% improvement on peak performance.
Anything that assists in enhancing the function and ability of the mitochondria is a potential tool to help in the treatment of cancer. Thanks for bringing this supplement to my attention!
The Oyster and Shiitake mushrooms are supposed to be very good sources of this aminoacid and some people claim they can improve workout performance and have antiaging properties. Does it make sense?
Ergothioneine was in my healing stack (arround 20 supps) 2 years ago. There was also reishi, chaga and all the antioksidantrs :D It cured my psoriasis. Tho as I said - 20 supps a same time - who knows what role Ergothioneine did there if any.
Awesome summary, thanks!
Methylene Blue increases mitochondria oxygen consumption around 30%, what happens when using both?
Do you turn green and rip your clothes to shreds?
How does oxygen concentration affect this process?
with the H2S coming out of the other side... u could become the human torch...or a rocket...
@@Mr_Penguins_Pet_Human If you don't mind, are your symptoms completely resolved? How much do you take, and how often? Do you have a recommended source?
Thank you for your consideration!
Can you take this and tell us the effects
You turn into papa smurf
I read shiitake mushrooms have 24mg ergothioneine per cup. That’s more than supplement brands sell
Exciting times. Looking forward to future research on ergothioneine
the mitochondria is the *_POWERHOUSE_* of the cell!
Middle aged guy here. Well, I picked up _Life Extension L-Ergothioneine_ @ 5mg / day to see how effective it might be. There was one study from Blue California _(also makes this stuff)_ showing improved sleep.
My sleep is notoriously bad, so if it improves, then maybe this product is perhaps also doing the other things this new study purports.
Please reply here after your trial.
Any update with your sleep going with Ergothioneine supplementation?
any update?
@@efrainmontanez8662 I responded a bit above. Dunno if it helps & it is wordy, but maybe it does!
@@ericjg1472 I responded a bit above. Dunno if it helps & it is wordy, but maybe it does!
Ergothioneine shows up as a misspelled word. I'll use it. I've been taking PQQ since Life Extension first made it available for purchase.
Seems promising. L-Ergothioneine seems to be available as caps with vague claims of beeing good for aging skin, is this the same stuff you think? We all could do our own n=1 study and see we notice anything in the gym :P
Now what's the dosing and what foods contain it?
@@mballerI think ergo is a type of fungi and various types of mushrooms contain ergothienine. Though some contain more than others. I am not sure which type contains the most.
Exciting if true!
I process and track pretty accurate data for running and have had seen no additional improvement from NMN supplementation during my current base phase. I might try this one to look for a statistically significant increase in avg GAP times over the improvements I have seen in May.
I have seen no improvement with NMN after taking more than one year. I’m done with NMN.
@@MrJohnson57 It begins to break down chemically after 30-45 days. The bottle I purchased from Nutricost has no manufacturing date, but the expiration date on it says "02/2027". Which is about 3.8 years past 45 days to give you a good idea about how reliable these suppliers really are.
NMN dosnt boost performance it boosts recovery. Your recovery time on NMN is greatly improved
@@thepatternforms859 Recovery? Your mitochondria are going to recover by the next day. That's not what you are recovering from after a workout day in running (higher intensity). You have all of these waste products from burning glycogen in your fuel mix. Go to threshold and muscles are going to require at least another day to recover fully. That has nothing to do with mitochondria, though. You can go out next day to do a base run. Mitochondria still work fine as you stick around mainly in your aerobic system. The products are marketed as mitochondrial boosters -- and I saw no improvement over what I normally would have seen from training. Furthermore, I have discovered the chemical breaks down after about four weeks. The bottle I bought has an expiration date like four years from now.
Have to listen to this twice.
... is powerhouse of the cell
@10:07- Just FYI, unless Ergothionene has an an exotic cousin named Ergotnionene, there's a typo.
Hmm... digging deeper on MPST:
Dietary Supplements: While specific chemicals directly enhancing MPST production are less documented, supplements that support mitochondrial health, such as Coenzyme Q10 and alpha-lipoic acid, might have an indirect positive effect.
Sulfur-Containing Compounds: Since MPST is involved in sulfur metabolism, dietary intake of sulfur-containing amino acids like cysteine and methionine might support its activity. (This is interesting because NAC is part of the GlyNAC duo that has been highlighted in another study for improving the hallmarks of aging.)
On another topic, could you ummarize research about klotho and give your impressions?
Excellent very clear. Thank you
Intriguing. Hopefully we'll learn more from future studies.
I get it in Vthrive mitochondrial energy support.😊
USC has discovered the protein humanin to play a significant role in the health of mt. Might be a good target for supplementation since its levels drop with age.
Wonder how it compares to taurine’s effect on mitochondria.
so our ancestors had it right?... work is necessary to live?... hummm. so sitting at a computer screen all day is not work in the sense that the body does not recognize it as work ? .... walking to school, walking to the store, walking up stairs not taking the elevator, .... ride a pedal bicycle not an electric bicycle... keep moving while you sit?.. answer : easy to do even if youre old disabled and cant drive, like i am. .... thanks❤
Most people still need to work on thinking so that they can make better decisions and keep brain function intact
OK, so if ergothioneine increases, that suggests either (1) exercising mice eat more ergothioneine containing foods or (2) they biosynthesise more ergothioneine.
However, there's no evidence animals can biosynthesise it themselves, and assuming food intake in the experiment was controlled... Where did it come from?
Good one! Thank you. I sure will try
Hi, I am interested in learning more about HDL, specifically when it’s measured as “too high” (90). My doctor said she’s not worried because it’s the “good kind”.
I'm trying 10:1 extract of Cordyceps mushrooms instead of 5mg Ergothioneine, since it's way cheaper, and most supplements are just derived from that mushroom anyway (and listing 5mg Ergothioneine followed by the mushroom in large quantities).
When i saw your Astaxanthin clip I wanted to ask you to make one for Ergothioneine since it's becoming the next antioxidant trend in the market. I believe Quercetin till now is the most "proven" antioxidant when it comes to it's benefits. Now, is Ergothioneine really beneficial especially for skincare?
I’ve been getting daily ergothioneine in the form of beef kidney. It’s done wonders for my hormones, hair/skin/nails and overall happiness levels. Now this could also be due to the wide range of other cofactors, peptides and minerals present in the bovine kidney.
Going on an animal based diet drastically reduced my need for most supplements, but when i do take them i love the food based ones such ans organs. They’re much easier to assimilate and breakdown for people with vulnerable digestive systems. Over time my body just totally rejects ultra processed supplements the same way it rejects ultra processed food
Is that beef kidney in capsule form or cooked as part of a meal?
Safety first! "The Panel on Dietetic Products for the European Food Safety Authority reported safe daily limits of 2.82 mg/kg of body weight for infants, 3.39 mg/kg for small children, and 1.31 mg/kg for adults, including pregnant and breastfeeding women." source Wikipedia
Has anyone suggested a likely optimum dosage for humans? If these numbers are correct, it would seem that most adults would want to stay under 100mg. A lot of the supplements seem to have about 5mg.
Also, what about panthothenic acid? thats a B vitamin right? the untaken path in choose your own adventure.
Thank You, Aloha.
I’ve been doing enemas with ergothioneine for months now and I feel like Lance Armstrong
A quick scan at Amazon makes one wonder if the study was financed by Big Mushroom
How do we know you're not a big mushroom?
There's a phallic joke to be made here but it's low hanging mushroom.
That the mushroom is hanging low speaks volumes.
According to the "volcano plot", it looks like pantothenic acid (aka vitamin B5) isn't far behind ergothioneine in exercise-vs-sedentary concentration.
Wow that MPST experiment was clever. Common dosage in supplements seems to 5 mg - I wondered if that would be enough, but a cup of Shitake mushrooms has nearly 25 mgs and would be much tastier
Make sure to cook those! Lentinan ! Flagellate Dermatitis !
What ever happened to DMAE it used to seem so promising as a supplement
What did happen to it? I have some.
I still take it. Not all the time but found that when I wake up, I am immediately awake. No dragging out of bed.
No one talks about it anymore
@@claythomas359Wow, could use that. What dose and just before bed? Do you have a recommended brand?
@@claythomas359 How do you take it? Like you wake up and take that and you're more energized? Or the night before?
I watched another video you Made because I was taking lion. Main mushroom and what I got from, it was that it really didn't do much now that i've Tossed it Now after watching this, I went to Amazon looking for the supplement. I'm surprised to find lion's maine was one of them
Good vid. Question: does Ergothioneine affect estrogen levels?
Thank you
Noticed cytochrome c oxidase and thought of a recent theory i had after considering a way to activate the mechanism naturally rather than through close proximity 600 nanometer red light therapy. While watching someone speak about how little known and studied the results are at the moment, i had recalled that there was a seemingly rare type of red fluorescent fluorite (due to elemental impurities and it's interaction with uv light); it was said to be found in two places, Mapami and another place i can't recall but feel free to ask and I'll check my saved research. Point is that I'm sure there are metal substrate flashlights and I'm assuming that any small electrical signal to the cell could prompt just enough of this light to elicit this response, maybe sent through the crystalline structure of some element.
The ATP increase was 16 fold
As with all supplements - and everything else, for that matter - it all comes down to situation-specific dose. Too little and too much are both bad, and higher or lower levels of something can cause other mechanisms in the body to shift to counteract the change, over time. Evolution has tuned biology well. Increasing the speed of one part of an engine without doing the same to all the other meshing parts is not going to result in better performance. Odds are, like so many other single button changes, it’s not going to be what the public thinks it is. Instead, it’s science learning another part of the puzzle by pushing and pulling at another small piece to see how it fits.
Eating healthy, sleeping right, exercising smart, and getting proper sunlight also improves mitochondrial function
Source: Trust me, bro. I've studied the Krebs Cycle
I eat mushrooms daily, in part because of their ergothioneine content.
Seriously?
Best to boil mushrooms acouple minutes as per Joel Fuhrman
Yup!
Can you do a video about potential mechanisms and theories of what causes PSSD and potential treatment avenues ?
Fun-attempt counter: 1. That is low, and given the 771 seconds video length hardly statistically significant. Wow, I like it.
Dietary ergothioneine = mushrooms.
Ergothioneine is icreased in mitochondria from exercise but the body doesn't make it. So more is transported to mitochondria do to exercise but also is increased by supplementation?
But Sir couldn't be that as more oxygen to the mitochondria more ROS ?
What is the effect of ergothioneine on trained athletes?
Increase oxidative stress?
Ergothioneine is an incredibly potent anti-oxidant.
thank you I will make sure that my Magics have more Ergothioneine in the future🍄
ah yes this was recently in the news, what is your opinion on this ?
"Fish oil supplements may increase the risk of someone developing a heart condition or stroke,
but could reduce the risk for those who already have cardiovascular disease, according to study."😅
Next week..
I know I'll get negative feedback on this. My Doc teaches all his patients to dowse (don't laugh) I've been dowsing for years which means I only take the supplements I get a "yes" to - works better and much more efficient - it means my daily vitamins are only being consumed when I know my body really needs them - economical and it works. It's really primitive to have a set list of stuff that you take religiously every day
colloidal silver, methyline blue, ergothioneine a little wierd supplements
The only thing that sort of scares me about supplements that improve cells...is not knowing if they'll be a nice performance enhancing drug for CANCER cells : /
Isn't this the same fungus that produces LSD? Interesting. I just happened to order some yesterday.
Happy tripping ha ha
Happened to order ergothioneine, mushrooms in general, or LSD, I wonder.
It produces LSA, not LSD.
I didn’t know any fungus produces lsd...
@@1TieDye1 It doesn't. LSD is semisynthetic.
amazing video
Interesting..
Not only does it sound beneficial but it sounds like it can provide info regarding other aspects of my mitochondria that Ive been attempting to identify on my own without additional testing.
Further research also suggests this is fantastic enough in a plethora of ways that I should probably be taking it regardless lol
Taking a look at where it is naturally found further solidifies my thought that all the different branches of life that evolved prior to us contain something we need on a regular basis in order to maintain our mitochondria.
Anywho.
Ordered some 25mg capsules that'll be here Wednesday🤷♀️😂
Urolthine A is almost $100 a month. Is this Amino Acid a suitable substitute?
And he proved recently that UR A has no benefits - def worth switching
I wonder if it's worth looking at lion's mane again, with an ergothioneine lens.
It is interesting that erythrocytes having no mitochondria and cogito whether ergo they do accumulate ergothioneine.
a 100 kg man would need to consume approximately 1218.98 grams (or about 1.22 kg) of dried Shiitake mushroom per day to achieve a dose of 33.4 mg/kg of ergothioneine.
Ergothioneine, derived from ergot, is ergogenic. What a lovely coincidence
If this amino does in fact enhance “physical performance” like the study indicates, would supplementing with it be best done as a pre workout or post workout ?
Shiitake mushrooms contain highest levels of Ergothioneine.
Not quite the highest and those need to be cooked well!
@@baldwad Among the 14 evaluated mushroom species, Lentinula edodes (LE), shiitake mushroom contains the highest ergothioneine content and hence was used for the in-vitro studies. pubmed.ncbi.nlm.nih.gov/38036238/
Shiitake mushrooms are a very common dietary ingredient in (normally cooked) Asian food, and adverse reactions (from normally cooked mushrooms) are so rare they're practically unheard of in Asia.
What happens in a low oxygen environment?
wondering if ergothionine levels have any effect on levels of MPST in the mitochondria or just on function.
Noticed a pattern. No animal products extend lifespan.
👍
Mushrooms are very very high top of the chart with this, eat more mushrooms and skip the vitamins
scrambling to come up with a good 'ergo' pun based on the study findings
Is MPST coded by mitochondrial, or nuclear DNA?
Is there any potential benefit with this for those suffering from Long Covid?
This piruvate generate buy ergo and MP happens before the phosphorylative oxidation so in the Krebs cycle whos dont generate to much ATP as the phosphorylative oxidation and there complex 1 to 4. At least in theory i who possess a mitochondrial disease in the complex 3 will not work. I dont no exactly my issue but they found fat in my muscle biopsy so i presume some thing related to fat metabolism and answer why i do have fat in the faeces iam still waitibg the complete result for analysis of cyrochrome c oxidase that transport electrons to the complexes.
Does anyone know what is required to generate Eurgo?
I'm guessing sulfer aminos and magnesium.
Looks like regular old pantothenic acid is high on the volcano chart too ….
Hey, Psyonics! What about L-theanine for blood pressure?
Ignorant viewer: sulfur again (alpha lipoic acid makes old mitochondria like new again and it contains sulfur)
If it hasn't been published, how did you come across this info? Just wondering.
PubMed has started publishing pre-prints before official journal publishing
Explained in the first minute of the video.
Physiological, doesn’t Metformin powerfully improve mitochondrial function via mitochondrial biogenesis?🤔
It’s so sad, they don’t even know if loading this substance is damaging when there is no physiological need for it. Always looking for results in a bottle, something to sell and make money.
Or you could work out and increase endogenous ergothioneine.