Personal anecdote here. I took collagen peptides for more than a year and noticed nothing. I then read somewhere that glycine is the rate limiting factor in how much collagen your body produces. I incorporated glycine into my diet, and there has been a huge difference in my skin. Even age spots (I am 50) have either disappeared or started to fade.Therefore, I am surprised you didn't say anything about glycine. FYI, I take about 4 to 6 grams per day. Edit: I've increased the amount I take to 9-15 grams per day. Considering it is estimated that our ancestors consumed up to 20 grams per day or more, and I haven't had any negative side effects, I don't see a problem with this. It's all been great so far.
I use a lysine supplement (for cold sores) w my collagen peptides, I feel it works for my skin too...where do you get glycine? is it from food sources or pill form?
Absolutely!! I'm a vampire too. Yes, there absolutely needs to be more focus on skin elasticity. Collagen without the elasticity will just give you thicker wrinkly skin like scleroderma, and that's actually the cause of it- lack of elastin. So astaxanthin is super important. On hyaluronic acid, the prevailing science shows high molecular weight hyaluronic acid is healthier due to the low molecular weight causing inflammation. And most supplements out there are the HMW. There are many studies and a brand new one citing ha as a cause of cancer and inflammation so that's not good. People are a bit freaked out about it right now especially those in the medical aesthetics community because of the injectable fillers industry. High blood serum levels of hyaluronic acid are a screening test for colon cancer. If there's no family history of cancer, I would go ahead and take HA supplements, but if there is a history I would be cautious. Elderberry supplements are another excellent source of body moisture for moisture retention.
@@FrozenAuroras yup! NAC (N- acetyl cysteine) is a precursor to glutathione. So it's a good idea to look up the effective dose of it and take it as you get older. Taking it with glycine, collagen supplements, along with vitamin C, is a good idea for collagen production. Glutathione has a very short half-life in the body, so the best way to take it is actually through injection, but even then it doesn't last very long. So taking NAC is more efficient, and cheaper. Gly-nac supplementation extended the lives of mice 24%. Doctors prescribe NAC for the lungs- It thins secretions and enables easier breathing. The FDA was thinking about taking it off the market to study it as a drug but you can't take something that occurs in nature of the market. That would be like taking water off the market. Glycine aids in collagen production and is another powerful antioxidant. NAC also cleans out the liver. You're not supposed to use it in conjunction with drinking alcohol- that's how effective it is.
For real elasticiy, I'd recommend an elastin supplement (pills, powder, whatever you like). It's still much harder to get than collagen and hyaluronic acid but more companies are selling it now. You can look hydrolyzed marine elastin up.
I know people don't enjoy it but Microneedling is probably the most effective method for increasing collagen and it's much cheaper then ongoing supplement purchasing. Red light therapy also more effective then supplements and more enjoyable than microneedling
@@nickmontanaro9638 The device I have is a red led mask, it doesn't appear to have a brand name. If you want to buy one just go for the one with the largest amount of LEDs.
@@iraschlothi5930 I have never heard of that but you should never exceed 30 mins. Skincare therapists have an interest in convincing clients that if they were to attempt such things by themselves harm will result
You’re right, vivaci RF controlled radio microneedle with PRP topical platelet replacement used with SEYPHYL a calcium carbonate “scaffold” RF energy creates new collagen formation . “You can’t supplement your way into better skin . This dude is entirely wrapped up in his academic wheelhouse as a molecular biochemist PhD candidate, he’s intellectually “smug “ and mildly condescending to his audience , masked as an attempt at HUMOR 😂.,
The effects of hyaluronic acid can be amazing. I had two courses of hyaluronic acid injections directly into the synovial fluid of my knees, and the effects were almost immediate and wonderful. All the knee-pain that had been slowly building up over the years went away within a few weeks and hasn't returned. Health insurance is usually gung-ho for these, because these HA injections reduce the number of knee-replacement surgeries, simply because it causes regrowth, thickening and strengthening of the cartilage shielding the boney wear-surfaces within the joint. (The fact that the nurse-practitioner used ultrasound to make sure the needle didn't nick any structures was great, too. The only discomfort was from the extra pressure right after each injection, but that faded after a couple of hours.)
Unfortunately, I don’t think cartilage regrows from hyaluronic acid injections (actually we don’t even see cartilage regrowth with stem cells!), but it can be a potent anti-inflammatory
A typical village lifestyle in Greece All you youtubers confuse and stress us out with what you suggest for health and longevity. My aunt died in 2022 and she was 108 years old, my uncle at 98 years old, my father died at 97 years old and my mother at 93. We all come from Greece, specifically from the island of Samos next to Ikaria. The style of their life, a typical day was as follows. They would wake up in the morning at 6, maybe have a mountain tea or some milk with wholemeal bread and leave for manual work on the estates. Around 10 o'clock they ate some wholemeal bread with a few olives or their own cheese, at noon they rested for about half an hour and usually ate Legumes, pulses, and in the afternoon when the vesper bell rang at about 6 pm they usually left on foot for the village because the donkey was loaded with tools and products. In the evening, light food, Salads, wild greens, Legumes and generally Greek cuisine, all almost their own production. They always used olive oil in the food. in the evening the men would go to the Cafe for a drink, usually wine or ouzo and the women would gather in a house or in the courtyards of the houses and chat about the events of the village. At 10pm everyone went to bed. They didn't eat much meat. They ate fish Eggs and some old hen on some Sundays with potatoes and rarely with spaghetti. They used tomato paste for the sauces they made themselves in the sun and maybe would drink some wine that produce themselves. They had fun at the festivals 4 to 5 times a year and on the religious holidays. We children went with them to the estates and helped on weekends when we didn't have school. I should mention that all the residents in the villages of Samos have more or less the same habits and economic level. Many residents of my home village left and went to the United States of America. I am very sad to say that all 5 of my classmates who left for the USA and adopted the lifestyle there, all died very early very young in their 50's and 60's.
So how much wrinkles do these people have? Exactly They might have had long lives and were not struck by cancer.. doesn't mean they aged pretty. People in the longevity and healthspan part aren't just looking to replicate the results from your family which might also have a genetic component to it like very low occurrence of cardiovascular disease, they are looking to perpetuate the effect of rejuvenation. The absence of aging at all and the absence of decay. This is where you completely miss the mark. Yes we can learn a lot from them. But they didn't have the fix. They still experienced significant bodily decay until failure. They still had reduced quality of life over time and at some points failed in their ability to do things they used to be able to. So your mindset is still in the 2004 of the blue zone studies. We are now looking past those and are trying to find the mechanisms that might improve on those outcomes. Of course modern mankind seems to be moving further away from this as we speak but not everyone when u isolate populations who do get the message. So "youtubers" like Psychionic aren't confused at all. They just have different outcomes of goals projected than you have when using these definitions.
@@deansusec8745 It is just because you lack imagination and experience of how it can be without. My glass of Khombucha with a thai plant based dinner checks those same marks. Yet the difference is I am not paying a price for it.
I ignored the warnings about sun exposure when I was younger and now in my 60s I’m paying the price. How I wish I had slathered on the sunscreen and avoided tanning beds.
LOL no. Actually I look younger than most my age as I’ve always been physically active, healthy diet, no smoking etc. But how I wish I had more elasticity. I’ve been a vegetarian for the last year but will make an exception for collagen peptides. I’ll try anything at this point.
While I'm interested in skin repair, my age is 69, I think creams are not my ultimate goal. Recently my dad passed at the age of 97. The one thing that surprised me was how thin and paper like his skin became. It was a miserable experience for him. I suspect that diet will be the only way to improve how my skin strength. I've been on keto for about a year and adding supplements like Omega 3, collagen powder, some vitamins. I recently tried retinol for my forearms and hands as I started showing the thin skin age large bruises. It does help a bit. So I'm actively looking into whole body solutions. Dad's skin issues became a major difficulty. He was mentally fine to his last days.
I think as you get older, its a multifactorial approach, reduce inflammation and increase antioxidants w food, supplements w specific benefits, creams, lotions and serums (and they do work) and sunscreen or sun protection.
Vitamin D is primarily produced in the oil of our skins, this is why it is very important to keep the skin of our elders moisturised. Use CeraVee, it's ceramides are proven to help the skin.
I watched this video with interest, not due to interest in improving skin condition, but rather because I have Ehlers-Danlos, and I look for info on anything collagen-oriented. I will however, say that when I increased my vitamin C intake from 250mg supplement/day to 2g supplement (spread over the day), that in addition to many other benefits, the quality of my skin improved markedly... a much more healthy sheen, color, hydration, not to mention a cessation of unexplained bruising. I enjoy your channel, regardless of how personally pertinent the info may be to me!
@@nickmontanaro9638 I'm hEDS too. I take Trader Joe's Chewable Orange, which has ascorbic acid/sodium ascorbate blend, which I have no idea whether it makes a difference, but am not going to muck around with success, and is cheap too. I started seeing multiple improvements in myalgia (which was really brutal for years), brain fog, anxiety, and a few other typical vitamin C deficiency symptoms within a couple days. Noticeable improvement in skin in 2-3 weeks. That was about 3 yrs ago, so has been sustained. I also take 2g/day of lysine spread through the day (important especially for the C to be spread out also (500mg every 4 hrs), I find best results on empty stomach, but some might not tolerate that well), and a multi-mineral with higher bioavailability than the cheapest stuff. I take a few other things too, but the C/lysine/multi-min have made the biggest diff, including assistance with ligament/tendon healing. Hope something helps you!
@@nickmontanaro9638 Welp, UA-cam deleted my lengthy reply... will recompose it when I get time. Short answer, a couple days for myalgia, brain fog and other stuff..... a couple weeks for skin.
Hi, just wanted to say be aware of vit c over 250 mg can cause oxalate kidney stones, this happened to me and Iignored the studies I saw. Worst pain ever so really be aware
Thanks! I love when you address skin health topics. Very helpful in a sea full of contradictory info without science to back it up. Appreciate your channel!
This was a good honest video. In addition to the above, regular exercise, hydration and the consumption of clean foods seems to help, at least it has for me.
The Nambour sunscreen study showed no signs of aging in 4,5 years in the daily sunscreen group. But keep in mind this study was done in Australia where even in winter the uv index is 6+. Differences between daily and occasionally sunscreen could be less or insignificant in countries with much lower uv indexes.
I didn't realise that it was Nambour. It does mean that skin aging can be reduced by limiting exposure. So since the alternative of dv3 supplementation exists the loss of uv exposure can ve mitigated.
This video is a treasure trove of info! I've been using red light therapy for a while now, specifically a panel from Future Form Official, which my dermatologist recommended. It's not just affordable but incredibly effective. I've noticed a significant improvement in my skin complexity and a reduction in wrinkles. I never thought such a simple addition to my routine could yield such noticeable results. There’s a lot of scientific literature backing red light therapy, which gave me the confidence to try it. Big thanks to everyone sharing their experiences and tips here-so helpful!
Thank you for mentioning UV as a major factor in aging. I don't take collagen or do much in the way of skincare, but I do slap on sunscreen faithfully and credit it with so many people telling me I look 10+ years younger than I am. I try to stick to mineral sunscreens, which I understand to be better? Maybe you can do a video on sunscreen sometime? It is summer in the northern hemisphere now.
Well and I’m 40 and nobody gives me more than 28. People don’t believe my age they ask for my ID. Never used sunscreen unless I was at a beach baking between 12-3pm. I’m against sunscreen, I hate it with passion, it makes my skin feel terrible, I don’t use it at all, I make sure all of my makeup up and skincare products are sunscreen free. I love the sun and expose my skin to sun regularly, in fact it’s my daily task to get sun exposure daily for at least 30 min. My skin looks great for my age, never had any procedures done, not planning on any adjustments, not planning on using poisonous sunscreen anytime soon. Regardless of the bs studies funded by corporations I can’t see any damage by the sun, and if anything, the benefits that I get from the Sun outweigh the possible hypothetical sun damage.
mineral sunscreens work...but does not work better than chemical sunscreens which offer higher protection, they often use adjuncts that lower inflammation or sunscreen boosters to get the higher numbers. But they work well enough, for ppl that if it is your first choice, its good enough. There is no bad choice if that's the formulation you prefer.
@@campersruincod6134 you mean the same type of evidence that kept insisting that vaccines are “safe and effective” or the evidence that fat is bad for us? Or perhaps the evidence that cholesterol in eggs makes your cholesterol go up and clog up your arteries ? Or.. I could go on and on the entire day with all the “evidence” that makes no sense but fills big pharma’s phockets. It could be a combination of things, if I eat actually healthy diet, not the diet recommended by the govt., if I don’t smoke, don’t drink alcohol, don’t take drugs etc, if my immune system works fine and my body manages to get the benefits from the sun while counteracting the negatives then that could be the reason why. I can’t tell I have particularly good genetics, I have white skin and I live in Australia- a country with high melanoma rates and other skin cancers. People bath themselves in sunscreen day and night yet the rates keep goin up.. something doesn’t add up here. Then we find science that the sun actually doesn’t cause many types of skin cancers and it’s in fact the lack of the sun that cause some of the bad ones. But of course you won’t find any of this info if you use google or other mainstream channels of information, you’d have to dig deep on pubmed to learn this. So yeah, perhaps, my comment is the only comment you came across that would give you an impression of n=1 anecdotal “evidence”, but the actual evidence is overwhelming. I didn’t stop using sunscreen for no reason, I followed the actual science. But you keep using your sunscreen and convince yourself it’s making you look younger 😌👍👍👍
@@ballinout92 It depends on the formulation and sometimes its the additives used can cause burning. If you have sensitive eyes, try Japanese Biore Watery Essence or Protect, Japanese Skin Aqua Moisture Essence, or any of the La Roche Posay. There are many others but this can get you started in your search. Another option is to use the regular sunscreen everywhere except the eyes and use a stick formula like Neutrogena, or the mineral sunscreen around your eyes.
Anecdotally, colostrum really helps me when I feel that I am about to get sick. It's almost miraculous how I don't catch most flus and I work with small kids. I used to always be sick
Thank you so much for true scientific data. I’m so tired of cosmeceutical companies presenting ridiculous, decontextualized data with no statistical power as “evidence” when in fact it’s just a marketing scheme. Thank you!
Years ago I watched some UA-cam video about hyaluronic acid and I was taking it for a long time and people told me how amazingly youthful my face looked. I stopped taking it and a bunch of years later I actually look older than I should now
Re: Vitamin D supplementation vs. sun exposure, I work with overweight/obese, diabetic and heart disease patients, and even though they all supplement because their levels of D are low, supplementation does not increase their levels. It seems that this is due to its tendency to store into adipose tissue. I have also seen many labs of folks who are not obese or have any condition, but have tested low for D, and their Vit D levels are also not increased with (correct dose and form) supplementation. Once you've seen hundreds of labs over a career, it becomes clear that the theoretical replacement of Vit D through supplementation does not occur in a significant number of people.
I think that depends on what type of vitamin D it is. There's different types and my understanding is that you need D3 not D2 which is what is typically prescribed. There's also other vitamins that must be taken along with Vitamin D as it works better and it helps with absorption. Do a search on UA-cam and you'll find videos that go more in depth, into the science.
Good catch. But you are likely wrong about the adipose tissue eating up the vitamin D. I am lean fit and muscular - vitamine D levels are low and supplementation appears to have low or no effect. Perhaps fish oils or foods containing it would lift my number - haven't tested it recently to know.
It's all about a healthy diet, low calorie, high protein, low sugar, high antioxidant diet, and sun protection. The rest do help. I use: 1. Red light (topical) 2. Methylene blue (oral) 3. Copper sulfate pentahydrate diluted in water (topical)
low calorie puts body in a starvation mode except if you dont use energy during day much whats another bizzare thing better to eat normal but fast, this actual does its job at each phase
I started taking Hydraulic Acid for my knees after a fall on my knees. Made a big difference. Took a few months. The exercises I was given only helped about 10 percent after 2 months. The Hydraulic filled in the other percent.
11:40 "and the sun is good because it's natural" -- it's good that Nic calls this out. Other things that are natural (and therefore good): wasps, uranium, syphilis... BTW my patented skin-rejuvenating blend of syphilis-infected uranium wasps should be on store shelves soon.
@@anyajohnson4471 that's dependent on dose -- too much and you get skin damage, aging and possibly cancer. Most of the research suggests sunscreen doesn't have much impact on vitamin D production, so you can get most of the benefits with less risk.
yes radiation around you is natural and healthy dose matters blood loss is also healthy with such mindset as yours you will be always limited by scientific averages without any overarcing idea why these work and what could work by analogy but you just stayed oblivious what we dont know is often more important than what we do know and needs to be taken into consideration at all times staying away from sun is mindbogglingly stupid idea
March 1st I got an AC Joint Grade 2 sprain in my dominant right arm. It’s been a few months of PT and healing later and the prominence of my bump has gone down a solid amount however I still feel it, especially when I sleep on my right side. Plus mild mild pain (a lot better than when I got the injury). I’m an active 22 year old male so I feel like I will heal up pretty well in the next few years going forward, especially since I’ll focus on more strength building exercises like face pulls, shoulder press, etc. I’m going to start taking BPC-157 at 1mg per day orally in about a week. I’m looking forward to healing the ligaments and tendons a lot better. My surgeon who didn’t operate but diagnosed my sprain told me my tendons and ligaments are in tact which made me relieved. Anyway, here are my current supplements and stuff I’m taking: -Collagen Peptides (Hydrolyzed) 11grams daily -NR (NAD+ Booster) 300mg daily -Hyaluronic Acid 1gram daily
I started taking astaxanthin years ago to save my vision and it worked. I got IBS really bad after covid and started taking collagen to repair the tissue. I didn't notice tremendous results. Then I found out that taurine is required for college in production. Are taurine levels start reducing in our 30s when we also begin showing signs of aging. I've added l-taurine and feel there's a difference.
@@raik.7510 I'm having more good days with my IBS, and much fewer bad days. I also started drinking burdock root tea which seems to have a stronger effect - though all effects are incremental and subject to perception.
@@WaterspoutsOfTheDeep I asked Google, it indicates that taurine does help in the production of collagen in skin and bones. There was a mention of is presence near right junctions which is what I really need. Lysine looks pretty interesting for the antiviral properties - I might actually be taking some of it in some of my supplements. I don't always take the immune boosters but try to load up when I think I might get exposed.
I'm not sure if you were looking for a sunscreen replacement but taking the standard process brand Cataplex F Two per hour along with Calcium lactate will prevent sunburn so you don't need to use sunscreen.
Thanks Nic! Love the study results breakdowns. Lots of sunscreen misinformation out there, for those interested, biochemist Dr. Michelle Wong is a great resource for sunscreen science (among other skincare science).
I’m on the Lion’s Diet currently. What’s interesting is that I don’t sunburn, just tan. I used to get crispy so fast on the Standard American Diet. It’s a strange, but awesome benefit
I experienced this too when I was vegan. At the time I thought it was from all the vitamin E I was eating but now I think it's more a function of eliminating processed food than a specific diet like carnivore vs vegan or whatever. ButI tend to think any benefits from specific diets comes from eliminating processed/manufactured foods.
A side benefit to the efficiency in listening time is that the speaker sounds so much more intelligent. On really well recorded audio one can increase the speed even more and it is completely intelligible.
@@heidikamrath1951 yea i don't remember how i found out about supplemental aloe vera but i did find studies showing supplementing with it internally increased collagen production and pretty much no one mentions either of these on youtube along with collagen peptides and hyalauronic acid that everyone mentions.
But I love the sun :( On a more serious note, I'd love to see more in depth discussion on the effect of skin color on UV-induced skin aging. I'm brown skinned, and get about a one to two hours of sunlight a day. I need my vitamin D... I live in Ghana where most people are very dark skinned, and the vast majority of Ghanaians never use sun screen, yet, many people who spend hours in the sun every day barely show signs of skin aging and skin cancers are very rare here. How much protection do different skin tones really afford us, especially for those of us who are neither very light-skinned or very dark-skinned?
@@vicz8899 yes, I know, but I find statements online like: "dark-skinned blacks have a natural skin protection factor (SPF) of up to 13", but is that true, then why is SPF 30 recommended if dark skinned blacks barely experience UV-damage, and what does that mean for lighter skinned blacks? Do we have SPF 6,5 o is it more complicated than that?
@@sundiataq There probably is "some" benefit to dark skinned blacks using SPF. It won't hurt. But the sunscreen makers also want to sell more product. My neighbor is black, she is 62 and smokes cigarettes. Not a wrinkle on her face. Her mother is at least 20 years older and smooth skin too. Lighter skinned would probably benefit more than darker skinned.
@@sundiataq The SPF of darker skinned people is more like SPF 4. And all races of people benefit from using sunscreen, especially if you live in a high UV index area and spent a lot of time outside.
Thank God you said it bro, yes! Guys, you've completely missed the point and need help if you're worried about these supplements...without even consistently using sunscreen and using chemical exfoliation.
My 2 cents living here in Southern Europe with about 11 months of sun a year; Most of us are deficient in VitD3; the most important hormone for overall health and the immune system... blocking out the little sun we get with sunblock seems unwise...just take care in the midday sun, wear a shirt... and avoid seed oils which also contribute to sunburn...
@@betzib8021They most commonly use some combination of glycolic acid, lactic acid and salicylic acid which helps exfoliate, reduces pore size/appearance of fine lines, and improves skin tone, texture and clarity (brightness). The most convenient ones are single use pads/peels and they should be paraben free such as m-61 PowerGlow peel and many other quality brands. They work great with immediate results and consistent use will help new collagen formation. MD approved
@@betzib8021 topical and at home, like glycolic acid, salicylic acid, lactic acid, etc. You know, the second thing dermatologists say is so important and only second two sunscreen. Exfoliation increases collagen synthesis, increases skin cell turnover, clears pores, etc. If you're worried about anything related to skin without sunscreen and exfoliation, you've missed the forest for the fungus on the floor. It's like worrying about sugar,...when you don't even exercise enough.
Hello Physionic -- really appreciate your work -- one slight pushback though. There's been some recent work on other benefits of sun exposure to skin, such as on NO production. Of course, that doesn't mean the benefits outweigh the costs, but its not all just about vitamin D. I'd love for you to do a video on this field of research!
I'm a 62 yo male living in South Africa. Vitamin D is not a problem here, but i do use factor 50 sunblock. My diet is pretty clean and I exercise three times a week. Most people said that i look at the most 55. I started to take collagen powder and the results were remarkable, nothing else changed. Friends who had not seen me for a while couldn't believe how good I look, people started asking me what I do for my skin, this had not happened before. I was stopped in a routine road block coming out of Johannesburg airport, the police checked my driving license and wanted to hold me whilst they checked me out as they couldn't believe it was me and thought I was using someone else's license. Nothing else changed, just the addition of collagen peptides. Most people say I look between 48 to 50.
Did you see the post by Dr Rhonda Patrick on sunscreen ingredients being absorbed into the body? Coincidentally Dr Greger also had a series on sunscreen ingredients and cancer. Then Prof Tim Spector chipped in writing a long article in the main UK newspaper on vitd deficiency and sunscreen
well he is on the pro chemical side and they have problems with holistic understanding and seeing theoretically big picture these studies are all about averages, and by default do not apply to everybody.. keepng baby skin while being mentally & physically ill inside isnt a perfect outcome
how about ceramides capsules supplement for skin hydration? also some make claims red light therapy drastically reduces skin damage from UV or the sun.
Prescription tret fucks my skin up but I started using the gentler trader Joe's retinol and it's a lot smoother experience. My partner has been commenting on how much better my skin looks now
Mr Physionic, I know you are usually not a guide to brands and are more focused on the compound. But could you please tell which collagen would work. A marine, bovine or porcine or is type 2 the answer ? And if there is a specific brand you recommend.
I'd be interested to hear what you recommend in a sunscreen please. Some scary stories out there about zinc oxide and no sunscreen being in contact with skin without causing other problems
I wont leave my bathroom without at LEAST 50 on. Ever. I developed melasma in my late teens from sun when i was a kid, and since i was 18, I don't go anywhere without it on
Hi, I'm not the original commenter. But I love Bioré kao aqua rich. They sell it on amazon, stylevana(where I get it from) and various other places. It's a Japanese Sunscreen and it seeps right into my skin, the 2019 version is my favourite, that one disappears completely after rubbing in, i am mentioning this because i think Bioré still produces it(the 2019 version). But the newer version is still good.
Try: Face - LRP UVMune 400 Creme Hydratante (eBay or Care To Beauty) Body - Bioderma Pediatrics Pump Spray (Care to Beauty) Protect yourself with a high PPD sunscreen.
Don’t know if you take video topic recommendations, or if this would interest you, but curious what you think of the studies pertaining to protein intakes effect on kidney health!!
Could you clarify your opinion on HA supplementation? I understood what you said about the low molecular weight, a certain well known brand only uses high molecular weight HA because they say it is implicated in longevity and that the low molecular weight HA mimics inflammatory markers. Is there any degree of evidence in this?
If I remember correctly there have been multiple older studies looking at collagen in topical formats and it showed basically what toxicologists and formulators suspected, which is that collagen is too large to pass through the skin and stimulate new collagen synthesis. You still find it in creams today because it happens to be a really fantastic moisturizer.
yay thanks for the collection :D.. I take them all....and with regards to the last note, ergothioneine, I'm going back on Cordyceps - good for 7 or 8 health functions.. and includes ergo, and great for a good night's sleep too. Check it out!
@@barbiekat6352 I just take Swanson. It's 3rd party tested but its very inexpensive compared to the other brands. I buy everything in bulk 2-3 times a year.
H. acid applied on my skin certainly has a cosmetic effect. Honestly, the biggest effect I have seen thus far is from essential oils. But also my greatest experimental catastrophes, which is why I think it is not widely recommended. But if you are serious about it, you should start researching which phytochemicals have various effects on collagen production, autophagy, antioxidants, and especially which ones kill off pathogenic bacteria and fungus that have colonized most westerner's skin (nasty). Once you have a short list, find carrier oils that bring benefits and complement the oils. Then use the oils in small patches first to see if you have bad reactions (and you will to some of them). Keep daily notes and that will actually help you figure out which ones work for you.
I have found the same. I have tried every product imaginable but recently switched to a castor/rosehip/frankincense mixture and wow my skin has improved so so much.
@@vchafab I like frankincense+patchouli+sunflower carrier oil. Recently I have been taking my chances with cinnamon+patchouli+sunflower oil. I have immune system issues so my main goal is creating a kind of barrier defense, and cinnamon is very effective, yet very dangerous if you have many mast cells sitting in your skin. However, cinnamon will kill the bacteria that causes acne in a week or so when nothing else would. Ylang ylang has effects slightly different from frankincense.
@@ballinout92 ylang ylang has effects. The cosmetics and pharmacology fields pay for quite a lot of research into these oils. You can find the data on all of them in publicly available research papers. What I suspect, though, is that the efficacy of an oil is unique to each person, so that while an oil might on paper be very effective at something, it might not be the best for you. You have to use the research to make informed guesses about what could work for what you are trying to accomplish, keep detailed notes with objective metrics to track, and weed out the oils that aren't as effective. Also learn to use the ones that have side effects but are very effective (for me that is cinnamon). There's no universal answer to give other than a short list of the top candidates to experiment with. I would also point out that addressing colonization by bacteria and fungus goes a very long way. Most Americans have very poor hygiene and are walking around with ongoing colonization by staph and candida pretty much all the time. This slows down the repair and replacement of collagen I think since your body is dealing with the infection on the skin instead of synthesizing new skin. There are also dietary considerations. I don't eat meat. I eat a lot of fruit and vegetables. I supplement with all the precursors amino acids and vitamins to making collagen. I activate my ampk signalling pathway very often in training. There are many things that go into it.
Hi Nic, I was wondering if you use or have a preference for a particular type of sunscreen please? There appear to be two main categories: chemical sunscreens (containing avobenzone, octinoxate and oxybenzone for example) and physical/mineral sunscreens (containing titanium dioxide and/or zinc oxide for example). Thank you
Hydrolyzed elastin peptides are needed in addiction to collagen and Hyaluronic acid. It's getting fairly easy to find elastin as a supplement (comes in pills or powder form)
If you are female, you will lose 30% of your collagen in the first three years of menopause, and a lot of skin dehydration occurs as well. This is due to hormones dropping dramatically. (There are estrogen receptors in your skin.) There are studies on topical estrogen as a way to mitigate this. One study showed glycolic acid boosting results. Do you have a video on this? I’d love to see it.
I do not like sunscreen due to the chemistry. I wear hats, cloths, avoid the mid day (10-2), sun, use the shade all as much as possible. I have very little skin aging at 62. The most exposed skin (hands, calves/shins, face) does have more aging that the non-exposed. But it is very minimal. Good genes likely help.
I'm one of those watchers who you wouldn't lose with the statistics stuff! :) Perhaps there are more like me. How about a one-off show on statistics needed for interpreting studies?
I rarely go outside and have a very pale skin naturally so I think my face skin makes me look 10 years younger. Spend your time in the sun 3 times a week 15 min each for vitamin D, and avoid the sun otherwise. Obviously never do solariums nor get sun tan.
I use sunscreen every day at work(SPF 30 that my employer provides although they are planning to upgrade to SPF 50), but it definitely isn't enough to prevent damage(I work outside). My significant other doesn't get much sun exposure and has a genetic condition that slows visible skin aging. I am not super bothered by it, but in a few decades I will look like I robbed the cradle.
Your colleague over at Medcram has been espousing the benefits of red light therapy (largely on the mitrochondia), so sun is healthy except for the UV I guess. Also supplementation of Vitamin D is not absorbed the same way as sunlight induced, nor is it stored in fat cells as I understand it.
HA needs to be good form if supplemented, otherwise topical. Collagen same. Astaxanthin everyday 4 mg. Glycine + Green tea also really good. And many others.
Hello! love your channel. Do you know about or have an opinion on the suppliment called Helocare? Supposed to maintain skins ability to protect against free radical aging. I've been taking it , but it is pricy. Hoping it's beneficial!
Was there a particular molecular weight for the collagen? Did you find marine or bovine is more effective and do you recommend types 1 and 3? Any reflections of UC-ii for health are usually reported for joints more than skin
![Astaxanthin for Skin Anti-Aging: Does it work? [Study 285 Analysis]](http://i.ytimg.com/vi/gI5XyVY_-n8/mqdefault.jpg)
Personal anecdote here. I took collagen peptides for more than a year and noticed nothing. I then read somewhere that glycine is the rate limiting factor in how much collagen your body produces. I incorporated glycine into my diet, and there has been a huge difference in my skin. Even age spots (I am 50) have either disappeared or started to fade.Therefore, I am surprised you didn't say anything about glycine. FYI, I take about 4 to 6 grams per day.
Edit: I've increased the amount I take to 9-15 grams per day. Considering it is estimated that our ancestors consumed up to 20 grams per day or more, and I haven't had any negative side effects, I don't see a problem with this. It's all been great so far.
Collagene is more effective but glycine = more bang for the buck. I take both
i thought collagen had glycine
@SeminarioMAE I think you're right, but in my case it wasn't enough. I saw no benefit until I added additional glycine in supplement form.
I use a lysine supplement (for cold sores) w my collagen peptides, I feel it works for my skin too...where do you get glycine? is it from food sources or pill form?
Very good point!
Collagen peptides - chow that powder down
Hyaluronic acid w low molecular weight
Sun exposure - vampire brigade represent!
Astaxanthin - skin elasticiy & moisture
=)
Absolutely!! I'm a vampire too.
Yes, there absolutely needs to be more focus on skin elasticity. Collagen without the elasticity will just give you thicker wrinkly skin like scleroderma, and that's actually the cause of it- lack of elastin. So astaxanthin is super important.
On hyaluronic acid, the prevailing science shows high molecular weight hyaluronic acid is healthier due to the low molecular weight causing inflammation. And most supplements out there are the HMW.
There are many studies and a brand new one citing ha as a cause of cancer and inflammation so that's not good. People are a bit freaked out about it right now especially those in the medical aesthetics community because of the injectable fillers industry.
High blood serum levels of hyaluronic acid are a screening test for colon cancer.
If there's no family history of cancer, I would go ahead and take HA supplements, but if there is a history I would be cautious.
Elderberry supplements are another excellent source of body moisture for moisture retention.
@@tracymullane8818great comment! Please, can you suggest some brands for each supplement?
You forgot GLUTATHIONE 🔥🔥🔥
@@FrozenAuroras yup! NAC (N- acetyl cysteine) is a precursor to glutathione. So it's a good idea to look up the effective dose of it and take it as you get older. Taking it with glycine, collagen supplements, along with vitamin C, is a good idea for collagen production. Glutathione has a very short half-life in the body, so the best way to take it is actually through injection, but even then it doesn't last very long. So taking NAC is more efficient, and cheaper.
Gly-nac supplementation extended the lives of mice 24%.
Doctors prescribe NAC for the lungs- It thins secretions and enables easier breathing. The FDA was thinking about taking it off the market to study it as a drug but you can't take something that occurs in nature of the market. That would be like taking water off the market.
Glycine aids in collagen production and is another powerful antioxidant.
NAC also cleans out the liver. You're not supposed to use it in conjunction with drinking alcohol- that's how effective it is.
For real elasticiy, I'd recommend an elastin supplement (pills, powder, whatever you like). It's still much harder to get than collagen and hyaluronic acid but more companies are selling it now. You can look hydrolyzed marine elastin up.
I know people don't enjoy it but Microneedling is probably the most effective method for increasing collagen and it's much cheaper then ongoing supplement purchasing. Red light therapy also more effective then supplements and more enjoyable than microneedling
Can i ask Which red light therapy do you use?
@@nickmontanaro9638 The device I have is a red led mask, it doesn't appear to have a brand name. If you want to buy one just go for the one with the largest amount of LEDs.
Red light therapy can also destroy collagen if it is used too long, I've heard from my skin therapist.
@@iraschlothi5930 I have never heard of that but you should never exceed 30 mins. Skincare therapists have an interest in convincing clients that if they were to attempt such things by themselves harm will result
You’re right, vivaci RF controlled radio microneedle with PRP topical platelet replacement used with SEYPHYL a calcium carbonate “scaffold” RF energy creates new collagen formation . “You can’t supplement your way into better skin . This dude is entirely wrapped up in his academic wheelhouse as a molecular biochemist PhD candidate, he’s intellectually “smug “ and mildly condescending to his audience , masked as an attempt at HUMOR 😂.,
My project of becoming a perfectly smooth human flamingo is still going on
🦩
This comment is soo funny
Flamingo isn't smooth tho..... Not that I have actually pet a flamingo
@@ZoeCuiM this is why I will be the coolest flamingo on earth.
@MilesDoyleSalttoo long, didn't read
The effects of hyaluronic acid can be amazing. I had two courses of hyaluronic acid injections directly into the synovial fluid of my knees, and the effects were almost immediate and wonderful. All the knee-pain that had been slowly building up over the years went away within a few weeks and hasn't returned. Health insurance is usually gung-ho for these, because these HA injections reduce the number of knee-replacement surgeries, simply because it causes regrowth, thickening and strengthening of the cartilage shielding the boney wear-surfaces within the joint. (The fact that the nurse-practitioner used ultrasound to make sure the needle didn't nick any structures was great, too. The only discomfort was from the extra pressure right after each injection, but that faded after a couple of hours.)
Awesome information!! Tk you
worth trying out high dose VitD3 as well, if u havent...
Wow! That’s an amazing result! I’m going to look into this.
Unfortunately, I don’t think cartilage regrows from hyaluronic acid injections (actually we don’t even see cartilage regrowth with stem cells!), but it can be a potent anti-inflammatory
@@ilevitatecs2 intra articular growth hormone is promising
+1 for algorithm. With the free knowledge this channel cranks out, you should have 2.2 billion subs!
You assume by default because he sounds nice he is correct, however many more experienced than this student reject his claims
A typical village lifestyle in Greece
All you youtubers confuse and stress us out with what you suggest for health and longevity. My aunt died in 2022 and she was 108 years old, my uncle at 98 years old, my father died at 97 years old and my mother at 93. We all come from Greece, specifically from the island of Samos next to Ikaria. The style of their life, a typical day was as follows. They would wake up in the morning at 6, maybe have a mountain tea or some milk with wholemeal bread and leave for manual work on the estates. Around 10 o'clock they ate some wholemeal bread with a few olives or their own cheese, at noon they rested for about half an hour and usually ate Legumes, pulses, and in the afternoon when the vesper bell rang at about 6 pm they usually left on foot for the village because the donkey was loaded with tools and products. In the evening, light food, Salads, wild greens, Legumes and generally Greek cuisine, all almost their own production. They always used olive oil in the food. in the evening the men would go to the Cafe for a drink, usually wine or ouzo and the women would gather in a house or in the courtyards of the houses and chat about the events of the village. At 10pm everyone went to bed. They didn't eat much meat. They ate fish Eggs and some old hen on some Sundays with potatoes and rarely with spaghetti. They used tomato paste for the sauces they made themselves in the sun and maybe would drink some wine that produce themselves. They had fun at the festivals 4 to 5 times a year and on the religious holidays. We children went with them to the estates and helped on weekends when we didn't have school. I should mention that all the residents in the villages of Samos have more or less the same habits and economic level. Many residents of my home village left and went to the United States of America. I am very sad to say that all 5 of my classmates who left for the USA and adopted the lifestyle there, all died very early very young in their 50's and 60's.
Sounds glorious that’s for sure. Doesn’t surprise me about American food supply either. Sorry about your classmates.
So how much wrinkles do these people have? Exactly They might have had long lives and were not struck by cancer.. doesn't mean they aged pretty. People in the longevity and healthspan part aren't just looking to replicate the results from your family which might also have a genetic component to it like very low occurrence of cardiovascular disease, they are looking to perpetuate the effect of rejuvenation. The absence of aging at all and the absence of decay.
This is where you completely miss the mark. Yes we can learn a lot from them. But they didn't have the fix. They still experienced significant bodily decay until failure. They still had reduced quality of life over time and at some points failed in their ability to do things they used to be able to.
So your mindset is still in the 2004 of the blue zone studies. We are now looking past those and are trying to find the mechanisms that might improve on those outcomes. Of course modern mankind seems to be moving further away from this as we speak but not everyone when u isolate populations who do get the message. So "youtubers" like Psychionic aren't confused at all. They just have different outcomes of goals projected than you have when using these definitions.
Very little meat and wine, I dont really want to live to 100 like that.
Humans can live into their 120's why did they die so young?
@@deansusec8745 It is just because you lack imagination and experience of how it can be without. My glass of Khombucha with a thai plant based dinner checks those same marks. Yet the difference is I am not paying a price for it.
I love this! I haven't seen anyone else on yt who would deliver such a great summary based on actual scientific papers
Thanks :) takes a lot of work, but well worth it
I ignored the warnings about sun exposure when I was younger and now in my 60s I’m paying the price. How I wish I had slathered on the sunscreen and avoided tanning beds.
LOL no. Actually I look younger than most my age as I’ve always been physically active, healthy diet, no smoking etc. But how I wish I had more elasticity. I’ve been a vegetarian for the last year but will make an exception for collagen peptides. I’ll try anything at this point.
@@anode-cathodein a few years, you will probably regret going vegan more than ignoring the warnings about sun exposure...
Lol I get sun every day and always will
Add fish.
Vegetarian doesn't automatically equal healthier.@@anode-cathode
@@jmw-q4u well whatever you do... don't use a tanning bed
I would absolutely love a video on the supplements / regimens you employ as a result of your scientific research.
His supplement stack is reported - check his other vids
@@ericsonhazeltine5064let us know what brands and supplements they are
A "regiment" is a specific group of men in the military.
While I'm interested in skin repair, my age is 69, I think creams are not my ultimate goal. Recently my dad passed at the age of 97. The one thing that surprised me was how thin and paper like his skin became. It was a miserable experience for him. I suspect that diet will be the only way to improve how my skin strength. I've been on keto for about a year and adding supplements like Omega 3, collagen powder, some vitamins. I recently tried retinol for my forearms and hands as I started showing the thin skin age large bruises. It does help a bit. So I'm actively looking into whole body solutions. Dad's skin issues became a major difficulty. He was mentally fine to his last days.
I think as you get older, its a multifactorial approach, reduce inflammation and increase antioxidants w food, supplements w specific benefits, creams, lotions and serums (and they do work) and sunscreen or sun protection.
Vitamin D is primarily produced in the oil of our skins, this is why it is very important to keep the skin of our elders moisturised. Use CeraVee, it's ceramides are proven to help the skin.
Sun protection will be one of the best things you can do
Look into laser resurfacing for the face at least.
Research Xtend life if trying to start supplements or skin products.
I watched this video with interest, not due to interest in improving skin condition, but rather because I have Ehlers-Danlos, and I look for info on anything collagen-oriented.
I will however, say that when I increased my vitamin C intake from 250mg supplement/day to 2g supplement (spread over the day), that in addition to many other benefits, the quality of my skin improved markedly... a much more healthy sheen, color, hydration, not to mention a cessation of unexplained bruising.
I enjoy your channel, regardless of how personally pertinent the info may be to me!
Same here type hypermobile. I'm going to try this thank you. 🙏
Howong did it take to start seeing a marked difference?
@@nickmontanaro9638 I'm hEDS too. I take Trader Joe's Chewable Orange, which has ascorbic acid/sodium ascorbate blend, which I have no idea whether it makes a difference, but am not going to muck around with success, and is cheap too. I started seeing multiple improvements in myalgia (which was really brutal for years), brain fog, anxiety, and a few other typical vitamin C deficiency symptoms within a couple days. Noticeable improvement in skin in 2-3 weeks. That was about 3 yrs ago, so has been sustained.
I also take 2g/day of lysine spread through the day (important especially for the C to be spread out also (500mg every 4 hrs), I find best results on empty stomach, but some might not tolerate that well), and a multi-mineral with higher bioavailability than the cheapest stuff. I take a few other things too, but the C/lysine/multi-min have made the biggest diff, including assistance with ligament/tendon healing. Hope something helps you!
@@nickmontanaro9638 Welp, UA-cam deleted my lengthy reply... will recompose it when I get time. Short answer, a couple days for myalgia, brain fog and other stuff..... a couple weeks for skin.
Careful with high dose C- can cause kidney stones
Hi, just wanted to say be aware of vit c over 250 mg can cause oxalate kidney stones, this happened to me and Iignored the studies I saw. Worst pain ever so really be aware
Thanks! I love when you address skin health topics. Very helpful in a sea full of contradictory info without science to back it up. Appreciate your channel!
This was a good honest video. In addition to the above, regular exercise, hydration and the consumption of clean foods seems to help, at least it has for me.
Broooo you have become so big! I remember how you had only 200 subs! So happy for you!
Thanks :) I deeply appreciate it
@@Physionic from rational learner with love! 💞
Bruuuuu
@@Physionic You definitely deserve it! The information you provide is fantastic.
The Nambour sunscreen study showed no signs of aging in 4,5 years in the daily sunscreen group. But keep in mind this study was done in Australia where even in winter the uv index is 6+. Differences between daily and occasionally sunscreen could be less or insignificant in countries with much lower uv indexes.
I didn't realise that it was Nambour. It does mean that skin aging can be reduced by limiting exposure. So since the alternative of dv3 supplementation exists the loss of uv exposure can ve mitigated.
This video is a treasure trove of info! I've been using red light therapy for a while now, specifically a panel from Future Form Official, which my dermatologist recommended. It's not just affordable but incredibly effective. I've noticed a significant improvement in my skin complexity and a reduction in wrinkles. I never thought such a simple addition to my routine could yield such noticeable results. There’s a lot of scientific literature backing red light therapy, which gave me the confidence to try it. Big thanks to everyone sharing their experiences and tips here-so helpful!
Take a look at L theanine,L threonine, and L methionine.they are major players in skin rejuvenation,but they must be taken with B6,B9, and B12.
Thank you for mentioning UV as a major factor in aging. I don't take collagen or do much in the way of skincare, but I do slap on sunscreen faithfully and credit it with so many people telling me I look 10+ years younger than I am. I try to stick to mineral sunscreens, which I understand to be better? Maybe you can do a video on sunscreen sometime? It is summer in the northern hemisphere now.
Well and I’m 40 and nobody gives me more than 28. People don’t believe my age they ask for my ID. Never used sunscreen unless I was at a beach baking between 12-3pm. I’m against sunscreen, I hate it with passion, it makes my skin feel terrible, I don’t use it at all, I make sure all of my makeup up and skincare products are sunscreen free. I love the sun and expose my skin to sun regularly, in fact it’s my daily task to get sun exposure daily for at least 30 min. My skin looks great for my age, never had any procedures done, not planning on any adjustments, not planning on using poisonous sunscreen anytime soon. Regardless of the bs studies funded by corporations I can’t see any damage by the sun, and if anything, the benefits that I get from the Sun outweigh the possible hypothetical sun damage.
mineral sunscreens work...but does not work better than chemical sunscreens which offer higher protection, they often use adjuncts that lower inflammation or sunscreen boosters to get the higher numbers. But they work well enough, for ppl that if it is your first choice, its good enough. There is no bad choice if that's the formulation you prefer.
@@campersruincod6134 you mean the same type of evidence that kept insisting that vaccines are “safe and effective” or the evidence that fat is bad for us? Or perhaps the evidence that cholesterol in eggs makes your cholesterol go up and clog up your arteries ? Or.. I could go on and on the entire day with all the “evidence” that makes no sense but fills big pharma’s phockets. It could be a combination of things, if I eat actually healthy diet, not the diet recommended by the govt., if I don’t smoke, don’t drink alcohol, don’t take drugs etc, if my immune system works fine and my body manages to get the benefits from the sun while counteracting the negatives then that could be the reason why. I can’t tell I have particularly good genetics, I have white skin and I live in Australia- a country with high melanoma rates and other skin cancers. People bath themselves in sunscreen day and night yet the rates keep goin up.. something doesn’t add up here. Then we find science that the sun actually doesn’t cause many types of skin cancers and it’s in fact the lack of the sun that cause some of the bad ones. But of course you won’t find any of this info if you use google or other mainstream channels of information, you’d have to dig deep on pubmed to learn this. So yeah, perhaps, my comment is the only comment you came across that would give you an impression of n=1 anecdotal “evidence”, but the actual evidence is overwhelming. I didn’t stop using sunscreen for no reason, I followed the actual science. But you keep using your sunscreen and convince yourself it’s making you look younger 😌👍👍👍
@@jrmint2what chemical sunscreen doesnt burn eyes? Every single chemical sunscreen ive used made my eyes tear up
@@ballinout92 It depends on the formulation and sometimes its the additives used can cause burning. If you have sensitive eyes, try Japanese Biore Watery Essence or Protect, Japanese Skin Aqua Moisture Essence, or any of the La Roche Posay. There are many others but this can get you started in your search. Another option is to use the regular sunscreen everywhere except the eyes and use a stick formula like Neutrogena, or the mineral sunscreen around your eyes.
Please do a video about colostrum. I’m curious what the science says about its benefits.
Anecdotally, colostrum really helps me when I feel that I am about to get sick. It's almost miraculous how I don't catch most flus and I work with small kids. I used to always be sick
Thank you so much for true scientific data. I’m so tired of cosmeceutical companies presenting ridiculous, decontextualized data with no statistical power as “evidence” when in fact it’s just a marketing scheme. Thank you!
Years ago I watched some UA-cam video about hyaluronic acid and I was taking it for a long time and people told me how amazingly youthful my face looked. I stopped taking it and a bunch of years later I actually look older than I should now
Re: Vitamin D supplementation vs. sun exposure, I work with overweight/obese, diabetic and heart disease patients, and even though they all supplement because their levels of D are low, supplementation does not increase their levels. It seems that this is due to its tendency to store into adipose tissue. I have also seen many labs of folks who are not obese or have any condition, but have tested low for D, and their Vit D levels are also not increased with (correct dose and form) supplementation. Once you've seen hundreds of labs over a career, it becomes clear that the theoretical replacement of Vit D through supplementation does not occur in a significant number of people.
So you recommend sun exposure?
Doesn't that also get into the adipose tissues?
I think that depends on what type of vitamin D it is. There's different types and my understanding is that you need D3 not D2 which is what is typically prescribed. There's also other vitamins that must be taken along with Vitamin D as it works better and it helps with absorption. Do a search on UA-cam and you'll find videos that go more in depth, into the science.
So, reduce fat stores in the body.
Good catch.
But you are likely wrong about the adipose tissue eating up the vitamin D.
I am lean fit and muscular - vitamine D levels are low and supplementation appears to have low or no effect.
Perhaps fish oils or foods containing it would lift my number - haven't tested it recently to know.
I get kidney pain every time I take vitamin d and sometimes stones. I do take it w/k2.
I'd like to see the effect of collagen supplements on repairing ligaments, tendons and cartilage.
My my my, look who is fast approaching 200K subs! I love the success you've had - incredibly well-deserved, Nicolas! Happy for ya :)
This channel kicks @ss, please never sell out Nick lol
Just don’t get burned in the sun. Also moisturize after.
It's all about a healthy diet, low calorie, high protein, low sugar, high antioxidant diet, and sun protection.
The rest do help. I use:
1. Red light (topical)
2. Methylene blue (oral)
3. Copper sulfate pentahydrate diluted in water (topical)
Low sugar, low animal protein, low calorie, eventually fasting, some exercise. A diet that isn’t fun
low calorie puts body in a starvation mode except if you dont use energy during day much whats another bizzare thing
better to eat normal but fast, this actual does its job at each phase
I started taking Hydraulic Acid for my knees after a fall on my knees. Made a big difference. Took a few months. The exercises I was given only helped about 10 percent after 2 months. The Hydraulic filled in the other percent.
Dang auto correct
@_zantetsuken_ But you feel _terrible!_
11:40 "and the sun is good because it's natural" -- it's good that Nic calls this out. Other things that are natural (and therefore good): wasps, uranium, syphilis... BTW my patented skin-rejuvenating blend of syphilis-infected uranium wasps should be on store shelves soon.
You really ran with that lol
The sun is good because we evolved in it.
It is required for vitamin d and for vascular function.
Getting sun is correlated with longevity.
@@anyajohnson4471 that's dependent on dose -- too much and you get skin damage, aging and possibly cancer. Most of the research suggests sunscreen doesn't have much impact on vitamin D production, so you can get most of the benefits with less risk.
yes radiation around you is natural and healthy
dose matters
blood loss is also healthy
with such mindset as yours you will be always limited by scientific averages without any overarcing idea why these work and what could work by analogy but you just stayed oblivious
what we dont know is often more important than what we do know and needs to be taken into consideration at all times
staying away from sun is mindbogglingly stupid idea
March 1st I got an AC Joint Grade 2 sprain in my dominant right arm. It’s been a few months of PT and healing later and the prominence of my bump has gone down a solid amount however I still feel it, especially when I sleep on my right side. Plus mild mild pain (a lot better than when I got the injury). I’m an active 22 year old male so I feel like I will heal up pretty well in the next few years going forward, especially since I’ll focus on more strength building exercises like face pulls, shoulder press, etc.
I’m going to start taking BPC-157 at 1mg per day orally in about a week. I’m looking forward to healing the ligaments and tendons a lot better. My surgeon who didn’t operate but diagnosed my sprain told me my tendons and ligaments are in tact which made me relieved.
Anyway, here are my current supplements and stuff I’m taking:
-Collagen Peptides (Hydrolyzed) 11grams daily
-NR (NAD+ Booster) 300mg daily
-Hyaluronic Acid 1gram daily
I started taking astaxanthin years ago to save my vision and it worked. I got IBS really bad after covid and started taking collagen to repair the tissue. I didn't notice tremendous results. Then I found out that taurine is required for college in production. Are taurine levels start reducing in our 30s when we also begin showing signs of aging. I've added l-taurine and feel there's a difference.
What difference exactly you notice ?
I might add taurine than as I do take lysine which also makes collagen
@@raik.7510 I'm having more good days with my IBS, and much fewer bad days. I also started drinking burdock root tea which seems to have a stronger effect - though all effects are incremental and subject to perception.
I think you mean lysine not taurine. Lysine and vitamin C are needed for collagen production. Taurine is amazing though.
@@WaterspoutsOfTheDeep I asked Google, it indicates that taurine does help in the production of collagen in skin and bones. There was a mention of is presence near right junctions which is what I really need. Lysine looks pretty interesting for the antiviral properties - I might actually be taking some of it in some of my supplements. I don't always take the immune boosters but try to load up when I think I might get exposed.
Would love a video on what helps supplements or products help Sun damage ( aside from sunscreen) n hair loss. I appreciate your study based videos!
morning and evening sun...
I'm not sure if you were looking for a sunscreen replacement but taking the standard process brand Cataplex F Two per hour along with Calcium lactate will prevent sunburn so you don't need to use sunscreen.
Incredible information, as usual!
Thanks Nic! Love the study results breakdowns. Lots of sunscreen misinformation out there, for those interested, biochemist Dr. Michelle Wong is a great resource for sunscreen science (among other skincare science).
Yes, she’s excellent
I’m on the Lion’s Diet currently. What’s interesting is that I don’t sunburn, just tan.
I used to get crispy so fast on the Standard American Diet. It’s a strange, but awesome benefit
Holy shit I'm on Ketovore
Tanning is also a sign of skin injury.
@@silvana8737 I know but to me it's worth the injury. I never burn but I do tan well.
I heard of this on reddit 10 yrs ago so this confirms it's real
I experienced this too when I was vegan. At the time I thought it was from all the vitamin E I was eating but now I think it's more a function of eliminating processed food than a specific diet like carnivore vs vegan or whatever. ButI tend to think any benefits from specific diets comes from eliminating processed/manufactured foods.
Very much suggest a playback speed of 1.5x guys… but great video!
A side benefit to the efficiency in listening time is that the speaker sounds so much more intelligent. On really well recorded audio one can increase the speed even more and it is completely intelligible.
Do a video on supplemental silica and aloe Vera for collagen production. There are studies about it
Yes! I've used both, I think silica is so underrated, and I dd use aloe vera for years...but still bring it back into rotation.
I use silica (Biosil) but have not heard of using aloe Vera as a supplement. Very interesting!
@@heidikamrath1951 yea i don't remember how i found out about supplemental aloe vera but i did find studies showing supplementing with it internally increased collagen production and pretty much no one mentions either of these on youtube along with collagen peptides and hyalauronic acid that everyone mentions.
@@jrmint2how do you use the aloe vera? Externally on skin or do you drink it? Thanks in advance.
@@ijh7192 orally, pill form.
Appreciate the video. Would be interested to see the list you mentioned with the supplements you take? How do I see that?
Since astaxanthin seems to be an unusual anti-aging supplement, how would we find the best dosage?
whats the best dosage for collegen and hyaluronic acid?
Astaxanthin also protects against sunburns
all carotenoids do, astaxanthin is not the best price-effectiveness wise.
And is beneficial for eyesight.
Just started taking it he talks about it last week
at what dosage is this significant ?
@@aaaaaa-aaaaaaaaaaaaaaa are you saying astaxanthin is not superior price aside?
Awesome video. Your thoughts on retinols?
I believe. RetinA!!
OTC is child plays compared to Tretinoin in terms of efficacy
But I love the sun :( On a more serious note, I'd love to see more in depth discussion on the effect of skin color on UV-induced skin aging. I'm brown skinned, and get about a one to two hours of sunlight a day. I need my vitamin D... I live in Ghana where most people are very dark skinned, and the vast majority of Ghanaians never use sun screen, yet, many people who spend hours in the sun every day barely show signs of skin aging and skin cancers are very rare here. How much protection do different skin tones really afford us, especially for those of us who are neither very light-skinned or very dark-skinned?
You have built in sunscreen.
@@vicz8899 yes, I know, but I find statements online like: "dark-skinned blacks have a natural skin protection factor (SPF) of up to 13", but is that true, then why is SPF 30 recommended if dark skinned blacks barely experience UV-damage, and what does that mean for lighter skinned blacks? Do we have SPF 6,5 o is it more complicated than that?
@@sundiataq There probably is "some" benefit to dark skinned blacks using SPF. It won't hurt. But the sunscreen makers also want to sell more product.
My neighbor is black, she is 62 and smokes cigarettes. Not a wrinkle on her face. Her mother is at least 20 years older and smooth skin too.
Lighter skinned would probably benefit more than darker skinned.
@@sundiataq The SPF of darker skinned people is more like SPF 4. And all races of people benefit from using sunscreen, especially if you live in a high UV index area and spent a lot of time outside.
Thank God you said it bro, yes! Guys, you've completely missed the point and need help if you're worried about these supplements...without even consistently using sunscreen and using chemical exfoliation.
Glycine. Proline. Hydroxyproline. Water with hyaluronic. SUN BLOCK. HAT.
What kind of chemical exfoliation?
My 2 cents living here in Southern Europe with about 11 months of sun a year; Most of us are deficient in VitD3; the most important hormone for overall health and the immune system... blocking out the little sun we get with sunblock seems unwise...just take care in the midday sun, wear a shirt... and avoid seed oils which also contribute to sunburn...
@@betzib8021They most commonly use some combination of glycolic acid, lactic acid and salicylic acid which helps exfoliate, reduces pore size/appearance of fine lines, and improves skin tone, texture and clarity (brightness). The most convenient ones are single use pads/peels and they should be paraben free such as m-61 PowerGlow peel and many other quality brands. They work great with immediate results and consistent use will help new collagen formation. MD approved
@@betzib8021 topical and at home, like glycolic acid, salicylic acid, lactic acid, etc. You know, the second thing dermatologists say is so important and only second two sunscreen. Exfoliation increases collagen synthesis, increases skin cell turnover, clears pores, etc. If you're worried about anything related to skin without sunscreen and exfoliation, you've missed the forest for the fungus on the floor. It's like worrying about sugar,...when you don't even exercise enough.
Hello Physionic -- really appreciate your work -- one slight pushback though. There's been some recent work on other benefits of sun exposure to skin, such as on NO production. Of course, that doesn't mean the benefits outweigh the costs, but its not all just about vitamin D. I'd love for you to do a video on this field of research!
Hi take sunlight before 9 am best is sunrise you get your infra red - good luck
I'm a 62 yo male living in South Africa. Vitamin D is not a problem here, but i do use factor 50 sunblock. My diet is pretty clean and I exercise three times a week. Most people said that i look at the most 55.
I started to take collagen powder and the results were remarkable, nothing else changed.
Friends who had not seen me for a while couldn't believe how good I look, people started asking me what I do for my skin, this had not happened before.
I was stopped in a routine road block coming out of Johannesburg airport, the police checked my driving license and wanted to hold me whilst they checked me out as they couldn't believe it was me and thought I was using someone else's license.
Nothing else changed, just the addition of collagen peptides. Most people say I look between 48 to 50.
I certainly hope that the placement of the sun behind your head in an aura/halo appearance was done on purpose. It was hilarious and made my day.
Did you see the post by Dr Rhonda Patrick on sunscreen ingredients being absorbed into the body? Coincidentally Dr Greger also had a series on sunscreen ingredients and cancer. Then Prof Tim Spector chipped in writing a long article in the main UK newspaper on vitd deficiency and sunscreen
well he is on the pro chemical side and they have problems with holistic understanding and seeing theoretically big picture
these studies are all about averages, and by default do not apply to everybody..
keepng baby skin while being mentally & physically ill inside isnt a perfect outcome
how about ceramides capsules supplement for skin hydration? also some make claims red light therapy drastically reduces skin damage from UV or the sun.
Ceramides are terrible for arteries
Use sunblock. Red light therapy is good, but it isn't a miracle cure if you have roasted your skin with baby oil under the sun.
Astaxanthin
Use HLA
@@betzib8021References if you have them, please?
"Pictorially depicted", "totality", "inter-study heterogeneity", "plethora"...such sagacious perspicacity.
Collagen and coffee is a nice combo.
coffee lowers supply of blood to brain by half, cheers
what about niacinimide? also i guess retinoids are topical but they are among the most effective skin hacks
Prescription tret fucks my skin up but I started using the gentler trader Joe's retinol and it's a lot smoother experience. My partner has been commenting on how much better my skin looks now
Great! I use every four of them :)
Mr Physionic, I know you are usually not a guide to brands and are more focused on the compound. But could you please tell which collagen would work. A marine, bovine or porcine or is type 2 the answer ? And if there is a specific brand you recommend.
I'd be interested to hear what you recommend in a sunscreen please. Some scary stories out there about zinc oxide and no sunscreen being in contact with skin without causing other problems
I wont leave my bathroom without at LEAST 50 on. Ever. I developed melasma in my late teens from sun when i was a kid, and since i was 18, I don't go anywhere without it on
I just wear a hat lol
Which sunscreens are your favorites, and why? I hate the feeling of sunscreen on my skin, especially my face. But I know it is important to wear..
@@heidih3048 I actually really like Scinic Super Mild Sun Essence 50 + pa. It's a Korea brand, and it's wonderful.
Hi, I'm not the original commenter. But I love Bioré kao aqua rich. They sell it on amazon, stylevana(where I get it from) and various other places. It's a Japanese Sunscreen and it seeps right into my skin, the 2019 version is my favourite, that one disappears completely after rubbing in, i am mentioning this because i think Bioré still produces it(the 2019 version). But the newer version is still good.
Try:
Face - LRP UVMune 400 Creme Hydratante (eBay or Care To Beauty)
Body - Bioderma Pediatrics Pump Spray (Care to Beauty)
Protect yourself with a high PPD sunscreen.
How do I stay looking young ? I follow the genius advice on Physionic of course.
Don’t know if you take video topic recommendations, or if this would interest you, but curious what you think of the studies pertaining to protein intakes effect on kidney health!!
Could you clarify your opinion on HA supplementation? I understood what you said about the low molecular weight, a certain well known brand only uses high molecular weight HA because they say it is implicated in longevity and that the low molecular weight HA mimics inflammatory markers. Is there any degree of evidence in this?
What do you think about creams based on hydrolyzed collagen and elastin? Absolutely zero benefit or is there still some benefit from them?
If I remember correctly there have been multiple older studies looking at collagen in topical formats and it showed basically what toxicologists and formulators suspected, which is that collagen is too large to pass through the skin and stimulate new collagen synthesis. You still find it in creams today because it happens to be a really fantastic moisturizer.
yay thanks for the collection :D.. I take them all....and with regards to the last note, ergothioneine, I'm going back on Cordyceps - good for 7 or 8 health functions.. and includes ergo, and great for a good night's sleep too. Check it out!
Brands you use please?
@@barbiekat6352 I just take Swanson. It's 3rd party tested but its very inexpensive compared to the other brands. I buy everything in bulk 2-3 times a year.
Nice channel, you got a new subscription 🙂
Welcome!
H. acid applied on my skin certainly has a cosmetic effect. Honestly, the biggest effect I have seen thus far is from essential oils. But also my greatest experimental catastrophes, which is why I think it is not widely recommended. But if you are serious about it, you should start researching which phytochemicals have various effects on collagen production, autophagy, antioxidants, and especially which ones kill off pathogenic bacteria and fungus that have colonized most westerner's skin (nasty). Once you have a short list, find carrier oils that bring benefits and complement the oils. Then use the oils in small patches first to see if you have bad reactions (and you will to some of them). Keep daily notes and that will actually help you figure out which ones work for you.
I have found the same. I have tried every product imaginable but recently switched to a castor/rosehip/frankincense mixture and wow my skin has improved so so much.
@@vchafab I like frankincense+patchouli+sunflower carrier oil. Recently I have been taking my chances with cinnamon+patchouli+sunflower oil. I have immune system issues so my main goal is creating a kind of barrier defense, and cinnamon is very effective, yet very dangerous if you have many mast cells sitting in your skin. However, cinnamon will kill the bacteria that causes acne in a week or so when nothing else would. Ylang ylang has effects slightly different from frankincense.
@@noosphericaltarzan What other oils are good for thickening skin and anti aging? I like tamanu
@@ballinout92 ylang ylang has effects. The cosmetics and pharmacology fields pay for quite a lot of research into these oils. You can find the data on all of them in publicly available research papers. What I suspect, though, is that the efficacy of an oil is unique to each person, so that while an oil might on paper be very effective at something, it might not be the best for you. You have to use the research to make informed guesses about what could work for what you are trying to accomplish, keep detailed notes with objective metrics to track, and weed out the oils that aren't as effective. Also learn to use the ones that have side effects but are very effective (for me that is cinnamon). There's no universal answer to give other than a short list of the top candidates to experiment with. I would also point out that addressing colonization by bacteria and fungus goes a very long way. Most Americans have very poor hygiene and are walking around with ongoing colonization by staph and candida pretty much all the time. This slows down the repair and replacement of collagen I think since your body is dealing with the infection on the skin instead of synthesizing new skin. There are also dietary considerations. I don't eat meat. I eat a lot of fruit and vegetables. I supplement with all the precursors amino acids and vitamins to making collagen. I activate my ampk signalling pathway very often in training. There are many things that go into it.
What were your oil catastrophes?
Hi Nic, I was wondering if you use or have a preference for a particular type of sunscreen please? There appear to be two main categories: chemical sunscreens (containing avobenzone, octinoxate and oxybenzone for example) and physical/mineral sunscreens (containing titanium dioxide and/or zinc oxide for example). Thank you
Hydrolyzed elastin peptides are needed in addiction to collagen and Hyaluronic acid. It's getting fairly easy to find elastin as a supplement (comes in pills or powder form)
💉
If you are female, you will lose 30% of your collagen in the first three years of menopause, and a lot of skin dehydration occurs as well. This is due to hormones dropping dramatically. (There are estrogen receptors in your skin.) There are studies on topical estrogen as a way to mitigate this. One study showed glycolic acid boosting results. Do you have a video on this? I’d love to see it.
menopause state isn't normal and hormonal state isnt normal then,
we are animals who defy our destiny, but pretend to not see it
Thanks for another great video. Thosen really grounds me and make me think thrice about adding another supplement.
I do not like sunscreen due to the chemistry. I wear hats, cloths, avoid the mid day (10-2), sun, use the shade all as much as possible. I have very little skin aging at 62. The most exposed skin (hands, calves/shins, face) does have more aging that the non-exposed. But it is very minimal. Good genes likely help.
Im surprised you didnt mention a time machine.
Not enough data
Thanks so much Nic. Interesting as always.
What about GHK-Cu?
14:53 Pretty weird how the reported SD and CI of all the studies were wildly different, but then the error bars are all the same width....
Thanks!
Thank you, Patricia!
I'm one of those watchers who you wouldn't lose with the statistics stuff! :) Perhaps there are more like me. How about a one-off show on statistics needed for interpreting studies?
Any brand recommendations by anyone for hyaluronic acid? I generally go with Donotage but their hyaluronic acid is high molecular weight
I guess my Astraxanthin is going to my skin not my eyes .. I can’t see the insider link mentioned.
😂
I put it on my face for UV protection next thing I know I got the DMV to remove my eye glasses restriction.
I rarely go outside and have a very pale skin naturally so I think my face skin makes me look 10 years younger. Spend your time in the sun 3 times a week 15 min each for vitamin D, and avoid the sun otherwise. Obviously never do solariums nor get sun tan.
Do you need sun on just one part to benefit the whole body? Eg arm, leg but not face?
Very informative! Thanks
To conclude... please share dose ranges in the summary or in a punned comment 🙏
Where do you stand on Polypoduim. Its veiwed as a skin specific antioxidant. There seems to be some evidence for that.
Haven’t looked into it, unfortunately
@@Physionic Have a look. It's meant to be a skin specific antioxidant and there is some evidence to that effect. I take it.
Been doing orange juice enemas since I was 24, no wrinkles at all. I truly think this is the best way to drink from the fountain of youth.
Hummm i used to do enemas I've done all kinds but it never accerd to me to do vit enemas thanks for the tip
@@carolmaplesden916 it was just a joke, Carol. Don’t actually do it.
@@BR525
Yeah haven't you heard of vit IVs I think it could be good
Cod liver oil is probably the best.
Fasting for autophagy would help skin aging?
Yes
what sunscreen do you use?
I use sunscreen every day at work(SPF 30 that my employer provides although they are planning to upgrade to SPF 50), but it definitely isn't enough to prevent damage(I work outside). My significant other doesn't get much sun exposure and has a genetic condition that slows visible skin aging. I am not super bothered by it, but in a few decades I will look like I robbed the cradle.
In relation to glycine, collagen is composed largely of glycine, therefore, you were likely consuming 2.5g of glycine with your Collagen
How does one know if the hyaluronic acid supplement is low or high molecular weight?
It should be mentioned in the label . Not sure if any otr means are there to determine that
Your colleague over at Medcram has been espousing the benefits of red light therapy (largely on the mitrochondia), so sun is healthy except for the UV I guess. Also supplementation of Vitamin D is not absorbed the same way as sunlight induced, nor is it stored in fat cells as I understand it.
HA needs to be good form if supplemented, otherwise topical.
Collagen same.
Astaxanthin everyday 4 mg.
Glycine + Green tea also really good.
And many others.
True. They mostly protected against UVB.
Does consuming bone broth equates to collegen peptide supplementation?
What about tretinoin?
That isn't a supplement.
Hello! love your channel. Do you know about or have an opinion on the suppliment called Helocare? Supposed to maintain skins ability to protect against free radical aging. I've been taking it , but it is pricy. Hoping it's beneficial!
Was there a particular molecular weight for the collagen? Did you find marine or bovine is more effective and do you recommend types 1 and 3?
Any reflections of UC-ii for health are usually reported for joints more than skin
Are you uploading your Omega-3 video soon?
I've heard HA might increase cancer rates so I'm scared to take it at this point in time.
What about castor oil??
thanks for the tips. i want to avoid having that slow roasted look some old people have.
How much Kollagen should you take per day?
Shaving is hurting my son. So many single mothers out here. Do you have time to discuss shaving tools and products?