This Gene controls Ergothioneine linked Mitochondrial Benefits
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- Опубліковано 2 лип 2024
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References [Copy & Paste DOI into Search Engine]
[1] doi:10.1101/2024.04.10.588849
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#mitochondrialhealth
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Regardless..., exercise, exercise, exercise. :) Thanks
Please do a video on Trigonelline. It’s been proven to raise NAD levels better than NMN or NR. Thank you.
Wonder if that's got something to do in ME/CFS and Long Covid. Apparently there has been an attempt to make a medication for the mitochondria in Japan and now some company is trying again. Hopefully in the next couple years there will be a medication that helps us folks...the dream to get ones life back.
In Japan I have seen some researcher cleaning with iodine I think inside the upper end parts of the nostrils, saying they are infected and inflamed . After 3 months of treatment patients recovered . I saw one teen girl on wheelchair start to walk again return to school once that inflammation goes away .
Its possible since long COVID and CFS etc began with a virus and that inflammation never got treated as doctors don't check or link it .
I want to go to Japan for my long COVID to get that treatment.
Nick, you are indeed The Man of the Future!
some day, I'll know why I needed to watch this ;)
thanks for posting!
You are a gem! Thank you.
I always enjoy your presentations. They're loaded with facts backed by references and I always learn something. Thanks for all of your efforts. This is the first time I have commented on your vids but I have seen so many of them.
I love you, man!
Whatever happened to protein folding distributed-compute projects like folding @ home? Did anything come of them to help us engineer biology? Do we know enough probabilistic recursive folding stage trends to decode the adaptive intent and natural selection feedback mechanisms of evolution?
Haven't ever looked into those, so I don't know
Wow, what an unexpected appearance of an Internet celebrity! As well as Tay Zonday!
@tayzonday Have you heard of alphafold?
@@maximj9782 I have not. That's very interesting.
Sounds like it could be more beneficial to take ergothioneine 2 to 4 hours after exercise. I'm guessing it might be most effective for quicker muscle recovery. Anecdotally, I tried it right before exercise with mixed results. NMN seems better with it than AKG. But I'm switching to using it as a post workout supplement than a pre-workout. Let's see what happens....
timing of ergothioneine is probably completely irrelevant - its half life in the body is very long. Rat half life being one month.
Daily intake will raise body levels over time. Even once a week intake will probably lead to steadily rising tissue levels (with an asymptotic approach to a maximum - to see an approximation of what concentration would look like search google for "graph voltage rc charging circuit" )
because it's a very powerful antioxidant it's likely to inhibit some exercise adaptations IMHO while improving others.
I know a couple of studies found some improvements in mitochondrial function in rodents, I'd like to see replicated HUMAN trials of this.
Although if there's money available for research a proper triage would be to study ERGO's effects in dementia & brain in general. It's promising there also and that's a much higher priority, again IMHO.
Amazed at the changed gene expression levels, disappointed at no fly-human hybrids
Understandable...
i LOVE your channel. Discovered you today. Hope to collab 1 day
Here is one for you Nick...the Solfeligia frequencies and their direct relationship to health (healing). All these molecules are nice to learn about but let's get down even deeper into the rabbit hole with all things are energy... frequency, vibration, resonance... Their impact on us is.... EVERYTHING!
Yea this sounds like quackery to me. But hey, happy to be proved a dunce.
Anecdotally this does in fact heal wounds and injuries faster. I've tried high doses on my offspring. All things equal, diet is mostly organ meats, beef tripe, eggs, bone marrow, greens, a bit of fruit, pistachios, macadamia nuts, cashews. Supplements are d2&d3, monomethylsilanetriol, Geranylgeraniol, astaxanthin, occasional rhodiola, lumbrokinase, hylauronic acid 200mg, pqq (20mg once a week). uridine monphosphate (on high potassium intake days, otherwise they'll get leg cramps), omega 3. The l-ergothioneine in high doses i.e 100mg-400mg daily when injury occurs (because kids are walking death traps) I've noticed substantial recovery time. For instance things that would take a couple weeks to heal would heal much faster.
so take it or nah?
underrated- and some might deem it obvious but the opinion of an expert in the area of "Would you take this or not" is quite important when distinguishing between specialized complexity which a lot fo people might not be able to abstract understanding out of- like biomedical studies. While the opposite: informed opinions, like an experts recommendation are more digestible. Mr. Physionic has a PhD, and seems quite fair, so I would love to hear his opinion.
Give it a try! I included it when I was tackling my mysterious health issue, along with 10-20 other supplements, and my health improved. Was ergothioneine the key? No one can say for sure.
take. a gym membership.
@@user-jt7wb3zc1m and when you finish your session come back and eat some liver.
supplements have routinely been shown to be not as effective as food.
so IMHO Eat mushrooms & tempeh, not pills and capsules.
Dr. Nicolas, I admit this is a strange question but i believe it is one that needs to be discussed if you ever do so. That is… for men, does chronic sex and/or masturbation accelerate aging? The reason I ask is because it would not surprise me if this causes stem cell exhaustion as it requires constant large energy resources to regenerate these cells. They are not unlimited from my understanding. Thoughts, video?
Can you do a video on ivermectin?
Pls fix high freq sound in background eg. 0:15
i feel a bit saturated with information recently anyone got a specific enzyme to help with that?
There's some research that shows the compound CH3CH2OH can help.... Although there are some reported side effects.
Plz reduce the volume of your outro. It is too loud to listen with headphones
Where does the ergothianeine come from? Food? Does the study have implications about when one should eat after training?
Foods found to contain ergothioneine include liver, kidney, black beans, kidney bean,
I believe it's also in mushrooms
Mainly mushrooms where it's highest, but varyingly in other crops like beans.
✌️😑
Some of the highest food sources are from mushrooms. The following have high levels of ergothioneine:
King Bolete (Boletus edulis) ( AKA porcini) - often available as dried. I grind them up and put them in my coffee.
Oyster Mushrooms. Shiitake Mushrooms. Maitake Mushrooms. Lion's Mane Mushrooms
The following have decent amounts: white button mushrooms, cremini and portobello.
What about inflammation of exercise and lowering thinks like
White blood cells and other Immine system things
And increasing some liver and kidney parsmeters.
PS. It also increase testosterone so can be used for body repair.... not because we actually increase testosterone