This is literally the first video that really helped me understand the communication within the brain structures themselves. Currently studying for my physical therapy Parkinson’s semester. Thanks a lot!
A big thank you to everyone who watched my first video! I was pleasantly surprised at all the support I got from both the Reddit and UA-cam community. Many of you have told me to get a better microphone, so hopefully this video's sound is an improvement from the last one. Once again, thanks everyone for the support!
Excellent.TY 3 areas of the brain are involved in voluntary movements : Motor cortex Basal ganglia Thalamus These 3 areas are connected by excitatory and inhibitory neurons. When we want to move the motor cortex sends a signal to the basal ganglia. The basal ganglia regulate movement by either activating or inactivating the inhibitory. neurons connecting the basal ganglia and the thalamus. If these inhibitory neurons are activated the neurons connecting the Thalamus to the motor cortex are not allowed to send signals. if those neurons do not fire the motor cortex receives no feedback and no movement occurs. Conversely if these inhibitory neurons are inactivated then nothing is stopping the neurons connecting the Thalamus and the motor cortex from being excited so they activate the motor cortex. which sends signals down the spine to cause certain parts of the body to move. Therefore the basal ganglia essentially decide whether a movement is allowed or not. Two distinct pathways within the basal ganglia can be activated. If the direct pathway is activated the inhibitory neurons connecting the basal ganglion and the thalamus are inactivated and movement occurs. If the indirect pathway is activated the inhibitory neurons are activated and movement is prevented. In fact the indirect pathway is constantly activated allowing you to stay still at rest. When you want to move your body you want the indirect pathway to stop being activated and the direct pathway to be activated. Dopamine released by neurons in the substantial niagra can both activate the direct pathway as well as inactivate the indirect pathway initiating movement. This is because dopamine released by neurons in the substantia nigra can cause both excitatory and inhibitory effects by binding two different receptors : It can bind to the D1 receptor in the starting neuron of the direct pathway to activate it as well as bind to D2 receptors in the starting neurons of the indirect pathway to inactivate it. In healthy people these dopaminergic neurons slowly die out as age increases but in patients with Parkinsons disease this decreases is dramatically accelerated. The reason for this is not known yet. Without dopamine the initiating of movements becomes extremely difficult.
Super useful! My psych prof showed us this video today. There was a girl at the camp I worked at who was diagnosed with Parkinson's disease at age 8 or 9, really great to know more about it.
Very very good.. Very informative, scientifically. We like to watch, in future, more videos of this type, on diseases, with scientifically explained, in details. Many many thanks.
Late/extreme stage Parkinsons can actually get close to killing. Parkinsons destroys swallowing ability in some cases to inhibit intake of fluid/food or necessary medications. Genetic and pesticide **correlates** are tangential. Medicine is better served by avoiding statistical comfort and fundamental causation.
Rigidity in Parkinson's is a symptom that isn't well understood, but it likely involves damage to other areas of the brain along with the basal ganglia. Here's a good article about the pathophysiology of rigidity: Baradaran N, Tan SN, Liu A, et al. Parkinson's disease rigidity: relation to brain connectivity and motor performance. Front Neurol. 2013;4:67. Published 2013 Jun 5.
awesome video, trying to explain to my family almost seems as hard as rocket science. i have fahrs disease, my mother was mis diagnosed with Parkinsons...i always knew it was connected because i have the same symptoms, only not constant and way too young, also parkinsons isnt inherited through a mutant gene. if they would have done a ct scan on her earlier in life it would have been uncovered also my whole family has the tremors. ive had tremors since i was 20, but only recently it has become resting tremor ans not Always. i also have many other parkinsons traits such as memory loss, loss of motor skills, slow coordination etc. could you pkssibly to a video on Fahrs disease or familial basal ganglia calcification?
Both are affected due to the loss of dopamine. Stimulating the direct pathway initiates movement, while stimulating the indirect pathway inhibits movement. Dopamine stimulates the direct pathway and inhibits the indirect pathway, which allows movement to occur. Therefore, a lack of dopamine means less stimulation of the direct pathway and less inhibition of the indirect pathway.
My mom going to three top neurologist all got it wrong except for a neurologist named David Dickof in Yonkers New York he said my mom had cortical basil ganglia degeneration not Alzheimer’s not Lewy body,not frontal temporal lobe and not Parkinson’s but he did say it falls in the family of Parkinson’s actually it’s the cousin of a disease is the same disease that Dudley Moore suffered from for four years before they figured out what he had which is called supra nuclear palsy and this is like the cousin of that disease in any Case my mom passed this past Palm Sunday 2024.... three house doctors in three different nursing homes never heard of it it’s very hard to diagnose we need to put more money towards these brain diseases and afflictions but my mom did live eight years in the dementia she had was short term she never forgot us in the end did he get very bad I’m sure he did but she smiled until she couldn’t open her eyes anymore when she saw us..... One of the red flags was that it shuts down one side of your body and my mom‘s case it was a right arm for years ...Other Doctor said she had bad arthritis and she got worse ..but she learned to write with her left hand and eat...her good arm was called a alien arm .....anyway I miss her dearly and so does the rest of my family.....
je veux vraiment vous aider je sais ce que vous ressentez mais je vous promets que cette fois, votre phytothérapie vous sera envoyée une fois que vous aurez envoyé l'argent
This is literally the first video that really helped me understand the communication within the brain structures themselves. Currently studying for my physical therapy Parkinson’s semester. Thanks a lot!
A big thank you to everyone who watched my first video! I was pleasantly surprised at all the support I got from both the Reddit and UA-cam community. Many of you have told me to get a better microphone, so hopefully this video's sound is an improvement from the last one. Once again, thanks everyone for the support!
It's cool to be one of the first subscribers to a youtube channel that's gonna be so good :)
Medicurio very informative!
This is the clearest explanation I have found - thank you! The "talking" basal ganglia and motor cortex were a nice touch.
This helped a lot for my pharmacology class!
Excellent.TY
3 areas of the brain are involved in voluntary movements :
Motor cortex
Basal ganglia
Thalamus
These 3 areas are connected by excitatory and inhibitory neurons.
When we want to move the motor cortex sends a signal to the basal ganglia.
The basal ganglia regulate movement by either activating or inactivating the inhibitory. neurons connecting the basal ganglia and the thalamus.
If these inhibitory neurons are activated the neurons connecting the Thalamus to the motor cortex are not allowed to send signals. if those neurons do not fire the motor cortex receives no feedback and no movement occurs. Conversely if these inhibitory neurons are inactivated then nothing is stopping the neurons connecting the Thalamus and the motor cortex from being excited so they activate the motor cortex. which sends signals down the spine to cause certain parts of the body to move.
Therefore the basal ganglia essentially decide whether a movement is allowed or not.
Two distinct pathways within the basal ganglia can be activated.
If the direct pathway is activated the inhibitory neurons connecting the basal ganglion and the thalamus are inactivated and movement occurs.
If the indirect pathway is activated the inhibitory neurons are activated and movement is prevented.
In fact the indirect pathway is constantly activated allowing you to stay still at rest. When you want to move your body you want the indirect pathway to stop being activated and the direct pathway to be activated.
Dopamine released by neurons in the substantial niagra can both activate the direct pathway as well as inactivate the indirect pathway initiating movement. This is because dopamine released by neurons in the substantia nigra can cause both excitatory and inhibitory effects by binding two different receptors :
It can bind to the D1 receptor in the starting neuron of the direct pathway to activate it as well as bind to D2 receptors in the starting neurons of the indirect pathway to inactivate it.
In healthy people these dopaminergic neurons slowly die out as age increases but in patients with Parkinsons disease this decreases is dramatically accelerated. The reason for this is not known yet. Without dopamine the initiating of movements becomes extremely difficult.
Keep it up. I am loving this series.
TierZoo brought me here. Please keep up the good work :)
I'm studying for a psychology test and this video really clarified many questions I had. Thank you so much for making it!
Super useful! My psych prof showed us this video today. There was a girl at the camp I worked at who was diagnosed with Parkinson's disease at age 8 or 9, really great to know more about it.
This was so clear and easy to keep up with, thank you so much!
the concept is presented in a very well organised and easy to understand manner. Great video
The animation was very good and the description was also very clear and to the point. Thanks!!
I discovered this channel very late, concise and sufficiently informative 👍
Great video, It would have been cool if you went into more detail about the Substantia Nigra!
You are life-saver! Finally I understand it! Thousand thanks to you!
Very very good.. Very informative, scientifically. We like to watch, in future, more videos of this type, on diseases, with scientifically explained, in details. Many many thanks.
This a great video to understand Parkinson. Thank you.
This video was amazing I am so glad, as a med student im about to watcht these videos all the time!!!!!
good explaination👍
Excellent! Great patient teaching tool.
Intuitive and clearly illustrated , thanks
Dude, you sound exactly like Prismo from adventure time ! So cool, as well as the series !
Good video crystal clear explanation. Thanks
Brilliant video, saved a lot time to read papers
So well explained. Thanks!
yay for reddit, keep it up. last video was cool too
Late/extreme stage Parkinsons can actually get close to killing. Parkinsons destroys swallowing ability in some cases to inhibit intake of fluid/food or necessary medications.
Genetic and pesticide **correlates** are tangential. Medicine is better served by avoiding statistical comfort and fundamental causation.
Well explained video❤.thanks
Thankyou really a very great and easy explanation !!! Congrats
Really well explained! Thanks a lot and again really good video!
Thanks this was so helpful!
Damn this is heaps good, the one i was exactly looking for! thank you so much and keep up the good work
Very clear
wow! great video, I understand this topic much better now!!!
this channel is lit
Well Done!
Thanks...Love from Berhampur, Odisha
You don't disappoint! Keep it up bud!
Nicely done thank you so mutch
What is cause for rigidity when there is less stimulation of direct and indirect pathway
Rigidity in Parkinson's is a symptom that isn't well understood, but it likely involves damage to other areas of the brain along with the basal ganglia. Here's a good article about the pathophysiology of rigidity: Baradaran N, Tan SN, Liu A, et al. Parkinson's disease rigidity: relation to brain connectivity and motor performance. Front Neurol. 2013;4:67. Published 2013 Jun 5.
Thanks 🙏
u made it very simple..... thanks 😊
Tier zoo sent me here aswel you got an subscription.
Dope videos man. keep up the good work
Great video !
Please make more videos :)
Great!
awesome video, trying to explain to my family almost seems as hard as rocket science. i have fahrs disease, my mother was mis diagnosed with Parkinsons...i always knew it was connected because i have the same symptoms, only not constant and way too young, also parkinsons isnt inherited through a mutant gene. if they would have done a ct scan on her earlier in life it would have been uncovered also my whole family has the tremors. ive had tremors since i was 20, but only recently it has become resting tremor ans not Always. i also have many other parkinsons traits such as memory loss, loss of motor skills, slow coordination etc. could you pkssibly to a video on Fahrs disease or familial basal ganglia calcification?
I will look into those diseases!
which type of pathway occurs in parkinson's disease? direct or indirect?
Both are affected due to the loss of dopamine. Stimulating the direct pathway initiates movement, while stimulating the indirect pathway inhibits movement. Dopamine stimulates the direct pathway and inhibits the indirect pathway, which allows movement to occur. Therefore, a lack of dopamine means less stimulation of the direct pathway and less inhibition of the indirect pathway.
Thanks a lot
❤️❤️❤️❤️
Thanks alot
My mom going to three top neurologist all got it wrong except for a neurologist named David Dickof in Yonkers New York he said my mom had cortical basil ganglia degeneration not Alzheimer’s not Lewy body,not frontal temporal lobe and not Parkinson’s but he did say it falls in the family of Parkinson’s actually it’s the cousin of a disease is the same disease that Dudley Moore suffered from for four years before they figured out what he had which is called supra nuclear palsy and this is like the cousin of that disease in any Case my mom passed this past Palm Sunday 2024.... three house doctors in three different nursing homes never heard of it it’s very hard to diagnose we need to put more money towards these brain diseases and afflictions but my mom did live eight years in the dementia she had was short term she never forgot us in the end did he get very bad I’m sure he did but she smiled until she couldn’t open her eyes anymore when she saw us..... One of the red flags was that it shuts down one side of your body and my mom‘s case it was a right arm for years ...Other Doctor said she had bad arthritis and she got worse ..but she learned to write with her left hand and eat...her good arm was called a alien arm .....anyway I miss her dearly and so does the rest of my family.....
nice
omg this is so hlewpful omg sdo helpful i now have an a+ i n everything ogmm
shit wrong video
waaaw💖💖💖goood💖💖💖
je veux vraiment vous aider je sais ce que vous ressentez mais je vous promets que cette fois, votre phytothérapie vous sera envoyée une fois que vous aurez envoyé l'argent
Again great explanation, keep it up man :)