My mom just had an ischemic stroke three weeks ago which led me to watch this video. The doctor is prescribing my mom dopamine, and I wanted to see how it works. Im an accounting major and has absolutely no background about this subject, but this makes so much sense. Thank you for a simple and clear explanation!
I honestly could have not done it without you! Thank you!! My professor took an hour explaining this and I got nothing from it, you took 10 minutes and completely opened my mind.
This was amazing. I finally understand😭😭 Came here after watching a quick two min video on the topic which completely shattered my concepts. But this was❣️🙌🏽
I wonder if Tourette’s stems from dysfunction in the globus paliidus or if their is some over sensitivity/over drive in the striatum. I wonder where the community is leaning…very good video
it's said the striatum sends inhibitory signals to the globus pallidus but the globus pallidus is a part of the striatum, should be a little more specific there
Why is it so that the motor cortex cant communicate directly with the muscles? What is the purpose of requiring conformation from the thalamus in order to move?
What is the name of the excitatory neurotransmitter that goes from the subthalamic nucleus to the substantia nigra? Is it Glu or Dop or something different? Also coming back is it gaba? It would be very helpful if you included all neurotransmitters in the future. : ) LOVE your work! I don't know if you work in connectomics much regarding the 3 types of learning in real time....(physical structure of content, history of content and real time experience of content) I think your mother type voice regulates students making it easy to learn...lol....I know it sounds crazy but I think there is some truth to this. I found it much easier to learn from your videos....I believe I already have circuits in place that recognize the soft tone of your voice....from -9 months to 8 years old my mom had a very gentle tone as I imagine most moms do. Anyway, the point is when we are regulated it is much easier to learn. : )
The neurotransmitter that goes from subthalamic nucleus to substantia nigra is glutamate. Not GABA, it is inhibitory neurotransmitter. Actually, as far as I have read, substantia nigra has two parts- substantia nigra pars compacta and substantia nigra pars reticulata. The one talking to striatum (sending dopamine to striatum) is pars compacta. Pars reticulata, along with globus pallidus (internal) (shown at 1:40), also works to inhibit the thalamus. The glutamate from subthalamic nucleus falls on, and excites, this pars reticulata part of substantia nigra (and on globus pallidus- internal), to increase the inhibition of thalamus, so that thalamus can't excite the motor cortex. This is, in fact, a part of indirect pathway which decreases the muscle movement when it is not needed. They have made another video on indirect pathway, where you might get more details on this.
That u show there in coronal section Gp externus on right side is not that one....but rather is internal capsule....I think the marking is incorrect wrt gp externus
She speaks so eloquently. Wish my prof speaks like her. Very clear, not too fast, not too slow. Love it!
took my professor 90 mins to explain this, and i was still confused came here watched once it now it all makes sense Eureka forrrealll
10 mins gone in a blink, so good and simple; thank you!!!!!
My mom just had an ischemic stroke three weeks ago which led me to watch this video. The doctor is prescribing my mom dopamine, and I wanted to see how it works. Im an accounting major and has absolutely no background about this subject, but this makes so much sense. Thank you for a simple and clear explanation!
I have damage here. Anyone have any treatments or medications that has helped this situation?
the best presentation i have ever seen concerning the basal ganglia. congratulations and thanks. YOU ARE THE BEST
I honestly could have not done it without you! Thank you!! My professor took an hour explaining this and I got nothing from it, you took 10 minutes and completely opened my mind.
4:29 for pathway (for those who just need the visual/audio)
Love your voice. So pleasant to listen to. Thank you.
The greatest explanation I've seen so far on this pathway. This is like the 5th video I'm watching and I finally understood. Thank you so much!
SubhanAllahh!! Thank you for sharing such a good lecture 💕
I’m wondering how all khanacademy members have flawless handwriting!!
🤣🤣🤣
Hiring critera
We can memorize this all day
But
Who are geniuses who figured this pathway out?
hard work and ten of thousands of experiments.
You're voice is so clear and nice way of teaching you got
Unbelievably simple and crisp.. God bless you people..
Not an RN but a DPT Student in neuro semester, thank you for this video!!!
Just so so so thankful to you for this video i got it all in 10 minutes.. God bless you
Learned this in neuroanatomy this week so great timing to revise :-)
This is Just amazing thank you 🤗
This was amazing. I finally understand😭😭
Came here after watching a quick two min video on the topic which completely shattered my concepts. But this was❣️🙌🏽
One of the best video I ever seen..... Thank you so much for understanding basal ganglion 👍
Wow, I love medicine.
2 hours lecture down to 10 mins. thank you
3 hours class in 10 mins......Thank you
Crystal clear concept for me.Thanks.
this is absolutely brilliant. How i wish my lectures were this good at explaining and simplifying
Honestly bless your soul
You guys are the best!! Makes it so much easier!!!
Because I always forget this, I come here every year before my exams and THANK YOU SO MUCH for this video.
That was fricking amazing! Med student here!
Explained everything.. Made very very easy.. Thank you
You're a lifesaver! Many thanks!
incredible that we know so much about how ourselves work
Your videos are incredible - so simply explained!
Great explanation. Thank you!
Very nice, clear and well understood
THE BEST VIDEO ON UA-camEEEE
one of the best video!!! Thank you for making the awesome one💖💖❣
英语听着舒服，讲得也清楚
Great explanation!!
Thank you for making this complex mechanism easy
Very neat lecture. I enjoyed this
YOU. ARE. AMAZING........
Brilliant explanation! Wish I had found this weeks ago! :)
Such a nice speaker🥰 thanks
Best explanation!
You nailed it
Love it.! Soo perfectly explained.! 👌🏻
Teacher! you are a blessing
agreat video , many thanks
Well explained thanks
short but clear. thanks!
thank you so much. very clear.
Excellent! I learned a lot in just 10 mins
Nice. Thank you.
Thank you !! Amazing work💗
You are the best
Best explanation ever..Thank you
Superb explanation!
Thank you very much, it was great
thanks alot.
Hey stop exciting me, I've had enough excitement!!! hahah!!! Loved this video!! Was glued to it till the end!
Wow you made it so simple to understand!! Thank-you!!😊
Clear and simple..tnq😊
very well and evenly understandable explained. thank you! :)
Helps me understand 😅
thankss ! soo helpful
Thank you!
thank you so much for this concise explanation! but could you please tell me, who order the subthalamic nuclei to excite at the 1st place? thanks!
Thank you 😊
Awesome.
I love you, thank you!!!!
So nice 🥰👌🏻😍
Great, thank you so much from Mongolia💕💗
this is amazing!
you made it easy, thank you
thank you very much
Make video on endocanabinoid system
great explanation
Awesome video!
Amazing ....I got the concept😍
You just blowed up my brains!
Eddy Allenby r u alive then
It's time you knowed, the word is blew instead of blowed😜
Great video
Good
Substansia Nigra to Subthalamic nucleus:- "Stop it! Get some help!"🤣🤣
Great, simple, very informative. Only one question: what stimulates Subthalamic Nucleus to send an excitatory signal to Substantia Nigra?)
nothing its constitutively active, like how the thalamus is constitutively inhibited
or at least you can think of it that way for this pathway watch the video on the indirect pathway might clear it up
I wonder if Tourette’s stems from dysfunction in the globus paliidus or if their is some over sensitivity/over drive in the striatum. I wonder where the community is leaning…very good video
Thank you. Really helpful :)
Made easy
this was faaaaaantastic
thank you very much :)
So how do you explain tremors(which I presume is an increase in involuntary movement), in loss of Dopamine in Substantial nigra?
wow super
and they call it direct pathway...WoW ...it looks like when a woman go to the market to buy something
lol
Lol 😂
😂
thank you so much, this explanation was so clear. I wish she was my neuroscience lecturer loool
it's said the striatum sends inhibitory signals to the globus pallidus but the globus pallidus is a part of the striatum, should be a little more specific there
globus pallidus is not part of the striatum. the striatum is the putamen and caudate
Why is it so that the motor cortex cant communicate directly with the muscles? What is the purpose of requiring conformation from the thalamus in order to move?
Please turn up the volume I can hardly hear this. Thank you.
What is the name of the excitatory neurotransmitter that goes from the subthalamic nucleus to the substantia nigra? Is it Glu or Dop or something different? Also coming back is it gaba? It would be very helpful if you included all neurotransmitters in the future. : ) LOVE your work! I don't know if you work in connectomics much regarding the 3 types of learning in real time....(physical structure of content, history of content and real time experience of content) I think your mother type voice regulates students making it easy to learn...lol....I know it sounds crazy but I think there is some truth to this. I found it much easier to learn from your videos....I believe I already have circuits in place that recognize the soft tone of your voice....from -9 months to 8 years old my mom had a very gentle tone as I imagine most moms do. Anyway, the point is when we are regulated it is much easier to learn. : )
The neurotransmitter that goes from subthalamic nucleus to substantia nigra is glutamate. Not GABA, it is inhibitory neurotransmitter.
Actually, as far as I have read, substantia nigra has two parts- substantia nigra pars compacta and substantia nigra pars reticulata. The one talking to striatum (sending dopamine to striatum) is pars compacta. Pars reticulata, along with globus pallidus (internal) (shown at 1:40), also works to inhibit the thalamus. The glutamate from subthalamic nucleus falls on, and excites, this pars reticulata part of substantia nigra (and on globus pallidus- internal), to increase the inhibition of thalamus, so that thalamus can't excite the motor cortex. This is, in fact, a part of indirect pathway which decreases the muscle movement when it is not needed. They have made another video on indirect pathway, where you might get more details on this.
Could you please tell me what is the program used in this clip? I have to make a clip for my senior project. Any recommended programs ? Thank you:)
That u show there in coronal section Gp externus on right side is not that one....but rather is internal capsule....I think the marking is incorrect wrt gp externus
What are the chemicals produced by the Subthalamic Nucleas that excite the Substansia Nigra, please?