Caffeine and Adenosine Receptors
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- Опубліковано 5 кві 2017
- We are all familiar with caffeine's stimulatory effects, but how does it actually work? Check out this episode of Medicurio to learn more about the world's most commonly used psychoactive drug.
I ended off with saying how caffeine has a variety of medicinal uses, but didn't really go in depth. If you would like to learn more, continue reading.
Caffeine as an adjuvant painkiller: Scientists aren't too sure how caffeine can boost the effects of various NSAIDs, but they have a few possible theories: caffeine may slow down the breakdown of NSAIDs, resulting in longer duration of their effect; block pain neurons that use adenosine as a neurotransmitter; or change a person's mood so that even though there is pain, the person doesn't really care about it. If you are interested, this Cochrane review (a paper that summarized the results of over 40 different studies) goes more in-depth into this phenomenon: onlinelibrary.wiley.com/doi/10...
Caffeine can prevent neurodegenerative disease: There have been studies that found a correlation between drinking a few cups of coffee a day and slower onset of neurodegenerative diseases, but it is still unclear how caffeine does this. If you recall from the video, when adenosine stimulates A2A receptors on wake-promoting neurons, those neurons increase in activity. A2A receptors are also found on other neurons and also increase their activity. The idea is that in neurodegenerative diseases, these neurons actually begin to become overworked and die off. When caffeine binds to A2A receptors, it actually allows them to rest, making caffeine a neuroprotective agent. Keep in mind that this is just one theory and may be shown to be completely wrong in a few years time when new research shows an entirely different mechanism, but it is the best guess that scientists have now. - Наука та технологія
Hello everyone! Apologies for not posting sooner, I have been swamped with schoolwork for the past few weeks.
I can't believe that I got my 1000th subscriber a few days ago! You guys are absolutely amazing and I truly appreciate your supportive comments in my videos. Thank you all so much!
I also have a Twitter account now, so feel free to follow me! twitter.com/medicurio
You should do video about LSD, THC and Amphetamine variant ( Medicine prescribe for ADHD )
You are amazing i am studying from you alot of information . Thank you ❤
Very good organized presentation 👏👏👏
"Somehow, caffeine can enhance their painkilling properties" - this will be down to adenosine receptors on the smooth muscles of blood vessels, causing them to constrict (which is what leads to the increase in blood pressure and faster heartbeat rate). One common cause of headache/migraine is caffeine withdrawal, which results in excessive vaso-dilation especially in the brain... this expansion of blood vessels can be very painful, so this pain can be mediated by taking some caffeine (giving people the "slow weening" process) and also anti-inflammatories like ibuprofen which also has a vaso-constrictor effect that counters the caffeine withdrawal through a different pathway (prostacyclin receptors) thus is usually a better option as it doesn't extend the withdrawal process, but may not be sufficient on its own for consumers of large amounts of caffeine.
so much subs by now.
After seeing this ... this confirms my aim to quit it completely once and for all. Always losing control ...dosage higher and higher.
3:25 "...So you wake up feeling refreshed."
No, no I do not.
• Riftis • me neither
So?? This is simply related to your adenosine removal rate *during your sleep* .
And caffeine actually *increases* this rate too (by keeping adenosine less often bound to receptors and thus more open to removal), which is why some people also consume caffeine before taking a power nap as well.
I've never actually woke up refreshed. Not once on my lifetime.
lmao same i feel like the adenosine just gets more
@@lahtine7431 i dont wanna call you a liar but i have a hard time believing that. i mean as a baby/toddler/kid that is very hard to believe.....i think youre exaggerating. but i know how annoying exhaustion is, same for me here since a few months.
extremely informative, this saved me hours of time on Google scholar, thank you for your contribution!
I really enjoyed this video. Well-described and explained. Your voice-overs are also very good! Easy to listen to and understand! Keep up the good work!
Came from Tier Zoo and enjoying it :D
Further down the video and I noticed that having music in the back would help during your pauses
Came from. Tier Zoo as well.
Music will make the voice harder to understand, and if it's simple enough to not be engaging in its own right, it'll soon be repetitive and annoying. Some things are better without music.
Mee too :'D
Me too!
Xanthine family of molecules such as caffeine cause vasoconstriction which is one way it may help with migraines. Purinergic signaling is a very fascinating field and Alan North and Geoff Burnstock have many videos talking about this topic. The P1 receptors family which comprises A₁, A2A, A2B and A₃ are also expressed on cells of the immune system. It is well worth exploring further. Thank you for a good representation of what occurs in the caffeine inhibition of adenosine pathway.
This was so clear and so visually understandable that it's now got me studying how different chemicals affect the body and brain thank you for your amazing work.
I love how you're finally getting consistent views. You deserve it!
Thank you. This deserves to be in a school curriculum. I love biochemistry with a focus on drugs.
I love biochemistry with focus on drugs, too...
This video has been of a tremendous help for me. Very well explained and illustrated, which makes it easy to understand. Thank you very much for sharing it with us!
This was a great video! I don't usually subscribe after one video but I've been convinced easily here.
I'm sad to see that you have so few videos on your channel, but if they're all as high quality as this one I'll eagerly watch them. BTW, you're one of the top searchers if someone searches for this topic.
I quit coffee and caffeine myself so i know how hard it can be. I actually have a couple videos on my channel about how ingot through it all and why I decided to step away from it for good! Great video! Thank you!
you suck
Wow, this was explained in such a simple and understandable way! Thank you!
BRUUUH WHY DOES THIS VIDEO ONLY HAS 165k views? This info is amazing!! Wow! Im subscribing now! Thanks for all this info man!
i went from 2g caffeine / day to quitting caffeine and trust me that first week all you want to do is sleep
2000 mgs a day? Jesus
yep.
that must have been so painful omg
This is TOP TIER channel and content. Insane Detail and easy to follow !
Loved this video. Incredibly well made and explained. Thanks
How didn't I know this amazing channel before?! Your videos are REALLY good!
Holy. Cow. This is so cool!
This was presented in such an easy to understand way and I am mind boggled by how the body operates and adapts.
Thank you for this new, extremely clarifying knowledge!
Thank you!! My Neuroscience Professor breezed passed this slide and I didn't understand it at all.
The diagrams helped!
History, science and great visuals. Keep it up!
Your videos are great! learning about how the body works is plugging into all kinds of thoughts. Thank you!
I am doing a report about caffeine, I found this to be very helpful! Thanks!!
I loved this video! I'm an MD studying for a addiction boards and it was a great way to break up the reading and boring lectures!
Excellent job. This will be helpful for my patients.
Awesome Channel! This is exactly the kind of content I always wanted.
Glad to see you posting again! And just to add my own personal anecdote, I'm pretty sensitive to caffeine. If I ingest it from sources without L-theanine to counter its effect (like soda or coffee) I get really jittery and hyper. It also makes it harder to sleep even if I had it earlier in the morning. Tea and a little dark chocolate are usually fine though.
Anyway, keep up the good work!
Try a chewable GABA supplement. Stops the jitters.
This was very well put. Nice animations with great facts!
These are great! Your videos are digestible and interesting, thanks for making them! I was wondering, what are the odds of you making a video on liver disease?
such a good vid! Decidedto quit my coffee consumption even tho I " only" have one cup a day.
This was awesome, and extremely helpful !
This is the best informational video I have seen on yt
Supplemented what was explained in my lecture perfectly!
Very informative. Thanks for uploading. A note though, acetaminophen (paracetamol) is not an anti-inflammatory.
Great video! Cramming for my presentation in a few hours and this really helped!!
Thank you for the clear explanation of how caffeine works
Just brilliantly explained. Thanks!
Most underrated channel ever.
I love coffee. It is nice to know how it works and how it affects my brain. Thank u.
These videos are great! Quality explanations followed by helpful visuals. Could you work on the audio?
omg I really like this video! I've never found such informative and beneficial thing Thx for making this one
Thank you very much, I have been trying to get to the bottom of my sleep problem for years, soon as I unwind I fall asleep, it is frustrating to loose so much time so regularly
most underrated channel on youtube! thanks brother.
Incredible work, thank you so very much!
Thanks. Now I know more about caffeine. And because I know more about caffeine I can enjoy caffeine more responsibly.
Thank you so much... Loved the way you explained it better than how it is explained at uni 👍
what a nice presentation
A cup of coffee will not fix a lifetime of bad food choices. Chronic diseases are lifestyle caused. Love the video - very informative.
great video!
thanka a lot for this video! you explain it a lot better than my book!
Excellent, understandable explanations!
I'm watching this video at 3:06AM because I might've had a lot of coffee trying to study for exams...I'm always tired though unless I tell myself I need to study :( This was a very informative video; thank you! :)
Excellent presentation!
That’s a very very good explanation how caffeine effects our neurons. Thank you so much for such a detailed information. Great work! 3:53 Amazing!
Wow, i'm drinking a cup of joe right now and this (and the effects of caffeine) are blowing my mind!
Thank you for this video.
Thank you for such an informative video.
I'm just an undergraduate student, and I just clicked this video, even though I don't have this topic in my syllabus, I clearly understood each and every point you said. The explanations are very clear.
Helped me so much with my homework thanks dude
Thanks for explanation.
really amazingly good video
Really interesting. Will be showing this vid to my coffee addicted friend!
This explains why I sometimes need an afternoon nap, even after my morning coffee ☕
Excellent content. love it!
great video. described well.
Great content bro, really great. 🙏🏻
Thank you very much for this video!
well done guy ,please keep it up,i learn so much'once more thank you...
Thank you so much!! This video is very helping💕
If caffeine disappears in 2 - 4 hours, why can I not fall asleep that night, like 8 hours after I've drunk coffee
Caffeine's duration is quite variable between people, so you might just break down caffeine slower than other people simply due to your genetics. I do have to clarify that not all the caffeine disappears within a few hours, only that enough caffeine is eliminated to no longer have a significant stimulatory effect in most people, but if you are genetically more sensitive to caffeine, that residual caffeine may still have an effect and increase the duration of caffeine's effect.
for me one cup of coffee equals 12 hours...or more...i thinkt he ceffeine has long left the brain byt his time but the chaos it caused is still there
the 2-4 hours is BS, actually the cafeine just starts working after 2 hours. Cafeine has a halftime of 6 hours.
*drank
it can take up to 2 months for caffeine to get out of your system.
Hey pal , good explanation..lot of things to learn..loving it🤝🏻
Excellent video. Keep it up!
good video mate! idk If you are still making these videos, but if you do, can you make one about fat breakdown and weight loss?
that was really useful . thanks a lot
Awesome video!!
thanks for sharing
Great video
great job. thank you
Hi I came here from Tier zoo. Your content is great!!
Amazing videos
Love your channel
thank you.
Excellent !!!!
A Brilliant video on Caffeine and Adenosine - essential to learn about adenosine receptors and SA node if you are a patient with palpitations and arrhythmias (I am one). Increases heart rate, activates your sympathetic nervous system and creates more ectopic beats. Also, understand the metabolism of Coffee - some among us are fast metabolizers, and others may be very slow metabolizers - the effects of caffeine last very long if you are a slow metabolizer (mainly depends on Liver p-cytochrome 450 and genetic factors). If you are patient with palpitations and also a slow metabolizer of caffeine, stay away from caffeine - Period. I am a physician, a patient of SVT, and a slow metabolizer of Caffeine, so this comment comes with personal experience.
What's SVT
Excellent
Thanks!!
GREAT VIDEO 😩😩❤️❤️❤️❤️
Good video
Thanks a lot for this very helpful video! However there's something I don't understand: if caffeine simply prevents more adenosin from binding, shouldn't it be that it makes us feel "not any more tired than we currently are", rather than "less tired than we currently are"?
You should try animating the cell nucleus moving around to simulate eye movements
greattttttttt video.. thanks for that
Ive just had the gnarliest caffeine crash of my life, 3 straight days of sleeping and complete exhaustion fatigue, quitting for sure
So it only takes one week to recover?????
I was stalling my productivity to prevent being non-alert in the future. Screw it, I am going take all the caffeine I can buy until I get my degree.
It actually takes 2-3 months to fully recover. First week is worst
I have only been drinking tea for 3 weeks now. It has caffeine but a lot less. Not I am at a point where I don't drink caffeine except from tea, and I don't feel withdrawal on a day without. You can try that.
Very nice
Regarding how caffeine is a diuretic (6m)... if you drink 8oz of coffee, will you urinate more or less than 8oz of water? i.e. can you become de-hydrated by drinking coffee?
Also, any thoughts on the coffee nap? Supposedly, waking up before the caffeine has had a chance to block the adenosine receptors pushes out the time when you would normally start feeling tired again... as sleep pressure increases during the day, the circadian rhythm is balanced by the brain protein hypocretin/orexin, which drives wakefulness... so bathing tnf-alpha / interleukin nuerons induce sleep!
I really appreciate this video. It is very well done. I was just looking for how caffeine and alcohol is not a good combination; and, instead I caught myself in 8 minutes looking at this video lol #cheers
I like your video too, just like your other viewers. Great job!
I got sleep epilepsy because I got addicted to energy drinks in the night. I've started to get better after a whilst - what's the best way of getting the adenosine mechanism back up a gear after being addicted to coffee for so long and possibly still having bits built up etc
It might've already been mentioned but acetaminophen (Tylenol) is not an NSAID, but an analgesic...easily confused! But you were right about aspirin, it is classified as anti-inflammatory!
Came here to say the same thing lol, great video tho